Effect of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cerebral Dysfunction Induced by Traumatic Brain Injury_West China Medical Journal

Authors：

 LUOChang-bin ,  CAOLing-hong , YANGCheng-hao

Emergency Department, the Fourth People's Hospital of Zigong, Zigong, Sichuan 643000, P. R. China;

Corresponding?author：

CAOLing-hong, Email: 591765270@qq.com

Keywords：

Hyperbaric oxygen; Nimodipine; Traumatic brain injury; Cerebral dysfunction

DOI：

10.7507/1002-0179.20150292

Video：

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Objective To study the effect of hyperbaric oxygen combined with nimodipine in the treatment of cerebral dysfunction resulted from traumatic brain injury. Method We retrospectively collected and analyzed the data of 124 patients with cerebral dysfunction induced by traumatic brain injury, admitted to the Neurosurgery Department during February 2011 to February 2014. All the patients were divided into the traditional treatment group (n=45), the traditional treatment with hyperbaric oxygen group (HBO group, n=40) and the traditional treatment with nimodipine and hyperbaric oxygen group (integrated group, n=39). The differences among the three groups in neurological injury severity evaluated by National Institute of Health Stroke Scale and the cerebral blood flow were recorded and analyzed at three time points (before the treatment, 2 and 4 weeks after treatment). Results There was no significant difference in neurological injury severity and cerebral blood flow among these three groups before treatment (P>0.05). Evaluated at 2 and 4 weeks after treatments, the neurological injury severity of HBO group and integrated group were significantly less than the traditional treatment group (P<0.05); the neurological severity score of integrated group was significantly lower than the HBO group (P<0.05); the cerebral blood flow of HBO group and integrated group were significantly higher than the traditional treatment group (P<0.05); and the cerebral blood flow of integrated group was significantly higher than the HBO group (P<0.05). Conclusions The combination therapy of hyperbaric oxygen combined with nimodipine is effective in the treatment of cerebral dysfunction induced by traumatic brain injury, because of its attenuation of neurological injury severity and increase of cerebral blood flow.

Citation： LUOChang-bin, CAOLing-hong, YANGCheng-hao. Effect of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cerebral Dysfunction Induced by Traumatic Brain Injury. West China Medical Journal, 2015, 30(6): 1015-1018. doi: 10.7507/1002-0179.20150292 Copy

1.	張建華, 楊文東. 高壓氧對重型閉合性顱腦損傷患者氧自由基和紅細胞CR1分子表達的影響[J]. 濱州醫學院學報, 2007, 30(2):157-159.
2.	王忠誠. 王忠誠神經外科學[M]. 武漢:湖北科學技術出版社, 2004:66-67.
3.	Weyland A, Buhre W, Grund S, et al. Cerebrovascular tone rather than intracranial pressure determines the effective downstream pressure of the cerebral circulation in the absence of intracranial hypertension[J]. J Neurosurg Anesthesiol, 2000, 12(3):210-216.
4.	Sukoff MH. Effects of hyperbaric oxygenation[J]. J Neurosurg, 2001, 95(3):544-546.
5.	Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients[J]. J Neurosurg, 2001, 94(3):403-411.
6.	高春錦, 楊捷運, 瞿曉輝. 高壓氧醫學基礎與臨床[M]. 北京:人民衛生出版社, 2008:300-309.
7.	易治, 翁其彪. 高壓氧醫學教程[M]. 廣州:暨南大學出版社, 2012:28-31.
8.	張艷平, 楊崇選, 任家庚, 等. 早期高壓氧治療彌漫性軸索損傷的療效分析[J]. 牡丹江醫學院學報, 2013, 34(5):17-19.
9.	胡青, 許小林, 陳益番, 等. 法舒地爾聯合尼莫地平治療蛛網膜下腔出血(SAH)的療效及安全性探討[J]. 中外醫療, 2013, 32(15):109, 111.
10.	楊鶴云, 楊正宇, 張紅蓮, 等. 尼莫地平對高血壓腦出血患者腦血腫,水腫及神經功能恢復的影響[J]. 中國醫藥科學, 2015, 5(1):121-123.
11.	楊玉亭, 許愛琴, 李光華. 尼莫地平對大鼠急性腦缺血再灌注損傷的保護機制[J]. 齊齊哈爾醫學院學報, 2006, 27(2):139-140.
12.	封林森, 馬建華, 劉藝春, 等. 高壓氧聯合尼莫地平治療對顱腦損傷血液流變學的影響[J]. 中國血液流變學雜志, 2008, 18(1):62-63, 95.
13.	Sun BL, Xia ZL, Yang MF, et al. Effects of Ginkgo biloba extract on somatosensory evoked potential, nitric oxide levels in serum and brain tissue in rats with cerebral vasospasm after subarachnoid hemorrhage[J]. Clin Hemorheol Mieroeire, 2000, 23(2/3/4):139-144.
14.	陳瑾歆, 唐聰明. 氧自由基的研究進展[J]. 海南醫學院學報, 2004, 10(3):206-208.
15.	Román GC, Erkinjuntti T, Wallin A, et al. Subcortical ischaemic vascular dementia[J]. Lancet Neurol, 2002, 1(7):426-436.
16.	薛連璧, 王擁軍, 于秋紅, 等. 超早期大劑量高壓氧治療急性腦卒中的實驗研究[J]. 中國臨床神經科學, 2007, 15(6):583-588.
17.	廖馭國. 早期高壓氧聯合尼莫地平治療腦彌漫性軸索損傷的療效觀察[J]. 中國傷殘醫學, 2015, 35(9):112-113.
18.	蔡志春, 黎敏, 李健哲, 等. 尼莫地平對過氧化氫誘導豬腦基底動脈氧化應激損傷的保護作用[J]. 中國臨床藥理學與治療學, 2007, 12(8):906-910.

1. 張建華, 楊文東. 高壓氧對重型閉合性顱腦損傷患者氧自由基和紅細胞CR1分子表達的影響[J]. 濱州醫學院學報, 2007, 30(2):157-159.
2. 王忠誠. 王忠誠神經外科學[M]. 武漢:湖北科學技術出版社, 2004:66-67.
3. Weyland A, Buhre W, Grund S, et al. Cerebrovascular tone rather than intracranial pressure determines the effective downstream pressure of the cerebral circulation in the absence of intracranial hypertension[J]. J Neurosurg Anesthesiol, 2000, 12(3):210-216.
4. Sukoff MH. Effects of hyperbaric oxygenation[J]. J Neurosurg, 2001, 95(3):544-546.
5. Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients[J]. J Neurosurg, 2001, 94(3):403-411.
6. 高春錦, 楊捷運, 瞿曉輝. 高壓氧醫學基礎與臨床[M]. 北京:人民衛生出版社, 2008:300-309.
7. 易治, 翁其彪. 高壓氧醫學教程[M]. 廣州:暨南大學出版社, 2012:28-31.
8. 張艷平, 楊崇選, 任家庚, 等. 早期高壓氧治療彌漫性軸索損傷的療效分析[J]. 牡丹江醫學院學報, 2013, 34(5):17-19.
9. 胡青, 許小林, 陳益番, 等. 法舒地爾聯合尼莫地平治療蛛網膜下腔出血(SAH)的療效及安全性探討[J]. 中外醫療, 2013, 32(15):109, 111.
10. 楊鶴云, 楊正宇, 張紅蓮, 等. 尼莫地平對高血壓腦出血患者腦血腫,水腫及神經功能恢復的影響[J]. 中國醫藥科學, 2015, 5(1):121-123.
11. 楊玉亭, 許愛琴, 李光華. 尼莫地平對大鼠急性腦缺血再灌注損傷的保護機制[J]. 齊齊哈爾醫學院學報, 2006, 27(2):139-140.
12. 封林森, 馬建華, 劉藝春, 等. 高壓氧聯合尼莫地平治療對顱腦損傷血液流變學的影響[J]. 中國血液流變學雜志, 2008, 18(1):62-63, 95.
13. Sun BL, Xia ZL, Yang MF, et al. Effects of Ginkgo biloba extract on somatosensory evoked potential, nitric oxide levels in serum and brain tissue in rats with cerebral vasospasm after subarachnoid hemorrhage[J]. Clin Hemorheol Mieroeire, 2000, 23(2/3/4):139-144.
14. 陳瑾歆, 唐聰明. 氧自由基的研究進展[J]. 海南醫學院學報, 2004, 10(3):206-208.
15. Román GC, Erkinjuntti T, Wallin A, et al. Subcortical ischaemic vascular dementia[J]. Lancet Neurol, 2002, 1(7):426-436.
16. 薛連璧, 王擁軍, 于秋紅, 等. 超早期大劑量高壓氧治療急性腦卒中的實驗研究[J]. 中國臨床神經科學, 2007, 15(6):583-588.
17. 廖馭國. 早期高壓氧聯合尼莫地平治療腦彌漫性軸索損傷的療效觀察[J]. 中國傷殘醫學, 2015, 35(9):112-113.
18. 蔡志春, 黎敏, 李健哲, 等. 尼莫地平對過氧化氫誘導豬腦基底動脈氧化應激損傷的保護作用[J]. 中國臨床藥理學與治療學, 2007, 12(8):906-910.

West China Medical Journal

Effect of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cerebral Dysfunction Induced by Traumatic Brain Injury

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