系統性紅斑狼瘡患者骨髓病態造血的臨床分析_West China Medical Journal

Authors：

 曹紅 , 何秋連 , 馬春蓉

南充市中心醫院血液內科四川南充 637000;

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Keywords：

系統性紅斑狼瘡; 血細胞減少; 骨髓病態造血

DOI：

10.7507/1002-0179.20150317

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目的探討系統性紅斑狼瘡（SLE）伴發血細胞減少的患者骨髓病態造血的出現概率及其與狼瘡病情的關系。方法回顧性分析2010年1月－2013年6月32例伴發血細胞減少的SLE患者資料，分析骨髓病態造血情況及其與臨床病情的關系。結果 SLE例患者中15例存在骨髓病態造血。粒、紅、巨核系均可出現，其中紅系單系病態造血5例，粒系單系病態造血4例，巨核系單系病態造血2例，粒紅兩系病態造血4例。出現病態造血的患者其疾病活動度[（38.5±10.3）分]較未出現病態造血的患者[（7.6±4.6）分]嚴重，差異有統計學意義（t’=10.714，P＜0.001）。3例患者狼瘡病情好轉后復查骨髓涂片，病態造血消失。結論 SLE伴發血細胞下降的患者出現病態造血的發生率不低，其病態造血隨病情好轉是可逆的。

Citation： 曹紅, 何秋連, 馬春蓉. 系統性紅斑狼瘡患者骨髓病態造血的臨床分析. West China Medical Journal, 2015, 30(6): 1109-1111. doi: 10.7507/1002-0179.20150317 Copy

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1. 胡喜梅, 樊志榮, 周水陽, 等. 系統性紅斑狼瘡血液學異常與臨床特點[J]. 中國實驗血液學雜志, 2004, 12(2):170-173.
2. 王桂菊. 系統性紅斑狼瘡相關性血液病血液學異常臨床特點[J]. 中國實驗血液學雜志, 2002, 10(4):359-361.
3. Oka Y, Kameoka J, Hirabayashi Y, et al. Reversible bone marrow dysplasia in patients with systemic lupus erythematosus[J]. Intern Med, 2008, 47(8):737-742.
4. Papadaki HA. Autoreactive T-lymphocytes are implicated in the pathogenesis of bone marrow failure in patients with systemic lupus erythematosus[J]. Leuk Lymphoma, 2003, 44(8):1301-1307.
5. Sun LY, Zhou KX, Feng XB, et al. Abnormal surface markers expression on bone marrow CD34⁺ cells and correlation with disease activity in patients with systemic lupus erythematosus[J]. Clin Rheumatol, 2007, 26(12):2073-2079.
6. 李只福. 系統性紅斑狼瘡病人的血液系統改變及處理[J]. 中華風濕病學雜志, 2001, 5(3):139-141.
7. Li X, Wu L, Ying S, et al. Clonality investigation of morphologically dysplastic hematopoietic cells in myelodysplastic syndrome marrows[J]. Int J Hematol, 2008, 87(2):176-183.
8. Papo T, Andre MH, Amoura Z, et al. The spectrum of reactive hemophagocytic syndrome in systemic lupus erythematosus[J].J Rheumatol, 1999, 26(4):927-930.
9. Nawata M, Suzuki J, Ikeda K, et al. Haemophagocytic syndrome in a systemic lupus erythematosus patient with antiphospholipid antibodies[J]. Rheumatology, 2001, 40(7):828-829.
10. van Bekkum DW. Autologous stem cell transplantation for treatment of autoimmune diseases[J]. Stem Cells, 1999, 17(3):172-178.
11. 黃林喜, 吳賢仁. 血細胞減少的系統性紅斑狼瘡45例骨髓細胞學表現及治療反應[J]. 中華全科醫師雜志, 2005, 4(1):44-45.
12. 許杰州, 曾慶馀, 肖征宇, 等. 血細胞減少的系統性紅斑狼瘡患者骨髓細胞學表現[J]. 中華皮膚科雜志, 2001, 34(5):382.

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系統性紅斑狼瘡患者骨髓病態造血的臨床分析

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