正電子發射計算機斷層顯像/磁共振成像的臨床應用新進展_West China Medical Journal

Authors：

沈國華 , 周綠漪 , 賈志云 , 張文杰 , 王喬 ,  鄧候富

Corresponding?author：

鄧候富, Email: 1017412478@qq.com

Keywords：

正電子發射計算機斷層顯像; 磁共振成像; 分子影像學; 腫瘤學; 神經精神疾病; 多模式成像理

DOI：

10.7507/1002-0179.20130567

Video：

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Abstract Full text Figures/Tables Video References Cited by

正電子發射計算機斷層顯像/磁共振成像這一新型設備和技術的出現，不僅為腫瘤學、神經精神疾病等的臨床應用開辟了新的道路，還為干細胞治療等基礎科研提供新的平臺。它不簡單是一種單一的技術變革，而是一種多模式成像理念的體現、多種技術的完美整合，它將給現代和將來的醫學發展模式帶來重大的影響。

Citation： 沈國華,周綠漪,賈志云,張文杰,王喬,鄧候富. 正電子發射計算機斷層顯像/磁共振成像的臨床應用新進展. West China Medical Journal, 2013, 28(11): 1787-1790. doi: 10.7507/1002-0179.20130567 Copy

1.	Drzezga A, Souvatzoglou M, Eiber M, et al. First clinical experience with integrated whole-body PET/Mr: comparison to PET/CT in patients with oncologic diagnoses[J]. J Nucl Med, 2012, 53(6): 845-855.
2.	Antoch G, Bockisch A. Combined PET/MRI: a new dimension in whole-body oncology imaging? [J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 113-120.
3.	Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis[J]. J Nucl Med, 2012, 53(6): 928-938.
4.	Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma[J]. J Nucl Med, 2012, 53(8): 1244-1252.
5.	Boss A, Stegger L, Bisdas S, et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area[J]. Eur Radiol, 2011, 21(7): 1439-1446.
6.	Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674.
7.	Sauter AW, Wehrl HF, Kolb A, et al. Combined PET/MRI: one step further in multimodality imaging[J]. Trends Mol Med, 2010, 16(11): 508-515.
8.	Ng TS, Bading JR, Park R, et al. Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner[J]. J Nucl Med, 2012, 53(7): 1102-1109.
9.	Schreiter NF, Nogami M, Steffen I, et al. Evaluation of the potential of PET-MRI fusion for detection of liver metastases in patients with neuroendocrine tumours[J]. Eur Radiol, 2012, 22(2): 458-467.
10.	Nagarajah J, Jentzen W, Hartung V, et al. Diagnosis and dosimetry in differentiated thyroid carcinoma using 124I PET: comparison of PET/MRI vs PET/CT of the neck[J]. Eur J Nucl Med Mol Imaging, 2011, 38(10): 1862-1868.
11.	Estorch M, Carrio I. Future challenges of multimodality imaging[J]. Recent Results Cancer Res, 2013, 187: 403-415.
12.	Takasawa M, Jones PS, Guadagno JV, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET[J]. Stroke, 2008, 39(3): 870-877.
13.	Guadagno JV, Warburton EA, Jones PS, et al. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study[J]. Neurology, 2006, 67(5): 824-829.
14.	LoPinto-Khoury C, Sperling MR, Skidmore C, et al. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy[J]. Epilepsia, 2012, 53(2): 342-348.
15.	Zaidi H, Del Guerra A. An outlook on future design of hybrid PET/MRI systems[J]. Med Phys, 2011, 38(10): 5667-5689.
16.	Goffin K, Dedeurwaerdere S, Van Laere K, et al. Neuronuclear assessment of patients with epilepsy[J]. Semin Nucl Med, 2008, 38(4): 227-239.
17.	Chen W, Silverman DH. Advances in evaluation of primary brain tumors[J]. Semin Nucl Med, 2008, 38(4): 240.
18.	Gilman, S. Imaging the brain[J]. N Engl J Med, 1998, 338(12): 812-820.
19.	Yakushev I, Fellgiebel A. Horizontal versus longitudinal axis of the hippocampus: metabolic differentiation as measured with high-resolution PET/MRI[J]. J Nucl Med, 2011, 52(2): 329-330.
20.	Yakushev I, Müller MJ, Lorscheider M, et al. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease[J]. Neuropsychologia, 2010, 48(5): 1447-1453.
21.	Behera D, Jacobs KE, Behera S, et al. (18) F-FDG PET/MRI can be used to identify injured peripheral nerves in a model of neuropathic pain[J]. J Nucl Med, 2011, 52(8): 1308-1312.
22.	Catana C, Drzezga A, Heiss WD, et al. PET/MRI for neurologic applications[J]. J Nucl Med, 2012, 53(12): 1916-1925.
23.	Heiss WD, Raab P, Lanfermann H. Multimodality assessment of brain tumors and tumor recurrence[J]. J Nucl Med, 2011, 52(10): 1585-1600.
24.	Nekolla SG, Martinez-Moeller A, Saraste A. PET and MRI in cardiac imaging: from validation studies to integrated applications[J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 121-130.
25.	Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead[J]. J Nucl Med, 2012, 53(5): 673-676.
26.	Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction[J]. J Am Coll Cardiol, 2012, 59(2): 153-163.
27.	Bjorklund LM, Sánchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model[J]. Proc Natl Acad Sci USA, 2002, 99(4): 2344-2349.
28.	Glaudemans AM, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement?[J]. Eur J Nucl Med Mol Imaging, 2012, 39(5):745-749.
29.	王強, 王榮福. 當代最先進分子影像新技術——PET/MRI[J]. 中國醫療器械信息, 2011, 17(4): 4-7.
30.	許震生, 譚海波, 管一暉. PET/MRI研制進展及展望[J]. 中國醫療器械信息, 2011, 17(4): 1-3, 26.

1. 　Drzezga A, Souvatzoglou M, Eiber M, et al. First clinical experience with integrated whole-body PET/Mr: comparison to PET/CT in patients with oncologic diagnoses[J]. J Nucl Med, 2012, 53(6): 845-855.
2. 　Antoch G, Bockisch A. Combined PET/MRI: a new dimension in whole-body oncology imaging? [J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 113-120.
3. 　Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis[J]. J Nucl Med, 2012, 53(6): 928-938.
4. 　Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma[J]. J Nucl Med, 2012, 53(8): 1244-1252.
5. 　Boss A, Stegger L, Bisdas S, et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area[J]. Eur Radiol, 2011, 21(7): 1439-1446.
6. 　Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674.
7. 　Sauter AW, Wehrl HF, Kolb A, et al. Combined PET/MRI: one step further in multimodality imaging[J]. Trends Mol Med, 2010, 16(11): 508-515.
8. 　Ng TS, Bading JR, Park R, et al. Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner[J]. J Nucl Med, 2012, 53(7): 1102-1109.
9. 　Schreiter NF, Nogami M, Steffen I, et al. Evaluation of the potential of PET-MRI fusion for detection of liver metastases in patients with neuroendocrine tumours[J]. Eur Radiol, 2012, 22(2): 458-467.
10. 　Nagarajah J, Jentzen W, Hartung V, et al. Diagnosis and dosimetry in differentiated thyroid carcinoma using 124I PET: comparison of PET/MRI vs PET/CT of the neck[J]. Eur J Nucl Med Mol Imaging, 2011, 38(10): 1862-1868.
11. 　Estorch M, Carrio I. Future challenges of multimodality imaging[J]. Recent Results Cancer Res, 2013, 187: 403-415.
12. 　Takasawa M, Jones PS, Guadagno JV, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET[J]. Stroke, 2008, 39(3): 870-877.
13. 　Guadagno JV, Warburton EA, Jones PS, et al. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study[J]. Neurology, 2006, 67(5): 824-829.
14. 　LoPinto-Khoury C, Sperling MR, Skidmore C, et al. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy[J]. Epilepsia, 2012, 53(2): 342-348.
15. 　Zaidi H, Del Guerra A. An outlook on future design of hybrid PET/MRI systems[J]. Med Phys, 2011, 38(10): 5667-5689.
16. 　Goffin K, Dedeurwaerdere S, Van Laere K, et al. Neuronuclear assessment of patients with epilepsy[J]. Semin Nucl Med, 2008, 38(4): 227-239.
17. 　Chen W, Silverman DH. Advances in evaluation of primary brain tumors[J]. Semin Nucl Med, 2008, 38(4): 240.
18. 　Gilman, S. Imaging the brain[J]. N Engl J Med, 1998, 338(12): 812-820.
19. 　Yakushev I, Fellgiebel A. Horizontal versus longitudinal axis of the hippocampus: metabolic differentiation as measured with high-resolution PET/MRI[J]. J Nucl Med, 2011, 52(2): 329-330.
20. 　Yakushev I, Müller MJ, Lorscheider M, et al. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease[J]. Neuropsychologia, 2010, 48(5): 1447-1453.
21. 　Behera D, Jacobs KE, Behera S, et al. (18) F-FDG PET/MRI can be used to identify injured peripheral nerves in a model of neuropathic pain[J]. J Nucl Med, 2011, 52(8): 1308-1312.
22. 　Catana C, Drzezga A, Heiss WD, et al. PET/MRI for neurologic applications[J]. J Nucl Med, 2012, 53(12): 1916-1925.
23. 　Heiss WD, Raab P, Lanfermann H. Multimodality assessment of brain tumors and tumor recurrence[J]. J Nucl Med, 2011, 52(10): 1585-1600.
24. 　Nekolla SG, Martinez-Moeller A, Saraste A. PET and MRI in cardiac imaging: from validation studies to integrated applications[J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 121-130.
25. 　Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead[J]. J Nucl Med, 2012, 53(5): 673-676.
26. 　Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction[J]. J Am Coll Cardiol, 2012, 59(2): 153-163.
27. 　Bjorklund LM, Sánchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model[J]. Proc Natl Acad Sci USA, 2002, 99(4): 2344-2349.
28. 　Glaudemans AM, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement?[J]. Eur J Nucl Med Mol Imaging, 2012, 39(5):745-749.
29. 　王強, 王榮福. 當代最先進分子影像新技術——PET/MRI[J]. 中國醫療器械信息, 2011, 17(4): 4-7.
30. 　許震生, 譚海波, 管一暉. PET/MRI研制進展及展望[J]. 中國醫療器械信息, 2011, 17(4): 1-3, 26.

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正電子發射計算機斷層顯像/磁共振成像的臨床應用新進展

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