創傷后應激障礙恢復力的研究進展_West China Medical Journal

Authors：

何倩 ,  鄧紅

Corresponding?author：

鄧紅, Email: j_q_1115@163.com

Keywords：

創傷后應激障礙; 恢復力; 候選基因; 生物學機制; 遺傳學研究

DOI：

10.7507/1002-0179.20130099

Video：

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Abstract Full text Figures/Tables Video References Cited by

個體在面臨創傷性事件后是否發生創傷后應激障礙（PTSD）以及PTSD持續的時間與多種因素相關，可能有兩方面決定個體的對創傷性事件的反應方向：一方面是發生PTSD的風險因素，另一方面是抵抗創傷性事件的反應和促進個體從創傷反應中恢復的恢復力。現對創傷抵抗與恢復起積極保護作用的恢復力的最新認識及其生物學機制和遺傳學研究進行綜述。

Citation： 何倩,鄧紅. 創傷后應激障礙恢復力的研究進展. West China Medical Journal, 2013, 28(2): 309-312. doi: 10.7507/1002-0179.20130099 Copy

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19.	Sajdyk TJ, Shekhar A, Gehlert DR. Interactions between NPY and CRF in the amygdala to regulate emotionality[J]. Neuropeptides, 2004, 38(4): 225-234.
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21.	Sajdyk TJ, Johnson PL, Leitermann RJ, et al. Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia[J]. J Neurosci, 2008, 28(4): 893-903.
22.	Duman RS, Monteggia LM. A neurotrophic model for stress-relate mood disorders[J]. Biol Psychiatry, 2006 , 59(12): 1116-1127.
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24.	Gillespie CF, Phifer J, Bradley B,et al. Risk and resilience-genetic and environmental influences on development of the stress response[J]. Depress Anxiety, 2009, 26(11): 984-992.
25.	Suomi SJ. Risk, resilience, and gene x environment interactions in rhesus monkeys[J]. Ann N Y Acad Sci, 2006, 1094: 52-62.
26.	Marques Valente NL, Vallada H, Cordeiro Q, et al. Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence[J]. J Mol Neurosci, 2011, 43(3) : 516-523.
27.	Chen ZY, Jing DQ, Bath KG,, et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior[J]. Science, 2006, 314(5796): 140-143.
28.	Heinz A, Smolka MN. The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks[J]. Rev Neurosci, 2006, 17(3): 359-367.
29.	Adamec R, Toth M, Haller J, et al. A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress[J]. Physiol Behav, 2012, 105(3): 628-638.

1. 　Ursano RJ, Zhang L, Li H, et al. PTSD and traumatic stress From gene to community and bench to bedside [J]. Brain Res, 2009, 1293(SI): 2-12.
2. 　Sederer LI. Are human made disasters different?[J]. Epidemiol Psychiatr Sci，2012, 21(1): 23-25.
3. 　deRoon-Cassini TA, Mancini AD, Rusch MD, et al. Psychopathology and resilience following traumatic injury:a latent growth mixture model analysis[J]. Rehabil, 2010, 55(1): 1-11.
4. 　Lutz W, Michael S, Milton K, et al. Dreaming in posttraumatic stress disorder: a critical review of phenomenology[J]. Psychother Psychosom, 2007, 76: 25-39.
5. 　Hobfoll SE, Johnson RJ, Canetti D, et al. Can people remain engaged and vigorous in the face of trauma? Palestinians in the West Bank and Gaza[J]. Psychiatry, 2012, 75(1): 60-75.
6. 　Feldman R, Vengrober A. Posttraumatic stress disorder in infants and young children exposed to war-related trauma[J]. J Am Acad Child Psy, 2011, 50(7): 645-658.
7. 　Richardson GE. The metatheory of resilience and resiliency[J]. J Clin Exp Neuropsyc. 2002, 58: 307-321.
8. 　Hunter AJ, Chandler GE. Adolescent resilience[J]. J Nurs Scholarship, 1999, 31(3): 243-247.
9. 　Bostock L, Sheikh AI, Barton S, et al. Posttraumatic growth and optimism in health-related trauma[J]. J Clin Psychol Med Setting, 2009, 16(4): 281-296.
10. 　Connor KM, Daavidson JK. Development of a new resilience scale: the connor-davidson resilience scale: the Connor-Davidson Resilience Resilience Scale (CD-RISC)[J]. Depr Anx, 2003, 18(2): 76-82.
11. 　于肖楠, 張建新.自我韌性量表與 Connor-Davidson韌性量表的應用比較[J]. 心理科學, 2007, 30(5): 1169-1171.
12. 　Mitra R, Adamec R, Sapolsky R, et al. Resilience against predator stress and dendritic morphology of amygdala neurons[J]. Behave Brain Res，2009, 205(2): 535-543.
13. 　Koenen KC, Amstadter AB, Nugent NR, et al. Gene-environment interaction in posttraumatid stress disorder: an update[J]. J Trauma Stress, 2009, 22(15): 416-426.
14. 　Liberzon I, Knox D. Expanding our understanding of neurobiological mechanisms of resilience by using animalmodels[J]. Neuro Psychopharmacol, 2012, 37(2): 317-318.
15. 　Feder A, Nestler EJ, Charney DS, et al. Psychobiology and molecular genetics of resilience[J]. Nat Rev Neurosci, 2009, 10(6): 446-457.
16. 　McEween BS, Milner TA. Hippocampal formation:shedding light on the influence of sex and stress on the brain[J]. Brain Res Rev, 2007, 55(2): 343-355.
17. 　McGaugh JL. The amygdala modulates the consolidation of memories of emotionally arousing experiences[J]. Annu Rev Neurosci, 2004, 27(1): 1-28.
18. 　Charney DS. Psychobiological mechanisms of resilience and vulnerability:implications for successful adaptation to extreme stress[J]. Am J Psychiatry, 2004, 161(3): 195-216.
19. 　Sajdyk TJ, Shekhar A, Gehlert DR. Interactions between NPY and CRF in the amygdala to regulate emotionality[J]. Neuropeptides, 2004, 38(4): 225-234.
20. 　Cohen H, Liu T, Kozlovsky N, et al. The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder[J]. Neuropsychopharmacol, 2012, 37(2): 350-363.
21. 　Sajdyk TJ, Johnson PL, Leitermann RJ, et al. Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia[J]. J Neurosci, 2008, 28(4): 893-903.
22. 　Duman RS, Monteggia LM. A neurotrophic model for stress-relate mood disorders[J]. Biol Psychiatry, 2006 , 59(12): 1116-1127.
23. 　Bradley RG, Binder EB, Epstein MP, et al. Influence of child abuse on adult depression:moderation by the corticotropin-releasing hormone receptor gene[J]. Arch Gen Psychiatry, 2008, 65(2): 190-200.
24. 　Gillespie CF, Phifer J, Bradley B,et al. Risk and resilience-genetic and environmental influences on development of the stress response[J]. Depress Anxiety, 2009, 26(11): 984-992.
25. 　Suomi SJ. Risk, resilience, and gene x environment interactions in rhesus monkeys[J]. Ann N Y Acad Sci, 2006, 1094: 52-62.
26. 　Marques Valente NL, Vallada H, Cordeiro Q, et al. Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence[J]. J Mol Neurosci, 2011, 43(3) : 516-523.
27. 　Chen ZY, Jing DQ, Bath KG,, et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior[J]. Science, 2006, 314(5796): 140-143.
28. 　Heinz A, Smolka MN. The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks[J]. Rev Neurosci, 2006, 17(3): 359-367.
29. 　Adamec R, Toth M, Haller J, et al. A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress[J]. Physiol Behav, 2012, 105(3): 628-638.

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創傷后應激障礙恢復力的研究進展

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