Clinical study of Glucosamine Hydrochloride as An Adjuvant therapy for Pilon Fractures_West China Medical Journal

Authors：

PU Yu , ZHANG Yiwu , CHEN Yonglong , GAO Weimin , DENG Tianqiong , WANG Qing.

Department of Orthopedics, No. 324 Hospital of CPLA, Chongqing, 400020, P. R. China;

Corresponding?author：

Keywords：

鹽酸氨基葡萄糖; 脛骨骨折; 創傷性關節炎

DOI：

10.7507/1002-0179.20130114

Video：

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目的　觀察鹽酸氨基葡萄糖對Pilon骨折的輔助治療作用。方法　 2007年6月－2010年9月，將43例接受手術治療的Pilon骨折患者隨機分成兩組，A組術后口服鹽酸氨基葡萄糖，B組作為對照組（僅服用安慰劑）。A組21例患者，平均年齡（35.7± 8.0）歲，B組22例患者，平均年齡（36.7 ± 7.1）歲。兩組患者年齡、性別、骨折分型及手術時機相比較，無統計學差異（P＞0.05）。定期隨診（術后6、12、18個月），根據美國足與踝關節協會踝與后足功能評分（AOFAS）評分系統對患者進行功能評分，進行前瞻、對照、雙盲研究。結果　術后6、12、18個月，A組患者的AOFAS評分均明顯高于B組，差異有統計學意義（t=2.530，2.856，2.881；P=0.015，0.007，0.006）；術后18個月，A組臨床療效優良率為95.2%，B組優良率為72.3%，差異有統計學意義（χ2=3.995，P=0.046）。A組2例患者分別發生輕度頭暈及惡心，無嚴重不良反應發生。結論　鹽酸氨基葡萄糖輔助治療Pilon骨折可改善踝關節功能，減少創傷性骨關節炎的發生。

Citation： PU Yu,ZHANG Yiwu,CHEN Yonglong,GAO Weimin,DENG Tianqiong,WANG Qing.. Clinical study of Glucosamine Hydrochloride as An Adjuvant therapy for Pilon Fractures. West China Medical Journal, 2013, 28(3): 352-355. doi: 10.7507/1002-0179.20130114 Copy

1.	Kilian O, Bündner MS, Horas U, et al. Long-term results in the surgical treatment of pilon tibial fractures. A retrospective study[J]．Chimrg, 2002, 73(1): 65-72．.
2.	Ruedi TP, Allgower M. The operative treatment of intra-articular frac tures of the lower end of the tibia[J]. Clin Orthop Relat Res, 1979, 1(13): 105-110.
3.	Kitaoka HB, Alexander IJ, Adelaar RS, et al. Clinical rating system for the ankle-hindfoot midfoot hallux and lesser toes[J]. Foot Ankle Int, 1994, 15(7):349-353.
4.	Horisberger M, Valderrabano V, Hintermann B. Posttraumatic ankle osteoarthritis after ankle-related fractures[J] . Orthop Trauma, 2009, 23(1): 60-67.
5.	張加良．限期手術內固定治療Pilon骨折[J]. 浙江創傷外科, 2011, 16(6): 766-767．.
6.	鮑曉毅, 鐘小明. 鹽酸氨基葡萄糖治療膝關節骨性關節炎的臨床觀察 [J]．中國骨腫瘤骨病, 2010, 9(4): 339-341．.
7.	Largo R, Alvarez-Soria MA, Díez-Ortego I, et al. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes [J] . Osteoarthritis Cartilage, 2003, 11(4): 290-298.
8.	楊南萍, 李江濤, 陳永濤, 等．多中心隨機雙盲雙模擬陽性藥平行對照臨床研究：評價國產鹽酸氨基葡萄糖片在治療骨關節炎中的有效性和安全性[J] . 華西醫學, 2005, 20(4): 668-670．.
9.	張偉濱, 莊澄宇, 李建民, 等．鹽酸氨基葡萄糖治療骨性關節炎有效性與安全性評價[J]. 中華外科雜志, 2007, 45(14): 998-1001.
10.	Meulyzer M, Vachon P, Beaudry F, et al. Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride[J]. Osteoarthritis Cartilage, 2009, 17(2): 228-234.
11.	Rovati LC, Girolami F, Persiani S. Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties[J]. Ther Adv Musculoskelet Dis, 2012, 4(3): 167-180.
12.	陳德生, 張志剛, 曹靖, 等．鹽酸氨基葡萄糖對兔膝關節炎的影響 [J]. 中國修復重建外科雜志, 2010, 24(3): 287-291．.
13.	Naito K, Watari T, Furuhata A, et al. Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model[J] . Life Sci, 2010, 27(3): 538-543.
14.	中華醫學會風濕病學分會．骨關節炎診斷及治療指南 [J]. 中華風濕病學雜志, 2010, 14(6): 416-419．.
15.	Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part Ⅲ: Changes in evidence following systematic cumulative update of research published through January 2009[J]. Osteoarthritis Cartilage, 2010, 18(4): 476-499.

1. 　Kilian O, Bündner MS, Horas U, et al. Long-term results in the surgical treatment of pilon tibial fractures. A retrospective study[J]．Chimrg, 2002, 73(1): 65-72．.
2. 　Ruedi TP, Allgower M. The operative treatment of intra-articular frac tures of the lower end of the tibia[J]. Clin Orthop Relat Res, 1979, 1(13): 105-110.
3. 　Kitaoka HB, Alexander IJ, Adelaar RS, et al. Clinical rating system for the ankle-hindfoot midfoot hallux and lesser toes[J]. Foot Ankle Int, 1994, 15(7):349-353.
4. 　Horisberger M, Valderrabano V, Hintermann B. Posttraumatic ankle osteoarthritis after ankle-related fractures[J] . Orthop Trauma, 2009, 23(1): 60-67.
5. 　張加良．限期手術內固定治療Pilon骨折[J]. 浙江創傷外科, 2011, 16(6): 766-767．.
6. 　鮑曉毅, 鐘小明. 鹽酸氨基葡萄糖治療膝關節骨性關節炎的臨床觀察 [J]．中國骨腫瘤骨病, 2010, 9(4): 339-341．.
7. 　Largo R, Alvarez-Soria MA, Díez-Ortego I, et al. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes [J] . Osteoarthritis Cartilage, 2003, 11(4): 290-298.
8. 　楊南萍, 李江濤, 陳永濤, 等．多中心隨機雙盲雙模擬陽性藥平行對照臨床研究：評價國產鹽酸氨基葡萄糖片在治療骨關節炎中的有效性和安全性[J] . 華西醫學, 2005, 20(4): 668-670．.
9. 　張偉濱, 莊澄宇, 李建民, 等．鹽酸氨基葡萄糖治療骨性關節炎有效性與安全性評價[J]. 中華外科雜志, 2007, 45(14): 998-1001.
10. 　Meulyzer M, Vachon P, Beaudry F, et al. Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride[J]. Osteoarthritis Cartilage, 2009, 17(2): 228-234.
11. 　Rovati LC, Girolami F, Persiani S. Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties[J]. Ther Adv Musculoskelet Dis, 2012, 4(3): 167-180.
12. 　陳德生, 張志剛, 曹靖, 等．鹽酸氨基葡萄糖對兔膝關節炎的影響 [J]. 中國修復重建外科雜志, 2010, 24(3): 287-291．.
13. 　Naito K, Watari T, Furuhata A, et al. Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model[J] . Life Sci, 2010, 27(3): 538-543.
14. 　中華醫學會風濕病學分會．骨關節炎診斷及治療指南 [J]. 中華風濕病學雜志, 2010, 14(6): 416-419．.
15. 　Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part Ⅲ: Changes in evidence following systematic cumulative update of research published through January 2009[J]. Osteoarthritis Cartilage, 2010, 18(4): 476-499.

West China Medical Journal

Clinical study of Glucosamine Hydrochloride as An Adjuvant therapy for Pilon Fractures

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