Clinical Review and Analysis of Sodium Chlorophyllin in the Treatment of Geriatric Oncology-related Anemia_West China Medical Journal

Authors：

 CHENHong ¹ ,  HELang ² , ZENGEn-quan ³

1. Department of Traditional Chinese Medicine, Affiliated Hospital;North Sichuan Medical College, Nanchong, Sichuan 637007, P. R. China;
2. Department of Oncology, the Second Clinical College;North Sichuan Medical College, Nanchong, Sichuan 637007, P. R. China;
3. Department of Forensic Medicine;North Sichuan Medical College, Nanchong, Sichuan 637007, P. R. China;

Corresponding?author：

HELang, Email: helang729@163.com

Keywords：

Sodium chlorophyllin; Oncology-related anemia; Elderly

DOI：

10.7507/1002-0179.20140671

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Objective To analyze the clinical effect of sodium chlorophyllin in the treatment of geriatric oncology-related anemia and its significance. Methods We retrospectively analyzed the clinical data of elderly cancer patients with similar treatment background between December 2011 and February 2013, and the patients were divided into sodium chlorophyllin treatment group and no special treatment group. Then, parallel comparative study was carried out for anemia-related indexes and scores of quality of life. Results Hemoglobin, red blood cells and quality of life of sodium chlorophyllin treatment group were improved after treatment, and these indexes were also better than those in the no special treatment group (P<0.05). Conclusion Sodium chlorophyllin can ameliorate anemia in elderly patients with oncology-related anemia, which is worthy of being popularized.

Citation： CHENHong, HELang, ZENGEn-quan. Clinical Review and Analysis of Sodium Chlorophyllin in the Treatment of Geriatric Oncology-related Anemia. West China Medical Journal, 2014, 29(12): 2220-2222. doi: 10.7507/1002-0179.20140671 Copy

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6.	Spivak JL. The anaemia of cancer:death by a thousand cuts[J]. Nat Rev Cancer, 2005, 5(7):543-555.
7.	Spivak JL. Iron and the anemia of chronic disease[J]. Oncology (Williston Park), 2002, 16(9 Suppl 10):25-33.
8.	Besarab A, H?rl WH, Silverberg D. Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome[J]. Oncologist, 2009, 14(Suppl 1):22-33.
9.	Streja E, Kovesdy CP, Greenland S, et al. Erythropoietin, iron depletion, and relative thrombocytosis:a possible explanation for hemoglobin-survival paradox in hemodialysis[J]. Am J Kidney Dis, 2008, 52(4):727-736.
10.	Ludwig H, Fritz E, Leitgeb C, et al. Prediction of response to erythropoietin treatment in chronic anemia of cancer[J]. Blood, 1994, 84(4):1056-1063.
11.	Leyland-Jones B, BEST investigators and Study Group. Breast cancer trial with erythro poietin terminated unexpcetedly[J]. Lancet Oncol, 2003, 4(8):459.
12.	Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neek cancer patients with anaemiaun undergoing radiotherapy:randomised, double-blind, placebo-controlled trial[J]. Lancet, 2003, 362(9392):1255-1260.
13.	Leyland-Jones B. Evidence for erythropoietin as a molecular targeting agent[J]. Semin Oncol, 2002, 29(3 Suppl 11):145-154.
14.	Yasuda Y, Fujita Y, Masuda S, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs[J]. Carcinogenesis, 2002, 23(11):1797-1805.
15.	吳一龍. 美國FDA警示:癌癥患者需慎用紅細胞生成素[J]. 循證醫學, 2007, 7(l):202.
16.	陳紅, 曾恩泉. 葉綠酸防治腫瘤的作用及其機制研究進展[J]. 中華腫瘤防治雜志, 2010, 17(16):1315-1318.
17.	柯有甫, 魏克民, 鄭軍獻, 等. 生血寧治療缺鐵性貧血的臨床研究[J]. 中國中西醫結合雜志, 2004, 24(10):893-896.

1. Caro JJ, Salas M, Ward A, et al. Anemia as an independent prognostic factor for survival in patients with cancer:a systemic, qualitative review[J]. Cancer, 2001, 91(12):2214-2221.
2. Ludwig H, Strasser K. Symptomatology of anemia[J]. Semin Oncol, 2001, 28(2 Suppl 8):7-14.
3. Tchekmedyian NS. Anemia in cancer patients:significance, epidemiology, and current therapy[J]. Oncology (Williston Park), 2002, 16(9 Suppl 10):17-24.
4. 周際昌. 實用腫瘤內科治療[M]. 北京:北京科學技術出版社, 2013:444.
5. 葉任高, 陸再英. 內科學[M]. 6版. 北京:人民衛生出版社, 2004:558.
6. Spivak JL. The anaemia of cancer:death by a thousand cuts[J]. Nat Rev Cancer, 2005, 5(7):543-555.
7. Spivak JL. Iron and the anemia of chronic disease[J]. Oncology (Williston Park), 2002, 16(9 Suppl 10):25-33.
8. Besarab A, H?rl WH, Silverberg D. Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome[J]. Oncologist, 2009, 14(Suppl 1):22-33.
9. Streja E, Kovesdy CP, Greenland S, et al. Erythropoietin, iron depletion, and relative thrombocytosis:a possible explanation for hemoglobin-survival paradox in hemodialysis[J]. Am J Kidney Dis, 2008, 52(4):727-736.
10. Ludwig H, Fritz E, Leitgeb C, et al. Prediction of response to erythropoietin treatment in chronic anemia of cancer[J]. Blood, 1994, 84(4):1056-1063.
11. Leyland-Jones B, BEST investigators and Study Group. Breast cancer trial with erythro poietin terminated unexpcetedly[J]. Lancet Oncol, 2003, 4(8):459.
12. Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neek cancer patients with anaemiaun undergoing radiotherapy:randomised, double-blind, placebo-controlled trial[J]. Lancet, 2003, 362(9392):1255-1260.
13. Leyland-Jones B. Evidence for erythropoietin as a molecular targeting agent[J]. Semin Oncol, 2002, 29(3 Suppl 11):145-154.
14. Yasuda Y, Fujita Y, Masuda S, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs[J]. Carcinogenesis, 2002, 23(11):1797-1805.
15. 吳一龍. 美國FDA警示:癌癥患者需慎用紅細胞生成素[J]. 循證醫學, 2007, 7(l):202.
16. 陳紅, 曾恩泉. 葉綠酸防治腫瘤的作用及其機制研究進展[J]. 中華腫瘤防治雜志, 2010, 17(16):1315-1318.
17. 柯有甫, 魏克民, 鄭軍獻, 等. 生血寧治療缺鐵性貧血的臨床研究[J]. 中國中西醫結合雜志, 2004, 24(10):893-896.

West China Medical Journal

Clinical Review and Analysis of Sodium Chlorophyllin in the Treatment of Geriatric Oncology-related Anemia

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