氨甲環酸在髖關節置換術中應用的研究進展_West China Medical Journal

Authors：

 劉莉 , 曾利輝 ,  李鵬程 , 寧寧

四川大學華西醫院骨科（成都 610041）;

Corresponding?author：

李鵬程, Email: 16699411@qq.com

Keywords：

氨甲環酸; 髖關節置換術; 失血

DOI：

10.7507/1002-0179.20150279

Video：

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全髖關節置換術于髖關節多種疾病中應用廣泛，由于其手術中出血量往往較大，因此如何減少手術引起的出血已成為越來越關注且急需解決的問題。近年來，氨甲環酸在髖關節置換術中應用價值得到肯定，但目前國內外文獻對于髖關節置換術后氨甲環酸使用時間、給藥方式和劑量上存在爭議，甚至對于氨甲環酸是否能夠減少髖關節置換術后的隱形失血也存在分歧。而目前文獻的研究方法單一，研究的例數不足，標準不統一，現在綜述上述文獻，并對目前的研究現狀進行分析報道。

Citation： 劉莉, 曾利輝, 李鵬程, 寧寧. 氨甲環酸在髖關節置換術中應用的研究進展. West China Medical Journal, 2015, 30(5): 980-982. doi: 10.7507/1002-0179.20150279 Copy

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3.	Hiippala ST, Strid LJ, Wennerstrand MI, et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty[J]. Anesth Analg, 1997, 84(4):839-844.
4.	Jansen AJ, Andreica S, Claeys M, et al. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty[J]. Br J Anaesth, 1999, 83(4):596-601.
5.	Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery[J]. Acta Chir Belg, 2007, 107(4):397-401.
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10.	Benoni G, Fredin H, Knebel R, et al. Blood conservation with tranexamic acid in total hip arthroplasty-a randomized, double-blind study in 40 primary operations[J]. Acta Orthop Scand, 2001, 72(5):442-448.
11.	Ekb?ck G, Axelsson K, Ryttberg L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery[J]. Anesth Analg, 2000, 91(5):1124-1130.
12.	Husted H, Bl?nd L, Sonne-Holm S, et al. Tranexamic acid reduces blood loss an blood transfusions in primary total hip arthroplasty:a prospective randomized double-blind study in 40 patients[J]. Acta Orthop Scand, 2003, 74(6):665-669.
13.	Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplast saves blood and money:a randomized, double-blind study in 100 patients[J]. Act Orthop, 2005, 76(3):314-319.
14.	Lemay E, Guay J, C?té C, et al. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement[J]. Can J Anaest, 2004, 51(1):31-37.
15.	Yamasaki S, Masuhara K, Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases[J]. Int Orthop, 2004, 28(2):69-73.
16.	Gill JB, Rosenstein A. The use of antifibrinolytic agents in total hip arthroplasty:meta-analysis[J]. J Arthroplasty, 2006, 21(6):869-873.
17.	Andersson L, Eriksson O, Hedlund PO, et al. Special considerations with regard to dosage of tranexamic acid in patients with chronic renal diseases[J]. Urol Res, 1978, 6(2):83-88.
18.	Eriksson O, Kjellman H, Pilbrant A, et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers[J]. Eur J Clin Pharmacol, 1974, 7(5):375-380.
19.	Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids[J]. J Clin Pathol(R Coll Pathol), 1980, 14:41-47.
20.	Sano K, Hakumizu H, Kojima T, et al. Absorption and excretion of tranexamic acid in human[J]. Clin Pharmacol Ther, 1976(7):375-382.

1. Lemaire R. Strategies for blood management in orthopaedic and trauma surgery[J]. J Bone Joint Surg Br, 2008, 90(9):1128-1136.
2. Sukeik M, Alshryda S, Haddad FS, et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement[J]. J Bone Joint Surg Br, 2011, 93(1):39-46.
3. Hiippala ST, Strid LJ, Wennerstrand MI, et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty[J]. Anesth Analg, 1997, 84(4):839-844.
4. Jansen AJ, Andreica S, Claeys M, et al. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty[J]. Br J Anaesth, 1999, 83(4):596-601.
5. Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery[J]. Acta Chir Belg, 2007, 107(4):397-401.
6. Ido K, Neo M, Asada Y, et al. Reduction of blood loss using tranexamic acid intotal knee and hip arthroplasties[J]. Arch Orthop Trauma Surg, 2000, 120(9):518-520.
7. Niskanen RO, Korkala OL. Tranexamic acid reduces blood loss in cemented hip arthroplasty-a randomized, double-blind study of 39 patients with osteoarthritis[J]. Acta Orthop, 2005, 76(6):829-832.
8. Garneti N, Field J. Bone bleeding during total hip arthroplasty after administration of tranexamic acid[J]. J Arthroplasty, 2004, 19(4):488-492.
9. Benoni G, Lethagen S, Nilsson P, et al. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty[J]. Acta Orthop Scand, 2000, 71(3):250-254.
10. Benoni G, Fredin H, Knebel R, et al. Blood conservation with tranexamic acid in total hip arthroplasty-a randomized, double-blind study in 40 primary operations[J]. Acta Orthop Scand, 2001, 72(5):442-448.
11. Ekb?ck G, Axelsson K, Ryttberg L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery[J]. Anesth Analg, 2000, 91(5):1124-1130.
12. Husted H, Bl?nd L, Sonne-Holm S, et al. Tranexamic acid reduces blood loss an blood transfusions in primary total hip arthroplasty:a prospective randomized double-blind study in 40 patients[J]. Acta Orthop Scand, 2003, 74(6):665-669.
13. Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplast saves blood and money:a randomized, double-blind study in 100 patients[J]. Act Orthop, 2005, 76(3):314-319.
14. Lemay E, Guay J, C?té C, et al. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement[J]. Can J Anaest, 2004, 51(1):31-37.
15. Yamasaki S, Masuhara K, Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases[J]. Int Orthop, 2004, 28(2):69-73.
16. Gill JB, Rosenstein A. The use of antifibrinolytic agents in total hip arthroplasty:meta-analysis[J]. J Arthroplasty, 2006, 21(6):869-873.
17. Andersson L, Eriksson O, Hedlund PO, et al. Special considerations with regard to dosage of tranexamic acid in patients with chronic renal diseases[J]. Urol Res, 1978, 6(2):83-88.
18. Eriksson O, Kjellman H, Pilbrant A, et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers[J]. Eur J Clin Pharmacol, 1974, 7(5):375-380.
19. Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids[J]. J Clin Pathol(R Coll Pathol), 1980, 14:41-47.
20. Sano K, Hakumizu H, Kojima T, et al. Absorption and excretion of tranexamic acid in human[J]. Clin Pharmacol Ther, 1976(7):375-382.

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氨甲環酸在髖關節置換術中應用的研究進展

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