Comparison between Pulsed Electromagnetic Field and Alendronate in the Treatment of Postmenopausal Osteoporosis_West China Medical Journal

Authors：

 LIUYing ^1,2 , WANGChun-yan ³ , LIUHui-fang ¹ ,  HECheng-qi ¹

1. Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Geriatric Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Rehabilitation, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China;

Corresponding?author：

HECheng-qi, Email: hxkfhcq@126.com

Keywords：

Pulsed electromagnetic fields; Postmenopausal osteoporosis; Bone mineral density; Pain; Muscle strength

DOI：

10.7507/1002-0179.20140019

Video：

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Objective To compare the clinical effects of pulsed electromagnetic fields (PEMFs) with oral alendronate in the treatment of postmenopausal osteoporosis. Methods Fourty patients diagnosed to have postmenopausal osteoporosis (OP) from September 2009 to September 2010 were included in our study. They were randomly divided into the experimental group and the control group. All patients were administered the same basic drugs:Caltrate 600 mg and Alfacalcidol 0.5 μg per day. For the experimental group, PEMFs were offered 6 times per week for 5 weeks (30 times in total), and patients in this group were followed up for 12 weeks. For the control group, alendronate was given at a dose of 70 mg per week for 12 weeks. Bone mineral density (BMD), visual analogue scale, and manual muscle testing (MMT) scale were evaluated before, 1 week, 5 weeks, and 12 weeks after intervention. Results Increasing of BMD, pain relieving, and improvement of MMT had a trend of increasing values after 5 weeks of treatment in the experimental group (P<0.05), but there was no significant difference between the two groups (P>0.05). However, there was a significant difference between the two groups in patients' lower back muscle strength after treatment (P<0.05). Conclusion PEMFs have the same effect as alendronate in pain relief, and bone mass and muscle strength improvement, and are even advantageous in increasing back muscle strength compared with alendronate.

Citation： LIUYing, WANGChun-yan, LIUHui-fang, HECheng-qi. Comparison between Pulsed Electromagnetic Field and Alendronate in the Treatment of Postmenopausal Osteoporosis. West China Medical Journal, 2014, 29(1): 67-72. doi: 10.7507/1002-0179.20140019 Copy

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2.	Melton LJ, Atkinson EJ, Cooper C, et al. Vertebral fractures predict subsequent fractures[J]. Osteoporos Int, 1999, 10(3):214-221.
3.	Gronholz MJ. Prevention、diagnosis and management of osteoporosis-related fracture:a multifactoral osteopathic approach[J]. Am Osteopath Assoc, 2008, 108(10):575-585.
4.	余雷, 羅二平, 申廣浩, 等. 低頻脈沖電磁場治療骨質疏松的作用[J]. 中國臨床康復, 2003, 7(12):1801-1802.
5.	Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis:executive summary of recommendations[J]. Endocr Pract, 2010, 16(3):1-37.
6.	Reid DM, Hosking D, Kendler D, et al. A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis:24-month results from FACTS-International[J]. Int J Clin Pract, 2008, 62(4):575-584.
7.	Markov MS. Magnetic field therapy:a review[J]. Electromagn Biol Med, 2007, 26(8):1-23.
8.	Ehatjfulelhan G, Festa MA, Angelete JE. Reproducibility of DXA absorp-tiometry:a model for bone loss estimates[J]. Bone Miner Res, 1995, 10(7):1004-1014.
9.	Miller PD. Guidelines for the diagnosis of osteoporosis:T-scores vs fractures[J]. Rev Endocr Metab Disord, 2006, 7(1-2):75-89.
10.	Chang WH, Chen LT, Sun JS, et al. Effect of pulse-burst electromagnetic field stimulation on osteoblast cell activities[J]. Bioelectromagnetics, 2004, 25(6):457-465.
11.	Bassett CAL, Pilla AA, Pawluk RJ. A nonoperative salvage of surgically-resist antpseudarthroses and non-unions by pulsing elecromagnetic fields:a preliminary report[J]. Clin Orth op, 1977, 12(124):128-143.
12.	Sert C, Mustafa D, Duz MZ, et al. The preventive effect on bone loss of 50 Hz, 1mT electrom agnetic field in ovariectomized rats[J]. Bone Miner Metab, 2002, 20(6):345-349.
13.	Giavaresi G, Fini M, Gnudi S, et al. Giardino. Effect of pulsed electromagnetic fields on ovariectomized rats[J]. Electro-Magnetobiol, 1998(18):119-131.
14.	黃禮群, 王維, 何成奇, 等. 不同治療時間脈沖電磁場對去勢大鼠股骨骨密度的影響[J]. 中國修復重建外科雜志, 2008, 22(5):548-550.
15.	高堪達, 俞永林, 周建偉. 脈沖電磁場治療骨質疏松癥研究進展[J]. 國外醫學·骨科學分冊, 2004, 25(5):307-309.
16.	Tabrah FL, Ross P, Hoffmeier M, et al. Clinical report on long-term bone density after short-term EMF application[J]. Bioelectromagnetics, 1998, 19:75-78.
17.	肖登, 楊霖, 雷中杰, 等. 不同治療時間脈沖電磁場對去卵巢大鼠股骨生物力學性能的影響[J]. 四川大學學報·醫學版, 2010, 41(2):296-298.
18.	Weintraub MI, Herrmann DN, Smith AG, et al. Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair:a randomized controlled trial[J]. Arch Phys Med Rehabil, 2009, 9(8):1102-1109.
19.	Ay S, Evcik D. The effects of pulsed electromagnetic fields in the treatment of knee osteoarthritis:a randomized, placebo-controlled trial[J]. Rheumatol Int, 2009, 29(6):663-666.
20.	郝雙林, 田寶斌, 王玲, 等. VAS測痛法的臨床初步評估[J]. 中國醫學科學院學報, 1994, 16(5):397-399.
21.	胡一順, 史玲, 鮑志民, 等. 低頻脈沖電磁場治療骨質疏松癥骨痛癥狀療效觀察[J]. 上海醫藥, 2012, 33(6):46-47.
22.	Snow S, Kirwan JR. Visual analogue scales:a source of error[J]. Ann Rheum Dis, 1988, 47(6):526.
23.	郝雙林. 臨床疼痛的測定方法及其評價[J]. 國外醫學·麻醉學與復蘇分冊, 1993, 14(4):228-230.
24.	張權, 黃煌淵. 降鈣素治療骨質疏松性疼痛的短期療效評估[J]. 上海醫科大學學報, 2000, 11(1):27-29.
25.	Smith TL, Wong-Gi bbons D, Maultsby J. Microcirculatory effects of pulse electromagnetic fields[J]. Orthop Res, 2004, 22(1):80-84.
26.	周萬松. 新編磁療學[M]. 北京:科學出版社, 1995:50-58, 130-151.
27.	Greenough CG. The effects of pulsed electromagnetic fields on blood vessel growth in the rabbit ear chamber[J]. Orthop Res, 1992, 10(2):256-262.
28.	張小云, 羅振國, 馬永鍵. 磁場對血漿B-內啡肽的影響[J]. 中華物理醫學與康復雜志, 1998, 20(3):129-132.
29.	Blain H, Vuillemin A, Teissier A, et al. Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over[J]. Gerontology, 2001, 47(4):207-212.
30.	楊霖, 雷中杰, 何成奇. 低頻脈沖電磁場治療骨質疏松癥的臨床觀察[J]. 中國骨質疏松雜志, 2006, 12(6):592-593.
31.	Zhao FZ, Han XS, Tao TZ. The treatment of primary osteoporosis by salmon calcitonin and physical therapy[J]. Chin J Osteoporos, 2007, 13(4):281-283.
32.	Weinans H, Huiskes R, Grootenboer HJ. The behavior of adaptive bone-remodeling simulation models[J]. Biomech, 1992, 25(12):1425-1441.
33.	李國新, 溫健, 湯晨達, 等. 低頻脈沖電磁場治療原發性骨質疏松癥的短期療效觀察[J]. 齊齊哈爾醫學院學報, 2010, 13(14):2203-2204.
34.	Forgacs Z, Somosy Z, Kubinyi G, et al. Effects of whole-body 50-Hz magnetic field exposure on mouse Leydig cell[J]. Sci World J, 2004, 4(2):83-90.
35.	Fitzsimmons R, Strong D, Mohan S, et al. Low-amplitude, low-frequency electric field-stimulated cell proliferation may in part be mediated by increased IGF-Ⅱ release[J]. Cell Physiol, 1992, 150(1):326-334.

1. Reginster JY, Burlet N. Osteoporosis:a still increasing prevalence[J]. Bone, 2006, 38(2):4-9.
2. Melton LJ, Atkinson EJ, Cooper C, et al. Vertebral fractures predict subsequent fractures[J]. Osteoporos Int, 1999, 10(3):214-221.
3. Gronholz MJ. Prevention、diagnosis and management of osteoporosis-related fracture:a multifactoral osteopathic approach[J]. Am Osteopath Assoc, 2008, 108(10):575-585.
4. 余雷, 羅二平, 申廣浩, 等. 低頻脈沖電磁場治療骨質疏松的作用[J]. 中國臨床康復, 2003, 7(12):1801-1802.
5. Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis:executive summary of recommendations[J]. Endocr Pract, 2010, 16(3):1-37.
6. Reid DM, Hosking D, Kendler D, et al. A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis:24-month results from FACTS-International[J]. Int J Clin Pract, 2008, 62(4):575-584.
7. Markov MS. Magnetic field therapy:a review[J]. Electromagn Biol Med, 2007, 26(8):1-23.
8. Ehatjfulelhan G, Festa MA, Angelete JE. Reproducibility of DXA absorp-tiometry:a model for bone loss estimates[J]. Bone Miner Res, 1995, 10(7):1004-1014.
9. Miller PD. Guidelines for the diagnosis of osteoporosis:T-scores vs fractures[J]. Rev Endocr Metab Disord, 2006, 7(1-2):75-89.
10. Chang WH, Chen LT, Sun JS, et al. Effect of pulse-burst electromagnetic field stimulation on osteoblast cell activities[J]. Bioelectromagnetics, 2004, 25(6):457-465.
11. Bassett CAL, Pilla AA, Pawluk RJ. A nonoperative salvage of surgically-resist antpseudarthroses and non-unions by pulsing elecromagnetic fields:a preliminary report[J]. Clin Orth op, 1977, 12(124):128-143.
12. Sert C, Mustafa D, Duz MZ, et al. The preventive effect on bone loss of 50 Hz, 1mT electrom agnetic field in ovariectomized rats[J]. Bone Miner Metab, 2002, 20(6):345-349.
13. Giavaresi G, Fini M, Gnudi S, et al. Giardino. Effect of pulsed electromagnetic fields on ovariectomized rats[J]. Electro-Magnetobiol, 1998(18):119-131.
14. 黃禮群, 王維, 何成奇, 等. 不同治療時間脈沖電磁場對去勢大鼠股骨骨密度的影響[J]. 中國修復重建外科雜志, 2008, 22(5):548-550.
15. 高堪達, 俞永林, 周建偉. 脈沖電磁場治療骨質疏松癥研究進展[J]. 國外醫學·骨科學分冊, 2004, 25(5):307-309.
16. Tabrah FL, Ross P, Hoffmeier M, et al. Clinical report on long-term bone density after short-term EMF application[J]. Bioelectromagnetics, 1998, 19:75-78.
17. 肖登, 楊霖, 雷中杰, 等. 不同治療時間脈沖電磁場對去卵巢大鼠股骨生物力學性能的影響[J]. 四川大學學報·醫學版, 2010, 41(2):296-298.
18. Weintraub MI, Herrmann DN, Smith AG, et al. Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair:a randomized controlled trial[J]. Arch Phys Med Rehabil, 2009, 9(8):1102-1109.
19. Ay S, Evcik D. The effects of pulsed electromagnetic fields in the treatment of knee osteoarthritis:a randomized, placebo-controlled trial[J]. Rheumatol Int, 2009, 29(6):663-666.
20. 郝雙林, 田寶斌, 王玲, 等. VAS測痛法的臨床初步評估[J]. 中國醫學科學院學報, 1994, 16(5):397-399.
21. 胡一順, 史玲, 鮑志民, 等. 低頻脈沖電磁場治療骨質疏松癥骨痛癥狀療效觀察[J]. 上海醫藥, 2012, 33(6):46-47.
22. Snow S, Kirwan JR. Visual analogue scales:a source of error[J]. Ann Rheum Dis, 1988, 47(6):526.
23. 郝雙林. 臨床疼痛的測定方法及其評價[J]. 國外醫學·麻醉學與復蘇分冊, 1993, 14(4):228-230.
24. 張權, 黃煌淵. 降鈣素治療骨質疏松性疼痛的短期療效評估[J]. 上海醫科大學學報, 2000, 11(1):27-29.
25. Smith TL, Wong-Gi bbons D, Maultsby J. Microcirculatory effects of pulse electromagnetic fields[J]. Orthop Res, 2004, 22(1):80-84.
26. 周萬松. 新編磁療學[M]. 北京:科學出版社, 1995:50-58, 130-151.
27. Greenough CG. The effects of pulsed electromagnetic fields on blood vessel growth in the rabbit ear chamber[J]. Orthop Res, 1992, 10(2):256-262.
28. 張小云, 羅振國, 馬永鍵. 磁場對血漿B-內啡肽的影響[J]. 中華物理醫學與康復雜志, 1998, 20(3):129-132.
29. Blain H, Vuillemin A, Teissier A, et al. Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over[J]. Gerontology, 2001, 47(4):207-212.
30. 楊霖, 雷中杰, 何成奇. 低頻脈沖電磁場治療骨質疏松癥的臨床觀察[J]. 中國骨質疏松雜志, 2006, 12(6):592-593.
31. Zhao FZ, Han XS, Tao TZ. The treatment of primary osteoporosis by salmon calcitonin and physical therapy[J]. Chin J Osteoporos, 2007, 13(4):281-283.
32. Weinans H, Huiskes R, Grootenboer HJ. The behavior of adaptive bone-remodeling simulation models[J]. Biomech, 1992, 25(12):1425-1441.
33. 李國新, 溫健, 湯晨達, 等. 低頻脈沖電磁場治療原發性骨質疏松癥的短期療效觀察[J]. 齊齊哈爾醫學院學報, 2010, 13(14):2203-2204.
34. Forgacs Z, Somosy Z, Kubinyi G, et al. Effects of whole-body 50-Hz magnetic field exposure on mouse Leydig cell[J]. Sci World J, 2004, 4(2):83-90.
35. Fitzsimmons R, Strong D, Mohan S, et al. Low-amplitude, low-frequency electric field-stimulated cell proliferation may in part be mediated by increased IGF-Ⅱ release[J]. Cell Physiol, 1992, 150(1):326-334.

West China Medical Journal

Comparison between Pulsed Electromagnetic Field and Alendronate in the Treatment of Postmenopausal Osteoporosis

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