Study on the Compatible Stability of Brevescapine Injection in Common Solvents_West China Medical Journal

Authors：

 WANGXia , MEILing

Pharmacy of Chengdu Fifth People's Hospital, Chengdu, Sichuan 611137, P. R. China;

Corresponding?author：

Keywords：

Breviscapine; Scutellarin; Compatible; Stability

DOI：

10.7507/1002-0179.20140089

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Objective To study on the compatible stability of brevescapine injection in common solvents. Methods Brevescapine injection was added into 0.9% sodium chloride injection,5% glucose injection,10% glucose injection (100,250,and 500 mL) respectively at room temperature.The pH value and visual appearance of the admixture were observed at immediate 0,1,2,4,6 hours after Brevescapine injection was added into the solvents.Scutellarin concentration was determined by the method of high performance liquid chromatography (HPLC). Results No significant change was found in appearance and pH value of the admixture.And Scutellarin concentration changed obviously in the admixture of 100 mL 0.9% sodium chloride injection,100 mL 10% glucose injection and the three types of 5% glucose injection. Conclusion Brevescapine injections have better compatibility with 250 mL and 500 mL 0.9% sodium chloride injection,and it is incompatible with 5% glucose injection.In addition,the admixture injection should be finished within six hours.

Citation： WANGXia, MEILing. Study on the Compatible Stability of Brevescapine Injection in Common Solvents. West China Medical Journal, 2014, 29(2): 293-296. doi: 10.7507/1002-0179.20140089 Copy

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2. Chai WS,Zhai SP,Wu SL,et al.The effect of breviseapine on pulmonary fibrosis induced by bleomycin in rats[J].China Phartrmcol Bull,2008,24(1):113-116.
3. 林潮炫.燈盞花素對促進骨性關節炎治愈的臨床療效觀察[J].吉林醫學,2013,34(6):1073.
4. Tan ZH,Yu LH,Wei HL,et al.The protective action of scutellarin against immunological liver injury induced by concanavalin A and its effect on pro-inflammatory cytokines in mice[J].J Pharm Pharmacol,2007,59(1):115-121.
5. 吳靜,鐘慧菊,孫志湘,等.燈盞花素治療糖尿病周圍神經病變的療效觀察[J].湖南醫科大學學報,2002,27(4):337-340.
6. 張虹,蘇小勇,張雪芳.燈盞花素與黃芪聯合應用治療糖尿病腎病臨床觀察[J].中國醫藥導報,2009,6(29):63-63,66.
7. Lin LL,Liu AJ,Liu JG,et al.Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats[J].J Cardiovasc Pharmacol,2007,50(3):327-332.
8. 國家藥典委員會.中華人民共和國藥典(2010年版一部)[M].北京:中國醫藥科技出版社,2010:378.
9. 覃樹先.黃芩甙水溶液性穩定性研究[J].廣西醫學,2000,22(4):920-922.
10. 石森林,徐蓮英,毛展凱,等.燈盞花素的理化性質及其穩定性影響因素研究[J].中國中藥雜志,2009,34(7):843-847.
11. 李煜.不同pH值對注射液燈盞花素的穩定性影響[J].航空航天醫院雜志,2013,24(4):401-402.
12. 熊魏,彭紅,廖夫生.HPLC法測定燈盞花素膠囊中野黃芩苷的含量[J].廣州化工,2013,41(4):138-139.
13. 楊強,楊俊毅,李思成,等.燈盞花素緩釋片在Beagle犬體內相對生物利用度的研究[J].華西藥學雜志,2004,19(3):175-178.
14. 陳大為,張彥青,鄒艷霜,等.燈盞花素緩釋微丸在家兔體內藥效學和藥動學研究[J].中國藥劑學雜志,2003,1(2):63-67.
15. 陳國廣,張柯萍,李學明,等.燈盞花素緩釋固體分散體的制備及溶出度的研究[J].華西藥學雜志,2007,22(2):169-171.
16. 張利平,吳海雯.燈盞花素注射液致不良反應8例[J].醫藥導報,2009,28(5):677-678.

West China Medical Journal

Study on the Compatible Stability of Brevescapine Injection in Common Solvents

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