Study on the Relationship between the Levels of Serum Transferrin, Prealbumin and Total Bile Acids and the Hepatic Reserve Function in Primary Liver Cancer Patients_West China Medical Journal

Authors：

 LIUQing-rong ¹ ,  XIAQing-jie ²

1. Clinical Laboratory, Chengdu Central Hospital of Women and Children, Chengdu, Sichuan 610091, P. R. China;
2. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

XIAQing-jie, Email: xiaqj2005@126.com

Keywords：

Primary hepatic carcinoma; Transferrin; Prealbumin; Total bile acid; Hepatic reserve function

DOI：

10.7507/1002-0179.20140569

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Objective To explore the relationship between the levels of transferrin (TRF), prealbumin (PAB) and total bile acids (TBA) in serum and the loss of the hepatic reserve function in primary liver cancer (PHC) patients and the importance of the former factors for diagnosis of PHC. Methods A total of 154 patients with PHC collected between March 2010 and February 2013 were included in our study. Based on the information of hepatic reserve function and the Child-Pugh classification standard, the patients were divided into Child-Pugh-A, B, and C groups with 67, 55 and 42 patients respectively. Another 58 healthy subjects were selected as the control group. Serum TRF, PAB and TBA levels were measured by automated chemiluminescence immunoassay, immune turbidimetric assay and enzymatic cycling respectively, and they were compared among the groups. Results TRF level of patients in the control group and Child-Pugh-A, B, and C groups was respectively (2.574±0.214), (1.618±0.135), (0.988±0.121), and (0.314±0.107) g/L, with significant differences among the groups (P<0.05). PAB level of patients in four groups was respectively (269.32±37.29), (165.22±21.01), (123.24±31.15), and (83.66±19.74) mg/L, with significant differences among the groups (P<0.05). TBA level in the above four groups was respectively (9.16±2.48), (65.13±4.25), (133.62±8.44), and (250.73±21.59) μmol/L, and there was also significant differences among the groups. A positive correlation between serum TRF and PAB was found (r=0.927, P<0.001), and negative correlations between serum TBA level and serum TRF and between TBA and PAB were found (r=-0.454, P<0.001; r=-0.432, P<0.001, respectively). Conclusion Serum TRF, PAB and TBA levels are closely related to the hepatic reserve function in PHC patients, and they can be used as an important indicator for PHC diagnosis.

Citation： LIUQing-rong, XIAQing-jie. Study on the Relationship between the Levels of Serum Transferrin, Prealbumin and Total Bile Acids and the Hepatic Reserve Function in Primary Liver Cancer Patients. West China Medical Journal, 2014, 29(10): 1883-1886. doi: 10.7507/1002-0179.20140569 Copy

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9.	Guerra LT, Rosa AR, Romani RF, et al. Serum transferrin and serum prealbumin as markers of response to nutritional support in patients with esophageal cancer[J]. Nutr Hosp, 2009, 24(2):241-242.
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11.	吳俊琪, 范順富, 何航兵. 血清PAB、AAG、AAT的檢測在肝臟疾病中的意義[J]. 江西醫學檢驗, 2000, 18(2):79-80, 86.
12.	梁影, 雷婷, 石秀芳, 等. 血清前白蛋白、總膽汁酸和膽堿酯酶聯合檢測在乙型肝炎進展中的臨床價值[J]. 淮海醫藥, 2013, 31(5):386-387.
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14.	程峰濤, 李鐸, 蔡敏. 乙型肝炎后肝硬化患者血清總膽汁酸測定的意義[J]. 中華消化雜志, 1998, 18(2):92.
15.	Ikeda S, Mitaka T, Harada K, et al. Tumor necrosis factor-alpha and interleukin-6 reduce bile canalicular contractions of rat hepatocytes[J]. Surgery, 2003, 133(1):101-109.
16.	Pazzi P, Morsiani E, Vilei MT, et al. Serum bile acids in patients with liver failure supported with a bioartificial liver[J]. Aliment Pharmacol Ther, 2002, 16(8):1547-1554.

1. Galiegos-Orozco JF, Vargas HE. Liver transplantation:from Child to MELD[J]. Med Clin North Am, 2009, 93(4):931-950.
2. 張陽東, 楚瑞雪. 血清甲胎蛋白與血清鐵蛋白檢測及其在原發性肝癌中的診斷意義[J]. 標記免疫分析與臨床, 2008, 15(1):26-27.
3. 章谷生. 發光分析和發光免疫技術[M]. 上海:上海醫科大學出版社, 1999:716.
4. 劉華平, 董藎, 蔡天沛. 血清轉鐵蛋白測定臨床意義的初步觀察[J]. 安徽醫學院學報, 1983, 18(3):34-35, 91-92.
5. Evans RW, Crawley JB, Garratt RC, et al. Characterization and structural analysis of a functional human serum transferrin variant and implications for receptor recognition[J]. Biochemistry, 1994, 33(41):12512-12520.
6. 張春慧, 崔法新. 血清轉鐵蛋白測定在小兒感染性疾病中的意義[J]. 臨床薈萃, 2002, 17(21):1285-1286.
7. 石勝, 盧岑. 原發性肝癌病人血清總膽汁酸和轉鐵蛋白水平與Child分級的關系[J]. 中國基層醫藥, 2004, 11(5):600-601.
8. Sobhonslidsuk A, Roongpisuthipong C, Nantiruj K, et al. Impact of liver cirrhosis on nutritional and immunological status[J]. J Med Assoc Thai, 2001, 84(7):982-988.
9. Guerra LT, Rosa AR, Romani RF, et al. Serum transferrin and serum prealbumin as markers of response to nutritional support in patients with esophageal cancer[J]. Nutr Hosp, 2009, 24(2):241-242.
10. Yasmin MY, Aziz B, Nazim M, et al. Prealbumni rather than albumin is a more sensitive indicator of acute liver disease[J]. Malays J Pathol, 1993, 15(2):147-150.
11. 吳俊琪, 范順富, 何航兵. 血清PAB、AAG、AAT的檢測在肝臟疾病中的意義[J]. 江西醫學檢驗, 2000, 18(2):79-80, 86.
12. 梁影, 雷婷, 石秀芳, 等. 血清前白蛋白、總膽汁酸和膽堿酯酶聯合檢測在乙型肝炎進展中的臨床價值[J]. 淮海醫藥, 2013, 31(5):386-387.
13. 楊旭, 雷建華, 張永紅, 等. 血清總膽汁酸測定的意義及其局限性[J]. 中華內科雜志, 2001, 40(1):16-17.
14. 程峰濤, 李鐸, 蔡敏. 乙型肝炎后肝硬化患者血清總膽汁酸測定的意義[J]. 中華消化雜志, 1998, 18(2):92.
15. Ikeda S, Mitaka T, Harada K, et al. Tumor necrosis factor-alpha and interleukin-6 reduce bile canalicular contractions of rat hepatocytes[J]. Surgery, 2003, 133(1):101-109.
16. Pazzi P, Morsiani E, Vilei MT, et al. Serum bile acids in patients with liver failure supported with a bioartificial liver[J]. Aliment Pharmacol Ther, 2002, 16(8):1547-1554.

West China Medical Journal

Study on the Relationship between the Levels of Serum Transferrin, Prealbumin and Total Bile Acids and the Hepatic Reserve Function in Primary Liver Cancer Patients

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