Discussion on the Value of MRI in the Diagnosis of Central Nervous System Lymphoma_West China Medical Journal

Authors：

 DENGZhen-ping ¹ , RENHong-ping ² ,  LIANGNa ¹ , CHENJun-hui ¹

1. Department of Radiology, the Second People's Hospital of Chengdu, Chengdu, Sichuan 610017, P. R. China;
2. Department of Radiology, the 363 Hospital of Chengdu, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LIANGNa, Email: 21516290@qq.com

Keywords：

Primary central nervous system lymphoma; Secondary central nervous system lymphoma; Magnetic resonance imaging

DOI：

10.7507/1002-0179.20150197

Video：

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Objective To investigate the value of MRI in the diagnosis of central nervous system lymphoma (CNSL). Methods We retrospectively analyzed the clinical data of 20 cases of primary CNSL (PCNSL) and 13 cases of secondary CNSL (SCNSL) from the Second People's Hospital of Chengdu and Chengdu 363 Hospital from January to December 2013, and analyzed their clinical data and MRI image data. We observed the tumor location, tumor size and signal, and carried out the statistical analysis. Results Twenty patients had PCNSL in the brain, including single lesion in 9 (45.0%), and multiple in 11 (55.0%). Among the 48 lesions, there were 23 (47.9%) nodular lesions, 21 (43.8%) crumb lesions, and 4 (8.3%) dot patch lesions; MRI showed slightly low T1 signal and slightly high T2 signal in most lesions, and showed significant even enhancing, and mild to moderate edema around the tumor. SCNSL lesions were mainly meningeal disseminated with 3 cases (23.1%) of single lesions and 10 cases (76.9%) of multiple ones, and there were a total of 30 lesions. MRI manifested that T1 and T2 mainly showed equal signals, and showed an obviously even enhancing status, and mild to moderate edema around the tumor. Conclusion The central nervous system lymphoma has a certain characteristic MRI image, and MRI images of the primary and secondary central nervous system lymphoma were similar.

Citation： DENGZhen-ping, RENHong-ping, LIANGNa, CHENJun-hui. Discussion on the Value of MRI in the Diagnosis of Central Nervous System Lymphoma. West China Medical Journal, 2015, 30(4): 688-691. doi: 10.7507/1002-0179.20150197 Copy

1.	Guo AC, Cummings TJ, Dash RC, et al. Lymphomas and high-grade astrocytomas:comparison of water diffusibility and histologic characteristics[J]. Radiology, 2002, 224(1):177-183.
2.	關鴻志, 陳琳, 郭玉璞, 等. 腦膜淋巴瘤的臨床腦脊液細胞學研究[J]. 中華神經科雜志, 2006, 39(2):113-117.
3.	Gerstner ER, Batchelor TT. Primary central nervous system lymphoma[J]. Arch Neurol, 2010, 67(3):291-297.
4.	曹崑, 李潔, 汪寧, 等. 非原發中樞神經系統非霍奇金淋巴瘤腦實質病變影像表現分析[J]. 實用放射學雜志, 2006, 22(1):17-19.
5.	Levin N, Soffer D, Grissaru S, et al. Primary T-cell CNS lymphoma presenting with leptomeningeal spread and neurolymphomatosis[J]. J Neurooncol, 2008, 90(1):77-83.
6.	Haldoren IS, Espeland A, Larsson EM. Central nervous system lymphoma:characteristic findings on traditional and advanced imaging[J]. AJNR Am J Neuroradiol, 2011, 32(6):984-992.
7.	張海捷, 張雪林. 原發性中樞神經系統淋巴瘤的MRI表現與病理學對照研究[J]. 臨床放射學雜志, 2010, 29(2):148-151.
8.	Olson JE, Janney CA, Rao RD, et al. The continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma:a surveillance, epidemiology, and end results analysis[J]. Cancer, 2002, 95(7):1504-1510.
9.	陳長青, 陳晨, 陳常勇, 等. 原發性腦內惡性淋巴瘤的CT、MRI診斷[J]. 臨床放射學雜志, 2004, 23(4):283-286.
10.	張禹, 張龍江, 葛銳, 等. 原發性腦淋巴瘤的MRI功能成像和延遲強化特點[J]. 中國醫學計算機成像雜志, 2011, 17(2):97-103.
11.	徐勝生, 歐陽羽, 張志偉, 等. 腦內原發性淋巴瘤MRI特征[J]. 臨床放射學雜志, 2011, 30(6):781-784.
12.	耿承軍, 陳君坤, 盧光明, 等. 原發性中樞神經系統淋巴瘤的CT、MRI表現與病理對照研究[J]. 中華放射學雜志, 2003, 37(3):246-250.
13.	高培毅, 林燕, 孫波. 原發性腦內惡性淋巴瘤的MRI研究[J]. 中華放射學雜志, 1999, 33(11):749-753.
14.	耿少梅, 焦保華, 孫曉楓. 原發性顱內惡性淋巴瘤的臨床特點及影像學診斷[J]. 中華神經醫學雜志, 2004, 3(3):188-190.
15.	趙蕓蕓, 劉劍羽, 徐輝. 淋巴瘤的磁共振彌散加權成像及其病理相關性[J]. 中國醫學影像技術, 2010, 26(6):1001-1004.
16.	楊群頂, 高炬, 孫培祥, 等. 顱內淋巴瘤的影像學診斷[J]. 醫學影像學雜志, 2007, 17(5):437-439.
17.	胡毅, 馮奉儀, 石遠凱, 等. 原發性中樞神經系統淋巴瘤28例臨床分析[J]. 中華腫瘤雜志, 2004, 26(6):375-378.
18.	Kim DS, Na DG, Kim KH, et al. Distinguishing tumefactive demyelinating lesions from glioma or central nervous system lymphoma:added value of unenhanced CT compared with conventional contrast-enhanced Mr imaging[J]. Radiology, 2009, 251(2):467-475.
19.	廖偉華, 王小宜, 黃軍, 等. 顱內原發性B細胞淋巴瘤MRI表現[J]. 中國醫學影像技術, 2008, 24(4):499-503.
20.	Zhang D, Hu LB, Henning TD, et al. MRI findings of primary CNS lymphoma in 26 immunocompetent patients[J]. Korean J Radiol, 2010, 11(3):269-277.

1. Guo AC, Cummings TJ, Dash RC, et al. Lymphomas and high-grade astrocytomas:comparison of water diffusibility and histologic characteristics[J]. Radiology, 2002, 224(1):177-183.
2. 關鴻志, 陳琳, 郭玉璞, 等. 腦膜淋巴瘤的臨床腦脊液細胞學研究[J]. 中華神經科雜志, 2006, 39(2):113-117.
3. Gerstner ER, Batchelor TT. Primary central nervous system lymphoma[J]. Arch Neurol, 2010, 67(3):291-297.
4. 曹崑, 李潔, 汪寧, 等. 非原發中樞神經系統非霍奇金淋巴瘤腦實質病變影像表現分析[J]. 實用放射學雜志, 2006, 22(1):17-19.
5. Levin N, Soffer D, Grissaru S, et al. Primary T-cell CNS lymphoma presenting with leptomeningeal spread and neurolymphomatosis[J]. J Neurooncol, 2008, 90(1):77-83.
6. Haldoren IS, Espeland A, Larsson EM. Central nervous system lymphoma:characteristic findings on traditional and advanced imaging[J]. AJNR Am J Neuroradiol, 2011, 32(6):984-992.
7. 張海捷, 張雪林. 原發性中樞神經系統淋巴瘤的MRI表現與病理學對照研究[J]. 臨床放射學雜志, 2010, 29(2):148-151.
8. Olson JE, Janney CA, Rao RD, et al. The continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma:a surveillance, epidemiology, and end results analysis[J]. Cancer, 2002, 95(7):1504-1510.
9. 陳長青, 陳晨, 陳常勇, 等. 原發性腦內惡性淋巴瘤的CT、MRI診斷[J]. 臨床放射學雜志, 2004, 23(4):283-286.
10. 張禹, 張龍江, 葛銳, 等. 原發性腦淋巴瘤的MRI功能成像和延遲強化特點[J]. 中國醫學計算機成像雜志, 2011, 17(2):97-103.
11. 徐勝生, 歐陽羽, 張志偉, 等. 腦內原發性淋巴瘤MRI特征[J]. 臨床放射學雜志, 2011, 30(6):781-784.
12. 耿承軍, 陳君坤, 盧光明, 等. 原發性中樞神經系統淋巴瘤的CT、MRI表現與病理對照研究[J]. 中華放射學雜志, 2003, 37(3):246-250.
13. 高培毅, 林燕, 孫波. 原發性腦內惡性淋巴瘤的MRI研究[J]. 中華放射學雜志, 1999, 33(11):749-753.
14. 耿少梅, 焦保華, 孫曉楓. 原發性顱內惡性淋巴瘤的臨床特點及影像學診斷[J]. 中華神經醫學雜志, 2004, 3(3):188-190.
15. 趙蕓蕓, 劉劍羽, 徐輝. 淋巴瘤的磁共振彌散加權成像及其病理相關性[J]. 中國醫學影像技術, 2010, 26(6):1001-1004.
16. 楊群頂, 高炬, 孫培祥, 等. 顱內淋巴瘤的影像學診斷[J]. 醫學影像學雜志, 2007, 17(5):437-439.
17. 胡毅, 馮奉儀, 石遠凱, 等. 原發性中樞神經系統淋巴瘤28例臨床分析[J]. 中華腫瘤雜志, 2004, 26(6):375-378.
18. Kim DS, Na DG, Kim KH, et al. Distinguishing tumefactive demyelinating lesions from glioma or central nervous system lymphoma:added value of unenhanced CT compared with conventional contrast-enhanced Mr imaging[J]. Radiology, 2009, 251(2):467-475.
19. 廖偉華, 王小宜, 黃軍, 等. 顱內原發性B細胞淋巴瘤MRI表現[J]. 中國醫學影像技術, 2008, 24(4):499-503.
20. Zhang D, Hu LB, Henning TD, et al. MRI findings of primary CNS lymphoma in 26 immunocompetent patients[J]. Korean J Radiol, 2010, 11(3):269-277.

West China Medical Journal

Discussion on the Value of MRI in the Diagnosis of Central Nervous System Lymphoma

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