Relationship between Clinicopathological Characteristics and Invasion Depth of Early Gastric Cancer_West China Medical Journal

Authors：

 JIANGZhi-ling , DENGGui-ying

Department of Gastroenterology, the Sixth People's Hospital of Chengdu City, Chengdu, Sichuan 610051, P. R. China;

Corresponding?author：

Keywords：

Early gastric cancer; Clinicopathological; Gastroscopy; Lymph node metastasis

DOI：

10.7507/1002-0179.20140619

Video：

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Objective To investigate the relationship between clinicopathological characteristics and invasion depth of early gastric cancer (EGC), in order to put forward suitable regimens for EGC with different clinicopathological characteristics. Methods The clinicopathological data of 18 patients with EGC diagnosed from January 2008 to January 2013 were retrospectively analyzed. Clinicopathologic variables such as age, gender, tumor size and location, Helicobacter pylori infection, melaena, macroscopic type, and histopathological type were investigated by using chi-square test for their possible relationship with the depth of invasion. Results Lymph node metastasis was more common in patients with submucous cancer (3/9, 33.3%) than in those with mucous cancer (0/9, 0%). Submucosal invasion was found in 77.8% (7/9) of undifferentiated adenocarcinoma cases, whereas only 22.2% (2/9) of differentiated adenocarcinoma had submucosal invasion. TypeⅢ EGC had a significant association with submucosal invasion (P<0.05). Conclusion Endoscopic treatment is unsuitable for patients with Type Ⅲ EGC.

Citation： JIANGZhi-ling, DENGGui-ying. Relationship between Clinicopathological Characteristics and Invasion Depth of Early Gastric Cancer. West China Medical Journal, 2014, 29(11): 2050-2054. doi: 10.7507/1002-0179.20140619 Copy

1.	Carter KJ, Schaffer HA, Ritchie WP Jr. Early gastric cancer[J]. Ann Surg, 1984, 199(5):604-609.
2.	Triantafillidis JK, Cheracakis P. Diagnostic evaluation of patients with early gastric cancer:a literature review[J]. Hepatogastroenterology, 2004, 51(56):618-624.
3.	Maehara Y, Kakeji Y, Oda S, et al. Tumor growth patterns and biological characteristics of early gastric carcinoma[J]. Oncology, 2001, 61(2):102-112.
4.	Everett SM, Axon AT. Early gastric cancer in Europe[J]. Gut, 1997, 41(2):142-150.
5.	施新崗, 李兆申. 內鏡黏膜下剝離術治療早期胃癌進展[J]. 中華消化內鏡雜志, 2008, 25(1):52-54.
6.	于皆平, 沈志祥, 羅和生. 實用消化病學[M]. 2版. 北京:科學出版社, 2008:317-354.
7.	日本胃癌學會. 胃癌治療指南[M]. 2版. 東京:金原出版社, 2004:6-9.
8.	Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma-2nd English edition[J]. Gastric Cancer, 1998, 1(1):10-24.
9.	The Paris endoscopic classification of superficial neoplastic lesions:esophagus, stomach, and colon:November 30 to December 1, 2002[J]. Gastrointest Endosc, 2003, 58(Suppl 6):S3-S43.
10.	夏玉亭, 吳云林, 房殿春. 胃病診治進展[M]. 上海:上海科技教育出版社, 2005:123.
11.	Hamanaka H, Gotoda T. Endoscopic resection for early gastric cancer and future expectations[J]. Dig Endosc, 2005(17):275-285.
12.	潘文勝, 曹敏. 伴淋巴結轉移的早期胃癌病理組織形態學研究[J]. 中華消化雜志, 2006, 26(2):104-107.
13.	Adachi Y, Shiraishi N, Kitano S. Modern treatment of early gastric cancer:review of the Japanese experience[J]. Dig Surg, 2002, 19(5):333-339.
14.	Nasu J, Nishina T, Hirasaki S, et al. Predictive factors of lymph node metastasis in patients with undifferentiated early gastric cancers[J]. J Clin Gastroenterol, 2006, 40(5):412-415.
15.	李小毅, 王常珺, 鐘定榮, 等. 166例早期胃癌的診治分析[J]. 中國醫學科學院學報, 2011, 33(3):325-329.
16.	Shinohara T, Ohyama S, Yamaguchi T, et al. Clinical value of multidetector row computed tomography in detecting lymph node metastasis of early gastric cancer[J]. Eur J Surg Oncol, 2005, 31(7):743-748.
17.	Kwee RM, Kwee TC. Imaging in assessing lymph node status in gastric cancer[J]. Gastric Cancer, 2009, 12(1):6-22.
18.	Tseng LJ, Mo LR, Tio TL, et al. Video-endoscopic ultrasonography in staging gastric carcinoma[J]. Hepatogastroenterology, 2000, 47(33):897-900.
19.	吳道宏, 吳本儼, 王孟薇, 等. 早期胃癌淋巴結轉移多因素分析[J]. 解放軍醫學雜志, 2006, 31(10):941-943.
20.	Kim DY, Joo JK, Ryu SY, et al. Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma[J]. World J Gastroenterol, 2004, 10(5):737-740.
21.	王戈, 張玉華, 呂謙, 等. 早期胃癌臨床病理特征與淋巴結轉移范圍的關系[J]. 山東醫藥, 2008, 48(45):60-61.
22.	Ohashi S, Segawa K, Okamura S, et al. The utility of endoscopic ultrasonography and endoscopy in the endoscopic mucosal resection of early gastric cancer[J]. Gut, 1999, 45(4):599-604.
23.	Kwee RM, Kwee TC. The accuracy of endoscopic ultrasonography in differentiating mucosal from deeper gastric cancer[J]. Am J Gastroenterol, 2008, 103(7):1801-1809.
24.	Yamamoto S, Nishida T, Kato M, et al. Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth[J]. Gastroenterol Res Pract, 2012:194530.
25.	張桂英, 王娟, 張曉梅, 等. 55例早期胃癌的臨床與病理分析[J]. 中國內鏡雜志, 2005, 11(12):1269-1272, 1276.
26.	Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer:estimation with a large number of cases at two large centers[J]. Gastric Cancer, 2000, 3(4):219-225.
27.	朱敏, 李明陽, 吳本儼. 早期胃癌內鏡下切除術后復發的相關因素分析[J]. 中華內科雜志, 2011, 50(5):366-369.
28.	Breslin NP, Thomson AB, Bailey RJ, et al. Gastric cancer and other endoscopic diagnoses in patients with benign dyspepsia[J]. Gut, 2000, 46(1):93-97.
29.	蕭樹東. 上海仁濟醫院消化內科專題講座[M]. 鄭州:鄭州大學出版社, 2005:71-77.
30.	王一平. 早期胃癌的內鏡治療[J]. 實用腫瘤雜志, 2008, 23(2):104-106.

1. Carter KJ, Schaffer HA, Ritchie WP Jr. Early gastric cancer[J]. Ann Surg, 1984, 199(5):604-609.
2. Triantafillidis JK, Cheracakis P. Diagnostic evaluation of patients with early gastric cancer:a literature review[J]. Hepatogastroenterology, 2004, 51(56):618-624.
3. Maehara Y, Kakeji Y, Oda S, et al. Tumor growth patterns and biological characteristics of early gastric carcinoma[J]. Oncology, 2001, 61(2):102-112.
4. Everett SM, Axon AT. Early gastric cancer in Europe[J]. Gut, 1997, 41(2):142-150.
5. 施新崗, 李兆申. 內鏡黏膜下剝離術治療早期胃癌進展[J]. 中華消化內鏡雜志, 2008, 25(1):52-54.
6. 于皆平, 沈志祥, 羅和生. 實用消化病學[M]. 2版. 北京:科學出版社, 2008:317-354.
7. 日本胃癌學會. 胃癌治療指南[M]. 2版. 東京:金原出版社, 2004:6-9.
8. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma-2nd English edition[J]. Gastric Cancer, 1998, 1(1):10-24.
9. The Paris endoscopic classification of superficial neoplastic lesions:esophagus, stomach, and colon:November 30 to December 1, 2002[J]. Gastrointest Endosc, 2003, 58(Suppl 6):S3-S43.
10. 夏玉亭, 吳云林, 房殿春. 胃病診治進展[M]. 上海:上海科技教育出版社, 2005:123.
11. Hamanaka H, Gotoda T. Endoscopic resection for early gastric cancer and future expectations[J]. Dig Endosc, 2005(17):275-285.
12. 潘文勝, 曹敏. 伴淋巴結轉移的早期胃癌病理組織形態學研究[J]. 中華消化雜志, 2006, 26(2):104-107.
13. Adachi Y, Shiraishi N, Kitano S. Modern treatment of early gastric cancer:review of the Japanese experience[J]. Dig Surg, 2002, 19(5):333-339.
14. Nasu J, Nishina T, Hirasaki S, et al. Predictive factors of lymph node metastasis in patients with undifferentiated early gastric cancers[J]. J Clin Gastroenterol, 2006, 40(5):412-415.
15. 李小毅, 王常珺, 鐘定榮, 等. 166例早期胃癌的診治分析[J]. 中國醫學科學院學報, 2011, 33(3):325-329.
16. Shinohara T, Ohyama S, Yamaguchi T, et al. Clinical value of multidetector row computed tomography in detecting lymph node metastasis of early gastric cancer[J]. Eur J Surg Oncol, 2005, 31(7):743-748.
17. Kwee RM, Kwee TC. Imaging in assessing lymph node status in gastric cancer[J]. Gastric Cancer, 2009, 12(1):6-22.
18. Tseng LJ, Mo LR, Tio TL, et al. Video-endoscopic ultrasonography in staging gastric carcinoma[J]. Hepatogastroenterology, 2000, 47(33):897-900.
19. 吳道宏, 吳本儼, 王孟薇, 等. 早期胃癌淋巴結轉移多因素分析[J]. 解放軍醫學雜志, 2006, 31(10):941-943.
20. Kim DY, Joo JK, Ryu SY, et al. Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma[J]. World J Gastroenterol, 2004, 10(5):737-740.
21. 王戈, 張玉華, 呂謙, 等. 早期胃癌臨床病理特征與淋巴結轉移范圍的關系[J]. 山東醫藥, 2008, 48(45):60-61.
22. Ohashi S, Segawa K, Okamura S, et al. The utility of endoscopic ultrasonography and endoscopy in the endoscopic mucosal resection of early gastric cancer[J]. Gut, 1999, 45(4):599-604.
23. Kwee RM, Kwee TC. The accuracy of endoscopic ultrasonography in differentiating mucosal from deeper gastric cancer[J]. Am J Gastroenterol, 2008, 103(7):1801-1809.
24. Yamamoto S, Nishida T, Kato M, et al. Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth[J]. Gastroenterol Res Pract, 2012:194530.
25. 張桂英, 王娟, 張曉梅, 等. 55例早期胃癌的臨床與病理分析[J]. 中國內鏡雜志, 2005, 11(12):1269-1272, 1276.
26. Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer:estimation with a large number of cases at two large centers[J]. Gastric Cancer, 2000, 3(4):219-225.
27. 朱敏, 李明陽, 吳本儼. 早期胃癌內鏡下切除術后復發的相關因素分析[J]. 中華內科雜志, 2011, 50(5):366-369.
28. Breslin NP, Thomson AB, Bailey RJ, et al. Gastric cancer and other endoscopic diagnoses in patients with benign dyspepsia[J]. Gut, 2000, 46(1):93-97.
29. 蕭樹東. 上海仁濟醫院消化內科專題講座[M]. 鄭州:鄭州大學出版社, 2005:71-77.
30. 王一平. 早期胃癌的內鏡治療[J]. 實用腫瘤雜志, 2008, 23(2):104-106.

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