An Initial Study of Tumor-vessel Signs in Malignant Change of Tubulovillous Adenoma on 64-slice Spiral CT_West China Medical Journal

Authors：

 LIHong , MAChun , LIRu-hui , MINGBing , ZHANGYong

Department of Radiology, the People's Hospital of Deyang City, Deyang, Sichuan 618000, P. R. China;

Corresponding?author：

Keywords：

Tumor vessels; Tubulovillous adenoma; Tumor malignant change; Tomography; X-ray computer

DOI：

10.7507/1002-0179.20150087

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the correlation between tumor-vessel signs on 64-slice spiral CT (MSCT) and malignant change of tubulovillous adenoma in the colon and rectum. Methods A retrospective study of the image and the clinical data of 16 patients with tubulovillous adenoma or malignant change proved by pathologies from February 2010 to October 2012 was conducted. The tumor-vessel signs were analyzed by multiplanar reformation (MPR) and maximum intensity projection (MIP) on picture archiving and communication systems workstation. Results Among the 16 cases of tubulovillous adenoma or malignant change, 2 cases of tumor diameter≤2 cm had no tumor-vessel sign; and in the 14 cases of tumor diameter >2 cm, 13 were observed to bear tumor-vessel signs. The size of the tumor and tumor-vessel signs showed a certain correlation (r=0.618, P=0.002). And the manifestation of tumor-vessel signs had obvious differences between benign and malignant tumor. For the adenoma group, it showed venous blood vessel involvement, and downy and natural contour; for the adenocarcinoma group, it showed arterial blood vessel involvement, blood vessels with uneven thickness, visible expansion and irregular defect manifestations. No obvious difference was detected among tumor-vessel signs of adenocarcinoma with different malignant degree. Conclusion MSCT combined with image reconstruction techniques (such as MPR and MIP) can clearly demonstrate tumor blood supply, and tumor-vessel in the arterial phase may suggest a high risk of malignant change of tubulovillous adenoma in the colon and rectum.

Citation： LIHong, MAChun, LIRu-hui, MINGBing, ZHANGYong. An Initial Study of Tumor-vessel Signs in Malignant Change of Tubulovillous Adenoma on 64-slice Spiral CT. West China Medical Journal, 2015, 30(2): 295-299. doi: 10.7507/1002-0179.20150087 Copy

1.	Shaked Y, Bertolini F, Man S, et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis:implications for cellular surrogate marker analysis of antiangiogenesis[J]. Cancer Cell, 2005, 7(1):101-111.
2.	Christenson J. Intestinal motor physiology[M]//Feldman M, Scharschmidt BF, Sleisenger MH. Gastrointestinal and liver disease. 6 th ed. Philadelphia:WB Saunders, 1998:1437-1450.
3.	楊雪, 李貞茂, 李易, 等. 大腸腺瘤性息肉的特點及與癌變關系的探討[J]. 西部醫學, 2010, 22(12):2223-2225.
4.	F.L.格林尼, D.L.佩基, I.D.弗萊明, 等. AJCC癌癥分期手冊[M]. 毛偉征, 蘇東明, 李雪萍, 等, 譯. 6版. 沈陽:遼寧科技出版社, 2005:113-119.
5.	Greene FL. TNM staging for malignancies of the digestive tract:2003 changes and beyond[J]. Semin Surg Oncol, 2003, 21(1):23-29.
6.	房靜遠. 關注結直腸腺瘤的診治研究[J]. 中華消化雜志, 2010, 30(7):433-435.
7.	Nicholls RJ, Zinicola R, Binda GA. Indications for colorectal resection for adenoma before and after polypectomy[J]. Tech Coloproctol, 2004, 8(Suppl 2):s291-s294.
8.	Gondal G, Grotmol T, Hofstad B, et al. Grading of distal colorectal adenomas as predictors for proximal colonic neoplasia and choice of endoscope in population screening:experience from the Norwegian Colorectal Cancer Prevention study (NORCCAP)[J]. Gut, 2003, 52(3):398-403.
9.	梁光春, 陳靜, 莫育芹, 等. 結腸息肉病理表現及臨床治療分析[J]. 中國醫藥科學, 2012, 2(6):88-89.
10.	董米連, 虞哲科, 王先福, 等. 大腸癌患者大腸腺瘤的發病、分布及其與癌的位置關系[J]. 實用臨床醫學, 2009, 10(2):69-70.
11.	田洪裕, 顧秀珍. 大腸息肉452例內鏡診治結果分析[J]. 中華消化內鏡雜志, 2002, 19(3):183-184.
12.	李慶龍, 高劍波, 呂培杰, 等. 直腸絨毛管狀腺瘤的CT診斷[J]. 實用放射學雜志, 2013, 29(7):1116-1118.
13.	Coe SG, Wallace MB. Colonoscopy:new approsches to better outcome[J]. Curr Opin Gastroenterol, 2012, 28(1):70-75.
14.	吳正陽, 趙俊功, 趙培榮, 等. 結腸絨毛狀腫瘤的CT表現[J]. 實用放射學雜志, 2011, 27(10):1512-1514.
15.	李啟明, 李寧, 陳正堂. 血管內皮生長因子與腫瘤轉移[J]. 重慶醫學, 2006, 35(22):2085-2087.
16.	潘宇祥. 血管內皮生長因子與腫瘤轉移的研究進展[J]. 四川生理科學雜志, 2013, 35(2):83-85.
17.	Hiratsuka S. Vasculogenensis, angiogenesis and special features of tumor blood vessels[J]. Front Biosci (Landmark Ed), 2011, 16:1413-1427.
18.	Folkman J. What is the evidence that tumors are angiogenesis dependent[J]. J Natl Cancer Inst, 1990, 82(1):4-6.
19.	楊丹, 王繼華. 腫瘤血管供應模式及其分子機制[J]. 中南醫學科學雜志, 2014, 42(2):196-200.
20.	劉佩芳, 鮑潤賢, 牛昀, 等. 乳腺良惡性病變動態增強MRI表現特征與血管生成相關性的初步研究[J]. 中華放射學雜志, 2002, 36(11):967-972.
21.	李攀. 胃癌及胃間質瘤64層螺旋CT灌注成像的初步臨床應用研究[D]. 鄭州:鄭州大學, 2011.
22.	徐妍妍, 王武, 孫宏亮, 等. 結直腸癌256層CT全腫瘤灌注與腫瘤血管生成間關系[J]. 實用放射學雜志, 2012, 28(9):1371-1375.
23.	吳俊本. 螺旋CT灌注成像與直腸癌腫瘤血管生成的相關性研究[D]. 青島:青島大學, 2008.
24.	李穎嘉, 文戈, 葉長生. 乳腺良惡性腫瘤血管生成形態學變化特征的研究[J]. 中國臨床醫學影像雜志, 2009, 20(9):681-684.
25.	Bian XW, Jiang XF, Chen JH, et al. Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas[J]. Int Immunopharmacol, 2006, 6(1):90-99.

1. Shaked Y, Bertolini F, Man S, et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis:implications for cellular surrogate marker analysis of antiangiogenesis[J]. Cancer Cell, 2005, 7(1):101-111.
2. Christenson J. Intestinal motor physiology[M]//Feldman M, Scharschmidt BF, Sleisenger MH. Gastrointestinal and liver disease. 6 th ed. Philadelphia:WB Saunders, 1998:1437-1450.
3. 楊雪, 李貞茂, 李易, 等. 大腸腺瘤性息肉的特點及與癌變關系的探討[J]. 西部醫學, 2010, 22(12):2223-2225.
4. F.L.格林尼, D.L.佩基, I.D.弗萊明, 等. AJCC癌癥分期手冊[M]. 毛偉征, 蘇東明, 李雪萍, 等, 譯. 6版. 沈陽:遼寧科技出版社, 2005:113-119.
5. Greene FL. TNM staging for malignancies of the digestive tract:2003 changes and beyond[J]. Semin Surg Oncol, 2003, 21(1):23-29.
6. 房靜遠. 關注結直腸腺瘤的診治研究[J]. 中華消化雜志, 2010, 30(7):433-435.
7. Nicholls RJ, Zinicola R, Binda GA. Indications for colorectal resection for adenoma before and after polypectomy[J]. Tech Coloproctol, 2004, 8(Suppl 2):s291-s294.
8. Gondal G, Grotmol T, Hofstad B, et al. Grading of distal colorectal adenomas as predictors for proximal colonic neoplasia and choice of endoscope in population screening:experience from the Norwegian Colorectal Cancer Prevention study (NORCCAP)[J]. Gut, 2003, 52(3):398-403.
9. 梁光春, 陳靜, 莫育芹, 等. 結腸息肉病理表現及臨床治療分析[J]. 中國醫藥科學, 2012, 2(6):88-89.
10. 董米連, 虞哲科, 王先福, 等. 大腸癌患者大腸腺瘤的發病、分布及其與癌的位置關系[J]. 實用臨床醫學, 2009, 10(2):69-70.
11. 田洪裕, 顧秀珍. 大腸息肉452例內鏡診治結果分析[J]. 中華消化內鏡雜志, 2002, 19(3):183-184.
12. 李慶龍, 高劍波, 呂培杰, 等. 直腸絨毛管狀腺瘤的CT診斷[J]. 實用放射學雜志, 2013, 29(7):1116-1118.
13. Coe SG, Wallace MB. Colonoscopy:new approsches to better outcome[J]. Curr Opin Gastroenterol, 2012, 28(1):70-75.
14. 吳正陽, 趙俊功, 趙培榮, 等. 結腸絨毛狀腫瘤的CT表現[J]. 實用放射學雜志, 2011, 27(10):1512-1514.
15. 李啟明, 李寧, 陳正堂. 血管內皮生長因子與腫瘤轉移[J]. 重慶醫學, 2006, 35(22):2085-2087.
16. 潘宇祥. 血管內皮生長因子與腫瘤轉移的研究進展[J]. 四川生理科學雜志, 2013, 35(2):83-85.
17. Hiratsuka S. Vasculogenensis, angiogenesis and special features of tumor blood vessels[J]. Front Biosci (Landmark Ed), 2011, 16:1413-1427.
18. Folkman J. What is the evidence that tumors are angiogenesis dependent[J]. J Natl Cancer Inst, 1990, 82(1):4-6.
19. 楊丹, 王繼華. 腫瘤血管供應模式及其分子機制[J]. 中南醫學科學雜志, 2014, 42(2):196-200.
20. 劉佩芳, 鮑潤賢, 牛昀, 等. 乳腺良惡性病變動態增強MRI表現特征與血管生成相關性的初步研究[J]. 中華放射學雜志, 2002, 36(11):967-972.
21. 李攀. 胃癌及胃間質瘤64層螺旋CT灌注成像的初步臨床應用研究[D]. 鄭州:鄭州大學, 2011.
22. 徐妍妍, 王武, 孫宏亮, 等. 結直腸癌256層CT全腫瘤灌注與腫瘤血管生成間關系[J]. 實用放射學雜志, 2012, 28(9):1371-1375.
23. 吳俊本. 螺旋CT灌注成像與直腸癌腫瘤血管生成的相關性研究[D]. 青島:青島大學, 2008.
24. 李穎嘉, 文戈, 葉長生. 乳腺良惡性腫瘤血管生成形態學變化特征的研究[J]. 中國臨床醫學影像雜志, 2009, 20(9):681-684.
25. Bian XW, Jiang XF, Chen JH, et al. Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas[J]. Int Immunopharmacol, 2006, 6(1):90-99.

West China Medical Journal

An Initial Study of Tumor-vessel Signs in Malignant Change of Tubulovillous Adenoma on 64-slice Spiral CT

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content