Research on Related Factors for Prognosis in Patients with Cholangiocarcinoma_West China Medical Journal

Authors：

 MAOZhi-yuan ^1,2 , GUOXiao-chuan ¹ , ZHANGTing-ting ¹ , SUDan ¹ , WANGLi-jie ¹ ,  BAILi ¹

1. Department of Oncology, PLA General Hospital, Beijing 100853, P. R. China;
2. Department of Oncology, PLA Air Force General Hospital, Beijing 100142, P. R. Chinav;

Corresponding?author：

BAILi, Email: baili0795@126.com

Keywords：

Cholangiocarcinoma; Prognosis; Cox analysis

DOI：

10.7507/1002-0179.20140618

Video：

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Objective To review and summarize the clinical data and survival information of patients with cholangiocarcinoma treated by surgery, and to explore the clinical and pathological features of cholangiocarcinoma, and the relationship between intraoperative and postoperative characteristics and prognosis. Methods We retrospectively analyzed the clinical data of 678 cholangiocarcinoma patients after operation in the PLA General Hospital from January 2004 to December 2010, including the follow-up results of 397 cases. Only 293 patients with surgical resection of cholangiocarcinoma and non-surgical reasons for death were analyzed using Cox proportional hazards model. All indicators were analyzed by univariate and multivariate analysis. Results The median follow-up time was 55.9 months. As of the end of follow-up, there were 158 cases of recurrence (53.9%) and 223 cases of death (76.1%). The median overall survival time was 21.2 months, and 1-year, 3-year and 5-year survival rates were 71.7%, 38.2% and 10.6%, respectively. Tumor differentiation, TNM stage, surgical margin, intraoperative blood transfusion, tumor location, alkaline phosphatase levels in blood and recurrence were independent risk factors for overall survival time. Conclusion Low degree of tumor differentiation, advanced TNM stage, cancer invasion on the surgical margin, intraoperative blood transfusion, tumor located outside the liver, alkaline phosphatase levels in blood higher than normal, and cholangiocarcinoma tumor recurrence are risk factors for overall survival rate in patients with cholangiocarcinoma.

Citation： MAOZhi-yuan, GUOXiao-chuan, ZHANGTing-ting, SUDan, WANGLi-jie, BAILi. Research on Related Factors for Prognosis in Patients with Cholangiocarcinoma. West China Medical Journal, 2014, 29(11): 2046-2049. doi: 10.7507/1002-0179.20140618 Copy

1.	王健東, 全志偉. 膽管癌基礎研究現狀[J]. 中國實用外科雜志, 2008, 28(4):297-300.
2.	Hezel AF, Zhu AX. Systemic therapy for biliary tract cancers[J]. Oncologist, 2008, 13(4):415-423.
3.	Ebata T, Nagino M, Kamiya J, et al. Hepatectomy with portal vein resection for hilar cholangiocarcinoma:audit of 52 consecutive cases[J]. Ann Surg, 2003, 238(5):720-727.
4.	Rea DJ, Munoz-Juarez M, Farnell MB, et al. Major hepatic resection for hilar cholangiocarcinoma:analysis of 46 patients[J]. Arch Surg, 2004, 139(5):514-523.
5.	陳中, 晏建軍, 黃亮, 等. 肝內膽管細胞癌預后因素分析[J]. 中華肝膽外科雜志, 2006, 12(10):654-656.
6.	陶連元, 何小東, 高飛, 等. 肝外膽管癌的臨床病理與預后分析[J]. 肝膽外科雜志, 2011, 19(4):251-253.
7.	董娜娜, 段曉峰, 張倜, 等. 103例肝內膽管癌臨床病理及診治分析[J]. 中國腫瘤臨床, 2012, 39(6):340-342, 347.
8.	陸凱, 張博, 董立巍, 等. 中下段膽管癌的預后影響因素分析[J]. 現代生物醫學進展, 2012, 12(26):5068-5071.
9.	張佳, 吳碩東, 孔靜. 肝內膽管細胞癌的早期診斷[J]. 臨床誤診誤治, 2010, 23(增刊1):49-49.
10.	Khan SA, Davidson BR, Gold IR, et al. Guide lines for the diagnosis and treatment of cholangiocarcinoma:consensus document[J]. Gut, 2002, 51(Suppl 6):s7-s9.
11.	Ribero D, Amisano M, Lo Tesoriere R, et al. Additional resection of an intraoperative margin-positive proximal bile duct improves survival in patients with hilar cholangiocarcinoma[J]. Ann Surg, 2011, 254(5):776-781.
12.	陸凱. 不同部位膽管癌的臨床病理特征與預后關系分析[D]. 上海:第二軍醫大學, 2007:1-55.
13.	De Jong MC, Nathan H, Sotiropoulos GC, et al. Intrahepatic cholangiocarcinoma:an international multi-institutional analysis of prognostic factors and lymph node assessment[J]. J Clin Oncol, 2011, 29(23):3140-3145.
14.	Shiba H, Ishida Y, Wakiyama S, et al. Negative impact of blood transfusion on recurrence and prognosis of hepatocellular carcinoma after hepatic resection[J]. J Gastrointest Surg, 2009, 13(9):1636-1642.
15.	石俊方, 楊椿. 輸血對惡性腫瘤手術預后的影響[J]. 中國腫瘤臨床, 1991, 18(增刊1):318-319.
16.	李書紅, 王俊, 張金野, 等. 手術切除肝內膽管細胞癌預后相關因素分析[J]. 中華腫瘤防治雜志, 2011, 18(24):1956-1959.
17.	張梅英, 溫志立, 許艷華. ALP、γ-GT和CHE檢測在慢性乙型肝炎、肝硬化、肝癌、膽道疾病中的臨床意義[J]. 南昌大學學報·醫學版, 2012, 52(2):34-36.

1. 王健東, 全志偉. 膽管癌基礎研究現狀[J]. 中國實用外科雜志, 2008, 28(4):297-300.
2. Hezel AF, Zhu AX. Systemic therapy for biliary tract cancers[J]. Oncologist, 2008, 13(4):415-423.
3. Ebata T, Nagino M, Kamiya J, et al. Hepatectomy with portal vein resection for hilar cholangiocarcinoma:audit of 52 consecutive cases[J]. Ann Surg, 2003, 238(5):720-727.
4. Rea DJ, Munoz-Juarez M, Farnell MB, et al. Major hepatic resection for hilar cholangiocarcinoma:analysis of 46 patients[J]. Arch Surg, 2004, 139(5):514-523.
5. 陳中, 晏建軍, 黃亮, 等. 肝內膽管細胞癌預后因素分析[J]. 中華肝膽外科雜志, 2006, 12(10):654-656.
6. 陶連元, 何小東, 高飛, 等. 肝外膽管癌的臨床病理與預后分析[J]. 肝膽外科雜志, 2011, 19(4):251-253.
7. 董娜娜, 段曉峰, 張倜, 等. 103例肝內膽管癌臨床病理及診治分析[J]. 中國腫瘤臨床, 2012, 39(6):340-342, 347.
8. 陸凱, 張博, 董立巍, 等. 中下段膽管癌的預后影響因素分析[J]. 現代生物醫學進展, 2012, 12(26):5068-5071.
9. 張佳, 吳碩東, 孔靜. 肝內膽管細胞癌的早期診斷[J]. 臨床誤診誤治, 2010, 23(增刊1):49-49.
10. Khan SA, Davidson BR, Gold IR, et al. Guide lines for the diagnosis and treatment of cholangiocarcinoma:consensus document[J]. Gut, 2002, 51(Suppl 6):s7-s9.
11. Ribero D, Amisano M, Lo Tesoriere R, et al. Additional resection of an intraoperative margin-positive proximal bile duct improves survival in patients with hilar cholangiocarcinoma[J]. Ann Surg, 2011, 254(5):776-781.
12. 陸凱. 不同部位膽管癌的臨床病理特征與預后關系分析[D]. 上海:第二軍醫大學, 2007:1-55.
13. De Jong MC, Nathan H, Sotiropoulos GC, et al. Intrahepatic cholangiocarcinoma:an international multi-institutional analysis of prognostic factors and lymph node assessment[J]. J Clin Oncol, 2011, 29(23):3140-3145.
14. Shiba H, Ishida Y, Wakiyama S, et al. Negative impact of blood transfusion on recurrence and prognosis of hepatocellular carcinoma after hepatic resection[J]. J Gastrointest Surg, 2009, 13(9):1636-1642.
15. 石俊方, 楊椿. 輸血對惡性腫瘤手術預后的影響[J]. 中國腫瘤臨床, 1991, 18(增刊1):318-319.
16. 李書紅, 王俊, 張金野, 等. 手術切除肝內膽管細胞癌預后相關因素分析[J]. 中華腫瘤防治雜志, 2011, 18(24):1956-1959.
17. 張梅英, 溫志立, 許艷華. ALP、γ-GT和CHE檢測在慢性乙型肝炎、肝硬化、肝癌、膽道疾病中的臨床意義[J]. 南昌大學學報·醫學版, 2012, 52(2):34-36.

West China Medical Journal

Research on Related Factors for Prognosis in Patients with Cholangiocarcinoma

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