Etiological Factor Analysis of Peptic Ulcer Hemorrhage with Negative <i>Helicobacter pylori</i>_West China Medical Journal

Authors：

 GUWen-fen , WANGBao-jian , WUJian , LINWei , LIUJie , LIUChun

Department of Gastroenterology, General Hospital of Panzhihua, Iron & Steel Group, Panzhihua, Sichuan 617023, P. R. China;

Corresponding?author：

Keywords：

Helicobacter pyloric; Peptic ulcer; Etiological factor analysis

DOI：

10.7507/1002-0179.20140270

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To discuss the etiological factors and risk factors for peptic ulcer hemorrhage with negative Helicobacter pylori (HP). Methods A total of 182 patients with peptic ulcer treated in our hospital from January 2010 to December 2012 were chosen in our study. There were 85 cases of hemorrhage among them, with 50 HP positive and 35 HP negative ones. The other 97 patients were without hemorrhage. Etiological factors and correlated risk factors for peptic ulcer hemorrhage with HP negative were analyzed. Results HP negative rate of the hemorrhage group was 41.2%, while that rate of the non-hemorrhage group was 14.4%, and the difference was significant (P<0.05). The patients with peptic ulcer hemorrhage with negative HP had correlations with age, sex, wine drinking, taking non-steroidal anti-inflammatory medicine and so on. Conclusion Peptic hemorrhage is easily complicated with peptic ulcer with negative HP, and it is intimately correlated with patients' age, sex, wine drinking history, and taking non-steroidal anti-inflammatory medicine, etc.

Citation： GUWen-fen, WANGBao-jian, WUJian, LINWei, LIUJie, LIUChun. Etiological Factor Analysis of Peptic Ulcer Hemorrhage with Negative Helicobacter pylori. West China Medical Journal, 2014, 29(5): 890-892. doi: 10.7507/1002-0179.20140270 Copy

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6.	Chan FK, Ching JY, Suen BY, et al. Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users[J]. Gastroenterology, 2013, 144(3):528-535.
7.	Chen TS, Chang FY. Clinical characteristics of Helicobacter pylori negative duodenal ulcer disease[J]. Hepatogastroenterology, 2008, 55(86/87):1615-1618.
8.	Debongnie JC, Donnay M, Mairesse J, et al. Gastric ulcers and Helicobacter heilmannii[J]. Eur J Gastroenterol Hepatol, 1998, 10(3):251-254.
9.	Chang CY, Wu MS, Lee CT, et al. Prospective survey for the etiology and outcome of peptic ulcer bleeding:a community based study in southern Taiwan[J]. J Formos Med Assoc, 2011, 110(4):223-229.
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12.	Xia HH, Phung N, Altiparmak E, et al. Reduction of peptic ulcer disease and Helicobacter pylori infection but increase of reflux esophagitis in Western Sydney between 1990 and 1998[J]. Dig Dis Sci, 2001, 46(12):2716-2723.
13.	Howden CW, Leontiadis GI. Current indications for acid suppressants in Helicobacter pylori-negative ulcer disease[J]. Best Pract Res Clin Gastroenterol, 2001, 15(3):401-412.
14.	Kurata JH, Nogawa AN. Meta-analysis of risk factors for peptic ulcer. Nonsteroidal antiinflammatory drugs, Helicobacter pylori, and smoking[J]. J Clin Gastroenterol, 1997, 24(1):2-17.
15.	刁萍萍, 杜奕奇, 李兆申, 等. 幽門螺桿菌陰性消化性潰瘍與出血關系的多中心對照研究[J]. 中華消化內鏡雜志, 2010, 27(8):410-414.
16.	Wong GL, Au KW, Lo AO, et al. Gastroprotective therapy does not improve outcomes of patients with Helicobacter pylori-negative idiopathic bleeding ulcers[J]. Clin Gastroenterol Hepatol, 2012, 10(10):1124-1129.

1. 蕭樹東, 許國銘. 中華胃腸病學[M]. 北京:人民衛生出版社, 2008:363.
2. Kurata JH, Nogawa AN. Meta-analysis of risk factors for peptic ulcer. Nonsteroidal antiinflammatory drugs, Helicobacter pylori, and smoking[J]. J Clin Gastroenterol, 1997, 24(1):2-17.
3. Mccoll KE, El-Nujumi AM, Chittajallu RS, et al. A study of the pathogenesis of Helicobacter pylori negative chronic duodenal ulceration[J]. Gut, 1993, 34(6):762-768.
4. Xia HH, Phung N, Kalantar JS, et al. Demographic and endoscopic characteristics of patients with Helicobacter pylori positive and negative peptic ulcer disease[J]. Med J Aust, 2000, 173(10):515-519.
5. Kang JM, Kim N, Lee BH, et al. Risk factors for peptic ulcer bleeding in terms of Helicobacter pylori, NSAIDs, and antiplatelet agents[J]. Scand J Gastroenterol, 2011, 46(11):1295-1301.
6. Chan FK, Ching JY, Suen BY, et al. Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users[J]. Gastroenterology, 2013, 144(3):528-535.
7. Chen TS, Chang FY. Clinical characteristics of Helicobacter pylori negative duodenal ulcer disease[J]. Hepatogastroenterology, 2008, 55(86/87):1615-1618.
8. Debongnie JC, Donnay M, Mairesse J, et al. Gastric ulcers and Helicobacter heilmannii[J]. Eur J Gastroenterol Hepatol, 1998, 10(3):251-254.
9. Chang CY, Wu MS, Lee CT, et al. Prospective survey for the etiology and outcome of peptic ulcer bleeding:a community based study in southern Taiwan[J]. J Formos Med Assoc, 2011, 110(4):223-229.
10. 陳灝珠, 林果為. 實用內科學[M]. 13版. 北京:人民衛生出版社, 1983.
11. 翁志雄, 余志金, 樂勝, 等. 老年人消化性潰瘍并發出血的危險因素分析[J]. 中國現代醫生, 2010, 48(11):127-129.
12. Xia HH, Phung N, Altiparmak E, et al. Reduction of peptic ulcer disease and Helicobacter pylori infection but increase of reflux esophagitis in Western Sydney between 1990 and 1998[J]. Dig Dis Sci, 2001, 46(12):2716-2723.
13. Howden CW, Leontiadis GI. Current indications for acid suppressants in Helicobacter pylori-negative ulcer disease[J]. Best Pract Res Clin Gastroenterol, 2001, 15(3):401-412.
14. Kurata JH, Nogawa AN. Meta-analysis of risk factors for peptic ulcer. Nonsteroidal antiinflammatory drugs, Helicobacter pylori, and smoking[J]. J Clin Gastroenterol, 1997, 24(1):2-17.
15. 刁萍萍, 杜奕奇, 李兆申, 等. 幽門螺桿菌陰性消化性潰瘍與出血關系的多中心對照研究[J]. 中華消化內鏡雜志, 2010, 27(8):410-414.
16. Wong GL, Au KW, Lo AO, et al. Gastroprotective therapy does not improve outcomes of patients with Helicobacter pylori-negative idiopathic bleeding ulcers[J]. Clin Gastroenterol Hepatol, 2012, 10(10):1124-1129.

West China Medical Journal

Etiological Factor Analysis of Peptic Ulcer Hemorrhage with Negative Helicobacter pylori

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