肺癌患者血清中脂質運載蛋白-2的表達及臨床意義_West China Medical Journal

Authors：

王宇 ¹ , 陳偉 ² ,  曾婷婷 ³

Corresponding?author：

曾婷婷, Email: lilichen1999@sohu.com

Keywords：

肺癌; 脂質運載蛋白-2; 酶聯免疫吸附試驗

DOI：

10.7507/1002-0179.20130137

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的　檢測脂質運載蛋白-2（Lipocalin-2）在肺癌患者血清中的表達情況及與臨床指標的關系。方法　2012年1月－5月采用酶聯免疫吸附試驗（ELISA）定量檢測42例肺癌患者和27例正常人血清中Lipocalin-2蛋白的表達水平。結果　肺癌組和正常對照組血清中Lipocalin-2蛋白含量分別為（89.63 ± 21.32）、（62.44 ± 18.25） ng/mL，差異有統計學意義（P＜0.05）。Lipocalin-2在小細胞癌組表達水平最高[（117.73 ± 8.76） ng/mL]，顯著高于腺癌組[（80.33 ± 16.6） ng/mL]和鱗癌組[（89.22 ± 18.53 ng/mL]，差異有統計學意義（P＜0.05）。Ⅲ＋Ⅳ期肺癌組的Lipocalin-2水平[（95.72 ± 15.33） ng/mL]，顯著高于Ⅰ期[（65.7 ± 8.77） ng/mL]和Ⅱ期[（72.75 ± 10.77） ng/mL]，差異有統計學意義（P＜0.05）。淋巴節轉移組的Lipocalin-2水平[（94.28 ± 20.92） ng/mL]，顯著高于未轉移組[（72.55 ± 12.69） ng/mL]，差異有統計學意義（P＜0.05）。結論　Lipocalin-2蛋白在肺癌患者血清中表達上調，該蛋白與肺癌的發生發展有關。

Citation： 王宇,陳偉,曾婷婷. 肺癌患者血清中脂質運載蛋白-2的表達及臨床意義. West China Medical Journal, 2013, 28(3): 428-430. doi: 10.7507/1002-0179.20130137 Copy

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2.	Flower DR. The lipocalin protein family:structure and function[J]. Biochem J, 1996, 318(Pt 1): 1-14.
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4.	Tong ZM, Wu XL, Ovcharenko D, et al. Neutrophil genatinase-associated lipocalin as a survival factor[J]. Biochem J, 2005, 391(Pt2): 441-448.
5.	Grundy SM. The metabolic syndrome:inflammation,diabetes mellitus,and cardiovascular disease[J]. Am J Cardio, 2006, 97(1): 3A-11A.
6.	林憶陽, 翁忠, 屈天生. 糖尿病腎病患者血清中性粒細胞明膠酶相關脂質運載蛋白的改變及其臨床意義[J]. 細胞與分子免疫學雜志, 2010, 26(11): 1113-1115.
7.	Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly[J]. Circ Res, 2002, 90(3): 251-262.
8.	Stoesz SP, Friedl A, Haag JD, et al. Heterogeneous expression of the lipocalin NGAL in primary breast cancers[J]. Int J Cancer, 1998, 79(6): 565-572.
9.	BauerM, Eickhoff JC, GouldMN, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is a p redictor of poor p rognosis in human primary breast cancer[J]. Breast Cancer Res Treat, 2008, 108(3): 389-397.
10.	Syrjanen S, Naud P, Sarian L, et al. Up-regulation of lipocalin 2 is associated with high-risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia[J]. Am J Clin Pathol, 2010, 134(1): 50-59.
11.	郭艷, 苑中甫. NGAL和MMP-9在卵巢上皮性癌中的表達及相關性研究[J]. 現代婦產科進展, 2012, 21(6): 440-443.
12.	Mannelqvist M, Stefansson I, Wik E, et al. Lipocalin 2 expression is associated with aggressive features of endometrial Cancer[J]. BMC Cancer, 2012, 12(5): 169.
13.	張秀峰, 張筱驊, 周素梅, 等. NGAL在83例結、直腸癌中的表達及其臨床意義[J]. 腫瘤學雜志, 2009, 15(2): 115-119.

1. 　張金山, 羅良平. 血清NSE、CYFRA21-1、CEA和CA50聯檢診斷肺癌及其與肺癌病理分型的關系[J]. 放射免疫學雜志, 2010, 23(4): 365-368.
2. 　Flower DR. The lipocalin protein family:structure and function[J]. Biochem J, 1996, 318(Pt 1): 1-14.
3. 　曾婷婷, 王宇. Lipocalin-2 蛋白在SD大鼠腦組織中的表達情況[J]. 現代預防醫學, 2010, 37(2): 318-323.
4. 　Tong ZM, Wu XL, Ovcharenko D, et al. Neutrophil genatinase-associated lipocalin as a survival factor[J]. Biochem J, 2005, 391(Pt2): 441-448.
5. 　Grundy SM. The metabolic syndrome:inflammation,diabetes mellitus,and cardiovascular disease[J]. Am J Cardio, 2006, 97(1): 3A-11A.
6. 　林憶陽, 翁忠, 屈天生. 糖尿病腎病患者血清中性粒細胞明膠酶相關脂質運載蛋白的改變及其臨床意義[J]. 細胞與分子免疫學雜志, 2010, 26(11): 1113-1115.
7. 　Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly[J]. Circ Res, 2002, 90(3): 251-262.
8. 　Stoesz SP, Friedl A, Haag JD, et al. Heterogeneous expression of the lipocalin NGAL in primary breast cancers[J]. Int J Cancer, 1998, 79(6): 565-572.
9. 　BauerM, Eickhoff JC, GouldMN, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is a p redictor of poor p rognosis in human primary breast cancer[J]. Breast Cancer Res Treat, 2008, 108(3): 389-397.
10. 　Syrjanen S, Naud P, Sarian L, et al. Up-regulation of lipocalin 2 is associated with high-risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia[J]. Am J Clin Pathol, 2010, 134(1): 50-59.
11. 　郭艷, 苑中甫. NGAL和MMP-9在卵巢上皮性癌中的表達及相關性研究[J]. 現代婦產科進展, 2012, 21(6): 440-443.
12. 　Mannelqvist M, Stefansson I, Wik E, et al. Lipocalin 2 expression is associated with aggressive features of endometrial Cancer[J]. BMC Cancer, 2012, 12(5): 169.
13. 　張秀峰, 張筱驊, 周素梅, 等. NGAL在83例結、直腸癌中的表達及其臨床意義[J]. 腫瘤學雜志, 2009, 15(2): 115-119.

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West China Medical Journal

肺癌患者血清中脂質運載蛋白-2的表達及臨床意義

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