Application of nanomaterials-enhanced magnetic resonance imaging in precise diagnosis of pan-vascular diseases_Journal of Biomedical Engineering

Authors：

LI Yao ¹ ,  ZHANG Peisen ¹ ,  ZHANG Ni ²

1. College of Chemical and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, P. R. China;
2. West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

Keywords：

Pan-vascular diseases; Nanomaterials; Magnetic resonance imaging

DOI：

10.7507/1001-5515.202412068

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Pan-vascular diseases encompass a range of systemic conditions characterized by sharing a common pathologic basis of vascular deterioration. Due to the complexity of these diseases, a thorough understanding on their similarities and differences is essential for optimizing diagnosis and treatment strategies. Magnetic resonance imaging (MRI), as one of the commonly used medical imaging techniques, has been widely applied in the diagnosis of pan-vascular diseases. Particularly, the integration of MRI with contrast agents and multi-parameter imaging techniques significantly enhances diagnostic accuracy, reducing the likelihood of missed or incorrect diagnoses. Recently, a variety of nano-magnetic resonance contrast agents have been developed and applied to the magnetic resonance diagnosis of diseases. These nanotechnology-based contrast agents provide multiple advantages, ensuring more precise and forward-looking imaging of pan-vascular conditions. In this review, the diverse application strategies of nanomaterials-enhanced MRI techniques in the diagnosis of pan-vascular diseases were systematically summarized, by classifying them into the commonly used MRI sequences in clinical practice. Additionally, the potential advantages and challenges associated with the clinical translation of nanomaterial-enhanced MRI were also discussed. This review not only offers a novel perspective on the precise diagnosis of pan-vascular diseases, but also serves as a valuable reference for future clinical practice and research in the field.

1.	Zhou X, Yu L, Zhao Y, et al. Panvascular medicine: an emerging discipline focusing on atherosclerotic diseases. Eur Heart J, 2022, 43(43): 4528-4531.
2.	朱德文, 陳麗娜. 泛血管病的抗栓治療進展. 心電與循環, 2024, 43(5): 530-534.
3.	Mehra M R, Boulet J, Pelletier-Galarneau M. The panvascular interplay in pathophysiology and prognosis of cardiac allograft vasculopathy. J Am Coll Cardiol, 2022, 80(17): 1629-1632.
4.	翁子騫, 朱月, 胡思寧, 等. 泛血管動脈粥樣硬化性疾病的研究進展. 心血管病學進展, 2023, 44(12): 1094-1097.
5.	Xu X, Xu X D, Liang Y, et al. Research trends and hotspots of exercise therapy in panvascular disease: a bibliometric analysis. Medicine, 2023, 102(45): e35879.
6.	Hu Y, Zhao Y, Li P, et al. Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies. Sci Bull, 2023, 68(17): 1954-1974.
7.	Li Y, Liu Y, Liu S, et al. Diabetic vascular diseases: molecular mechanisms and therapeutic strategies. Signal Transduct Target Ther, 2023, 8(1): 152.
8.	Li J. Application of nanoscale microparticle technology in medical imaging diagnosis and treatment. J Nanomater, 2022, 2022: 5735757.
9.	Liu J, Zhou X, Guan W, et al. Research on detection method of bleeding point in two-dimensional DSA image based on parametric color imaging. Comput Biol Med, 2022, 146: 105496.
10.	楊金生, 曾鵬程, 陶輝, 等. 頭頸CTA聯合全腦CT灌注成像對早期缺血性腦卒中的臨床應用價值. 影像研究與醫學應用, 2024, 8(22): 76-78.
11.	Qaseem Y, Cassidy F, Aganovic L, et al. Renovascular involvement of systemic vascular disease: a pictorial review. Abdom Radiol, 2022, 47(10): 3531-3545.
12.	Soufi G J, Hekmatnia A, Iravani S, et al. Nanoscale contrast agents for magnetic resonance imaging: a review. ACS Appl Nano Mater, 2022, 5(8): 10151-10166.
13.	Foster D, Larsen J. Polymeric metal contrast agents for T1-weighted magnetic resonance imaging of the brain. ACS Biomater Sci Eng, 2023, 9(3): 1224-1242.
14.	Werner E J, Datta A, Jocher C J, et al. High-relaxivity MRI contrast agents: where coordination chemistry meets medical imaging. Angew Chem Int Ed Engl, 2008, 47(45): 8568-8580.
15.	孟俊, 畢俊英, 劉良進, 等. T1加權灌注成像在肝細胞癌診斷中的應用研究. 現代醫用影像學, 2022, 31(1): 1-4.
16.	Zhang P, Cheng J, Lu Y, et al. Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases. Nat Commun, 2023, 14(1): 6149.
17.	Gao Y, Liu S, Zeng X, et al. Reduction of reactive oxygen species accumulation using gadolinium-doped ceria for the alleviation of atherosclerosis. ACS Appl Mater Interfaces, 2023, 15(8): 10414-10425.
18.	Fang Y, Yang R, Hou Y, et al. Dual-modality imaging of angiogenesis in unstable atherosclerotic plaques with VEGFR2-targeted upconversion nanoprobes in vivo. Mol Imaging Biol, 2022, 24(5): 721-731.
19.	Li X, Huang W, Holmes J H. Dynamic contrast-enhanced (DCE) MRI. Magn Reson Imaging Clin N Am, 2024, 32(1): 47-61.
20.	Kinota N, Kameda H, Bai Xiawei, et al. Blockage of CSF outflow in rats after deep cervical lymph node ligation observed using Gd-based MR Imaging. Magn Reson Med Sci, 2024, 23(4): 449-459.
21.	Lu Y, Xu Y J, Zhang G B, et al. Iron oxide nanoclusters for T1 magnetic resonance imaging of non-human primates. Nat Biomed Eng, 2017, 1(8): 637-643.
22.	徐陽, 甄俊平. 增強磁共振成像對比劑的研究進展. 臨床放射學雜志, 2023, 42(9): 1523-1526.
23.	Zhang P, Cheng J, Liu C, et al. Hypersensitive MR angiography for diagnosis of ischemic stroke and reperfusion subarachnoid hemorrhage. Anal Chem, 2024, 96(29): 11742-11750.
24.	He F, Zhu L, Zhou X, et al. Red blood cell membrane-coated ultrasmall NaGdF4 nanoprobes for high-resolution 3D magnetic resonance angiography. ACS Appl Mater Interfaces, 2022, 14(23): 26372-26381.
25.	Li W, Cheng J, Zhang X, et al. High-resolution magnetic resonance angiography of tumor vasculatures with an interlocking contrast agent. ACS nano, 2024, 18(37): 25647-25656.
26.	Briola C. Magnetic resonance imaging and magnetic resonance imaging cholangiopancreatography of the pancreas in small animals. Vet Sci, 2022, 9(8): 378.
27.	余日勝, 楊曉艷. 診療一體化超順磁性氧化鐵納米顆粒用于胰腺癌靶向成像與治療的研究進展. 浙江醫學, 2022, 44(16): 1687-1693.
28.	喬瑞瑞, 曾劍峰, 賈巧娟, 等. 磁性氧化鐵納米顆粒——通向腫瘤磁共振分子影像的重要基石. 物理化學學報, 2012, 28(5): 993-1011.
29.	Wen S, Liu D F, Liu Z, et al. OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice. J Lipid Res, 2012, 53(5): 829-838.
30.	Qiao H, Wang Y, Zhang R, et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe₃O₄ nanoparticles. Biomaterials, 2017, 112: 336-345.
31.	Wu Q, Pan W, Wu G, et al. CD40-targeting magnetic nanoparticles for MRI/optical dual-modality molecular imaging of vulnerable atherosclerotic plaques. Atherosclerosis, 2023, 369: 17-26.
32.	Geng Z, Wang S, Ma L, et al. Prediction of microvascular invasion in hepatocellular carcinoma patients with MRI radiomics based on susceptibility weighted imaging and T2-weighted imaging. Radiol Med, 2024, 129(8): 1130-1142.
33.	鄭玉明. 磁敏感加權成像在腦血管疾病診斷中的應用. 中國冶金工業醫學雜志, 2024, 41(6): 704-705.
34.	Wang T, Hou Y, Bu B, et al. Timely visualization of the collaterals formed during acute ischemic stroke with Fe₃O₄ nanoparticle-based MR imaging probe. Small, 2018, 14(23): e1800573.
35.	Zhang P, Li W, Liu C, et al. Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe. Mater Design, 2023, 233: 112211.
36.	Zhang P, Feng Y, Zhu L, et al. Predicting thrombolytic haemorrhage risk of acute ischemic stroke through angiogenesis/inflammation dual-targeted MR imaging. Nano Today, 2023, 48: 101707.
37.	Laothamatas I, Al Mubarak H, Reddy A, et al. Multiparametric MRI of solid renal masses: principles and applications of advanced quantitative and functional methods for tumor diagnosis and characterization. J Magn Reson Imaging, 2023, 58(2): 342-359.
38.	Li W, Zhang R, Zhang X, et al. Precise diagnosis of cardiac-cerebral vascular diseases with magnetic resonance imaging-based nanoprobes. iRadiology, 2024, 2(3): 264-284.
39.	Li W, Cheng J, Liu C, et al. Shine and darkle the blood vessels: multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases. Sci Adv, 2024, 10(40): eadq4082.
40.	Wang J, Jia Y, Wang Q, et al. An ultrahigh-field-tailored T1-T2 dual-mode MRI contrast agent for high-performance vascular imaging. Adv Mater, 2021, 33(2): e2004917.

1. Zhou X, Yu L, Zhao Y, et al. Panvascular medicine: an emerging discipline focusing on atherosclerotic diseases. Eur Heart J, 2022, 43(43): 4528-4531.
2. 朱德文, 陳麗娜. 泛血管病的抗栓治療進展. 心電與循環, 2024, 43(5): 530-534.
3. Mehra M R, Boulet J, Pelletier-Galarneau M. The panvascular interplay in pathophysiology and prognosis of cardiac allograft vasculopathy. J Am Coll Cardiol, 2022, 80(17): 1629-1632.
4. 翁子騫, 朱月, 胡思寧, 等. 泛血管動脈粥樣硬化性疾病的研究進展. 心血管病學進展, 2023, 44(12): 1094-1097.
5. Xu X, Xu X D, Liang Y, et al. Research trends and hotspots of exercise therapy in panvascular disease: a bibliometric analysis. Medicine, 2023, 102(45): e35879.
6. Hu Y, Zhao Y, Li P, et al. Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies. Sci Bull, 2023, 68(17): 1954-1974.
7. Li Y, Liu Y, Liu S, et al. Diabetic vascular diseases: molecular mechanisms and therapeutic strategies. Signal Transduct Target Ther, 2023, 8(1): 152.
8. Li J. Application of nanoscale microparticle technology in medical imaging diagnosis and treatment. J Nanomater, 2022, 2022: 5735757.
9. Liu J, Zhou X, Guan W, et al. Research on detection method of bleeding point in two-dimensional DSA image based on parametric color imaging. Comput Biol Med, 2022, 146: 105496.
10. 楊金生, 曾鵬程, 陶輝, 等. 頭頸CTA聯合全腦CT灌注成像對早期缺血性腦卒中的臨床應用價值. 影像研究與醫學應用, 2024, 8(22): 76-78.
11. Qaseem Y, Cassidy F, Aganovic L, et al. Renovascular involvement of systemic vascular disease: a pictorial review. Abdom Radiol, 2022, 47(10): 3531-3545.
12. Soufi G J, Hekmatnia A, Iravani S, et al. Nanoscale contrast agents for magnetic resonance imaging: a review. ACS Appl Nano Mater, 2022, 5(8): 10151-10166.
13. Foster D, Larsen J. Polymeric metal contrast agents for T1-weighted magnetic resonance imaging of the brain. ACS Biomater Sci Eng, 2023, 9(3): 1224-1242.
14. Werner E J, Datta A, Jocher C J, et al. High-relaxivity MRI contrast agents: where coordination chemistry meets medical imaging. Angew Chem Int Ed Engl, 2008, 47(45): 8568-8580.
15. 孟俊, 畢俊英, 劉良進, 等. T1加權灌注成像在肝細胞癌診斷中的應用研究. 現代醫用影像學, 2022, 31(1): 1-4.
16. Zhang P, Cheng J, Lu Y, et al. Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases. Nat Commun, 2023, 14(1): 6149.
17. Gao Y, Liu S, Zeng X, et al. Reduction of reactive oxygen species accumulation using gadolinium-doped ceria for the alleviation of atherosclerosis. ACS Appl Mater Interfaces, 2023, 15(8): 10414-10425.
18. Fang Y, Yang R, Hou Y, et al. Dual-modality imaging of angiogenesis in unstable atherosclerotic plaques with VEGFR2-targeted upconversion nanoprobes in vivo. Mol Imaging Biol, 2022, 24(5): 721-731.
19. Li X, Huang W, Holmes J H. Dynamic contrast-enhanced (DCE) MRI. Magn Reson Imaging Clin N Am, 2024, 32(1): 47-61.
20. Kinota N, Kameda H, Bai Xiawei, et al. Blockage of CSF outflow in rats after deep cervical lymph node ligation observed using Gd-based MR Imaging. Magn Reson Med Sci, 2024, 23(4): 449-459.
21. Lu Y, Xu Y J, Zhang G B, et al. Iron oxide nanoclusters for T1 magnetic resonance imaging of non-human primates. Nat Biomed Eng, 2017, 1(8): 637-643.
22. 徐陽, 甄俊平. 增強磁共振成像對比劑的研究進展. 臨床放射學雜志, 2023, 42(9): 1523-1526.
23. Zhang P, Cheng J, Liu C, et al. Hypersensitive MR angiography for diagnosis of ischemic stroke and reperfusion subarachnoid hemorrhage. Anal Chem, 2024, 96(29): 11742-11750.
24. He F, Zhu L, Zhou X, et al. Red blood cell membrane-coated ultrasmall NaGdF4 nanoprobes for high-resolution 3D magnetic resonance angiography. ACS Appl Mater Interfaces, 2022, 14(23): 26372-26381.
25. Li W, Cheng J, Zhang X, et al. High-resolution magnetic resonance angiography of tumor vasculatures with an interlocking contrast agent. ACS nano, 2024, 18(37): 25647-25656.
26. Briola C. Magnetic resonance imaging and magnetic resonance imaging cholangiopancreatography of the pancreas in small animals. Vet Sci, 2022, 9(8): 378.
27. 余日勝, 楊曉艷. 診療一體化超順磁性氧化鐵納米顆粒用于胰腺癌靶向成像與治療的研究進展. 浙江醫學, 2022, 44(16): 1687-1693.
28. 喬瑞瑞, 曾劍峰, 賈巧娟, 等. 磁性氧化鐵納米顆粒——通向腫瘤磁共振分子影像的重要基石. 物理化學學報, 2012, 28(5): 993-1011.
29. Wen S, Liu D F, Liu Z, et al. OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice. J Lipid Res, 2012, 53(5): 829-838.
30. Qiao H, Wang Y, Zhang R, et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe₃O₄ nanoparticles. Biomaterials, 2017, 112: 336-345.
31. Wu Q, Pan W, Wu G, et al. CD40-targeting magnetic nanoparticles for MRI/optical dual-modality molecular imaging of vulnerable atherosclerotic plaques. Atherosclerosis, 2023, 369: 17-26.
32. Geng Z, Wang S, Ma L, et al. Prediction of microvascular invasion in hepatocellular carcinoma patients with MRI radiomics based on susceptibility weighted imaging and T2-weighted imaging. Radiol Med, 2024, 129(8): 1130-1142.
33. 鄭玉明. 磁敏感加權成像在腦血管疾病診斷中的應用. 中國冶金工業醫學雜志, 2024, 41(6): 704-705.
34. Wang T, Hou Y, Bu B, et al. Timely visualization of the collaterals formed during acute ischemic stroke with Fe₃O₄ nanoparticle-based MR imaging probe. Small, 2018, 14(23): e1800573.
35. Zhang P, Li W, Liu C, et al. Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe. Mater Design, 2023, 233: 112211.
36. Zhang P, Feng Y, Zhu L, et al. Predicting thrombolytic haemorrhage risk of acute ischemic stroke through angiogenesis/inflammation dual-targeted MR imaging. Nano Today, 2023, 48: 101707.
37. Laothamatas I, Al Mubarak H, Reddy A, et al. Multiparametric MRI of solid renal masses: principles and applications of advanced quantitative and functional methods for tumor diagnosis and characterization. J Magn Reson Imaging, 2023, 58(2): 342-359.
38. Li W, Zhang R, Zhang X, et al. Precise diagnosis of cardiac-cerebral vascular diseases with magnetic resonance imaging-based nanoprobes. iRadiology, 2024, 2(3): 264-284.
39. Li W, Cheng J, Liu C, et al. Shine and darkle the blood vessels: multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases. Sci Adv, 2024, 10(40): eadq4082.
40. Wang J, Jia Y, Wang Q, et al. An ultrahigh-field-tailored T1-T2 dual-mode MRI contrast agent for high-performance vascular imaging. Adv Mater, 2021, 33(2): e2004917.

Journal of Biomedical Engineering

Latest ArticlesApplication of nanomaterials-enhanced magnetic resonance imaging in precise diagnosis of pan-vascular diseases

Abstract Full text Figures/Tables Video References Cited by

Format

Content