A Meta-analysis on Prostat Combined with Antibiotic for Chronic Prostatitis_West China Medical Journal

Authors：

 YANFeng-hua ,  YANXing-ke , HETian-you , YAOXu-hong

School of Acupuncture-moxibustion and Massotherapy, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, P. R. China;

Corresponding?author：

YANXing-ke, Email: yanxingke@126.com

Keywords：

Chronic prostatitis; Prostat; Antibiotic; Randomized controlled trial; Meta-analysis

DOI：

10.7507/1002-0179.20140463

Video：

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Objective To evaluate the efficacy and safety of prostat in combination with antibiotic on the treatment of chronic proatatitis. Methods We searched the literatures which were randomized controlled trials (RCT) on the treatment of combination of prostat and antibiotic for chronic prostatitis published between January 2003 and August 2013 in the Databases including CNKI, Wanfang database, VIP, CBM, PubMed, according to the demand of Cochrane Colloboration, combining computer retrieval with manual retrieval. The quality of literature was assessed by using Jadad scale and extract data from literature. Meta-analyses were performed by using the RevMan 5.1 Software. Results A total of 12 clinical RCT, involving 3 947 patients were identified. One study was double-blind and three studies were single-blind. Only one study had a Jadad scale score of 3, belonging to high quality document; the rest had a score of 2 or 1, and all were low quality documents. The results of the Meta-analysis showed that compared with the control groups, the treatment of combination of prostat with gatifloxacin on chronic prostatitis had a significant difference in total effective rate[OR=3.98, 95%CI (2.67, 5.94), P<0.000 01], NIH-CPSI score[WMD=-6.45, 95%CI(-7.55, -5.34), P<0.000 01]; the treatment of combination of prostat with Levofloxacin on chronic prostatitis had a significant difference in total effective rate[OR=1.71, 95%CI (1.43, 2.05), P<0.000 01], NIH-CPSI score[WMD=-2.85, 95%CI(-3.39, -2.31), P<0.000 01]. Conclusion The treatment of combination of prostat with antibiotic was superior to the treatment of prostat or antibiotics on chronic prostatitis. It is an effective therapeutic schedule. But the safety of the treatment of combination of prostat and antibiotic on chronic prostatitis needs further evaluation.

Citation： YANFeng-hua, YANXing-ke, HETian-you, YAOXu-hong. A Meta-analysis on Prostat Combined with Antibiotic for Chronic Prostatitis. West China Medical Journal, 2014, 29(8): 1512-1517. doi: 10.7507/1002-0179.20140463 Copy

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2.	Loschen G, Ebeling L. Inhibition of the arachidonate metabolism by an extract from rye pollen[J]. Arzneimittelforschung, 1991, 41(2):162-167.
3.	邵強, 張玉海. 舍尼通治療慢性非細菌性前列腺炎和前列腺痛的臨床研究(附40例報告)[J]. 現代泌尿外科雜志, 1999, 64(2):94-96.
4.	Buck AC, Rees RWM, Ebeling L. Treatment of chronic prostatitis andprostatodynia with pollen extract[J]. Br J Urol, 1989, 64(5):496-499.
5.	嚴興科, 崔海福, 陳程, 等. 針灸治療慢性前列腺炎隨機對照臨床研究文獻的Meta分析[J]. 時珍國醫國藥, 2012, 23(10):2592-2595.
6.	Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials:is blinding necessary?[J]. Control Clin Trials, 1996, 17(1):1-12.
7.	Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?[J]. Lancet, 1998, 352(9128):609-613.
8.	葉章群, 藍儒竹, 王少剛, 等. 舍尼通^?和抗生素聯合用藥治療慢性非細菌性前列腺炎臨床研究[J]. 中華男科學雜志, 2006, 12(9):807-810.
9.	楊偉忠, 袁錚豪, 曹志彬, 等. 舍尼通聯合左氧氟沙星治療慢性非細菌性前列腺炎臨床研究[J]. 臨床醫學, 2010, 30(11):66-67.
10.	顧本宏, 徐瑞云, 吳滿香, 等. 舍尼通聯合左氧氟沙星治療慢性非細菌性前列腺炎臨床研究[J]. 南通醫學院學報, 2009, 29(1):38-39, 41.
11.	舒增平, 徐生濤, 歐海軍. 舍尼通聯合抗生素治療慢性非細菌性前列腺炎的臨床研究[J]. 西南軍醫, 2011, 13(6):1035-1037.
12.	韋強, 羅艷紅, 于沛濤. 依替米星聯合舍尼通治療前列腺炎臨床療效[J]. 中國男科學雜志, 2010, 24(7):58-59.
13.	劉隨. 米諾環素、舍尼通聯合治療慢性盆腔疼痛綜合征療效觀察[J]. 中國麻風皮膚病雜志, 2005, 21(5):402.
14.	黃文林. 加替沙星聯合普適泰治療慢性前列腺炎130例療效觀察[J]. 山西醫藥雜志, 2011, 40(3):283-284.
15.	區烈良, 宋平, 易東生, 等. 舍尼通聯合希舒美治療慢性前列腺炎103例的療效觀察[J]. 廣東醫學院學報, 2007, 25(2):171-172.
16.	張芬芝, 寧群宜. 加替沙星聯合普適泰治療慢性前列腺炎的療效觀察[J]. 亞太傳統醫藥, 2012, 8(4):140-141.
17.	王俊嶺, 邵強, 劉光華. 普適泰聯合加替沙星治療慢性前列腺炎患者的臨床療效[J]. 醫學臨床研究, 2012, 29(12):2404-2405.
18.	黃誼. 加替沙星聯合普適泰治療慢性前列腺炎138例療效觀察[J]. 中外醫療, 2011, 30(34):131.
19.	孫振祥, 王繼忠, 徐真. 舍尼通聯合左氧氟沙星治療Ⅲ型前列腺炎臨床觀察[J]. 中國性科學, 2011, 20(1):7-8, 15.

1. 許明, 張永康. 抗菌藥對慢性非細菌性前列腺炎的治療作用[J]. 臨床泌尿外科雜志, 2000, 15(5):195-196.
2. Loschen G, Ebeling L. Inhibition of the arachidonate metabolism by an extract from rye pollen[J]. Arzneimittelforschung, 1991, 41(2):162-167.
3. 邵強, 張玉海. 舍尼通治療慢性非細菌性前列腺炎和前列腺痛的臨床研究(附40例報告)[J]. 現代泌尿外科雜志, 1999, 64(2):94-96.
4. Buck AC, Rees RWM, Ebeling L. Treatment of chronic prostatitis andprostatodynia with pollen extract[J]. Br J Urol, 1989, 64(5):496-499.
5. 嚴興科, 崔海福, 陳程, 等. 針灸治療慢性前列腺炎隨機對照臨床研究文獻的Meta分析[J]. 時珍國醫國藥, 2012, 23(10):2592-2595.
6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials:is blinding necessary?[J]. Control Clin Trials, 1996, 17(1):1-12.
7. Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?[J]. Lancet, 1998, 352(9128):609-613.
8. 葉章群, 藍儒竹, 王少剛, 等. 舍尼通^?和抗生素聯合用藥治療慢性非細菌性前列腺炎臨床研究[J]. 中華男科學雜志, 2006, 12(9):807-810.
9. 楊偉忠, 袁錚豪, 曹志彬, 等. 舍尼通聯合左氧氟沙星治療慢性非細菌性前列腺炎臨床研究[J]. 臨床醫學, 2010, 30(11):66-67.
10. 顧本宏, 徐瑞云, 吳滿香, 等. 舍尼通聯合左氧氟沙星治療慢性非細菌性前列腺炎臨床研究[J]. 南通醫學院學報, 2009, 29(1):38-39, 41.
11. 舒增平, 徐生濤, 歐海軍. 舍尼通聯合抗生素治療慢性非細菌性前列腺炎的臨床研究[J]. 西南軍醫, 2011, 13(6):1035-1037.
12. 韋強, 羅艷紅, 于沛濤. 依替米星聯合舍尼通治療前列腺炎臨床療效[J]. 中國男科學雜志, 2010, 24(7):58-59.
13. 劉隨. 米諾環素、舍尼通聯合治療慢性盆腔疼痛綜合征療效觀察[J]. 中國麻風皮膚病雜志, 2005, 21(5):402.
14. 黃文林. 加替沙星聯合普適泰治療慢性前列腺炎130例療效觀察[J]. 山西醫藥雜志, 2011, 40(3):283-284.
15. 區烈良, 宋平, 易東生, 等. 舍尼通聯合希舒美治療慢性前列腺炎103例的療效觀察[J]. 廣東醫學院學報, 2007, 25(2):171-172.
16. 張芬芝, 寧群宜. 加替沙星聯合普適泰治療慢性前列腺炎的療效觀察[J]. 亞太傳統醫藥, 2012, 8(4):140-141.
17. 王俊嶺, 邵強, 劉光華. 普適泰聯合加替沙星治療慢性前列腺炎患者的臨床療效[J]. 醫學臨床研究, 2012, 29(12):2404-2405.
18. 黃誼. 加替沙星聯合普適泰治療慢性前列腺炎138例療效觀察[J]. 中外醫療, 2011, 30(34):131.
19. 孫振祥, 王繼忠, 徐真. 舍尼通聯合左氧氟沙星治療Ⅲ型前列腺炎臨床觀察[J]. 中國性科學, 2011, 20(1):7-8, 15.

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