Objective Monitoring of Neonatal Nosocomial Infection and Analysis of Antibiotic Resistance_West China Medical Journal

Authors：

 LIRong ^1,2 , WANGLu ² , ZHANGHai-jin ² ,  YANYong-ping ¹

1. Teaching and Research Section of Epidemiology, the Fourth Military Medical University, Xi'an, Shaanxi 710032, P. R. China;
2. Department of Hospital Infection Control, The Children's Hospital of Xi'an, Xi'an, Shaanxi 710003, P. R. China;

Corresponding?author：

YANYong-ping, Email: yanyping@fmmu.edu.cn

Keywords：

Neonates; Nosocomial infections; Risk factors; Resistance

DOI：

10.7507/1002-0179.20140457

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo explore the risk factors for neonatal nosocomial infection and the pathogen resistance, in order to provide the basis for hospital infection control. MethodsSurveillance of hospital infection in newborns hospitalized for more than 48 hours were carried out from January to December 2012, and the risk factors for hospital infection were analyzed. ResultsThere were 54 newborn cases with neonatal nosocomial infection, and the infection rate of newborns was 1.25%. The major infection sites were respiratory tract (66.7%), gastrointestinal tract (18.5%), skin and soft tissues (9.2%). Birth weight (χ²_Trend=126.88, P<0.001), hospitalization days (χ²_Trend=106.89, P<0.001), invasive operation (χ²=5.338, P=0.021) were the major risk factors. A total of 54 strains of pathogenic bacteria were isolated from 54 newborn cases with neonatal nosocomial infection. Twenty-three strains of gram-positive bacteria accounted for 42.6%, which were generally resistant to penicillin and large ring lactone class antibiotic drugs. Thirty-one strains of gram-negative bacteria accounted for 57.4%, which were mainly resistant to the three generations of cephalosporins. ConclusionThe hospital infection rate of newborns is low. Birth weight, hospitalization days and invasive operation are the major risk factors for neonatal nosocomial infection.

Citation： LIRong, WANGLu, ZHANGHai-jin, YANYong-ping. Objective Monitoring of Neonatal Nosocomial Infection and Analysis of Antibiotic Resistance. West China Medical Journal, 2014, 29(8): 1491-1493. doi: 10.7507/1002-0179.20140457 Copy

1.	中華人民共和國衛生部. 醫院感染診斷標準(試行)[J]. 中華醫學雜志, 2001, 81(5):314-320.
2.	曾成惠, 何俊, 李雪梅, 等. 新生兒患者多重耐藥菌篩查結果與分析[J]. 華西醫學, 2013, 28(8):1149-1151.
3.	徐蓮香, 徐康立, 鄧軍霞. 新生兒醫院感染因素分析及控制措施[J]. 中華醫院感染學雜志, 2010, 20(7):937-938.
4.	袁曉明, 王杏茶, 趙立雙. 母嬰同室新生兒醫院感染的相關分析與研究[J]. 護士進修雜志, 2011, 26(21):2004-2006.
5.	徐珍, 唐素琴, 曹先偉, 等. 新生兒病房醫院感染目標性監測結果分析[J]. 中華醫院感染學雜志, 2010, 20(21):3324-3326.
6.	龔秀萍. 新生兒醫院感染監測與護理對策[J]. 中國醫藥導報, 2010, 7(12):141-142.
7.	Oeseburg B, Wynia K, Middel B, et al. Effects of case management for frail older people or those with chronic illness:a systematic review[J]. Nurs Res, 2009, 58(3):201-210.
8.	Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients:results from the first national point-prevalence survey[J]. J Pediatr, 2001(139):821-827.
9.	呂婕, 陳峰, 是俊鳳, 等. 新生兒醫院感染病例分析與干預措施[J]. 中華醫院感染學雜志, 2010, 20(12):1702-1703.
10.	管利榮, 徐冰, 何曉蕓, 等. 新生兒呼吸機相關性肺炎臨床分析[J]. 華西醫學, 2007, 22(2):353-354.
11.	陳大鵬, 陳娟, 熊英, 等. 新生兒呼吸機相關性肺炎病原學分析[J]. 華西醫學, 2005, 20(2):344.
12.	謝堅, 劉蓉, 余靜, 等. 新生兒呼吸機相關性肺炎發病情況、病原及耐藥菌分析[J]. 華西醫學, 2008, 23(3):584-585.
13.	吳安華, 李丹. 重癥監護病房臨床與環境、手分離耐藥革蘭陰性桿菌的同源性研究[J]. 中華醫院感染學雜志, 2008, 18(7):909-912.

1. 中華人民共和國衛生部. 醫院感染診斷標準(試行)[J]. 中華醫學雜志, 2001, 81(5):314-320.
2. 曾成惠, 何俊, 李雪梅, 等. 新生兒患者多重耐藥菌篩查結果與分析[J]. 華西醫學, 2013, 28(8):1149-1151.
3. 徐蓮香, 徐康立, 鄧軍霞. 新生兒醫院感染因素分析及控制措施[J]. 中華醫院感染學雜志, 2010, 20(7):937-938.
4. 袁曉明, 王杏茶, 趙立雙. 母嬰同室新生兒醫院感染的相關分析與研究[J]. 護士進修雜志, 2011, 26(21):2004-2006.
5. 徐珍, 唐素琴, 曹先偉, 等. 新生兒病房醫院感染目標性監測結果分析[J]. 中華醫院感染學雜志, 2010, 20(21):3324-3326.
6. 龔秀萍. 新生兒醫院感染監測與護理對策[J]. 中國醫藥導報, 2010, 7(12):141-142.
7. Oeseburg B, Wynia K, Middel B, et al. Effects of case management for frail older people or those with chronic illness:a systematic review[J]. Nurs Res, 2009, 58(3):201-210.
8. Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients:results from the first national point-prevalence survey[J]. J Pediatr, 2001(139):821-827.
9. 呂婕, 陳峰, 是俊鳳, 等. 新生兒醫院感染病例分析與干預措施[J]. 中華醫院感染學雜志, 2010, 20(12):1702-1703.
10. 管利榮, 徐冰, 何曉蕓, 等. 新生兒呼吸機相關性肺炎臨床分析[J]. 華西醫學, 2007, 22(2):353-354.
11. 陳大鵬, 陳娟, 熊英, 等. 新生兒呼吸機相關性肺炎病原學分析[J]. 華西醫學, 2005, 20(2):344.
12. 謝堅, 劉蓉, 余靜, 等. 新生兒呼吸機相關性肺炎發病情況、病原及耐藥菌分析[J]. 華西醫學, 2008, 23(3):584-585.
13. 吳安華, 李丹. 重癥監護病房臨床與環境、手分離耐藥革蘭陰性桿菌的同源性研究[J]. 中華醫院感染學雜志, 2008, 18(7):909-912.

West China Medical Journal

Objective Monitoring of Neonatal Nosocomial Infection and Analysis of Antibiotic Resistance

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content