Clinical Study of the Treatment of Knee Osteoarthritis with Arthroscopic Debridement and Glucosamine Hydrochloride_West China Medical Journal

Authors：

CHEN Xiaobing , CUI Jing.

Department of Orthopedics, People’s Hospital of Xinjiang District of Aletai, Aletai, Xinjiang 836500, P. R. China;

Corresponding?author：

Keywords：

關節鏡清理術; 鹽酸氨基葡萄糖; 骨關節炎，膝

DOI：

10.7507/1002-0179.20130487

Video：

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目的　探討關節鏡清理術配合鹽酸氨基葡萄糖對膝骨關節炎的治療作用。方法　2009年6月－2011年6月納入輕度膝骨關節炎（AhlbackⅠ級）患者135例，隨機分成3組。A組（n=45）接受關節鏡清理術治療；B組（n=45）口服鹽酸氨基葡萄糖膠囊治療；C組（（n=45）先行關節鏡清理術治療，術后口服鹽酸氨基葡萄糖膠囊。觀察3組Lequesne評分和WOMAC指數，用以評價治療效果。結果　成功隨訪患者123例，隨訪時間8個月。治療后各組Lequesne評分和WOMAC指數較治療前均顯著好轉（P＜0.01），其中治療后C組好轉較A組和B組具有顯著性（P＜0.01），但B組和C組之間差異無統計學意義（P＞0.05）。結論　關節鏡清理術配合鹽酸氨基葡萄糖，較之單用關節鏡清理術或鹽酸氨基葡萄糖，對膝骨關節炎的治療有更好的效果。

Citation： CHEN Xiaobing,CUI Jing.. Clinical Study of the Treatment of Knee Osteoarthritis with Arthroscopic Debridement and Glucosamine Hydrochloride. West China Medical Journal, 2013, 28(10): 1541-1544. doi: 10.7507/1002-0179.20130487 Copy

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3.	Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
4.	Moseley JB, O’malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002, 347(2): 81-88.
5.	蘇江, 張晶, 吳侗, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的隨機對照研究[J]. 華西醫學, 2012, 14(12): 34.
6.	McAlindon T, Formica M, LaValley M, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial[J]. Am J Med, 2004, 117(9): 643-649.
7.	Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12): 1145-1155.
8.	Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18): 2113-2123.
9.	Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial[J]. Lancet, 2001, 357(9252): 251-256.
10.	Spahn G, Mückley T, Kahl E, et al. Factors affecting the outcome of arthroscopy in medial-compartment osteoarthritis of the knee[J]. Arthroscopy, 2006, 22(11): 1233-1240.
11.	Aaron RK, Skolnick AH, Reinert SE. Arthroscopic debridement for osteoarthritis of the knee[J]. J Bone Jt Surg Am, 2006, 88(5): 936-943.
12.	Dervin GF, Stiell IG, Rody K, et al. Effect of arthroscopic débridement for osteoarthritis of the knee on health-related quality of Life[J]. J Bone Joint Surg Am, 2003, 85-A(1): 10-19.
13.	Siparsky P, Ryzewicz M, Peterson B, et al. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications?[J]. Clin Orthop Relat Res, 2007, 455: 107-112.
14.	Dervin GF, Stiell IG, Wells GA, et al. Physicians’ accuracy and interrator reliability for the diagnosis of unstable meniscal tears in patients having osteoarthritis of the knee[J]. Can J Surg, 2001, 44(4): 267-274.
15.	Bernard J, Lemon M, Patterson MH. Arthroscopic washout of the knee: a 5-year survival analysis[J]. Knee, 2004, 11(3): 233-235.
16.	Harrison MM, Morrell J, Hopman WM. Influence of obesity on outcome after knee arthroscopy[J]. Arthroscopy, 2004, 20(7): 691-695.
17.	Fond J, Rodin D, Ahmad S, et al. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2-and 5-year results[J]. Arthroscopy, 2002, 18(8): 829-834.
18.	Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up[J]. Arthroscopy, 2003, 19(1): 13-20.

1. 　Calamia V, Ruiz-Romero C, Rocha B, et al. Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes[J]. Arthritis Res Ther, 2010, 12(4): R138.
2. 　Berenbaum F. New horizons and perspectives in the treatment of osteoarthritis[J]. Arthritis Res Ther, 2008, 10 (Suppl 2): 1.
3. 　Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
4. 　Moseley JB, O’malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002, 347(2): 81-88.
5. 　蘇江, 張晶, 吳侗, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的隨機對照研究[J]. 華西醫學, 2012, 14(12): 34.
6. 　McAlindon T, Formica M, LaValley M, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial[J]. Am J Med, 2004, 117(9): 643-649.
7. 　Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12): 1145-1155.
8. 　Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18): 2113-2123.
9. 　Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial[J]. Lancet, 2001, 357(9252): 251-256.
10. 　Spahn G, Mückley T, Kahl E, et al. Factors affecting the outcome of arthroscopy in medial-compartment osteoarthritis of the knee[J]. Arthroscopy, 2006, 22(11): 1233-1240.
11. 　Aaron RK, Skolnick AH, Reinert SE. Arthroscopic debridement for osteoarthritis of the knee[J]. J Bone Jt Surg Am, 2006, 88(5): 936-943.
12. 　Dervin GF, Stiell IG, Rody K, et al. Effect of arthroscopic débridement for osteoarthritis of the knee on health-related quality of Life[J]. J Bone Joint Surg Am, 2003, 85-A(1): 10-19.
13. 　Siparsky P, Ryzewicz M, Peterson B, et al. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications?[J]. Clin Orthop Relat Res, 2007, 455: 107-112.
14. 　Dervin GF, Stiell IG, Wells GA, et al. Physicians’ accuracy and interrator reliability for the diagnosis of unstable meniscal tears in patients having osteoarthritis of the knee[J]. Can J Surg, 2001, 44(4): 267-274.
15. 　Bernard J, Lemon M, Patterson MH. Arthroscopic washout of the knee: a 5-year survival analysis[J]. Knee, 2004, 11(3): 233-235.
16. 　Harrison MM, Morrell J, Hopman WM. Influence of obesity on outcome after knee arthroscopy[J]. Arthroscopy, 2004, 20(7): 691-695.
17. 　Fond J, Rodin D, Ahmad S, et al. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2-and 5-year results[J]. Arthroscopy, 2002, 18(8): 829-834.
18. 　Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up[J]. Arthroscopy, 2003, 19(1): 13-20.

West China Medical Journal

Clinical Study of the Treatment of Knee Osteoarthritis with Arthroscopic Debridement and Glucosamine Hydrochloride

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