Diagnosis Accuracy of Interleukin-12 for Tuberculous Pleurisy: A Meta-analysis_West China Medical Journal

Authors：

 CHENFu-xiang ¹ , GONGYa-nan ² , ZHANGHai-fei ¹

1. Department of Respiratory Medicine;the Traditional Chinese Medicine Hospital of Pengzhou, Pengzhou, Sichuan 611930, P. R. China;
2. Department of Emergency;the Traditional Chinese Medicine Hospital of Pengzhou, Pengzhou, Sichuan 611930, P. R. China;

Corresponding?author：

Keywords：

Interleukin-12; Tuberculous pleurisy; Meta-analysis

DOI：

10.7507/1002-0179.20140507

Video：

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Objective To investigate the overall accuracy of interleukin-12 (IL-12) for diagnosis of tuberculous pleurisy. Methods We searched in PubMed, Embase, Web of Science, China National Knowledge Infrastructure databases, WanFang Data, and VIP Information for qualified studies that reported diagnostic accuracy of IL-12 for tuberculous pleurisy up to February 2014. The methodological quality of each study was evaluated by Quality assessment of diagnostic accuracy studies. Statistical analyses were performed by Meta-Disc 1.4 software and the pooled sensitivity, specificity and other diagnostic indexes. Meta-analysis of the reported accuracy of each study and summary receiver operating characteristic (SROC) curve were also performed. Results Eight studies met the inclusion criteria for the analysis. The summary estimates for IL-12 in the diagnosis of tuberculous pleurisy were:sensitivity 0.80 [95% CI (0.76, 0.84)], specificity 0.76 [95% CI (0.71, 0.81)], positive likelihood ratio 3.23 [95% CI (2.26, 4.60)], negative likelihood ratio 0.30 [95% CI (0.20, 0.45)], diagnostic odds ratio 13.57 [95% CI (6.66, 27.64)], and the area under the curve of SROC was 0.86. Conclusion IL-12 plays a valuable role in the diagnosis of tuberculous pleurisy, and IL-12 may be a useful diagnostic marker for tuberculous pleurisy.

Citation： CHENFu-xiang, GONGYa-nan, ZHANGHai-fei. Diagnosis Accuracy of Interleukin-12 for Tuberculous Pleurisy: A Meta-analysis. West China Medical Journal, 2014, 29(9): 1653-1657. doi: 10.7507/1002-0179.20140507 Copy

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10.	Valdés L,San José E,Alvarez Doba?o JM,et al.Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions[J].Eur Respir J,2009,33(4):816-820.
11.	姜振東,王蔚然,劉心.白細胞介素12在結核性胸膜炎診斷中的應用價值[J].中國實用醫藥,2010,5(1):50-51.
12.	陳利華,蔣捍東,林存智.γ干擾素、白細胞介素18、白細胞介素12及可溶性白細胞介素2受體在結核性和惡性胸腔積液中表達意義分析[J].中華臨床醫師雜志·電子版,2011,5(12):3602-3604.
13.	Fernández de Larrea C,Duplat A,Giampietro F,et al.Diagnostic accuracy of immunological methods in patients with tuberculous pleural effusion from Venezuela[J].Invest Clin,2011,52(1):23-34.
14.	周世新,譚金,肖學平.腺苷脫氨酶與腫瘤壞死因子-α和白細胞介素-12檢測在診斷結核性胸腔積液中臨床價值的比較[J].檢驗醫學與臨床,2012,9(12):1436-1437.
15.	Bays AM,Pierson DJ.Tuberculous pleural effusion[J].Respir Care,2012,57(10):1682-1684.
16.	劉關鍵,吳泰相.診斷性試驗的Meta分析——SROC曲線法介紹[J].中國循證醫學雜志,2003,3(1):41-44.
17.	童峰,陳坤,何寒青.優勢比在診斷試驗評價中的應用[J].中華流行病學雜志,2005,26(10):813-814.
18.	Hiraki A,Aoe K,Eda R,et al.Comparison of six biological markers for the diagnosis of tuberculous pleuritis[J].Chest,2004,125(3):987-989.

1. Zhou Q,Chen YQ,Qin SM,et al.Diagnostic accuracy of T-cell interferon-gamma release assays in tuberculous pleurisy:a meta-analysis[J].Respirology,2011,16(3):473-480.
2. Pandit S,Chaudhuri AD,Datta SB,et al.Role of pleural biopsy in etiological diagnosis of pleural effusion[J].Lung India,2010,27(4):202-204.
3. 吳桂輝,何畏,馬瑤,等.胸膜活檢在結核性胸膜炎中的診斷價值[J].華西醫學,2010,25(8):1412-1414.
4. Shafiani S,Dinh C,Ertelt JM,et al.Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12[J].Immunity,2013,38(6):1261-1270.
5. Whiting P,Weswood ME,Rutjes AW,等.QUADAS評價:一種用于診斷性研究的質量評價工具(修訂版)[J].中國循證醫學雜志,2007,7(7):531-536.
6. Devillé WL,Buntinx F,Bouter LM,et al.Conducting systematic reviews of diagnostic studies:didactic guidelines[J].BMC Med Res Methodol,2002,2:9.
7. 顧秀英,李殿云,王淑艷,等.胸液白細胞介素12檢測對結核性胸膜炎診斷價值的探討[J].中國防癆雜志,2002,24(4):240-240.
8. 田瑞雪,高占成.干擾素γ、白細胞介素12及腺苷脫氨酶同工酶對結核性胸腔積液的診斷價值[J].中華結核和呼吸雜志,2004,27(7):435-438.
9. Okamoto M,Kawabe T,Iwasaki Y,et al.Evaluation of interferon-gamma,interferon-gamma-inducing cytokines,and interferon-gamma-inducible chemokines in tuberculous pleural effusions[J].J Lab Clin Med,2005,145(2):88-93.
10. Valdés L,San José E,Alvarez Doba?o JM,et al.Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions[J].Eur Respir J,2009,33(4):816-820.
11. 姜振東,王蔚然,劉心.白細胞介素12在結核性胸膜炎診斷中的應用價值[J].中國實用醫藥,2010,5(1):50-51.
12. 陳利華,蔣捍東,林存智.γ干擾素、白細胞介素18、白細胞介素12及可溶性白細胞介素2受體在結核性和惡性胸腔積液中表達意義分析[J].中華臨床醫師雜志·電子版,2011,5(12):3602-3604.
13. Fernández de Larrea C,Duplat A,Giampietro F,et al.Diagnostic accuracy of immunological methods in patients with tuberculous pleural effusion from Venezuela[J].Invest Clin,2011,52(1):23-34.
14. 周世新,譚金,肖學平.腺苷脫氨酶與腫瘤壞死因子-α和白細胞介素-12檢測在診斷結核性胸腔積液中臨床價值的比較[J].檢驗醫學與臨床,2012,9(12):1436-1437.
15. Bays AM,Pierson DJ.Tuberculous pleural effusion[J].Respir Care,2012,57(10):1682-1684.
16. 劉關鍵,吳泰相.診斷性試驗的Meta分析——SROC曲線法介紹[J].中國循證醫學雜志,2003,3(1):41-44.
17. 童峰,陳坤,何寒青.優勢比在診斷試驗評價中的應用[J].中華流行病學雜志,2005,26(10):813-814.
18. Hiraki A,Aoe K,Eda R,et al.Comparison of six biological markers for the diagnosis of tuberculous pleuritis[J].Chest,2004,125(3):987-989.

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West China Medical Journal

Diagnosis Accuracy of Interleukin-12 for Tuberculous Pleurisy: A Meta-analysis

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