Clinical analysis on the influencing factors of cognitive impairment in 65 alcohol dependent patients_West China Medical Journal

Authors：

 CAO Bingrong , CHEN Juan , HE Ying , YANG Zi , XIA Ying

Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

CAO Bingrong, Email: roth13579@163.com

Keywords：

Alcohol dependence; Cognitive function; Montreal Cognitive Assessment

DOI：

10.7507/1002-0179.201507149

Video：

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Objective To explore the characteristics of cognitive impairment in patients with alcohol dependence, and analyze the related influencing factors. Methods The Montreal Cognitive Assessment Scale (MoCA) was used to evaluate the cognitive function of 65 alcohol dependent patients hospitalized between January 1st and December 31st, 2014. The features of cognitive impairment and related influencing factors were analyzed. Results The differences of MoCA attention and delayed recall between different drinking year groups had statistical significance (P<0.05). The correlations of drinking year with MoCA attention (r=–0.250,P=0.044), and with delayed recall (r=–0.326,P=0.008) were both negative. MoCA scores, naming, attention and delayed recall were different statistically among different age groups (P<0.05). The correlations of ages with MoCA scores (r=–0.429,P<0.001), naming (r=–0.261,P=0.035), attention (r=–0.391,P=0.001) and delayed recall (r=–0.461,P<0.001) were all negative. MoCA scores, the visuoconstructional skills, language, abstraction and delayed recall were significantly different among different education level groups (P<0.05). The correlations of education level with MoCA scores (r_s=0.650,P<0.001), the visuoconstructional skills (r_s=0.540,P<0.001), language (r_s=0.486,P<0.001), abstraction (r=0.602,P<0.001) and delayed recall (r_s=0.593,P<0.001) were all positive. Ages had an effect on MoCA scores by multiple linear regression analysis (P<0.01). Conclusions For alcohol dependent patients with cognitive impairment, cognitive function is correlated with drinking year, age and education level. The cognitive function is much serious in patients with older age and longer drinking years. This kind of patients should be focused on and intervened early.

Citation： CAO Bingrong, CHEN Juan, HE Ying, YANG Zi, XIA Ying. Clinical analysis on the influencing factors of cognitive impairment in 65 alcohol dependent patients. West China Medical Journal, 2017, 32(5): 731-735. doi: 10.7507/1002-0179.201507149 Copy

1.	?李艷祥, 王學義. 酒依賴對認知功能的影響. 中國藥物依賴性雜志, 2009, 18(5): 380-383.
2.	Gupta S, Warner J. Alcohol-related dementia: a 21st-century silent epidemic? Br J Psychiatry, 2008, 193(5): 351-353.
3.	黃燕萍. 慢性酒依賴者認知功能的對照研究. 中國行為醫學科學, 2005, 14(4): 332-333.
4.	閆社因, 葛金釗, 牛艷, 等. 酒精所致精神障礙患者的 P300、智能損害及相關因素研究. 臨床精神醫學雜志, 2012, 22(1): 21-23.
5.	張惠光, 張天琦, 商玉潔, 等. 蒙特利爾認知評估量表在評估慢性酒精中毒致認知損害的應用與相關臨床因素分析. 中風與神經疾病雜志, 2012, 29(3): 229-231.
6.	孫云闖, 秦斌. MoCA 和 MMSE 在輕度認知障礙中的應用比較. 中國神經免疫學和神經病學雜志, 2010, 17(2): 138-140.
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8.	王偉男, 李喜潑, 叢曉山. 保定市酒精濫用和酒精依賴的流行病學調查. 上海精神醫學, 2008, 20(4): 209-212.
9.	黃敬, 栗克清, 劉德芳, 等. 河北省酒精濫用和依賴性障礙流行病學調查. 中國藥物濫用防治雜志, 2008, 14(1): 33-34, 58.
10.	華俊杰, 胡峻梅, Coid JW等. 成都市 18-34 歲男性青年酒精濫用影響因素分析. 中國公共衛生, 2014, 30(5): 556-559.
11.	劉剛, 謝世平, 范儉雄, 等. 結構磁共振和¹H-磁共振波譜對酒精性認知損害的研究. 國際精神病學雜志, 2007, 34(4): 228-230.
12.	李艷祥, 王學義, 姚紹敏, 等. 酒依賴者戒飲期認知功能及其相關因素研究. 中國藥物依賴性雜志, 2010, 19(2): 100-104.
13.	郭佳翔. 蒙特利爾認知評估量表中文版的初步應用. 北京協和醫學院: 中國醫學科學院, 2011.
14.	張立秀, 劉雪琴. 蒙特利爾認知評估量表中文版的信效度研究. 護理研究, 2007, 21(31): 2906-2907.

1. ?李艷祥, 王學義. 酒依賴對認知功能的影響. 中國藥物依賴性雜志, 2009, 18(5): 380-383.
2. Gupta S, Warner J. Alcohol-related dementia: a 21st-century silent epidemic? Br J Psychiatry, 2008, 193(5): 351-353.
3. 黃燕萍. 慢性酒依賴者認知功能的對照研究. 中國行為醫學科學, 2005, 14(4): 332-333.
4. 閆社因, 葛金釗, 牛艷, 等. 酒精所致精神障礙患者的 P300、智能損害及相關因素研究. 臨床精神醫學雜志, 2012, 22(1): 21-23.
5. 張惠光, 張天琦, 商玉潔, 等. 蒙特利爾認知評估量表在評估慢性酒精中毒致認知損害的應用與相關臨床因素分析. 中風與神經疾病雜志, 2012, 29(3): 229-231.
6. 孫云闖, 秦斌. MoCA 和 MMSE 在輕度認知障礙中的應用比較. 中國神經免疫學和神經病學雜志, 2010, 17(2): 138-140.
7. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 2005, 53(4): 695-699.
8. 王偉男, 李喜潑, 叢曉山. 保定市酒精濫用和酒精依賴的流行病學調查. 上海精神醫學, 2008, 20(4): 209-212.
9. 黃敬, 栗克清, 劉德芳, 等. 河北省酒精濫用和依賴性障礙流行病學調查. 中國藥物濫用防治雜志, 2008, 14(1): 33-34, 58.
10. 華俊杰, 胡峻梅, Coid JW等. 成都市 18-34 歲男性青年酒精濫用影響因素分析. 中國公共衛生, 2014, 30(5): 556-559.
11. 劉剛, 謝世平, 范儉雄, 等. 結構磁共振和¹H-磁共振波譜對酒精性認知損害的研究. 國際精神病學雜志, 2007, 34(4): 228-230.
12. 李艷祥, 王學義, 姚紹敏, 等. 酒依賴者戒飲期認知功能及其相關因素研究. 中國藥物依賴性雜志, 2010, 19(2): 100-104.
13. 郭佳翔. 蒙特利爾認知評估量表中文版的初步應用. 北京協和醫學院: 中國醫學科學院, 2011.
14. 張立秀, 劉雪琴. 蒙特利爾認知評估量表中文版的信效度研究. 護理研究, 2007, 21(31): 2906-2907.

West China Medical Journal

Clinical analysis on the influencing factors of cognitive impairment in 65 alcohol dependent patients

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