Research on a portable shielding-free ultra-low field magnetic resonance imaging system_Journal of Biomedical Engineering

Authors：

ZHANG Yuxiang ¹ , HE wei ¹ , YANG Lei ¹ , HE Yucheng ² , WU Jiamin ² ,  XU Zheng ¹

1. School of Electrical Engineering, Chongqing University, Chongqing 400044, P. R. China;
2. Shenzhen Academy of Aerospace Technology, Shenzhen 518057, P. R. China;

Corresponding?author：

XU Zheng, Email: xuzheng@cqu.edu.cn

Keywords：

Magnetic resonance imaging; Ultra-low field; Shielding-free; Noise reduction

DOI：

10.7507/1001-5515.202303060

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The portable light-weight magnetic resonance imaging system can be deployed in special occasions such as Intensive Care Unit (ICU) and ambulances, making it possible to implement bedside monitoring imaging systems, mobile stroke units and magnetic resonance platforms in remote areas. Compared with medium and high field imaging systems, ultra-low-field magnetic resonance imaging equipment utilizes light-weight permanent magnets, which are compact and easy to move. However, the image quality is highly susceptible to external electromagnetic interference without a shielded room and there are still many key technical problems in hardware design to be solved. In this paper, the system hardware design and environmental electromagnetic interference elimination algorithm were studied. Consequently, some research results were obtained and a prototype of portable shielding-free 50 mT magnetic resonance imaging system was built. The light-weight magnet and its uniformity, coil system and noise elimination algorithm and human brain imaging were verified. Finally, high-quality images of the healthy human brain were obtained. The results of this study would provide reference for the development and application of ultra-low-field magnetic resonance imaging technology.

Citation： ZHANG Yuxiang, HE wei, YANG Lei, HE Yucheng, WU Jiamin, XU Zheng. Research on a portable shielding-free ultra-low field magnetic resonance imaging system. Journal of Biomedical Engineering, 2023, 40(5): 829-836. doi: 10.7507/1001-5515.202303060 Copy

1.	Sarracanie M, Lapierre C D, Salameh N, et al. Low-cost high-performance MRI. Sci Rep, 2015(5): 15177.
2.	He Yucheng, He Wei, Tan Liang, et al. Use of 2. 1 MHz MRI scanner for brain imaging and its preliminary results in stroke. J Magn Reson, 2020, 319: 106829.
3.	O’Reilly T, Teeuwisse W M, Webb A G, et al. In vivo 3D brain and extremity MRI at 50 mT using a permanent magnet Halbach array. Magn Reson Med, 2020, 85(1): 495-505.
4.	Sheth K N, Mazurek M H, Yuen M M, et al. Assessment of brain injury using portable, low-field magnetic resonance imaging at the bedside of critically ill patients. JAMA Neurol, 2021, 78: 41-47.
5.	Mazurek M H, Cahn B A, Yuen M M, et al. Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage. Nat Commun, 2021, 12: 5119.
6.	Liu Y, Leong A T L, Zhao Y, et al. A low-cost and shielding-free ultra-low-field brain MRI scanner. Nat Commun, 2021, 12: 7238.
7.	Restivo M C, Ramasawmy R, Bandettini W P, et al. Efficient spiral in-out and EPI balanced steady-state free precession cine imaging using a high-performance 0. 55T MRI. Magn Reson Med, 2020, 84(5): 2364-2375.
8.	賀中華, 何為, 賀玉成, 等. 皮膚燒傷深度檢測的單邊核磁共振淺層成像磁體系統. 電工技術學報, 2019, 34(3): 449-458.
9.	郭盼, 何為, Juan C, 等. 一種新型 Inside-Out 核磁共振傳感器-三圓柱磁體陣列. 電工技術學報, 2016, 31(8): 96-101.
10.	王洪一. 頭部超低場磁共振裝置的主磁體結構研究. 重慶: 重慶大學, 2020.
11.	Marble A E, Mastikhin I V, Colpitts B G, et al. A constant gradient unilateral magnet for near-surface MRI profiling. J Magn Reson, 2006, 183(2): 228-234.
12.	He Wei, He Zhonghua. A hybrid passive shimming method applied to the design of a unilateral NMR magnet. Int J Appl Electromagn Mech, 2015, 49(4): 597-606.
13.	王軼楠. 核磁成像的無源被動勻場研究分析. 現代制造技術與裝備, 2019, 270(5): 89-90.
14.	田錄林, 賈嶸, 楊國清, 等. 永磁鐵磁貼合體的磁場及磁力. 電工技術學報, 2008, 23(6): 7-13.
15.	Xu Z, Qi J, Guo P, et al. Equivalent magnetic dipole method for designing gradient coils of the halbach magnetic resonance device. Appl Electromagnet Mech, 2018, 56(4): 595-604.
16.	白燁, 王秋良, 余運佳, 等. 一種基于目標場法的球型線圈設計方法. 中國電機工程學報, 2004, 24(6): 132-136.
17.	Chen Q, Xu Y, Chang Y, et al. Design and optimization of a four-channel received coil for vertical-field MRI. Appl Magn Reson, 2016, 47(10): 1147-1158.
18.	Xuan L, Kong X, Wu J, et al. A smoothly-connected crescent transverse gradient coil design for 50mT MRI system. Appl Magn Reson, 2021, 52(6): 649-660.
19.	Shen S, Koonjoo N, Kong X, et al. Gradient coil design and optimization for an ultra-low-field MRI system. Appl Magn Reson, 2022, 53: 895-914.
20.	王昌, 秦鑫, 劉艷, 等. 一種自適應慣性權重粒子群算法在磁共振圖像偏移場矯正中的應用. 生物醫學工程學雜志, 2016, 33(3): 564-569.
21.	劉柳, 劉勝道, 何保委. 基于粒子群優化算法的線圈系統設計. 計算技術與自動化, 2021, 40(3): 84-87.
22.	Shen S, Xu Z, Koonjoo N, et al. Optimization of a close-fitting volume RF coil for brain imaging at 6.5 mT using linear programming. IEEE Trans Biomed Eng, 2021, 68(4): 1106-1114.
23.	Gu X Q. The least-square method in complex number domain. Prog Nat Sci, 2006, 16: 307-312.
24.	Haacke E M, Brown R W, Thompson M R, et al. Magnetic resonance imaging: Physical principles and sequence design. New Jersey: John Wiley & Sons, 1999: 272-280.
25.	Su J, Pellicer-Guridi R, Edwards T, et al. A CNN based software gradiometer for electromagnetic background noise reduction in low field MRI applications. IEEE Trans Med Imaging, 2022, 41(5): 1007-1016.
26.	Javed A, Ramasawmy R, O’Brien K, et al. Self-gated 3D stack-of-spirals UTE pulmonary imaging at 0. 55T. Magn Reson Med, 2022, 87(4): 1784-1798.
27.	Zhang Y, He W, Chen F, et al. Denoise ultra-low-field 3D magnetic resonance images using a joint signal-image domain filter. J Magn Reson, 2022, 344: 107319.
28.	李中源, 李光, 孫翌, 等. 一種基于全局字典學習的小動物低劑量計算機斷層掃描降噪方法. 生物醫學工程學雜志, 2016, 33(2): 279-286.
29.	王華東, 孫挺. 變換域多尺度信息蒸餾網絡的醫學影像超分辨率重建. 生物醫學工程學雜志, 2022, 39(5): 887-896.
30.	Iglesias J E, Schleicher R, Laguna S, et al. Accurate super-resolution low-field brain MRI. arXiv e-prints, 2022: 2202.03564.

1. Sarracanie M, Lapierre C D, Salameh N, et al. Low-cost high-performance MRI. Sci Rep, 2015(5): 15177.
2. He Yucheng, He Wei, Tan Liang, et al. Use of 2. 1 MHz MRI scanner for brain imaging and its preliminary results in stroke. J Magn Reson, 2020, 319: 106829.
3. O’Reilly T, Teeuwisse W M, Webb A G, et al. In vivo 3D brain and extremity MRI at 50 mT using a permanent magnet Halbach array. Magn Reson Med, 2020, 85(1): 495-505.
4. Sheth K N, Mazurek M H, Yuen M M, et al. Assessment of brain injury using portable, low-field magnetic resonance imaging at the bedside of critically ill patients. JAMA Neurol, 2021, 78: 41-47.
5. Mazurek M H, Cahn B A, Yuen M M, et al. Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage. Nat Commun, 2021, 12: 5119.
6. Liu Y, Leong A T L, Zhao Y, et al. A low-cost and shielding-free ultra-low-field brain MRI scanner. Nat Commun, 2021, 12: 7238.
7. Restivo M C, Ramasawmy R, Bandettini W P, et al. Efficient spiral in-out and EPI balanced steady-state free precession cine imaging using a high-performance 0. 55T MRI. Magn Reson Med, 2020, 84(5): 2364-2375.
8. 賀中華, 何為, 賀玉成, 等. 皮膚燒傷深度檢測的單邊核磁共振淺層成像磁體系統. 電工技術學報, 2019, 34(3): 449-458.
9. 郭盼, 何為, Juan C, 等. 一種新型 Inside-Out 核磁共振傳感器-三圓柱磁體陣列. 電工技術學報, 2016, 31(8): 96-101.
10. 王洪一. 頭部超低場磁共振裝置的主磁體結構研究. 重慶: 重慶大學, 2020.
11. Marble A E, Mastikhin I V, Colpitts B G, et al. A constant gradient unilateral magnet for near-surface MRI profiling. J Magn Reson, 2006, 183(2): 228-234.
12. He Wei, He Zhonghua. A hybrid passive shimming method applied to the design of a unilateral NMR magnet. Int J Appl Electromagn Mech, 2015, 49(4): 597-606.
13. 王軼楠. 核磁成像的無源被動勻場研究分析. 現代制造技術與裝備, 2019, 270(5): 89-90.
14. 田錄林, 賈嶸, 楊國清, 等. 永磁鐵磁貼合體的磁場及磁力. 電工技術學報, 2008, 23(6): 7-13.
15. Xu Z, Qi J, Guo P, et al. Equivalent magnetic dipole method for designing gradient coils of the halbach magnetic resonance device. Appl Electromagnet Mech, 2018, 56(4): 595-604.
16. 白燁, 王秋良, 余運佳, 等. 一種基于目標場法的球型線圈設計方法. 中國電機工程學報, 2004, 24(6): 132-136.
17. Chen Q, Xu Y, Chang Y, et al. Design and optimization of a four-channel received coil for vertical-field MRI. Appl Magn Reson, 2016, 47(10): 1147-1158.
18. Xuan L, Kong X, Wu J, et al. A smoothly-connected crescent transverse gradient coil design for 50mT MRI system. Appl Magn Reson, 2021, 52(6): 649-660.
19. Shen S, Koonjoo N, Kong X, et al. Gradient coil design and optimization for an ultra-low-field MRI system. Appl Magn Reson, 2022, 53: 895-914.
20. 王昌, 秦鑫, 劉艷, 等. 一種自適應慣性權重粒子群算法在磁共振圖像偏移場矯正中的應用. 生物醫學工程學雜志, 2016, 33(3): 564-569.
21. 劉柳, 劉勝道, 何保委. 基于粒子群優化算法的線圈系統設計. 計算技術與自動化, 2021, 40(3): 84-87.
22. Shen S, Xu Z, Koonjoo N, et al. Optimization of a close-fitting volume RF coil for brain imaging at 6.5 mT using linear programming. IEEE Trans Biomed Eng, 2021, 68(4): 1106-1114.
23. Gu X Q. The least-square method in complex number domain. Prog Nat Sci, 2006, 16: 307-312.
24. Haacke E M, Brown R W, Thompson M R, et al. Magnetic resonance imaging: Physical principles and sequence design. New Jersey: John Wiley & Sons, 1999: 272-280.
25. Su J, Pellicer-Guridi R, Edwards T, et al. A CNN based software gradiometer for electromagnetic background noise reduction in low field MRI applications. IEEE Trans Med Imaging, 2022, 41(5): 1007-1016.
26. Javed A, Ramasawmy R, O’Brien K, et al. Self-gated 3D stack-of-spirals UTE pulmonary imaging at 0. 55T. Magn Reson Med, 2022, 87(4): 1784-1798.
27. Zhang Y, He W, Chen F, et al. Denoise ultra-low-field 3D magnetic resonance images using a joint signal-image domain filter. J Magn Reson, 2022, 344: 107319.
28. 李中源, 李光, 孫翌, 等. 一種基于全局字典學習的小動物低劑量計算機斷層掃描降噪方法. 生物醫學工程學雜志, 2016, 33(2): 279-286.
29. 王華東, 孫挺. 變換域多尺度信息蒸餾網絡的醫學影像超分辨率重建. 生物醫學工程學雜志, 2022, 39(5): 887-896.
30. Iglesias J E, Schleicher R, Laguna S, et al. Accurate super-resolution low-field brain MRI. arXiv e-prints, 2022: 2202.03564.

Previous Article
Overview of the application of knowledge graphs in the medical field
Next Article
Analysis of neural fragility in epileptic zone based on stereoelectroencephalography

Journal of Biomedical Engineering

Research on a portable shielding-free ultra-low field magnetic resonance imaging system

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content