Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4<sup>+</sup> T Lymphocyte Number_West China Medical Journal

Authors：

 CAOFen ¹ , YEQing ²

1. Department of Ultrasound, Infectious Diseases Hospital of Chengdu, Chengdu, Sichuan 610061, P. R. China;
2. Department of Tranditional Chinese Medicine, Infectious Diseases Hospital of Chengdu, Chengdu, Sichuan 610061, P. R. China;

Corresponding?author：

Keywords：

HIV; AIDS; Chronic hepatitis; Ultrasonic inspection; Pathological changes of the liver

DOI：

10.7507/1002-0179.20140022

Video：

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Objective To investigate the ultrasonic changes of liver during various immune periods with different number of CD4⁺ T lymphocytes in HIV/AIDS patients with chronic viral hepatitis. Methods The clinical data of 100 patients with chronic viral hepatitis diagnosed between January 2010 and December 2012 were selected. Among them, 50 simple chronic viral hepatitis patients were designated as the control group, and the other 50 HIV/AIDS patients with chronic viral hepatitis were regarded as the experimental group. Ultrasonographic observation was applied on patients of the experimental group according to different immune period based on the number of CD4⁺ T lymphocytes. Indexes observed included liver size, the edge of liver, capsule of liver and hepatic parenchymal echo. The cross-check analysis was employed between observed results and clinical laboratory results. Results Abnormal changes of the experimental group were shown on the ultrasound observation of liver in different CD4⁺ T lymphocyte count immune periods, including enlargement of the liver, slightly blunt liver margin, slightly thick capsule, dense and uniform, slightly rough and not so uniform, or rough and not uniform hepatic parenchymal echo. There was no significant difference in ultrasonic changes of liver between the two groups when the CD4⁺ T cell number was over 300/mm³. However, the difference was significant when the CD4⁺ T cell number was below 100/mm³. Conclusion Liver abnormalities become more obvious as CD4⁺ T cell count decreases in HIV/AIDS patients with chronic viral hepatitis. Comprehensive considerations of various liver ultrasound indicators are helpful in clinical evaluation of HIV/AIDS patients with chronic viral hepatitis.

Citation： CAOFen, YEQing. Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4⁺ T Lymphocyte Number. West China Medical Journal, 2014, 29(1): 80-82. doi: 10.7507/1002-0179.20140022 Copy

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2. 中華醫學會傳染病與寄生蟲病分會、肝病分會. 病毒性肝炎防治方案[J]. 中華肝臟病雜志, 2000, 8(6):324-329.
3. 郭萬學.超聲醫學[M]. 6版. 北京:人民衛生出版社, 2012:795-796.
4. den Brinker M, Wit FW, Wertheim-van Dillen PM, et al. Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection[J]. AIDS, 2000, 14(18):2895-2902.
5. 福軍亮, 王福生. HIV和丙型肝炎病毒合并感染的臨床特點和研究進展[J]. 中國艾滋病性病, 2005, 11(2):153-155.
6. 張新力, 陳重, 蘇穎, 等. 慢性乙型及丙型病毒性肝炎的超聲表現與病理對照分析[J]. 中華實驗和臨床病毒性雜志, 2003, 17(4):337-338.
7. 孟繁坤, 徐策, 張海英, 等. 對慢性病毒性肝炎超聲診斷指標的再探討[J]. 中國超聲診斷雜志, 2002, 3(8):592-594.
8. 鄭穎, 孟凡坤, 張海美, 等. 艾滋病腹部的聲像圖改變[J]. 中國超聲診斷雜志, 2004, 5(5):358-360.
9. 莫讓輝, 李論, 陸鵬.艾滋病合并乙、丙型肝炎96例分析[J]. 中國熱帶醫學雜志, 2008, 8(10):1746-1748.

West China Medical Journal

Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4⁺ T Lymphocyte Number

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West China Medical Journal

Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4+ T Lymphocyte Number

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Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4⁺ T Lymphocyte Number