The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China_West China Medical Journal

Authors：

 MAXiao-xiang ^1,2 , CHENXiao-ping ² , CHENGYou-fu ¹ , HEXia ³ , SHUAIPing ¹ , YANGYan-hua ¹ , XIAOXian ¹ ,  LIUYu-ping ¹

1. Center of Health Physical Examination and Health Management, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;
2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Pharmacogenomics Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

LIUYu-ping, Email: 651231899@qq.com

Keywords：

Aldehyde dehydrogenase 2; Gene polymorphism; Carotid intima-media thickness

DOI：

10.7507/1002-0179.20150119

Video：

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Objective To investigate the relationship between the aldehyde dehydrogenase 2 gene (ALDH2) polymorphism and carotid intima-media thickness (IMT). Methods From April 2013 to February 2014, 310 cases of carotid IMT thickening (IMT thickening group) from the physical examination center were included in the study and 280 cases of normal carotid IMT were regarded as controls. DNA was extracted from peripheral blood. ALDH2 gene polymorphism was detected by DNA microarray method. Results Genotype distributions had no deviation from Hardy-Weinberg equilibrium in both groups. Compared with controls, the frequency of AA/AG genotypes (67.4%, 41.1%; P<0.01) and the frequency of A allele (37.9%, 22.3%; P<0.001) of ALDH2 gene were apparently increased in the subjects of IMT thickening group. There was a significant difference in the frequency distribution of genotype and allele in ALDH2 between the two groups. The logistic analysis showed that the ALDH2 gene polymorphism was associated with the increased carotid IMT [OR=2.381, 95%CI (1.356, 4.213), P=0.004]. Conclusion The ALDH2 gene polymorphism is correlated with the increased carotid IMT in the Han population of China Sichuan. The ALDH2 gene polymorphism may play an important role in genetic susceptibility of increased carotid IMT.

Citation： MAXiao-xiang, CHENXiao-ping, CHENGYou-fu, HEXia, SHUAIPing, YANGYan-hua, XIAOXian, LIUYu-ping. The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China. West China Medical Journal, 2015, 30(3): 401-406. doi: 10.7507/1002-0179.20150119 Copy

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1. 趙鵬飛, 張怡, 季曉云, 等. 高血壓病人eNOS基因Glu298Asp多態性與頸動脈內中膜厚度的關聯性[J]. 青島大學醫學院學報, 2014,50(1): 26-28, 30.
2. 張強, 鄧峰美, 唐斌. 頸動脈內膜-中層厚度與高血壓相關性的研究進展[J]. 醫學綜述, 2011, 17(11): 1611-1613.
3. 毛跟年, 李鑫, 瞿建波. 乙醛脫氫酶及其醫療領域研究進展[J]. 天然產物研究與開發, 2011, 23(1): 193-197.
4. 錢士勻, 鄔強. 對氧磷酶生物學特性及臨床研究進展[J]. 國際檢驗醫學雜志, 2007, 28(4): 361-362, 365.
5. 楊寧, 田軍, 董彥, 等. 高血壓患者血清脂聯素與頸動脈內膜中層厚度及血壓相關因素的研究[J]. 新鄉醫學院學報, 2013, 30(1): 62-65.
6. 尚蓉, 殷軍. 彩色多普勒超聲在糖尿病頸動脈硬化中的應用[J]. 第三軍醫大學報, 2010, 32(11): 1232-1234.
7. 楊秀云, 陶劍虹, 蔡力. 過氧化物酶體增殖物激活受體與動脈粥樣硬化研究進展[J]. 實用醫院臨床雜志, 2008, 5(3): 99-102.
8. Yu MA, Sánchez-Lozada LG, Johnson RJ, et al. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction[J]. J Hypertens, 2010, 28(6): 1234-1242.
9. 劉海紅, 李海珍. 動脈粥樣硬化的研究進展[J].中國醫藥導報,2010, 7(19): 9-10.
10. 劉坤梅, 丁小君, 劉修燕, 等. 阿托伐他汀鈣對頸動脈粥樣硬化患者血管內皮的保護作用[J]. 華西醫學, 2013, 28(1): 33-35.
11. 金修才, 趙寶珍. 頸動脈內中膜厚度的測量及其與心血管危險因素的關系[J]. 中國醫學影像學雜志, 2006, 14(1): 55-57.
12. Shenkin SD, Bastin ME, Macgillivray TJ, et al. Carotid intima-media thickness and cerebrovascular disease in community-dwelling older people without stroke[J]. Stroke, 2010, 41(9): 2083-2086.
13. Nasri H, Baradaran A. Association of serum lipoprotein-a with ultrasonographically determined early atherosclerotic changes in the carotid and femoral arteries in kidney transplanted patients[J]. Transplant Proc, 2004, 36(9): 2683-2686.
14. 賈曉利, 曹曉紅, 陳樹. 老老年患者頸動脈中層厚度的相關危險因素分析[J]. 華西醫學, 2010, 25(1): 16-19.
15. 艾智華, 金小嵐, 游志清, 等. PPAR-γ_2基因Pro12Ala多態性與2型糖尿病患者動脈粥樣硬化的關系[J]. 實用醫院臨床雜志,2011, 8(3): 22-24.
16. Za KA, Tsivoulis G, Barlas G, et al. Time rate of blood pressure variation is associated with increased common carotid artery intimamedia thickness[J]. Hypertension, 2005, 45(4): 505-512.
17. Seitz HK, Matsuzaki S, Yokoyama A, et al. Alcohol and cancer[J]. Alcohol Clin Res, 2001, 25(5 Suppl SBRA): 137S-143S.
18. 萬琪, 王飛, 陳亞麗, 等. 乙醛脫氫酶1與腫瘤干細胞相關性研究[J]. 華西醫學, 2011, 26(3): 476-478.
19. Li TK, Yin SJ, Crabb DW, et al. Genetic and environment infl uence on alcohol metabolism in human[J]. Alcohol Clin Exp Res, 2001, 25(1): 136-144.
20. Hood JD, Cheresh D. Role of integrins in cell invasion and migration[J]. Nat Rev Cancer, 2002, 2(2): 91-100.
21. Zhang M, Shah AM. Role of reactive oxygen species in myocardial remodeling[J]. Curr Heart Fail Rep, 2007, 4(1): 26-30.
22. Narita M. Effects of aldehydrogenase genotypes on carotid atherosclerosis[J]. Utrasound Med Bio, 2003, 29(9): 1415-1419.

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The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China

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