Incidence of Congenital Heart Disease in Neonates and Its Risk Factors in Mianyang after“ 5·12” Earthquake_West China Medical Journal

Authors：

 GUANLi-rong ¹ ,  HUYu ¹ , YUJing ¹ , LIZhuo-ya ² , WUXiao-ji ³ , LIJian-jun ⁴ , CHENJia ¹ , ZHENGXiao-lan ¹ , WUXiao-fang ¹ , WANGXiao-shuang ¹

1. Department of Pediatrics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;
2. Department of Pediatrics, Mianyang People's Hospital, Mianyang, Sichuan 621000, P. R. China;
3. Department of Pediatrics, Mianyang Fulin Hospital, Mianyang, Sichuan 621000, P. R. China;
4. Department of Pediatrics, the Third People's Hospital of Mianyang, Mianyang, Sichuan 621000, P. R. China;

Corresponding?author：

HUYu, Email: huyu02001a@163.com

Keywords：

Earthquake; Congenital heart disease; Incidence; Risk factors

DOI：

10.7507/1002-0179.20140389

Video：

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Objective To comprehend the incidence of and to search for the possible risk factors for neonatal congenital heart disease (CHD) in Mianyang after "5·12" Earthquake. Methods CHD screening was performed on 5536 neonates born between December 2011 and December 2012 by cardiac auscultation, respiration evaluation, blood oxygen saturation determination and color doppler flow imaging. Case control study was applied to study the diagnosed cases of CHD. Results Sixty-five cases of CHD were found during the screening, and the incidence was 11.74‰. The most common CHD was ventricular septal defect, followed by atrial septum defect and patent ductusarteriosus. Possible risk factors were listed in order of their risks were as follows:family history of CHD, infection history in the early period of pregnancy, drug and alcohol history during pregnancy, and aged pregnancy and smoking history of the parents. However, earthquake experience history of parents was not correlated with CHD incidence. Conclusion Earthquake experience of parents is not correlated with CHD incidence. Enforcing health education for women before gestation, and avoiding or decreasing risk factors exposure can reduce the risk of CHD. CHD screening for neonates can detect CHD as early as possible, which is helpful for intervention during the follow-up, reduction of fatality, and improvement of neonates' quality of life.

Citation： GUANLi-rong, HUYu, YUJing, LIZhuo-ya, WUXiao-ji, LIJian-jun, CHENJia, ZHENGXiao-lan, WUXiao-fang, WANGXiao-shuang. Incidence of Congenital Heart Disease in Neonates and Its Risk Factors in Mianyang after“ 5·12” Earthquake. West China Medical Journal, 2014, 29(7): 1271-1274. doi: 10.7507/1002-0179.20140389 Copy

1.	胡煜, 劉斌. 結締組織生長因子對血管平滑肌細胞增殖、遷移和細胞外基質沉積影響的研究進展[J]. 國際兒科學雜志, 2010, 37(2):152-154.
2.	高燕、黃國英. 先天性心臟病病因及流行病學研究進展[J]. 中國循證兒科雜志,2008, 3(3):213-222.
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4.	王慧珊,袁雪,奚一生. 19432名嬰幼兒先天性心臟病患病率的調查研究[J]. 中國兒童保健雜志, 2001, 9(4):236-238.
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6.	崔愛平, 劉伯寧. 胎兒先天性心臟病的孕期篩查[J]. 中國實用婦科與產科雜志, 2002, 18(9):520-522.
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10.	DeGroff CG, BhatikarS, Hertzberg J, et al. Artificial neural network-based method of screening heart murmurs in children[J]. Circulation, 2001, 103(22):2711-2716.
11.	D'Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease[J]. Eur Respir Rev, 2012, 21(126):328-337.
12.	Apostolopoulou SC, Manginas A, Cokkinos DV, et al. Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease[J]. Heart, 2005, 91(11):1447-1452.
13.	Mahle WT, Martin GR, Beekman RH, et al. Endorsement of health and human services recommendation for pulse oximetry screening for critical congenital heart disease[J]. Pediatrics, 2012, 129(1):190-192.
14.	Mahle WT, Newburger JW, Matherne GP, et al. Role of pulse oximetry in examining newborns for congenital heart disease:a scientific statement from the American Heart Association and American Academy of Pediatrics[J]. Circulation, 2009, 120(5):447-458.
15.	Okubo A, Miyoshi O, Baba K, et al. A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family[J]. J Med Genet, 2004, 41(7):e97.
16.	王連生, 黃峻, 曹克將, 等. 家族性房間隔缺損調查及遺傳特點分析[J]. 臨床心血管病雜志, 2002, 18(12):654-655.
17.	Duppenthaler A, Ammann RA, Gorgievski-Hrisoho M, et al. Low incidence of respiratory syncytial virus hospitalisations in haemodynamically significant congenital heart disease[J]. Arch Dis Child, 2004, 89(10):961-965.
18.	Goyal P, Kiran U, Chauhan S, et al. Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease[J]. Br J Anaesth, 2006, 97(2):208-214.
19.	Baardman ME, Kerstjens-Frederikse WS, Corpeleijn E, et al. Combined adverse effects of maternal smoking and high body mass index on heart development in offspring:evidence for interaction?[J]. Heart, 2012, 98(6):474-479.
20.	Khairy P, Ouyang DW, Fernandes SM, et al. Pregnancy outcomes in women with congenital heart disease[J]. Circulation, 2006, 113(4):517-524.
21.	Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population:changing prevalence and age distribution[J]. Circulation, 2007, 115(2):163-172.
22.	Olsen M, Videb?k J, Johnsen SP, et al. The Danish register of congenital heart disease[J]. Scand J Public Health, 2011, 39(7):50-53.
23.	劉世煒, 季加芬. 孕早期精神刺激與先天性心臟病關系探索[J]. 現代預防醫學, 2005, 32(3):260-261.
24.	陳芳, 趙鈾, 胡宗瓊, 等. 5·12汶川地震期間綿陽市婦女生殖道感染率的變化[J]. 中國計劃生育和婦產科, 2010, 1(2):47-49.
25.	李小紅, 李尚為, 秦朗, 等. 地震喪子對再生育婦女月經和心理的影響[J]. 實用婦產科雜志, 2011, 1(27):69-72.
26.	楊帆, 白祥軍, 劉開俊, 等. 60例汶川地震經歷者創傷后應激障礙分析[J]. 重慶醫學, 2009, 23(38):2987-2990.

1. 胡煜, 劉斌. 結締組織生長因子對血管平滑肌細胞增殖、遷移和細胞外基質沉積影響的研究進展[J]. 國際兒科學雜志, 2010, 37(2):152-154.
2. 高燕、黃國英. 先天性心臟病病因及流行病學研究進展[J]. 中國循證兒科雜志,2008, 3(3):213-222.
3. 高秉仁、岳風珍. 甘肅等六地市先天性心臟病流行病學調查研究[J]. 中國循環雜志,2000, 15(5):298-299.
4. 王慧珊,袁雪,奚一生. 19432名嬰幼兒先天性心臟病患病率的調查研究[J]. 中國兒童保健雜志, 2001, 9(4):236-238.
5. 閏宗榮,吳明昌,鄭秀華,等. 隨訪后校正的新生兒先天性心臟病發病率研究[J]. 中華圍產醫學雜志, 2009, 12(1):32-35.
6. 崔愛平, 劉伯寧. 胎兒先天性心臟病的孕期篩查[J]. 中國實用婦科與產科雜志, 2002, 18(9):520-522.
7. Simpson LL. Indications for fetal eehocardiography from a tertiarycare obstetricsonography practice[J]. J Clin Ultrasuond, 2004, 32(3):123-128.
8. 任秀珍, 張曉新, 姜紅紅,等. CDFI在新生兒先天性心臟病篩查中的應用[J]. 中國循證心血管醫學雜志, 2011, 8(3):220-221.
9. Wurst KE, Ephross SA, Loehr J, et al. Evaluation of the Gengeal Practice Reseaech Datdbase congenital heart defects prevalence:comparison to United Kingdom national systems[J]. Brith Defects Res A Clin Mol Teratol, 2007, 79(4):309-316.
10. DeGroff CG, BhatikarS, Hertzberg J, et al. Artificial neural network-based method of screening heart murmurs in children[J]. Circulation, 2001, 103(22):2711-2716.
11. D'Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease[J]. Eur Respir Rev, 2012, 21(126):328-337.
12. Apostolopoulou SC, Manginas A, Cokkinos DV, et al. Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease[J]. Heart, 2005, 91(11):1447-1452.
13. Mahle WT, Martin GR, Beekman RH, et al. Endorsement of health and human services recommendation for pulse oximetry screening for critical congenital heart disease[J]. Pediatrics, 2012, 129(1):190-192.
14. Mahle WT, Newburger JW, Matherne GP, et al. Role of pulse oximetry in examining newborns for congenital heart disease:a scientific statement from the American Heart Association and American Academy of Pediatrics[J]. Circulation, 2009, 120(5):447-458.
15. Okubo A, Miyoshi O, Baba K, et al. A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family[J]. J Med Genet, 2004, 41(7):e97.
16. 王連生, 黃峻, 曹克將, 等. 家族性房間隔缺損調查及遺傳特點分析[J]. 臨床心血管病雜志, 2002, 18(12):654-655.
17. Duppenthaler A, Ammann RA, Gorgievski-Hrisoho M, et al. Low incidence of respiratory syncytial virus hospitalisations in haemodynamically significant congenital heart disease[J]. Arch Dis Child, 2004, 89(10):961-965.
18. Goyal P, Kiran U, Chauhan S, et al. Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease[J]. Br J Anaesth, 2006, 97(2):208-214.
19. Baardman ME, Kerstjens-Frederikse WS, Corpeleijn E, et al. Combined adverse effects of maternal smoking and high body mass index on heart development in offspring:evidence for interaction?[J]. Heart, 2012, 98(6):474-479.
20. Khairy P, Ouyang DW, Fernandes SM, et al. Pregnancy outcomes in women with congenital heart disease[J]. Circulation, 2006, 113(4):517-524.
21. Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population:changing prevalence and age distribution[J]. Circulation, 2007, 115(2):163-172.
22. Olsen M, Videb?k J, Johnsen SP, et al. The Danish register of congenital heart disease[J]. Scand J Public Health, 2011, 39(7):50-53.
23. 劉世煒, 季加芬. 孕早期精神刺激與先天性心臟病關系探索[J]. 現代預防醫學, 2005, 32(3):260-261.
24. 陳芳, 趙鈾, 胡宗瓊, 等. 5·12汶川地震期間綿陽市婦女生殖道感染率的變化[J]. 中國計劃生育和婦產科, 2010, 1(2):47-49.
25. 李小紅, 李尚為, 秦朗, 等. 地震喪子對再生育婦女月經和心理的影響[J]. 實用婦產科雜志, 2011, 1(27):69-72.
26. 楊帆, 白祥軍, 劉開俊, 等. 60例汶川地震經歷者創傷后應激障礙分析[J]. 重慶醫學, 2009, 23(38):2987-2990.

West China Medical Journal

Incidence of Congenital Heart Disease in Neonates and Its Risk Factors in Mianyang after“ 5·12” Earthquake

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