Clinical Analysis of Common Inhalant Allergens Causing Allergic Rhinitis in Underage Patients_West China Medical Journal

Authors：

 XILing

Department of Otolaryngology, Sichuan Academy of Medical Science & Sichuan Provincial Peoples'Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

Keywords：

Underage patients; Allergic rhinitis; Allergen; Skin prick test

DOI：

10.7507/1002-0179.20140212

Video：

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Objective To investigate the common inhalant allergens causing allergic rhinitis in underage patients, and provide references for clinical prevention of allergic rhinitis. Methods Underage patients with allergic rhinitis admitted to our hospital between January 2010 and June 2013 were screened and skin prick test (SPT) was applied to investigate the response intensity to 22 kinds of common inhalant allergens and analyze the correlation of the positive rates and grades of allergens with age and sex. Results A total of 402 patients were included, and 77.6% (312/402) of them reported positive reaction of SPT; and the top five allergens were dust mites (242/402, 60.2%), house dust (235/402, 58.5%), housefly (142/402, 35.3%), spring pollen Ⅲ (133/402, 33.1%) and mulberry silk (121/402, 30.1%), respectively. Compared with patients whose age was younger than 5 years, both the positive rates and grades of SPT were significantly higher in patients above 5 years old. Additionally, the higher positive rates and grades of SPT were also observed much more in male patients than female patients. Conclusion The most common inhalant allergens causing allergic rhinitis in underage patients are dust mites and house dust. And the SPT response intensity of inhalant allergens can be affected by age and gender.

Citation： XILing. Clinical Analysis of Common Inhalant Allergens Causing Allergic Rhinitis in Underage Patients. West China Medical Journal, 2014, 29(4): 710-713. doi: 10.7507/1002-0179.20140212 Copy

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11.	方美善, 李景華, 竇逾常, 等. 531例變應性鼻炎吸入性變應原檢測分析[J]. 中國實驗診斷學, 2010, 14(8):1311-1312.
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14.	Platts-Mills TA, Thomas WR, Aalberse RC, et al. Dust mite allergens and asthma:report of a second international workshop[J]. J Allergy Clin Immunol, 1992, 89(5):1046-1060.
15.	張宏譽. 變態反應學在中國[J]. 中華臨床免疫和變態反應雜志, 2008, 2(4):255-260.
16.	Osman M, Hansell AL, Simpson CR, et al. Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care[J]. Prim Care Respir J, 2007, 16(1):28-35.
17.	徐文飛, 劉恩梅, 周燕榮, 等. 重慶地區1105例變應性疾病患兒吸入性變應原臨床分析[J]. 實用兒科臨床雜志, 2008, 23(9):654-656.
18.	茅松, 劉光陵, 夏正坤, 等. 兒童支氣管哮喘變應原檢測與年齡、性別的關系探討[J]. 實用醫學雜志, 2011, 27(18):3366-3368.
19.	傅靜芬, 俞怡, 蘇亮, 等. 舟山地區兒童過敏性鼻炎主要變應原調查及護理[J]. 上海預防醫學, 2013, 25(10):590-591, 594.
20.	趙卓慧, 張昕, 劉冉冉, 等. 太原市學齡前兒童哮喘、過敏性鼻炎及濕疹與出生前及早期家居環境的相關性[J]. 科學通報, 2013, 58(25):2582-2588.

1. Van Gysel D, Govaere E, Verhamme KM, et al. Messages from the Aalst Allergy Study[J]. World J Pediatr, 2009, 5(3):182-190.
2. 余艷云. 皮膚點刺在過敏性鼻炎與哮喘變應原檢測中的應用[J]. 中國醫藥指南, 2012, 10(18):566-567.
3. 周艷, 周欣. 變態性鼻炎(過敏性鼻炎)病因與治療[J]. 中國中醫藥現代遠程教育, 2008, 6(12):1524-1525.
4. 張羅, 王成碩, 王向東. 過敏性鼻炎診治進展[J]. 中國實用內科雜志, 2012, 32(2):86-88.
5. Johansson SG. ImmunoCAP specific IgE test:an objective tool for research and routine allergy diagnosis[J]. Expert Rev Mol Diagn, 2004, 4(3):273-279.
6. 劉飛, 徐艷, 潘現波, 等. 過敏性鼻炎吸入性變應原IgE檢測分析[J]. 現代中西醫結合雜志, 2013, 22(3):292-293.
7. 王元, 孔憲明, 曹蘭芳, 等. 上海地區過敏性疾病患者過敏原研究[J]. 上海醫學, 2008, 31(4):241-244.
8. 林英, 王波, 郭素華. 兒童910例變應原皮膚點刺試驗結果分析[J]. 中國醫師雜志, 2010, 12(11):1552-1555.
9. 艾濤, 羅榮華, 吳英, 等. 兒童哮喘1952例吸入變應原皮膚點刺結果分析[J]. 四川醫學, 2010, 31(12):1742-1744.
10. 王剛, 陳建平, 汪萬軍, 等. 西南地區2071例變應性疾病患兒變應原臨床分析[J]. 重慶醫學, 2011, 40(19):1911-1914.
11. 方美善, 李景華, 竇逾常, 等. 531例變應性鼻炎吸入性變應原檢測分析[J]. 中國實驗診斷學, 2010, 14(8):1311-1312.
12. 陳黎, 夏仕英, 張泓. 上海地區哮喘兒童過敏原調查[J]. 檢驗醫學, 2006, 21(5):516, 520.
13. 張曉霞, 晏曉波, 楊秀云. 萊蕪地區常見吸入性變應原皮膚點刺試驗結果分析[J]. 齊魯護理雜志, 2013, 19(20):16-18.
14. Platts-Mills TA, Thomas WR, Aalberse RC, et al. Dust mite allergens and asthma:report of a second international workshop[J]. J Allergy Clin Immunol, 1992, 89(5):1046-1060.
15. 張宏譽. 變態反應學在中國[J]. 中華臨床免疫和變態反應雜志, 2008, 2(4):255-260.
16. Osman M, Hansell AL, Simpson CR, et al. Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care[J]. Prim Care Respir J, 2007, 16(1):28-35.
17. 徐文飛, 劉恩梅, 周燕榮, 等. 重慶地區1105例變應性疾病患兒吸入性變應原臨床分析[J]. 實用兒科臨床雜志, 2008, 23(9):654-656.
18. 茅松, 劉光陵, 夏正坤, 等. 兒童支氣管哮喘變應原檢測與年齡、性別的關系探討[J]. 實用醫學雜志, 2011, 27(18):3366-3368.
19. 傅靜芬, 俞怡, 蘇亮, 等. 舟山地區兒童過敏性鼻炎主要變應原調查及護理[J]. 上海預防醫學, 2013, 25(10):590-591, 594.
20. 趙卓慧, 張昕, 劉冉冉, 等. 太原市學齡前兒童哮喘、過敏性鼻炎及濕疹與出生前及早期家居環境的相關性[J]. 科學通報, 2013, 58(25):2582-2588.

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