Therapeutic Results of Glucosamine Hydrochloride Capsules in Combination with Sodium Hyaluronate in the Treatment of Hip Osteoarthritis_West China Medical Journal

Authors：

WEN Chuanbing , DAI Yuee , LIN Tao , XU Yongjian ,  LAN Zhixun.

Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People´s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

LAN Zhixun., Email: sunwenshi2006@sohu.com

Keywords：

透明質酸鈉; 鹽酸氨基葡萄糖; 骨關節炎，髖

DOI：

10.7507/1002-0179.20130583

Video：

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目的　探討鹽酸氨基葡萄糖膠囊聯合透明質酸鈉注射液治療髖骨關節炎的臨床療效。方法　納入疼痛門診2010年7月－2011年7月收治的髖骨關節炎患者60例，隨機分為透明質酸鈉關節腔內注射聯合口服鹽酸氨基葡萄糖膠囊組（A組）和單獨透明質酸鈉關節腔內注射組（B組），每組30例。透明質酸鈉關節腔內注射均為2.5 mL/次，每周1次，連續5周為1療程。鹽酸氨基葡萄糖膠囊口服，0.75 g/次，2次/d，6周為1個療程。評估兩組患者治療后6周后髖關節疼痛視覺模擬評分（VAS評分）及Lequesne指數評定髖關節休息痛、運動痛、局部壓痛、關節活動度、晨僵及行走能力，并觀察兩組不良反應發生情況。結果　治療6周后A組Lequesne功能指數及VAS評分較B組顯著降低（P＜0.05），兩組不良反應比較差異無統計學意義（P＞0.05）。結論　治療髖骨關節炎患者時，聯合應用透明質酸鈉及鹽酸氨基葡萄糖膠囊療效優于單獨應用透明質酸鈉者，且并未增加不良反應的發生。

Citation： WEN Chuanbing,DAI Yuee,LIN Tao,XU Yongjian,LAN Zhixun.. Therapeutic Results of Glucosamine Hydrochloride Capsules in Combination with Sodium Hyaluronate in the Treatment of Hip Osteoarthritis. West China Medical Journal, 2013, 28(12): 1843-1845. doi: 10.7507/1002-0179.20130583 Copy

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4.	Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol Suppl, 1991, 27(27): 16-18.
5.	Leslie M. Knee osteoarthritis management therapiea[J]. Pain Manag Nurs, 2000, 1(2): 51-57.
6.	Fine PG. Treatment guidelines for the pharmacological management of pain in older persons[J]. Pain Med, 2012, 13 (Suppl 2): S57-S66.
7.	Petrella LJ, Prospective PA. Randomizd, double-blind, placebo controlled study to evaluate the efficacy of intra-articular hyaluronic acid for asteoarthritis of the knee[J]. J Rheumatol, 2006, 33(5): 951-956.
8.	劉漢華, 蔣毅, 孫躍玲, 等. 玻璃酸鈉聯合鹽酸氨基葡萄糖對膝骨關節炎患者血清MMP-9、TNF-α的影響[J]. 內科急危重癥雜志, 2011, 17(1): 26-27.
9.	Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis[J]. Arzneimittelforschung, 1998, 48(5): 469-474.
10.	Tanaka H, Ueta Y, Yamashita U, et al. Biphasic changes in behaveiora, l indocrine, and sympathyetic systemes in adjuvant arthritis in lewis rats[J]. Bra in Res Bul, 1996, 39(1): 33-37.
11.	David E, Christopher J, Mark B, et al. Efficacy of intraarticular hyaluronic acid injections in knee osteoarthritis[J]. Clin Orthop Relat Res, 2001, 390(9): 173-181.
12.	Lomander LS, Dalen N, Englund G, et al. Intraarticular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled multicenter trial[J]. Ann Rheum Dis, 1996, 55(7): 424-431.
13.	Da-Camara CC, Dowless GV. Glueesamine sulfate for ostonarthritis[J]. Ann Pharmacother, 1998, 32(5): 580.

1. 　孫瑛. 實用關節炎診斷治療學[M]. 北京: 北京大學出版社, 2002: 319-333.
2. 　張里援, 冮湘保. 透明質酸鈉關節內注射配合口服鹽酸氨基葡萄糖膠囊治療膝關節骨性關節炎的療效分析[J]. 中國骨與關節外科, 2009, 2(6): 478-480.
3. 　中華醫學會風濕病學分會. 骨關節炎診斷及治療指南[J]. 中華風濕病學雜志, 2010, 14(6): 416-419.
4. 　Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol Suppl, 1991, 27(27): 16-18.
5. 　Leslie M. Knee osteoarthritis management therapiea[J]. Pain Manag Nurs, 2000, 1(2): 51-57.
6. 　Fine PG. Treatment guidelines for the pharmacological management of pain in older persons[J]. Pain Med, 2012, 13 (Suppl 2): S57-S66.
7. 　Petrella LJ, Prospective PA. Randomizd, double-blind, placebo controlled study to evaluate the efficacy of intra-articular hyaluronic acid for asteoarthritis of the knee[J]. J Rheumatol, 2006, 33(5): 951-956.
8. 　劉漢華, 蔣毅, 孫躍玲, 等. 玻璃酸鈉聯合鹽酸氨基葡萄糖對膝骨關節炎患者血清MMP-9、TNF-α的影響[J]. 內科急危重癥雜志, 2011, 17(1): 26-27.
9. 　Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis[J]. Arzneimittelforschung, 1998, 48(5): 469-474.
10. 　Tanaka H, Ueta Y, Yamashita U, et al. Biphasic changes in behaveiora, l indocrine, and sympathyetic systemes in adjuvant arthritis in lewis rats[J]. Bra in Res Bul, 1996, 39(1): 33-37.
11. 　David E, Christopher J, Mark B, et al. Efficacy of intraarticular hyaluronic acid injections in knee osteoarthritis[J]. Clin Orthop Relat Res, 2001, 390(9): 173-181.
12. 　Lomander LS, Dalen N, Englund G, et al. Intraarticular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled multicenter trial[J]. Ann Rheum Dis, 1996, 55(7): 424-431.
13. 　Da-Camara CC, Dowless GV. Glueesamine sulfate for ostonarthritis[J]. Ann Pharmacother, 1998, 32(5): 580.

West China Medical Journal

Therapeutic Results of Glucosamine Hydrochloride Capsules in Combination with Sodium Hyaluronate in the Treatment of Hip Osteoarthritis

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