Pathogens and Antibiotic Resistance Analysis of Primary Nephrotic Syndrome Complicated with Urinary Tract Infection in Children_West China Medical Journal

Authors：

 LIBo , PENGQian , ZHENGZhi , CHENWan-yuan

Department of Pediatrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

Keywords：

Child; Primary nephrotic syndrome; Urinary tract infection; Pathogens; Resistance

DOI：

10.7507/1002-0179.20140015

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Objective To investigate the distribution and antibiotic resistance of pathogens isolated from children with primary nephrotic syndrome (PNS) complicated with urinary tract infection (UTI), so as to provide references for reasonable use of anti-infective agents in clinical practice. Methods A total of 218 eligible patients who hospitalized in our department between January 2009 and December 2012 were included, and the data of distribution and antibiotic resistance of pathogens were analyzed retrospectively. Results In this cohort, asymptomatic UTI in children with PNS accounted for 75.7% (165/218). And a total of 249 pathogenic strains were isolated and cultivated. The main pathogens of those subjects were G^- bacilli, accounting for 64.3% (160/249), and 63.8% (102/160) of G^- bacilli was Escherichia coli (E.coli); G⁺ cocci accounted for 31.7% (79/249), and 59.5% (47/79) of them was Enterococci faecalis; and fungi accounted for only 4.0%. Drug-susceptibility testing suggested that E.coli had a high resistance rate to hydroxyl ampicillin, cefazolin and ceftriaxone (>50%), but had lower resistance rate to cefoperazone/sulbactam and imipenem (<10%). Enterococci faecalis had a high resistance rate to rifampicin (74.6%), but had low resistance to vancomycin and linezolid (<10%). Conclusion Asymptomatic UTI is common in children with PNS. E.coli is the major pathogen and the proportion of enterococcus infection is also not low, and these pathogens have a high antibiotic resistance and most of them are multi-resistant.

Citation： LIBo, PENGQian, ZHENGZhi, CHENWan-yuan. Pathogens and Antibiotic Resistance Analysis of Primary Nephrotic Syndrome Complicated with Urinary Tract Infection in Children. West China Medical Journal, 2014, 29(1): 54-56. doi: 10.7507/1002-0179.20140015 Copy

1.	劉麗輝. 兒童原發性腎病綜合征復發危險因素分析[J]. 臨床醫學工程, 2012, 19(8):1313-1314.
2.	李志娟, 王墨. 61例小兒原發性腎病綜合征合并尿路感染的病原菌及耐藥性分析[J]. 中國藥業, 2010, 19(9):7-9.
3.	郭德明. 無癥狀性菌尿對原發性腎病綜合征療效的影響[J]. 實用兒科臨床雜志, 2001, 16(5):293-294.
4.	高曉潔, 李永柏, 趙維玲, 等. 兒童泌尿感染的臨床特點、病原菌分布及耐藥性分析[J].實用兒科臨床雜志, 2010, 25(5):330-332.
5.	中華醫學會兒科學分會腎臟病學組. 小兒腎小球疾病的臨床分類、診斷及治療[J]. 中華兒科雜志, 2001, 39(12):746-747.
6.	胡亞美, 江載芳. 諸福棠實用兒科學[M]. 7版. 北京:人民衛生出版社, 2002:1667-1672.
7.	Adedoyin OT, Ojuawo IA, Odimayo MS, et al. Urinary tract infections in children with primary nephrotic syndrome and acute glomerulonephritis[J]. West Afr J Med, 2010, 29(4):235-238.
8.	關富山. 兒童腎病綜合征醫院感染的病因與預防措施[J]. 中國現代兒科志, 2005, 2(3):249-250.
9.	伍尚平, 陳仕銀, 樊均明, 等. 原發性腎病綜合征合并尿路感染的病原菌及耐藥性分析[J]. 四川省衛生管理干部學院學報, 2005, 24(4):272-273.
10.	宋少娜, 張碧麗, 王文紅, 等. 97例腎病綜合征合并尿路感染患兒的病原菌分布及藥敏分析[J]. 中國當代兒科雜志, 2012, 14(9):657-660.
11.	徐錦雯, 張唯真, 張愛華, 等. 兒童腎病綜合征伴尿路感染的臨床分析[J]. 南京醫科大學學報·自然科學版, 2010, 30(4):530-532.
12.	舒雪芹, 薛利霞, 石娜, 等. 產ESBLs大腸埃希氏菌醫院尿路感染調查及預防護理措施[J]. 現代預防醫學, 2006, 33(3):323-324.

1. 劉麗輝. 兒童原發性腎病綜合征復發危險因素分析[J]. 臨床醫學工程, 2012, 19(8):1313-1314.
2. 李志娟, 王墨. 61例小兒原發性腎病綜合征合并尿路感染的病原菌及耐藥性分析[J]. 中國藥業, 2010, 19(9):7-9.
3. 郭德明. 無癥狀性菌尿對原發性腎病綜合征療效的影響[J]. 實用兒科臨床雜志, 2001, 16(5):293-294.
4. 高曉潔, 李永柏, 趙維玲, 等. 兒童泌尿感染的臨床特點、病原菌分布及耐藥性分析[J].實用兒科臨床雜志, 2010, 25(5):330-332.
5. 中華醫學會兒科學分會腎臟病學組. 小兒腎小球疾病的臨床分類、診斷及治療[J]. 中華兒科雜志, 2001, 39(12):746-747.
6. 胡亞美, 江載芳. 諸福棠實用兒科學[M]. 7版. 北京:人民衛生出版社, 2002:1667-1672.
7. Adedoyin OT, Ojuawo IA, Odimayo MS, et al. Urinary tract infections in children with primary nephrotic syndrome and acute glomerulonephritis[J]. West Afr J Med, 2010, 29(4):235-238.
8. 關富山. 兒童腎病綜合征醫院感染的病因與預防措施[J]. 中國現代兒科志, 2005, 2(3):249-250.
9. 伍尚平, 陳仕銀, 樊均明, 等. 原發性腎病綜合征合并尿路感染的病原菌及耐藥性分析[J]. 四川省衛生管理干部學院學報, 2005, 24(4):272-273.
10. 宋少娜, 張碧麗, 王文紅, 等. 97例腎病綜合征合并尿路感染患兒的病原菌分布及藥敏分析[J]. 中國當代兒科雜志, 2012, 14(9):657-660.
11. 徐錦雯, 張唯真, 張愛華, 等. 兒童腎病綜合征伴尿路感染的臨床分析[J]. 南京醫科大學學報·自然科學版, 2010, 30(4):530-532.
12. 舒雪芹, 薛利霞, 石娜, 等. 產ESBLs大腸埃希氏菌醫院尿路感染調查及預防護理措施[J]. 現代預防醫學, 2006, 33(3):323-324.

West China Medical Journal

Pathogens and Antibiotic Resistance Analysis of Primary Nephrotic Syndrome Complicated with Urinary Tract Infection in Children

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