Clinical Features and Treatment of Small Cell Osteosarcoma: A Report of Twelve Cases and Literature Review_West China Medical Journal

Authors：

Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China;

Corresponding?author：

Keywords：

小細胞性骨肉瘤; 診斷; 治療

DOI：

10.7507/1002-0179.20130223

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　總結小細胞性骨肉瘤的臨床特征及診治情況。方法　回顧性分析1995年12月－2012年6月收治的12例小細胞性骨肉瘤患者的臨床資料。結合文獻分析該病的診治特點。結果　全組患者手術11例，化學治療（化療）8例，術后輔助放射治療（放療）2例。隨訪截止時，全組患者總生存4～55個月。文獻回顧方面，通過檢索策略獲得探討相關治療方案的文獻8篇，涉及小細胞性骨肉瘤患者79例。治療方式以手術+輔助化療為主。結論　小細胞性骨肉瘤發病率低，預后較普通骨肉瘤更差。手術為主要治療方式，新輔助化療及輔助化療可能使患者進一步受益，放療的治療效果目前還不明確。

Citation： WAN XiaoLi,ZHOU Lin.. Clinical Features and Treatment of Small Cell Osteosarcoma: A Report of Twelve Cases and Literature Review. West China Medical Journal, 2013, 28(5): 715-718. doi: 10.7507/1002-0179.20130223 Copy

1.	McPherson F, Chamyan G, Gilbert-Barness E. Pathology quiz: Small cell osteosarcoma [J]. Pediatr Pathol Mol Med, 2001, 20(4): 345-348.
2.	Kyriakos M, Gilula LA, Becich MJ, et al. Intracortical small cell osteosarcoma [J]. Clin Orthop Relat Res, 1992, (279): 269-280.
3.	Sim FH, Unni KK, Beabout JW, et al. Osteosarcoma with small cells simulating ewing’s tumor [J]. J Bone Joint Surg Am, 1979, 61(2): 207-215.
4.	Boldrini R, Devito R, Bosman C. Small-cell osteosarcoma[J]. Pathologica, 2000, 92: 133-134.
5.	Tsuchiya H, Yasutake H, Yokogawa A, et al. Effect of chemotherapy combined with caffeine for osteosarcoma [J]. J Cancer Res Clin Oncol, 1992, 118(8): 567-569.
6.	Nakajima H, Sim FH, Bond JR, et al. Small cell osteosarcoma of bone. Review of 72 cases [J]. Cancer, 1997, 79(11): 2095-2106.
7.	Li SMD, Siegal GPMDP. Small cell tumors of bone. [review] [M]. Advances in Anatomic Pathology January, 2010, 17(1): 1-11.
8.	Sipos EP, Tamargo RJ, Epstein JI, et al. Primary intracerebral small-cell osteosarcoma in an adolescent girl: Report of a case [J]. J Neurooncol, 1997, 32(2): 169-174.
9.	Park SH, Kim I. Small cell osteogenic sarcoma of the ribs: Cytological, immunohistochemical, and ultrastructural study with literature review [J]. Ultrastruct Pathol, 1999, 23(2): 133-140.
10.	Hameed M. Small round cell tumors of bone [J]. Arch Pathol Lab Med, 2007, 131(2): 192-204.
11.	Ayala AG, Ro JY, Raymond AK, et al. Small cell osteosarcoma. A clinicopathologic study of 27 cases [J]. Cancer, 1989, 64(10): 2162-2173.
12.	Machado I, Alberghini M, Giner F, et al. Histopathological characterization of small cell osteosarcoma with immuno-histochemistry and molecular genetic support. A study of 10 cases [J]. Histopathology, 2010, 57(1): 162-167.
13.	Bertoni F, Present D, Bacchini P, et al. The istituto rizzoli experience with small cell osteosarcoma [J]. Cancer, 1989, 64(12): 2591-2599.
14.	Devaney K, Vinh TN, Sweet DE. Small cell osteosarcoma of bone: An immunohistochemical study with differential diagnostic considerations [J]. Hum Pathol, 1993, 24(11): 1211-1225.
15.	徐萬鵬，李佛保. 骨與軟組織腫瘤學 [M] .北京：人民衛生出版社，2008: 451-452.
16.	吳文娟，張英澤. 骨與軟組織腫瘤 [M] .北京：人民衛生出版社，2009: 203.
17.	Noguera R, Navarro S, Triche TJ. Translocation (11;22) in small cell osteosarcoma [J]. Cancer Genet Cytogenet, 1990, 45(1): 121-124.
18.	Lee AF, Hayes MM, Lebrun D, et al. Fli-1 distinguishes ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma [J]. Appl Immunohistochem Mol Morphol, 2011, 19(3): 233-238.
19.	Stea B, Cavazzana A, Kinsella TJ. Small-cell osteosarcoma: Correlation of in vitro and clinical radiation response [J]. Int J Radiat Oncol Biol Phys, 1988, 15(5): 1233-1238.
20.	Todesco A, Carli M, Iacona I, et al. All-trans retinoic acid and interferon-alpha in the treatment of a patient with resistant metastatic osteosarcoma [J]. Cancer, 2000, 89(12): 2661-2666.
21.	Nakamura T, Ishimaru J, Mizui T, et al. Osteosarcoma metastatic to the mandible: A case report [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(4): 452-454.
22.	Kallel R, Ayadi L, Toumi N, et al. Small cell osteosarcoma: A case report [J]. Pathologica, 2009, 101(2): 101-104.
23.	Futani H, Fukunaga S, Tsukamoto Y, et al. Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin [J]. Anticancer Res, 2012, 32(3): 965-971.

1. 　McPherson F, Chamyan G, Gilbert-Barness E. Pathology quiz: Small cell osteosarcoma [J]. Pediatr Pathol Mol Med, 2001, 20(4): 345-348.
2. 　Kyriakos M, Gilula LA, Becich MJ, et al. Intracortical small cell osteosarcoma [J]. Clin Orthop Relat Res, 1992, (279): 269-280.
3. 　Sim FH, Unni KK, Beabout JW, et al. Osteosarcoma with small cells simulating ewing’s tumor [J]. J Bone Joint Surg Am, 1979, 61(2): 207-215.
4. 　Boldrini R, Devito R, Bosman C. Small-cell osteosarcoma[J]. Pathologica, 2000, 92: 133-134.
5. 　Tsuchiya H, Yasutake H, Yokogawa A, et al. Effect of chemotherapy combined with caffeine for osteosarcoma [J]. J Cancer Res Clin Oncol, 1992, 118(8): 567-569.
6. 　Nakajima H, Sim FH, Bond JR, et al. Small cell osteosarcoma of bone. Review of 72 cases [J]. Cancer, 1997, 79(11): 2095-2106.
7. 　Li SMD, Siegal GPMDP. Small cell tumors of bone. [review] [M]. Advances in Anatomic Pathology January, 2010, 17(1): 1-11.
8. 　Sipos EP, Tamargo RJ, Epstein JI, et al. Primary intracerebral small-cell osteosarcoma in an adolescent girl: Report of a case [J]. J Neurooncol, 1997, 32(2): 169-174.
9. 　Park SH, Kim I. Small cell osteogenic sarcoma of the ribs: Cytological, immunohistochemical, and ultrastructural study with literature review [J]. Ultrastruct Pathol, 1999, 23(2): 133-140.
10. 　Hameed M. Small round cell tumors of bone [J]. Arch Pathol Lab Med, 2007, 131(2): 192-204.
11. 　Ayala AG, Ro JY, Raymond AK, et al. Small cell osteosarcoma. A clinicopathologic study of 27 cases [J]. Cancer, 1989, 64(10): 2162-2173.
12. 　Machado I, Alberghini M, Giner F, et al. Histopathological characterization of small cell osteosarcoma with immuno-histochemistry and molecular genetic support. A study of 10 cases [J]. Histopathology, 2010, 57(1): 162-167.
13. 　Bertoni F, Present D, Bacchini P, et al. The istituto rizzoli experience with small cell osteosarcoma [J]. Cancer, 1989, 64(12): 2591-2599.
14. 　Devaney K, Vinh TN, Sweet DE. Small cell osteosarcoma of bone: An immunohistochemical study with differential diagnostic considerations [J]. Hum Pathol, 1993, 24(11): 1211-1225.
15. 　徐萬鵬，李佛保. 骨與軟組織腫瘤學 [M] .北京：人民衛生出版社，2008: 451-452.
16. 　吳文娟，張英澤. 骨與軟組織腫瘤 [M] .北京：人民衛生出版社，2009: 203.
17. 　Noguera R, Navarro S, Triche TJ. Translocation (11;22) in small cell osteosarcoma [J]. Cancer Genet Cytogenet, 1990, 45(1): 121-124.
18. 　Lee AF, Hayes MM, Lebrun D, et al. Fli-1 distinguishes ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma [J]. Appl Immunohistochem Mol Morphol, 2011, 19(3): 233-238.
19. 　Stea B, Cavazzana A, Kinsella TJ. Small-cell osteosarcoma: Correlation of in vitro and clinical radiation response [J]. Int J Radiat Oncol Biol Phys, 1988, 15(5): 1233-1238.
20. 　Todesco A, Carli M, Iacona I, et al. All-trans retinoic acid and interferon-alpha in the treatment of a patient with resistant metastatic osteosarcoma [J]. Cancer, 2000, 89(12): 2661-2666.
21. 　Nakamura T, Ishimaru J, Mizui T, et al. Osteosarcoma metastatic to the mandible: A case report [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(4): 452-454.
22. 　Kallel R, Ayadi L, Toumi N, et al. Small cell osteosarcoma: A case report [J]. Pathologica, 2009, 101(2): 101-104.
23. 　Futani H, Fukunaga S, Tsukamoto Y, et al. Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin [J]. Anticancer Res, 2012, 32(3): 965-971.

Previous Article
Clinicopathological Analysis of Primary Signet Ring Cell Adenocarcinoma of the Lung
Next Article
CT Guided Percutaneous Osteoplasty of Ilium to Treat Metastatic Tumor of Ilium

West China Medical Journal

Clinical Features and Treatment of Small Cell Osteosarcoma: A Report of Twelve Cases and Literature Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content