Analysis on the Risk Factors of Hyperuricemia in Chengdu Area_West China Medical Journal

Authors：

SUN Aijuan ¹ , QU Bangrong ² , GUO Jiaojiao ² ,  WANG Youjuan. ²

1. Out-patient Department; 2. Center of Health Examination Service; West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

WANG Youjuan., Email: aijuans@gmail.com

Keywords：

高尿酸血癥; 危險因素; Logistic回歸

DOI：

10.7507/1002-0179.20130005

Video：

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目的　探討成都地區高尿酸血癥發生的危險因素。方法　收集2009年10月－2010年4月在四川大學華西醫院體檢中心進行健康體檢的36 639人的臨床資料，對資料進行單因素分析和多因素logistic回歸分析。結果　進行健康體檢的36 639人，其中男21 175人，女15 464人。高尿酸血癥患者5 233例，患病率為14.3%。年齡＞50歲、男性、飲酒、糖尿病、高血壓病、甘油三酯增高、低密度脂蛋白增高和血清肌酐水平增高與高尿酸血癥的發生有關。Logistic回歸分析顯示男性（OR=13.300，P=0.000）、飲酒（OR=4.219，P=0.009）、糖尿病（OR=3.609，P=0.024）是發生高尿酸血癥獨立危險因素。結論　成都地區高尿酸血癥的患病率略高于全國平均水平，臨床治療和護理高尿酸血癥的患者時應積極控制與高尿酸血癥發生密切相關的危險因素。

Citation： SUN Aijuan,QU Bangrong,GUO Jiaojiao,WANG Youjuan.. Analysis on the Risk Factors of Hyperuricemia in Chengdu Area. West China Medical Journal, 2013, 28(1): 18-20. doi: 10.7507/1002-0179.20130005 Copy

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1. 　Richette P, Bardin T. Gout[J]. Lancet, 2010, 375(9711): 318-328.
2. 　Lee SJ, Terkeltaub RA. New developments in clinically relevant mechanisms and treatment of hyperuricemia[J]. Curr Rheumatol Rep, 2006, 8(3): 224-230.
3. 　陳灝珠. 實用內科學（下冊）[M]. 12版. 北京: 人民衛生出版社, 2005: 2602-2610.
4. 　Choi HK. A prescription for lifestyle change in patients with hyperuricemia and gout[J]. Curr Opin Rheumatol, 2010, 22(2): 165-172.
5. 　Kang DH, Nakagawa T. Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease[J]. Semin Nephrol, 2005, 25(1): 43-49.
6. 　Miao Z, Li C, Chen Y, et al. Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China [J]. J Rheumatol, 2008, 35(9): 1859-1864.
7. 　陸青青, 賴尾蘭. 福州市8 083名健康體檢者高尿酸血癥的流行病學調查[J]. 福建醫藥雜志, 2008, 30(3): 133.
8. 　Becker MA, Jolly M. Hyperuricemia and associated diseases[J]. Rheum Dis Clin North Am, 2006, 32(2): 275-293.
9. 　Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study[J]. Lancet, 2004, 363(9417): 1277-1281.
10. 　Rodríguez G, Soriano LC, Choi HK. Impact of diabetes against the future risk of developing gout[J]. Ann Rheum Dis, 2010, 69(12): 2090-2094.

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