<trans-title xml:lang="en"/>_West China Medical Journal

Authors：

劉雯 ¹ ,  苗佳 ¹ , 王佑娟 ²

1. ;
2. ;

Corresponding?author：

苗佳, Email: miaosiyi1971@163.com

Keywords：

脂肪餐負荷試驗; 餐后高脂血癥; 心血管疾病; 胰島素抵抗; 2 型糖尿病

DOI：

10.7507/1002-0179.201507038

Video：

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Abstract Full text Figures/Tables Video References Cited by

臨床常規血脂檢查要求采集清晨空腹血，但現實生活中人體絕大部分時間處于餐后狀態，僅檢測空腹血脂水平不足以反映機體真實的脂代謝全貌。近年來國內外較多研究通過脂肪餐負荷試驗，探討了餐后血脂的變化過程及其與血管內皮病變、心血管疾病及胰島素抵抗、2 型糖尿病等發生發展的相關性。本文對脂肪餐負荷試驗及餐后高脂血癥與相關疾病的研究進行了綜述。

Citation： 劉雯, 苗佳, 王佑娟. . West China Medical Journal, 2017, 32(3): 465-470. doi: 10.7507/1002-0179.201507038 Copy

1.	諸駿仁, 高潤霖, 趙水平, 等. 中國成人血脂異常防治指南(2016年修訂版). 中國循環雜志, 2016(10): 937-953.
2.	Boquist S, Ruotolo G, Tang R,et al. Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation, 1999, 100(7): 723-728.
3.	Sharrett AR, Chambless LE, Heiss G,et al. Association of postprandial triglyceride and retinyl palmitate resposes with asymptomatic carotid artery atherosclerosis in middle-aged men and women. The Atherosclerosis Risk in Communities Study. Arterioscler Thromb Vasc Biol, 1995, 15(12): 2122-2129.
4.	Maraki M, Aggelopoulou N, Christodoulou N,et al. Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia. Clin Nutr, 2011, 30(6): 852-857.
5.	劉玲, 趙水平, 程艷春, 等. 檢測高脂餐后高甘油三酯血癥的最佳時間切點. 中華內分泌代謝雜志, 2004, 20(1): 23-25.
6.	張原力, 游凱, 方圻. 脂餐后血清甘油三酯代謝異常作為冠心病獨立危險因素的探討. 中華心血管病雜志, 1998, 26(2): 89.
7.	劉悅, 沈建國. 老年糖尿病患者脂肪餐后甘油三酯的變化及其對血管內皮功能的影響. 中國老年學雜志, 2014(17): 4775-4777.
8.	Mihas C, Kolovou GD, Mikhailidis DP,et al. Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis. Curr Vasc Pharmacol, 2011, 9(3): 271-280.
9.	Hald EM, Br?kkan SK, Vik A,et al. Postprandial lipemia is not increased in patients with previous unprovoked venous thromboembolism. J Clin Lipidol, 2013, 7(1): 48-55.
10.	Kolovou GD, Mikhailidis DP, Kovar J,et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol, 2011, 9(3): 258-270.
11.	Teno S, Uto Y, Nagashima H,et al. Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. Diabetes Care, 2000, 23(9): 1401-1406.
12.	Albert MA, Glynn RJ, Buring J,et al. Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events. Circulation, 2006, 114(24): 2619-2626.
13.	Ambrose JA, Singh M. Pathophysiology of coronary artery disease leading to acute coronary syndromes. F1000Prime Rep, 2015, 7: 08.
14.	Tesfamariam B, Defelice AF. Endothelial injury in the initiation and progression of vascular disorders. Vascul Pharmacol, 2007, 46(4): 229-237.
15.	Anderson TJ, Gerhard MD, Meredith IT,et al. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol, 1995, 75(6): 71B-74B.
16.	Petnehazy T, Stokes KY, Russell JM,et al. Angiotensin II type-1 receptor antagonism attenuates the inflammatory and thrombogenic responses to hypercholesterolemia in venules. Hypertension, 2005, 45(2): 209-215.
17.	Steinberg D. Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans. J Lipid Res, 2005, 46(2): 179-190.
18.	Austin MA. Plasma triglyceride and coronary heart disease. Arterioscler Thromb, 1991, 11(1): 2-14.
19.	Bae JH, Bassenge E, Kim KB,et al. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis, 2001, 155(2): 517-523.
20.	Blendea MC, Bard M, Sowers JR,et al. High-fat meal impairs vascular compliance in a subgroup of young healthy subjects. Metabolism, 2005, 54(10): 1337-1344.
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24.	Nordestgaard BG, Benn M, Schnohr P,et al. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA, 2007, 298(3): 299-308.
25.	Bansal S, Buring JE, Rifai N,et al. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA, 2007, 298(3): 309-316.
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30.	Karpe F, Bell M, Bj?rkegren J,et al. Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100. Arterioscler Thromb Vasc Biol, 1995, 15(2): 199-207.
31.	Schneeman BO, Kotite L, Todd KM,et al. Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proc Natl Acad Sci U S A, 1993, 90(5): 2069-2073.
32.	Moreton JR. Chylomicronemia, fat tolerance, and atherosclerosis. International Journal of Epidemiology, 1950, 35(3): 373-384.
33.	Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation, 1979, 60(3): 473-485.
34.	Anderson TJ. Assessment and treatment of endothelial dysfunction in humans. J Am Coll Cardiol, 1999, 34(3): 631-638.
35.	Karpe F, Steiner G, Uffelman K,et al. Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis, 1994, 106(1): 83-97.
36.	Barritt DW. Alimentary lipaemia in men with coronary artery disease and in controls. Br Med J, 1956, 2(4993): 640-644.
37.	張若青, 楊春燕, 李潔冰, 等. 餐后血脂代謝異常與冠狀動脈病變嚴重程度關系研究. 河北醫藥, 2009, 31(13): 1556-1558.
38.	楊勝茹, 郜舟順, 趙志強, 等. 空腹血脂正常的冠心病患者高、低脂肪餐后血脂的變化. 天津醫藥, 2009, 37(3): 215-216.
39.	Boquist S, Ruotolo G, Tang R,et al. Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation, 1999, 100(7): 723-728.
40.	Langsted A, Freiberg JJ, Tybjaerg-Hansen A,et al. Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up. J Intern Med, 2011, 270(1): 65-75.
41.	Lindman AS, Veier?d MB, Tverdal A,et al. Nonfasting triglycerides and risk of cardiovascular death in men and women from the Norwegian Counties Study. Eur J Epidemiol, 2010, 25(11): 789-798.
42.	Fletcher B, Lamendola C. Insulin resistance syndrome. J Cardiovasc Nurs, 2004, 19(5): 339-345.
43.	Mcgarry JD. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes, 2002, 51(1): 7-18.
44.	Smith-Marsh D. Pharmacological strategies for preventing type 2 diabetes in patients with impaired glucose tolerance. Drugs Today (Barc), 2013, 49(8): 499-507.
45.	Lewis GF, O'meara NM, Soltys PA,et al. Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities. J Clin Endocrinol Metab, 1991, 72(4): 934-944.
46.	Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes, 2001, 50 Suppl 1(2): S118.
47.	Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev, 1998, 14(4): 263-283.
48.	Mcgarry JD. What if minkowski had been ageusic? an alternative angle on diabetes. Science, 1992, 258(583): 766-770.
49.	Koyama K, Chen G, Lee Y,et al. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol, 1997, 273(4 Pt 1): E708-E713.
50.	Lee Y, Hirose H, Ohneda M,et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A, 1994, 91(23): 10878-10882.
51.	Marceau P, Biron S, Hould FS,et al. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab, 1999, 84(5): 1513-1517.
52.	Picard F, Boivin A, Lalonde J,et al. Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Am J Physiol Endocrinol Metab, 2002, 282(2): E412-E418.
53.	Schrezenmeir J, Keppler I, Fenselau S,et al. The phenomenon of a high triglyceride response to an oral lipid load in healthy subjects and its link to the metabolic syndrome. Ann N Y Acad Sci, 1993, 683(1): 302-314.
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1. 諸駿仁, 高潤霖, 趙水平, 等. 中國成人血脂異常防治指南(2016年修訂版). 中國循環雜志, 2016(10): 937-953.
2. Boquist S, Ruotolo G, Tang R,et al. Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation, 1999, 100(7): 723-728.
3. Sharrett AR, Chambless LE, Heiss G,et al. Association of postprandial triglyceride and retinyl palmitate resposes with asymptomatic carotid artery atherosclerosis in middle-aged men and women. The Atherosclerosis Risk in Communities Study. Arterioscler Thromb Vasc Biol, 1995, 15(12): 2122-2129.
4. Maraki M, Aggelopoulou N, Christodoulou N,et al. Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia. Clin Nutr, 2011, 30(6): 852-857.
5. 劉玲, 趙水平, 程艷春, 等. 檢測高脂餐后高甘油三酯血癥的最佳時間切點. 中華內分泌代謝雜志, 2004, 20(1): 23-25.
6. 張原力, 游凱, 方圻. 脂餐后血清甘油三酯代謝異常作為冠心病獨立危險因素的探討. 中華心血管病雜志, 1998, 26(2): 89.
7. 劉悅, 沈建國. 老年糖尿病患者脂肪餐后甘油三酯的變化及其對血管內皮功能的影響. 中國老年學雜志, 2014(17): 4775-4777.
8. Mihas C, Kolovou GD, Mikhailidis DP,et al. Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis. Curr Vasc Pharmacol, 2011, 9(3): 271-280.
9. Hald EM, Br?kkan SK, Vik A,et al. Postprandial lipemia is not increased in patients with previous unprovoked venous thromboembolism. J Clin Lipidol, 2013, 7(1): 48-55.
10. Kolovou GD, Mikhailidis DP, Kovar J,et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol, 2011, 9(3): 258-270.
11. Teno S, Uto Y, Nagashima H,et al. Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. Diabetes Care, 2000, 23(9): 1401-1406.
12. Albert MA, Glynn RJ, Buring J,et al. Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events. Circulation, 2006, 114(24): 2619-2626.
13. Ambrose JA, Singh M. Pathophysiology of coronary artery disease leading to acute coronary syndromes. F1000Prime Rep, 2015, 7: 08.
14. Tesfamariam B, Defelice AF. Endothelial injury in the initiation and progression of vascular disorders. Vascul Pharmacol, 2007, 46(4): 229-237.
15. Anderson TJ, Gerhard MD, Meredith IT,et al. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol, 1995, 75(6): 71B-74B.
16. Petnehazy T, Stokes KY, Russell JM,et al. Angiotensin II type-1 receptor antagonism attenuates the inflammatory and thrombogenic responses to hypercholesterolemia in venules. Hypertension, 2005, 45(2): 209-215.
17. Steinberg D. Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans. J Lipid Res, 2005, 46(2): 179-190.
18. Austin MA. Plasma triglyceride and coronary heart disease. Arterioscler Thromb, 1991, 11(1): 2-14.
19. Bae JH, Bassenge E, Kim KB,et al. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis, 2001, 155(2): 517-523.
20. Blendea MC, Bard M, Sowers JR,et al. High-fat meal impairs vascular compliance in a subgroup of young healthy subjects. Metabolism, 2005, 54(10): 1337-1344.
21. 林金秀, 柴大軍, 吳可貴, 等. 正常人餐后甘油三酯動態代謝對血清一氧化氮和血漿內皮素1的影響. 中國動脈硬化雜志, 2001, 9(3): 227-230.
22. 張繪莉, 趙水平, 劉玲. 冠心病患者攝入不同量脂肪餐后血脂水平的變化及其對血管內皮功能的影響. 中國循環雜志, 2001, 16(1): 24-26.
23. 陳玲, 柴大軍, 林新霖, 等. 高分辨率超聲研究餐后高甘油三酯血癥對正常人血管內皮功能的損傷. 中國超聲醫學雜志, 2001, 17(11): 848-851.
24. Nordestgaard BG, Benn M, Schnohr P,et al. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA, 2007, 298(3): 299-308.
25. Bansal S, Buring JE, Rifai N,et al. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA, 2007, 298(3): 309-316.
26. Freiberg JJ, Tybjaerg-Hansen A, Jensen JS,et al. Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA, 2008, 300(18): 2142-2152.
27. Zilversmit DB. A proposal linking atherogenesis to the interaction of endothelial lipoprotein lipase with triglyceride-rich lipoproteins. Circ Res, 1973, 33(6): 633-638.
28. Ross R, Harker L. Hyperlipidemia and atherosclerosis. Science, 1976, 193(4258): 1094-1100.
29. Cohn JS, Johnson EJ, Millar JS,et al. Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J Lipid Res, 1993, 34(12): 2033-2040.
30. Karpe F, Bell M, Bj?rkegren J,et al. Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100. Arterioscler Thromb Vasc Biol, 1995, 15(2): 199-207.
31. Schneeman BO, Kotite L, Todd KM,et al. Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proc Natl Acad Sci U S A, 1993, 90(5): 2069-2073.
32. Moreton JR. Chylomicronemia, fat tolerance, and atherosclerosis. International Journal of Epidemiology, 1950, 35(3): 373-384.
33. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation, 1979, 60(3): 473-485.
34. Anderson TJ. Assessment and treatment of endothelial dysfunction in humans. J Am Coll Cardiol, 1999, 34(3): 631-638.
35. Karpe F, Steiner G, Uffelman K,et al. Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis, 1994, 106(1): 83-97.
36. Barritt DW. Alimentary lipaemia in men with coronary artery disease and in controls. Br Med J, 1956, 2(4993): 640-644.
37. 張若青, 楊春燕, 李潔冰, 等. 餐后血脂代謝異常與冠狀動脈病變嚴重程度關系研究. 河北醫藥, 2009, 31(13): 1556-1558.
38. 楊勝茹, 郜舟順, 趙志強, 等. 空腹血脂正常的冠心病患者高、低脂肪餐后血脂的變化. 天津醫藥, 2009, 37(3): 215-216.
39. Boquist S, Ruotolo G, Tang R,et al. Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation, 1999, 100(7): 723-728.
40. Langsted A, Freiberg JJ, Tybjaerg-Hansen A,et al. Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up. J Intern Med, 2011, 270(1): 65-75.
41. Lindman AS, Veier?d MB, Tverdal A,et al. Nonfasting triglycerides and risk of cardiovascular death in men and women from the Norwegian Counties Study. Eur J Epidemiol, 2010, 25(11): 789-798.
42. Fletcher B, Lamendola C. Insulin resistance syndrome. J Cardiovasc Nurs, 2004, 19(5): 339-345.
43. Mcgarry JD. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes, 2002, 51(1): 7-18.
44. Smith-Marsh D. Pharmacological strategies for preventing type 2 diabetes in patients with impaired glucose tolerance. Drugs Today (Barc), 2013, 49(8): 499-507.
45. Lewis GF, O'meara NM, Soltys PA,et al. Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities. J Clin Endocrinol Metab, 1991, 72(4): 934-944.
46. Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes, 2001, 50 Suppl 1(2): S118.
47. Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev, 1998, 14(4): 263-283.
48. Mcgarry JD. What if minkowski had been ageusic? an alternative angle on diabetes. Science, 1992, 258(583): 766-770.
49. Koyama K, Chen G, Lee Y,et al. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol, 1997, 273(4 Pt 1): E708-E713.
50. Lee Y, Hirose H, Ohneda M,et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A, 1994, 91(23): 10878-10882.
51. Marceau P, Biron S, Hould FS,et al. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab, 1999, 84(5): 1513-1517.
52. Picard F, Boivin A, Lalonde J,et al. Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Am J Physiol Endocrinol Metab, 2002, 282(2): E412-E418.
53. Schrezenmeir J, Keppler I, Fenselau S,et al. The phenomenon of a high triglyceride response to an oral lipid load in healthy subjects and its link to the metabolic syndrome. Ann N Y Acad Sci, 1993, 683(1): 302-314.
54. Jeppesen J, Hollenbeck CB, Zhou MY,et al. Relation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia. Arterioscler Thromb Vasc Biol, 1995, 15(3): 320-324.
55. Vansant G, Mertens A, Muls E. Determinants of postprandial lipemia in obese women. Int J Obes Relat Metab Disord, 1999, 23(Suppl 1): 14-21.
56. Hahn PF. ABOLISHMENT OF ALIMENTARY LIPEMIA FOLLOWING INJECTION OF HEPARIN. Science, 1943, 98(2531): 19-20.
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