Clinical Investigation of Laparoscopic Cytoreductive Surgery Combined with Gestrinone in the Treatment of Adenomyosis_West China Medical Journal

Authors：

 WEIZeng-tao ^1,2 , CUIXiao-yan ^1,3 , WANGZhan-ying ¹ , WANGSu-qin ⁴ , WANGXiao-yan ²

1. Department of Gynecology, Central Hospital of Jinan City Affiliated to Shandong University, Jinan, Shandong 250012, P. R. China;
2. Teaching Section of Gynecology, Medical College of Shandong University, Jinan, Shandong 250012, P. R. China;
3. Teaching Section of Gynecology, Weifang Medical College, Weifang, Shandong 261053, P. R. China;
4. Department of Gynecology, the Second People's Hospital of Qihe County, Qihe, Shandong 251100, P. R. China;

Corresponding?author：

Keywords：

Adenomyosis; Laparoscopy; Cytoreductive surgery; Gestrinone; Clinical effect

DOI：

10.7507/1002-0179.20140513

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the clinical effect and safety of laparoscopic cytoreductive surgery combined with gestrinone in the treatment of adenomyosis. Methods We retrospectively analyzed the clinical data of 82 patients with adenomyosis who accepted treatment in our hospital from January 2008 to April 2011. According to different treatment method, the patients were divided into three groups. Twenty-seven patients in the treatment group underwent laparoscopic cytoreductive surgery combined with postoperative treatment with gestrinone. For the 25 patients in the surgery group, only laparoscopic cytoreductive surgery was performed, and 30 other patients who only received oral gestrinone were designated as the medicine group. Dysmenorrhea, menstrual volume, uterine size, serum carcinoembryonic antigen 125 (CA125), anemia, and drug side effects were respectively recorded before and after surgery. Results The dysmenorrhea degree reduced significantly in all the three groups. There was no significant difference in the degree of dysmenorrhea, menstrual volume, and uterine volume between the treatment group and the surgery group (P>0.05); the dysmenorrhea degree was significantly different between the treatment group and the medicine group (P<0.05); the differences in hemoglobin levels and the serum CA125 level between the treatment group and the surgery group 12 months later were significant (P=0.019, P=0.049). Conclusion The laparoscopic cytoreductive surgery combined with gestrinone in treating adenomyosis can improve recent curative effect and provide more effective symptom control compared with surgery alone.

Citation： WEIZeng-tao, CUIXiao-yan, WANGZhan-ying, WANGSu-qin, WANGXiao-yan. Clinical Investigation of Laparoscopic Cytoreductive Surgery Combined with Gestrinone in the Treatment of Adenomyosis. West China Medical Journal, 2014, 29(9): 1682-1686. doi: 10.7507/1002-0179.20140513 Copy

1.	Kim MD,Won JW,Lee DY,et al.Uterine artery embolization for adenomyosis without fibroids[J].Clin Radiol,2004,59(6):520-526.
2.	艾小燕,程玉芬,張曉玲.腹腔鏡病灶切除術聯合戈舍瑞林治療子宮腺肌瘤30例臨床分析[J].實用婦產科雜志,2009(12):755-756.
3.	陳春林,劉萍,呂軍,等.子宮動脈栓塞術在子宮腺肌病治療中的應用[J].中華婦產科雜志,2002,37(2):77-79.
4.	Kim MD,Kim S,Kim NK,et al.Long-term results of uterine artery embolization for symptomatic adenomyosis[J].AJR Am J Roentgenol,2007,188(1):176-181.
5.	Pepas L,Deguara C,Davis C.Update on the surgical management of adenomyosis[J].Curr Opin Obstet Gynecol,2012,24(4):259-264.
6.	樂杰.婦產科學[M].7版.北京:人民衛生出版社,2008:331-332.
7.	Wang PH,Liu WM,Fuh JL,et al.Comparison of surgery alone and combined surgical-medical treatment in the management of symptomatic uterine adenomyoma[J].Fertil Steril,2009,92(3):876-885.
8.	Katz A.Sexuality after hysterectomy[J].J Obstet Gynecol Neonatal Nurs,2002,31(3):256-262.
9.	Mobarakeh MD,Maghsudi A,Rashidi I.Adenomyosis among samples from hysterectomy due to abnormal uterine bleeding in Ahwaz,southern Iran[J].Adv Biomed Res,2012:49.
10.	李鼎恒,徐愔燁,壽堅,等.腹腔鏡下腺肌瘤病灶切除聯合曼月樂治療子宮腺肌病疼痛53例觀察[J].中華危重癥醫學雜志·電子版,2010,3(5):331-334.
11.	李娟,溫澤清.子宮腺肌病的治療進展[J].中國現代醫學雜志,2012,22(11):60-65.
12.	張惜陰.實用婦產科學[M].2版.北京:人民衛生出版社,2003:746.
13.	沈宏偉,曾海濤,柯佩琪,等.CA125對子宮動脈栓塞術治療子宮腺肌病療效和復發的預測價值[J].中山大學學報·醫學科學版,2007,28(增刊1):74-75.
14.	Huang BS,Seow KM,Tsui KH,et al.Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist:long-term follow-up in a series of nine patients[J].Taiwan J Obstet Gynecol,2012,51(2):212-216.
15.	李雷,冷金花,郎景和.子宮內膜異位癥和子宮腺肌癥手術治療的經濟學指標分析[J].中華醫學雜志,2011,91(37):2619-2622.
16.	Wang PH,Fuh JL,Chao HT,et al.Is the surgical approach beneficial to subfertile women with symptomatic extensive adenomyosis?[J].J Obstet Gynaecol Res,2009,35(3):495-502.

1. Kim MD,Won JW,Lee DY,et al.Uterine artery embolization for adenomyosis without fibroids[J].Clin Radiol,2004,59(6):520-526.
2. 艾小燕,程玉芬,張曉玲.腹腔鏡病灶切除術聯合戈舍瑞林治療子宮腺肌瘤30例臨床分析[J].實用婦產科雜志,2009(12):755-756.
3. 陳春林,劉萍,呂軍,等.子宮動脈栓塞術在子宮腺肌病治療中的應用[J].中華婦產科雜志,2002,37(2):77-79.
4. Kim MD,Kim S,Kim NK,et al.Long-term results of uterine artery embolization for symptomatic adenomyosis[J].AJR Am J Roentgenol,2007,188(1):176-181.
5. Pepas L,Deguara C,Davis C.Update on the surgical management of adenomyosis[J].Curr Opin Obstet Gynecol,2012,24(4):259-264.
6. 樂杰.婦產科學[M].7版.北京:人民衛生出版社,2008:331-332.
7. Wang PH,Liu WM,Fuh JL,et al.Comparison of surgery alone and combined surgical-medical treatment in the management of symptomatic uterine adenomyoma[J].Fertil Steril,2009,92(3):876-885.
8. Katz A.Sexuality after hysterectomy[J].J Obstet Gynecol Neonatal Nurs,2002,31(3):256-262.
9. Mobarakeh MD,Maghsudi A,Rashidi I.Adenomyosis among samples from hysterectomy due to abnormal uterine bleeding in Ahwaz,southern Iran[J].Adv Biomed Res,2012:49.
10. 李鼎恒,徐愔燁,壽堅,等.腹腔鏡下腺肌瘤病灶切除聯合曼月樂治療子宮腺肌病疼痛53例觀察[J].中華危重癥醫學雜志·電子版,2010,3(5):331-334.
11. 李娟,溫澤清.子宮腺肌病的治療進展[J].中國現代醫學雜志,2012,22(11):60-65.
12. 張惜陰.實用婦產科學[M].2版.北京:人民衛生出版社,2003:746.
13. 沈宏偉,曾海濤,柯佩琪,等.CA125對子宮動脈栓塞術治療子宮腺肌病療效和復發的預測價值[J].中山大學學報·醫學科學版,2007,28(增刊1):74-75.
14. Huang BS,Seow KM,Tsui KH,et al.Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist:long-term follow-up in a series of nine patients[J].Taiwan J Obstet Gynecol,2012,51(2):212-216.
15. 李雷,冷金花,郎景和.子宮內膜異位癥和子宮腺肌癥手術治療的經濟學指標分析[J].中華醫學雜志,2011,91(37):2619-2622.
16. Wang PH,Fuh JL,Chao HT,et al.Is the surgical approach beneficial to subfertile women with symptomatic extensive adenomyosis?[J].J Obstet Gynaecol Res,2009,35(3):495-502.

Previous Article
Clinical Study of Carbon Dioxide Laser in Treating Laryngeal Papilloma
Next Article
雙下肢及顏面部水腫為首發表現的POEMS綜合征一例

West China Medical Journal

Clinical Investigation of Laparoscopic Cytoreductive Surgery Combined with Gestrinone in the Treatment of Adenomyosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content