Clinical Efficacy of High-glucose Insulin Mixture on the Local Treatment of Grade Ⅱ and Ⅲ Pressure Ulcers_West China Medical Journal

Authors：

 CHENGWen-li ,  PUHong-ying , LUGui-ying , HUANGLi , WULi , ZHANGJing

Department of Otorhinolaryngology, Head & Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding?author：

PUHong-ying, Email: 1473374370@qq.com

Keywords：

Pressure ulcers; High-glucose insulin mixture; Local treatment

DOI：

10.7507/1002-0179.20140697

Video：

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Objective To investigate the clinical effectiveness of high-glucose insulin mixture on the local treatment of patients with grade Ⅱ and Ⅲ pressure ulcers. Methods A total of 124 patients with grade Ⅱ and Ⅲ pressure ulcers treated between January 2011 and June 2012 were randomly divided into three groups: saline group (group A, n=41), high-glucose insulin mixture group (group B, n=41) and modern dressing group (group C, n=42). We observed and compared the treatment effects among the three groups using both measurements of traditional evaluation criteria and pressure ulcer scale for healing (PUSH) after a week of dressing. Results The overall treatment effects among the three groups were significantly different (χ²=30.453, P<0.001). The results of pairwise comparisons was that the treatment effect was significantly different between group B or C and group A (P<0.01), but the treatment effect was not statistically different between group B and C (P>0.05). Subgroup analysis for patients with grade Ⅱ or Ⅲ pressure ulcers also came to the similar results. Conclusion Both high-glucose insulin mixture and modern dressing have significant effects on patients with grade Ⅱ and Ⅲ pressure ulcers. However, the high-glucose insulin mixture costs less and is worthy of extensive promotion.

Citation： CHENGWen-li, PUHong-ying, LUGui-ying, HUANGLi, WULi, ZHANGJing. Clinical Efficacy of High-glucose Insulin Mixture on the Local Treatment of Grade Ⅱ and Ⅲ Pressure Ulcers. West China Medical Journal, 2014, 29(12): 2304-2308. doi: 10.7507/1002-0179.20140697 Copy

1.	Schoonhoven L, Haalboom JR, Bousema MT, et al. Prospective cohort study of routine use of risk assessment scales for prediction of pressure ulcers[J]. BMJ, 2002, 325(7368):797.
2.	Smith BM, Guihan M, Lavela SL, et al. Factors predicting pressure ulcers in veterans with spinal cord injuries[J]. Am J Phys Med Rehabil, 2008, 87(9):750-757.
3.	Fonder MA, Mamelak AJ, Lazarus GS, et al. Occlusive wound dressings in emergency medicine and acute care[J]. Emerg Med Clin North Am, 2007, 25(1):235-242.
4.	李小青, 李金輝, 羅俊. 壓瘡的預防和護理的最新進展[J]. 華西醫學, 2008, 23(2):428-428.
5.	Beeckman D, Schoonhoven L, Fletcher J, et al. EPUAP classification system for pressure ulcers:European reliability study[J]. J Adv Nurs, 2007, 60(6):682-691.
6.	Dowsett C, Ayello E. TIME principles of chronic wound bed preparation and treatment[J]. Br J Nurs, 2004, 13(15):S16-S23.
7.	Gardner SE, Frantz RA, Bergquist S, et al. A prospective study of the pressure ulcer scale for healing (PUSH)[J]. J Gerontol A Biol Sci Med Sci, 2005, 60(1):93-97.
8.	陳茜, 朱丹, 袁麗. 壓瘡治療措施有效性的研究進展[J]. 護士進修雜志, 2008, 23(11):975-978.
9.	程毛鳳. 43例壓瘡患者的護理體會[J]. 中國當代醫藥, 2010, 17(16):118-119.
10.	王玲. 濕性愈合理論在壓瘡治療與護理中的運用[J]. 當代護士·學術版, 2009(6):69-70.
11.	蔣琪霞, 李曉華. 濕性愈合理念及方法在壓瘡治療中的應用進展[J]. 護理研究, 2009, 23(29):2635-2637.
12.	宋崢. 濕性愈合在壓瘡治療過程中的效果觀察[J]. 中國醫藥導報, 2008, 5(19):166.
13.	文利, 和華元, 李瑞, 等. 高糖胰島素在外科傷口中的巧用[J]. 西南軍醫, 2008, 10(1):128.
14.	Pompeo M. Implementing the push tool in clinical practice:revisions and results[J]. Ostomy Wound Manage, 2003, 49(8):32-36, 38, 40.
15.	Berlowitz DR, Ratliff C, Cuddigan J, et al. The PUSH tool:a survey to determine its perceived usefulness[J]. Adv Skin Wound Care, 2005, 18(9):480-483.
16.	Günes UY. A prospective study evaluating the Pressure Ulcer Scale for Healing (PUSH Tool) to assess stage Ⅱ, stage Ⅲ and stage Ⅳ pressure ulcers[J]. Ostomy Wound Manage, 2009, 55(5):48-52.
17.	George-Saintilus E, Tommasulo B, Cal CE, et al. Pressure ulcer PUSH score and traditional nursing assessment in nursing home residents:do they correlate?[J]. J Am Med Dir Assoc, 2009, 10(2):141-144.

1. Schoonhoven L, Haalboom JR, Bousema MT, et al. Prospective cohort study of routine use of risk assessment scales for prediction of pressure ulcers[J]. BMJ, 2002, 325(7368):797.
2. Smith BM, Guihan M, Lavela SL, et al. Factors predicting pressure ulcers in veterans with spinal cord injuries[J]. Am J Phys Med Rehabil, 2008, 87(9):750-757.
3. Fonder MA, Mamelak AJ, Lazarus GS, et al. Occlusive wound dressings in emergency medicine and acute care[J]. Emerg Med Clin North Am, 2007, 25(1):235-242.
4. 李小青, 李金輝, 羅俊. 壓瘡的預防和護理的最新進展[J]. 華西醫學, 2008, 23(2):428-428.
5. Beeckman D, Schoonhoven L, Fletcher J, et al. EPUAP classification system for pressure ulcers:European reliability study[J]. J Adv Nurs, 2007, 60(6):682-691.
6. Dowsett C, Ayello E. TIME principles of chronic wound bed preparation and treatment[J]. Br J Nurs, 2004, 13(15):S16-S23.
7. Gardner SE, Frantz RA, Bergquist S, et al. A prospective study of the pressure ulcer scale for healing (PUSH)[J]. J Gerontol A Biol Sci Med Sci, 2005, 60(1):93-97.
8. 陳茜, 朱丹, 袁麗. 壓瘡治療措施有效性的研究進展[J]. 護士進修雜志, 2008, 23(11):975-978.
9. 程毛鳳. 43例壓瘡患者的護理體會[J]. 中國當代醫藥, 2010, 17(16):118-119.
10. 王玲. 濕性愈合理論在壓瘡治療與護理中的運用[J]. 當代護士·學術版, 2009(6):69-70.
11. 蔣琪霞, 李曉華. 濕性愈合理念及方法在壓瘡治療中的應用進展[J]. 護理研究, 2009, 23(29):2635-2637.
12. 宋崢. 濕性愈合在壓瘡治療過程中的效果觀察[J]. 中國醫藥導報, 2008, 5(19):166.
13. 文利, 和華元, 李瑞, 等. 高糖胰島素在外科傷口中的巧用[J]. 西南軍醫, 2008, 10(1):128.
14. Pompeo M. Implementing the push tool in clinical practice:revisions and results[J]. Ostomy Wound Manage, 2003, 49(8):32-36, 38, 40.
15. Berlowitz DR, Ratliff C, Cuddigan J, et al. The PUSH tool:a survey to determine its perceived usefulness[J]. Adv Skin Wound Care, 2005, 18(9):480-483.
16. Günes UY. A prospective study evaluating the Pressure Ulcer Scale for Healing (PUSH Tool) to assess stage Ⅱ, stage Ⅲ and stage Ⅳ pressure ulcers[J]. Ostomy Wound Manage, 2009, 55(5):48-52.
17. George-Saintilus E, Tommasulo B, Cal CE, et al. Pressure ulcer PUSH score and traditional nursing assessment in nursing home residents:do they correlate?[J]. J Am Med Dir Assoc, 2009, 10(2):141-144.

West China Medical Journal

Clinical Efficacy of High-glucose Insulin Mixture on the Local Treatment of Grade Ⅱ and Ⅲ Pressure Ulcers

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