Influence of Propofol and Sevoflurane on the Mivacurium Chloride-induced Histamine Release_West China Medical Journal

Authors：

 JIANGYing-ying ,  LIUBin

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LIUBin, Email: liubinhx@foxmail.com

Keywords：

Mivacurium chloride; Histamine; Propofol; Sevoflurane

DOI：

10.7507/1002-0179.20150252

Video：

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Objective To explore the influence of propofol as well as sevoflurane on the histamine release induced by mivacurium chloride. Methods Forty patients with American Sociaty of Anesthesiologists stage Ⅰ-Ⅱ scheduled to receive ear-nose-throat surgery between March and October 2012 were recruited and were randomly assigned into two groups:propofol group and sevoflurane group. Patients in the propofol group were induced with targeted intravenous infusion with propofol. Patients in the sevoflurane group was induced with sevoflurane. The blood specimen was prepared before mivacurium chloride (0.16 mg/kg) infusion (T₀), 1 minute (T₁), 3 minutes (T₂), and 5 minutes (T₃) after the infusion. Mean blood pressure (MBP) and heart rate (HR) were recorded at corresponding time points. In addition, we recorded the symptoms of anaphylactic reaction such as skin erythema or bronchospasm. Results Both MBP and HR decreased after anesthesia induction. However, there was no significant difference from that before the induction in both groups, and no difference was found between the two groups (P>0.05). The concentration of histamine in both groups at T₁ and T₂ was significantly higher than that at T₀ (P<0.05). The concentration of histamine in both groups at T4 was significantly higher than that at T₀ (P<0.05). The concentration of histamine in the propofol group was higher than that in the sevoflurane group. No skin erythema or bronchospasm was found in any of the two groups. Conclusion Mivacurium chloride at a dose of 0.16 mg/kg can be safely used in propofol anesthesia, as well as sevofluane anesthesia, with no clinically significant histamine release or adverse hemodynamic fluctuation.

Citation： JIANGYing-ying, LIUBin. Influence of Propofol and Sevoflurane on the Mivacurium Chloride-induced Histamine Release. West China Medical Journal, 2015, 30(5): 877-880. doi: 10.7507/1002-0179.20150252 Copy

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2.	Molbegott L, Baker T. Speed and ease of tracheal intubation:priming with mivacurium compared with succinylcholine[J]. Can J Anaesth, 1995, 42(9):780-784.
3.	Dieck T, Steffens J, Sander B, et al. Propofol, remifentanil and mivacurium:fast track surgery with poor intubating conditions[J]. Minerva Anestesiol, 2011, 77(6):585-591.
4.	Dong SW, Mertes PM, Petitpain N, et al. Hypersensitivity reactions during anesthesia. Results from the ninth French survey (2005-2007)[J]. Minerva Anestesiol, 2012, 78(8):868-878.
5.	Sadleir P, Clarke RC, Bunning DL, et al. Anaphylaxis to neuromuscular blocking drugs:incidence and cross-reactivity in Western Australia from 2002 to 2011[J]. Br J Anaesth, 2013, 110(6):981-987.
6.	Saager L, Turan A, Egan C, et al. Incidence of intraoperative hypersensitivity reactions:a registry analysis[J/OL]. Anesthesiology, 2014(26). http://www.ncbi.nlm.nih.gov/pubmed/?term=Saager+L%2C+Turan+A%2C+Egan+C%2C+et+al.+Incidence+of+intraoperative+hypersensitivity+reactions%3Aa+registry+analysis%5BZ%5D%2C+2014.
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8.	趙琳, 韓如泉, 崔偉華. 抗組胺藥預防米庫氯銨引起組胺釋放反應的臨床研究[J]. 世界中西醫結合雜志, 2013, 8(12):1239-1242.
9.	Grim KJ, Abcejo AJ, Barnes A, et al. Caveolae and propofol effects on airway smooth muscle[J]. Br J Anaesth, 2012, 109(3):444-453.
10.	Tas P, Stoessel C, Roewer N. Inhibition of the histamine-induced Ca²⁺ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics[J]. Eur J Anaesthesiol, 2008, 25(12):976-985.
11.	李曼玲. 異丙酚引起過敏反應一例報告[J]. 臨床麻醉學雜志, 2000, 16(2):80.
12.	Nishiyama T. Propofol results in higher incidence of bronchoconstriction in allergic patients[J]. Med Arch, 2013, 67(3):168-170.
13.	Murphy A, Campbell DE, Baines D, et al. Allergic reactions to propofol in egg-allergic children[J]. Anesth Analg, 2011, 113(1):140-144.
14.	葉沈平, 刁玉剛, 赫凌峰, 等. 異丙酚引起支氣管痙攣2例[J]. 實用醫學雜志, 2007, 23(10):1513.
15.	Xiang Z, Yan-Liang Q, Xiao-Yang S, et al. Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children[J]. Paediatr Anesth, 2014, 24(3):322-326.
16.	Osman ES, Khafagy HF, Radwan KG, et al. Role of cholinesterase activity on pharmacodynamics of mivacurium preceded by pancuronium in elderly and young adults[J]. J Egypt Soc Parasitol, 2007, 37(1):243-255.

1. 呂慧, 馬鶴, 朱卓, 等. 新型非去極化肌松藥-米庫氯銨[J]. 中國實驗診斷學, 2013, 17(7):1359-1361.
2. Molbegott L, Baker T. Speed and ease of tracheal intubation:priming with mivacurium compared with succinylcholine[J]. Can J Anaesth, 1995, 42(9):780-784.
3. Dieck T, Steffens J, Sander B, et al. Propofol, remifentanil and mivacurium:fast track surgery with poor intubating conditions[J]. Minerva Anestesiol, 2011, 77(6):585-591.
4. Dong SW, Mertes PM, Petitpain N, et al. Hypersensitivity reactions during anesthesia. Results from the ninth French survey (2005-2007)[J]. Minerva Anestesiol, 2012, 78(8):868-878.
5. Sadleir P, Clarke RC, Bunning DL, et al. Anaphylaxis to neuromuscular blocking drugs:incidence and cross-reactivity in Western Australia from 2002 to 2011[J]. Br J Anaesth, 2013, 110(6):981-987.
6. Saager L, Turan A, Egan C, et al. Incidence of intraoperative hypersensitivity reactions:a registry analysis[J/OL]. Anesthesiology, 2014(26). http://www.ncbi.nlm.nih.gov/pubmed/?term=Saager+L%2C+Turan+A%2C+Egan+C%2C+et+al.+Incidence+of+intraoperative+hypersensitivity+reactions%3Aa+registry+analysis%5BZ%5D%2C+2014.
7. 孫大金. 麻醉期間的藥物過敏反應[J]. 國際麻醉學與復蘇雜志, 2007, 28(5):477-480.
8. 趙琳, 韓如泉, 崔偉華. 抗組胺藥預防米庫氯銨引起組胺釋放反應的臨床研究[J]. 世界中西醫結合雜志, 2013, 8(12):1239-1242.
9. Grim KJ, Abcejo AJ, Barnes A, et al. Caveolae and propofol effects on airway smooth muscle[J]. Br J Anaesth, 2012, 109(3):444-453.
10. Tas P, Stoessel C, Roewer N. Inhibition of the histamine-induced Ca²⁺ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics[J]. Eur J Anaesthesiol, 2008, 25(12):976-985.
11. 李曼玲. 異丙酚引起過敏反應一例報告[J]. 臨床麻醉學雜志, 2000, 16(2):80.
12. Nishiyama T. Propofol results in higher incidence of bronchoconstriction in allergic patients[J]. Med Arch, 2013, 67(3):168-170.
13. Murphy A, Campbell DE, Baines D, et al. Allergic reactions to propofol in egg-allergic children[J]. Anesth Analg, 2011, 113(1):140-144.
14. 葉沈平, 刁玉剛, 赫凌峰, 等. 異丙酚引起支氣管痙攣2例[J]. 實用醫學雜志, 2007, 23(10):1513.
15. Xiang Z, Yan-Liang Q, Xiao-Yang S, et al. Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children[J]. Paediatr Anesth, 2014, 24(3):322-326.
16. Osman ES, Khafagy HF, Radwan KG, et al. Role of cholinesterase activity on pharmacodynamics of mivacurium preceded by pancuronium in elderly and young adults[J]. J Egypt Soc Parasitol, 2007, 37(1):243-255.

West China Medical Journal

Influence of Propofol and Sevoflurane on the Mivacurium Chloride-induced Histamine Release

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