Clinical Effect of Irbesartan on Patients with Senile Hypertension Complicated with Paroxysmal Atrial Fibrillation_West China Medical Journal

Authors：

 LIUJie

People's Hospital of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;

Corresponding?author：

Keywords：

Irbesartan; Senile hypertension; Atrial fibrillation

DOI：

10.7507/1002-0179.20140002

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Objective To explore the effect of irbesartan on patients with senile hypertension complicated with paroxysmal atrial fibrillation. Methods A total of 126 inpatients and outpatients over 60 years of age with senile hypertension complicated with paroxysmal atrial fibrillation treated in our hospital from July 2010 to August 2012 were randomized into the study group (n=63, treated with irbesartan) and the control group (n=63, treated with amlodipine besylate). Diuretics was added according to blood pressure of the patients. All the patients were followed up for 12 months. Blood pressure control situation, atrial fibrillation recurrence frequency and duration time, alteration of left atrial inner diameter were compared between the two groups. Results The level of blood pressure in both groups after treatment was significantly decreased compared with baseline, and there was no statistically significant difference in the decrease of blood pressure after treatment between the two groups (P>0.05). Atrial fibrillation recurrence frequency in the study group was (5.28±1.14) times, which was significantly lower than that in the control group[(9.24±1.34) times] (P<0.01). The paroxysmal atrial fibrillation duration time in the study group was (14.3±4.8) hours, which was significantly lower than that in the control group[(21.3±4.9) hours] (P<0.01). After treatment, the left atrial inner diameter in the study group was significantly diminished compared with that before treatment (P<0.01). Conclusion For patients with senile hypertension complicated with paroxysmal atrial fibrillation, irbesartan is effective to control blood pressure, decrease atrial fibrillation recurrence frequency and duration, and inhibit left atrioventricular remodeling.

Citation： LIUJie. Clinical Effect of Irbesartan on Patients with Senile Hypertension Complicated with Paroxysmal Atrial Fibrillation. West China Medical Journal, 2014, 29(1): 5-7. doi: 10.7507/1002-0179.20140002 Copy

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13.	鄧仁生. 心房顫動復律后聯用纈沙坦與胺碘酮的療效[J]. 嶺南心血管病雜志, 2006, 12(3):188-189.

1. 胡大一, 孫藝紅. 心房顫動的流行病學和治療現狀[J]. 中國全科醫師雜志, 2006, 5(1):5-7.
2. 魏子秀,楊雪珍, 叢培玲, 等. 厄貝沙坦聯合阿托伐他汀對急性心肌梗塞合并陣發性心房顫動患者復發的影響[J]. 中華老年心腦血管病雜志, 2011, 13(7):604-607.
3. 楊進剛. 心房顫動的診斷與藥物治療(中國專家共識)[J]. 心腦血管病防治, 2008, 8(4):215-221.
4. 劉力生. 2010年中國高血壓防治指南[J]. 中華高血壓雜志, 2011, 8(8):701-742.
5. 趙秀麗, 陳捷, 崔艷麗, 等. 中國14省市高血壓現狀的流行病學研究[J]. 中華醫學雜志, 2006, 86(16):1148-1152.
6. 馬宇虹, 李廣平, 劉彤, 等. RAAS激活與急性心肌梗塞早期新發心房顫動的關系[J]. 山東醫藥, 2010, 50(4):6-28.
7. 周力, 王翠英, 陳暉, 等. 血管緊張素轉換酶抑制劑和血管緊張素受體拮抗劑在心房顫動一級預防中的可能作用[J]. 中華老年心腦血管病雜志, 2010, 12(12):1149-1150.
8. 薛玉梅, 吳書林, 鄧春玉, 等. 纈沙坦對血管緊張素Ⅱ引起人心房肌細胞離子電流改變的調節作用[J]. 臨床心血管雜志, 2005, 21(8):493-494.
9. 湯東澄. 厄貝沙坦與苯磺酸左旋氨氯地平治療原發性高血壓的療效觀察[J]. 中國藥房, 2010, 21(40):397-398.
10. 趙穎, 胡大一, 楊新春, 等. 肽類血管緊張素Ⅱ受體拮抗劑對心肌細胞離子通道的影響[J]. 中華心血管病雜志, 2000, 28(1):58-60.
11. 周曉芳, 蔡力, 周魯, 等. 氯沙坦對高血壓患者生存質量影響的研究[J]. 西部醫學, 2003, 14(1):23-25.
12. 裘晟, 陳肖君, 金慶吉, 等. 厄貝沙坦預防陣發性心房顫動復發作用的觀察[J]. 心電學雜志, 2005, 24(2):74-75.
13. 鄧仁生. 心房顫動復律后聯用纈沙坦與胺碘酮的療效[J]. 嶺南心血管病雜志, 2006, 12(3):188-189.

West China Medical Journal

Clinical Effect of Irbesartan on Patients with Senile Hypertension Complicated with Paroxysmal Atrial Fibrillation

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