The Distribution of Mite Allergens in Chronic Obstructive Pulmonary Disease Patients and the Role of Allergen in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hainan Province_West China Medical Journal

Authors：

 XIETian , HUANGYi-jiang , GAOFang-die

Department of Respiratory Medicine, Hainan Provincial People's Hospital, Haikou, Hainan 570311, P. R. China;

Corresponding?author：

Keywords：

Chronic obstructive pulmonary disease; Skin prick test; Blomia Tropicalis

DOI：

10.7507/1002-0179.20140611

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Objective To explore the distribution of mite allergens in chronic obstructive pulmonary disease (COPD) patients and the role of allergen in acute exacerbation of COPD (AECOPD) in Hainan Province. Methods We selected 65 COPD patients, 58 other patients without allergic disease and 34 healthy subjects as the control group from January to June in 2009. All subjects underwent skin prick test (SPT) to make statistical analysis. We observed the COPD patients for 3 years to analyze the correlation between SPT positive incidence and frequency of acute exacerbation. Results The SPT positive incidence was higher in the COPD group (P<0.05). The most frequent allergen in COPD group was Blomia Tropicalis. But the SPT positive incidence and frequency of acute exacerbation was not obvious correlated (P>0.05). Conclusion The exogenous allergens may participate in the pathogenesis of COPD. Blomia Tropicalis may be an important allergen of COPD patients in Hainan Province other than Dermatophagoides Pteronyssinus and Dermatophagoides Farinae. But allergy does not play a role in acute exacerbation of COPD.

Citation： XIETian, HUANGYi-jiang, GAOFang-die. The Distribution of Mite Allergens in Chronic Obstructive Pulmonary Disease Patients and the Role of Allergen in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hainan Province. West China Medical Journal, 2014, 29(11): 2016-2018. doi: 10.7507/1002-0179.20140611 Copy

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1. 辛曉峰, 施毅. 支氣管哮喘和慢性阻塞性肺疾病的相似關系[J]. 中華結核和呼吸雜志, 2006, 29(6):428-430.
2. Orie NGM, Sluiter HJ, de Vries K, et al. The host factor in bronchitis[M]//Orie NGM, Sluiter HJ. Bronchitis:an international symposium[M]. Assen:Royal van Gorcum, 1961:43-59.
3. 秦興國, 周瑛, 肖平, 等. 塵螨過敏在慢性阻塞性肺病急性加重中的作用[J]. 河南診斷與治療雜志, 1999, 13(1):11, 13.
4. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南(2013年修訂版)[J]. 中華結核和呼吸雜志, 2013, 36(4):1-10.
5. 張曉軍, 何韶衡, 謝華, 等. 慢性阻塞性肺疾病患者痰中肥大細胞和嗜酸粒細胞因子變化及其相關性研究[J]. 中華結核和呼吸雜志, 2004, 27(10):649-653.
6. Pesci A, Rossi GA, Bertorelli G, et al. Mast cells in the airway lumen and bronchial mucosa of patients with chronic bronchitis[J]. Am J Respir Crit Care Med, 1994, 149(5):1311-1316.
7. 劉云霞, 黃家淼, 宗曉福, 等. COPD與哮喘體外過敏原血清特異性IgE檢測的結果分析[J]. 東南國防醫藥, 2007, 9(2):84-85, 104.
8. Liao EC, Ho CM, Tsai JJ. Prevalence of Tyrophagus putrescentiae hypersensitivity in subjects over 70 years of age in a veterans' nursing home in Taiwan[J]. Int Arch Allergy Immunol, 2010, 152(4):368-377.
9. Li J, Sun B, Huang Y, et al. A multicenter study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64(7):1083-1092.
10. 崔玉寶. 塵螨的生物學、生態學與流行概況[J]. 國外醫學·寄生蟲病分冊, 2004, 31(6):277-281.
11. 謝甜, 黃奕江. 熱帶螨與支氣管哮喘[J]. 國際呼吸雜志, 2010, 30(11):693-696.
12. 朱洪, 崔玉寶, 饒朗毓. 哮喘患者居室內塵螨孳生種類、密度及其與抗原濃度的相關性研究[J]. 中國媒介生物學及控制雜志, 2007, 18(5):381-383.
13. 陳實, 鄭軼武, 王靈, 等. 海南變態反應性疾病患兒對屋塵螨/粉塵螨和倉儲螨的特異性IgE[J]. 中華臨床免疫和變態反應雜志, 2010, 4(3):191-195.
14. 喻海瓊, 劉志剛, 于琨瑛, 等. 重組屋塵螨2類變應原疫苗免疫治療小鼠過敏性氣道炎癥的研究[J]. 中國寄生蟲學與寄生蟲病雜志, 2006, 24(6):414-419.
15. 國華, 朱清仙, 劉志剛, 等. 粉塵螨-殼聚糖疫苗經鼻免疫治療小鼠過敏性哮喘的實驗研究[J]. 現代免疫學, 2008, 28(1):21-25.
16. Sato MN, Oliveira CR, Futata EA, et al. Oral tolerance induction to Dermatophagoides pteronyssinus and Blomia tropicalis in sensitized mice:occurrence of natural autoantibodies to immunoglobulin E[J]. Clin Exp Allergy, 2002, 32(11):1667-1674.

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West China Medical Journal

The Distribution of Mite Allergens in Chronic Obstructive Pulmonary Disease Patients and the Role of Allergen in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hainan Province

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