Analysis of Ultrasonographic and Pathological Manifestations in Patients with Primary Bilateral Breast Cancer_West China Medical Journal

Authors：

 ZHANGMeng-lu ,  MABu-yun

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

MABu-yun, Email: ws_mby@126.com

Keywords：

Primary bilateral breast cancer; Ultrasonography; Pathological examinations

DOI：

10.7507/1002-0179.20150017

Video：

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Objective To explore the ultrasonographic and pathological manifestations of primary bilateral breast cancer (PBBC). Methods The ultrasonographic and clinical manifestations of 24 patients with PBBC confirmed by surgical pathology and clinical examination between January 2001 and April 2009 were studied retrospectively. The study contained 9 bilateral synchronous breast cancer patients aged from 41 to 60 years old, averaging 47.3 years, and 15 bilateral asynchronous breast cancer patients. For patients with bilateral asynchronous breast cancer, the age on the first lesion diagnosis was between 33 to 61 years with an average of 43.2; the age on the second lesion diagnosis was from 38 to 69 years old averaging 49.1; and the interval time between the first and second lesion diagnosis was from 3 to 8 years, averaging 5.9 years. Results The site of PBBC was more located in upper outer quadrant. Most lesions had obscure boundary, irregular shape, and heterogeneous internal echo in ultrasonographic manifestation. The vertical and horizontal diameter ratio > 1, acoustic shadowing, and microcalcification occurred in some of the lesions. The bloodstream of the lesions were mainly Adler gradeⅡorⅢ. Conclusions Most PBBC has typical ultrasonographic manifestations. The follow-up of PBBC patients should be based on imaging such as ultrasonography. The biopsy guided by ultrasonography can elevate the detection rate of PBBC.

Citation： ZHANGMeng-lu, MABu-yun. Analysis of Ultrasonographic and Pathological Manifestations in Patients with Primary Bilateral Breast Cancer. West China Medical Journal, 2015, 30(1): 63-65. doi: 10.7507/1002-0179.20150017 Copy

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8.	Rutguist LE, Cedermark B, Glas U, et al. Contralateral primary tumor in breast cancer patients in a randomized trial of adjuvant tamoxifen therapy[J]. J Natl Cancer Inst, 1991, 83(18):1299-1306.
9.	Mose S, Adamietz IA, Thilmann C, et al. Bilateral breast carcinoma versus unilateral disease. Review of 498 patients[J]. Am J Clin Oncol, 1997, 20(6):541-545.
10.	Dawson LA, Chow E, Gross PE. Evolving perspectives in contralateral breast cancer[J]. Eur J Cancer, 1998, 34(13):2000-2009.
11.	婁麗, 叢新麗, 馬玉香, 等.原發性雙側乳腺癌的超聲診斷價值[J].醫學影像學雜志, 2006, 16(8):808-810.
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1. Heron DE, Komarnicky LT, Hyslop T, et al. Bilateral breast carcinoma:risk factors and outcomes for patients with synchronous and metachronous disease[J]. Cancer, 2000, 88(12):2739-2750.
2. 林燕, 周易冬, 孫強, 等.原發性雙側乳腺癌[J].癌癥進展, 2005, 3(3):207-211.
3. 闞秀.乳腺癌臨床病理學[M].北京:北京醫科大學、中國協和醫科大學聯合社, 1993:98-102.
4. Hartman M, Czene K, Reilly M, et al. Genetic implications of bilateral breast cancer:a population based cohort study[J]. Lancet Oncol, 2005, 6(6):377-382.
5. 余科達, 狄根紅, 柳光宇, 等.原發性雙側乳腺癌預后分析[J].實用癌癥雜志, 2006, 21(1):66-69, 76.
6. Bergthorsson JT, Ejlertsen B, Olsen JH, et al. BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age[J]. J Med Genet, 2001, 38(6):361-368.
7. Grzybowska E, Siemińska M, Zientek H, et al. Germline mutations in the BRCA1 gene predisposing to breast and ovarian cancers in Upper Silesia population[J]. Acta Biochim Pol, 2002, 49(2):351-356.
8. Rutguist LE, Cedermark B, Glas U, et al. Contralateral primary tumor in breast cancer patients in a randomized trial of adjuvant tamoxifen therapy[J]. J Natl Cancer Inst, 1991, 83(18):1299-1306.
9. Mose S, Adamietz IA, Thilmann C, et al. Bilateral breast carcinoma versus unilateral disease. Review of 498 patients[J]. Am J Clin Oncol, 1997, 20(6):541-545.
10. Dawson LA, Chow E, Gross PE. Evolving perspectives in contralateral breast cancer[J]. Eur J Cancer, 1998, 34(13):2000-2009.
11. 婁麗, 叢新麗, 馬玉香, 等.原發性雙側乳腺癌的超聲診斷價值[J].醫學影像學雜志, 2006, 16(8):808-810.
12. Wilkinson LS, Given-Wilson R, Hall T, et al. Increasing the diagnosis of multifocal primary breast cancer by the use of bilateral whole-breast ultrasound[J]. Clin Radiol, 2005, 60(5):573-578.

West China Medical Journal

Analysis of Ultrasonographic and Pathological Manifestations in Patients with Primary Bilateral Breast Cancer

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