Clinical Analysis on Noninvasive Ventilator in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Failure_West China Medical Journal

Authors：

 HUANGLiu-qiu ,  LIShao-jun

Department of Respiratory Medicine, Hospital of Guangxi Liuzhou Iron and steel(Group) Company, Liuzhou, Guangxi 545000, P. R. China;

Corresponding?author：

LIShao-jun, Email: 120689690@qq.com

Keywords：

Bilevel positive airway pressure; Chronic obstructive pulmonary disease; Respiratory failure

DOI：

10.7507/1002-0179.20140551

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the clinical curative effect of bilevel positive airway pressure (BiPAP) noninvasive ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with respiratory failure. Methods The clinical materials of 80 patients with AECOPD with respiratory failure were reviewed and analyzed from January 2010 to December 2012. The patients were divided into two groups based on whether BiPAP mechanical ventilation therapy was implemented or not. The vital signs and arterial blood gas analysis, curative effect and medical expenses were compared between the two groups. Results The indexes of vital signs and blood gas analysis before and after treatment showed the consistency of the trend of gradual improvement (P<0.05). After 3-day treatment, the indexes of vital signs and blood gas analysis in the study group were significantly better than the control group (P<0.05). Compared with the control group, the total effective rate was significantly higher, the hospital stay was significantly shorter, the intubation was significantly less, and the medical expenses were significantly lower in the study group (P<0.05). Conclusion The BiPAP non-invasive ventilator has significant effect in improving vital sign, index of blood gas analysis, rate of endotracheal intubation and length of stay, which is worthy of further promotion.

Citation： HUANGLiu-qiu, LIShao-jun. Clinical Analysis on Noninvasive Ventilator in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Failure. West China Medical Journal, 2014, 29(10): 1810-1813. doi: 10.7507/1002-0179.20140551 Copy

1.	張婷. 無創正壓通氣在急性呼吸衰竭中的應用[J]. 醫學綜述, 2010, 16(14):2180-2182.
2.	Agarwal R, Gupta R, Aggarwal AN, et al. Noninvasive positive pressure ventilation in acute respiratory failure due to COPD vs other causes:effectiveness and predictors of failure in a respiratory ICU in North India[J]. Int J Chron Obstruct Pulmon Dis, 2008, 3(4):737-743.
3.	中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南(2007年修訂版)[J]. 中華內科雜志, 2007, 30(3):254-261.
4.	Lim W, Bardwell WA, Lorsdo JS, et al. Neuropsychological effect of week continuous positive airway pressure treatment and supplemental oxygen in patients with obstructive sleep apnea:a randomized placebo-controlled study[J]. J Clin Sleep Med, 2007, 3(4):380-386.
5.	王麗霞, 趙靜, 古力·喀德爾, 等. BiPAP聯合納洛酮治療COPD急性加重期合并Ⅱ型呼吸衰竭的療效觀察[J]. 臨床和實驗醫學雜志, 2011, 10(20):1611-1612.
6.	Rothberg MB, Pekow PS, Lahti M, et al. Comparative effectiveness of macrolides and quinolones for patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD)[J]. J Hosp Med, 2010, 5(5):261-267.
7.	虞松平, 梁永杰. 慢性阻塞性肺疾病合并心力衰竭的診治進展[J]. 內科理論與實踐, 2012, 7(3):237-240.
8.	馬繼揚, 高健, 梁民勇. BiPAP呼吸機治療AECOPD合并Ⅱ型呼吸衰竭的療效觀察[J]. 臨床和實驗醫學雜志, 2011, 10(11):819-821.
9.	Williams AM, Abramo TJ, Shah MV, et al. Safety and clinical findings of BiPAP utilization in children 20 kg or less for asthma exacerbations[J]. Intensive Care Med, 2011, 37(8):1338-1343.
10.	李艷肖, 史金英, 袁德琴, 等. 無創正壓通氣治療慢性阻塞性肺疾病急性加重期并重度二氧化碳潴留效果觀察[J]. 臨床誤診誤治, 2013, 26(3):75-77.
11.	Bassanezi BS, Oliveira-Filho AG, Miranda ML, et al. Use of BiPAP for safe anesthesia in a child with a large anterior mediastinal mass[J]. Paediatr Anaesth, 2011, 21(9):985-987.
12.	Roy B, Cordova FC, Travaline JM, et al. Full face mask for noninvasive positive-pressure ventilation in patients with acute respiratory failure[J]. J Am Osteopath Assoc, 2007, 107(4):148-156.
13.	蘇陽楚. BiPAP呼吸機治療COPD并Ⅱ型呼吸衰竭48例療效觀察[J]. 臨床和實驗醫學雜志, 2010, 9(22):1697-1698.
14.	Lellouche F, Brochard L. Advanced closed loops during mechanical ventilation (PAV, NAVA, ASV, SmartCare)[J]. Best Pract Res Clin Anaesthesiol, 2009, 23(1):81-93.
15.	劉新茹, 安立紅, 賈紅光, 等. COPD合并Ⅱ型呼衰應用無創通氣患者依從性的原因及對策[J]. 臨床肺科雜志, 2012, 17(7):1319-1320.
16.	王化強. BiPAP無創通氣治療急性左心功能衰竭對心功能和血漿內皮素、一氧化氮和腦鈉肽濃度的影響[J]. 臨床醫學, 2011, 31(7):16-18.

1. 張婷. 無創正壓通氣在急性呼吸衰竭中的應用[J]. 醫學綜述, 2010, 16(14):2180-2182.
2. Agarwal R, Gupta R, Aggarwal AN, et al. Noninvasive positive pressure ventilation in acute respiratory failure due to COPD vs other causes:effectiveness and predictors of failure in a respiratory ICU in North India[J]. Int J Chron Obstruct Pulmon Dis, 2008, 3(4):737-743.
3. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南(2007年修訂版)[J]. 中華內科雜志, 2007, 30(3):254-261.
4. Lim W, Bardwell WA, Lorsdo JS, et al. Neuropsychological effect of week continuous positive airway pressure treatment and supplemental oxygen in patients with obstructive sleep apnea:a randomized placebo-controlled study[J]. J Clin Sleep Med, 2007, 3(4):380-386.
5. 王麗霞, 趙靜, 古力·喀德爾, 等. BiPAP聯合納洛酮治療COPD急性加重期合并Ⅱ型呼吸衰竭的療效觀察[J]. 臨床和實驗醫學雜志, 2011, 10(20):1611-1612.
6. Rothberg MB, Pekow PS, Lahti M, et al. Comparative effectiveness of macrolides and quinolones for patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD)[J]. J Hosp Med, 2010, 5(5):261-267.
7. 虞松平, 梁永杰. 慢性阻塞性肺疾病合并心力衰竭的診治進展[J]. 內科理論與實踐, 2012, 7(3):237-240.
8. 馬繼揚, 高健, 梁民勇. BiPAP呼吸機治療AECOPD合并Ⅱ型呼吸衰竭的療效觀察[J]. 臨床和實驗醫學雜志, 2011, 10(11):819-821.
9. Williams AM, Abramo TJ, Shah MV, et al. Safety and clinical findings of BiPAP utilization in children 20 kg or less for asthma exacerbations[J]. Intensive Care Med, 2011, 37(8):1338-1343.
10. 李艷肖, 史金英, 袁德琴, 等. 無創正壓通氣治療慢性阻塞性肺疾病急性加重期并重度二氧化碳潴留效果觀察[J]. 臨床誤診誤治, 2013, 26(3):75-77.
11. Bassanezi BS, Oliveira-Filho AG, Miranda ML, et al. Use of BiPAP for safe anesthesia in a child with a large anterior mediastinal mass[J]. Paediatr Anaesth, 2011, 21(9):985-987.
12. Roy B, Cordova FC, Travaline JM, et al. Full face mask for noninvasive positive-pressure ventilation in patients with acute respiratory failure[J]. J Am Osteopath Assoc, 2007, 107(4):148-156.
13. 蘇陽楚. BiPAP呼吸機治療COPD并Ⅱ型呼吸衰竭48例療效觀察[J]. 臨床和實驗醫學雜志, 2010, 9(22):1697-1698.
14. Lellouche F, Brochard L. Advanced closed loops during mechanical ventilation (PAV, NAVA, ASV, SmartCare)[J]. Best Pract Res Clin Anaesthesiol, 2009, 23(1):81-93.
15. 劉新茹, 安立紅, 賈紅光, 等. COPD合并Ⅱ型呼衰應用無創通氣患者依從性的原因及對策[J]. 臨床肺科雜志, 2012, 17(7):1319-1320.
16. 王化強. BiPAP無創通氣治療急性左心功能衰竭對心功能和血漿內皮素、一氧化氮和腦鈉肽濃度的影響[J]. 臨床醫學, 2011, 31(7):16-18.

West China Medical Journal

Clinical Analysis on Noninvasive Ventilator in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Failure

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content