Application of automatic injection device based on automatic hemostasis in injection of radiopharmaceutical bolus injection_Journal of Biomedical Engineering

Authors：

 LI Jin ^1,2 , FAN Wenhong ³ , MA Jianxiong ¹ , ZHOU Wei ² , PANG Xinxin ² , TIAN Cungui ² , YANG Guohui ² , WANG Yan ¹ , ZHAO Na ²

1. Tianjin Hospital, Tianjin University, Tianjin 300211, P. R. China;
2. CNNC High Energy Equipment (Tianjin) Co., Ltd., Tianjin 300300, P. R. China;
3. Tianjin Medical University General Hospital, Tianjin 300052, P. R. China;

Corresponding?author：

LI Jin, Email: mjx969@163.com

Keywords：

Radiopharmaceutical dynamic imaging; Bolus injection; Automatic injection device

DOI：

10.7507/1001-5515.202301013

Video：

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In clinical practice, radiopharmaceutical dynamic imaging technology requires the bolus injection method to complete injection. Due to the failure rate and radiation damage of manual injection, even experienced technicians still bear a lot of psychological burden. This study combined the advantages and disadvantages of various manual injection modes to develop the radiopharmaceutical bolus injector, and explored the application of automatic injection in the field of bolus injection from four aspects: radiation protection, occlusion response, sterility of injection process and effect of bolus injection. Compared with the current mainstream manual injection method, the bolus manufactured by the radiopharmaceutical bolus injector based on the automatic hemostasis method had a narrower full width at half maximum and better repeatability. At the same time, radiopharmaceutical bolus injector had reduced the radiation dose of the technician’s palm by 98.8%, and ensured more efficient vein occlusion recognition performance and sterility of the entire injection process. The radiopharmaceutical bolus injector based on automatic hemostasis has application potential in improving the effect and repeatability of bolus injection.

Citation： LI Jin, FAN Wenhong, MA Jianxiong, ZHOU Wei, PANG Xinxin, TIAN Cungui, YANG Guohui, WANG Yan, ZHAO Na. Application of automatic injection device based on automatic hemostasis in injection of radiopharmaceutical bolus injection. Journal of Biomedical Engineering, 2023, 40(2): 320-326. doi: 10.7507/1001-5515.202301013 Copy

1.	Jeong S, Park S B, Chang I H, et al. Estimation of renal function using kidney dynamic contrast material-enhanced CT perfusion: accuracy and feasibility. Abdom Radiol (NY), 2021, 46(5): 2045-2051.
2.	Marripudi K, Tulasi R K. Bone scan and MRI findings in a case of paediatric multifocal osteomyelitis. Clin Radiol Extra, 2021, 1(65): 99-200.
3.	Launey Y, Fryer T D, Hong Y T, et al. Spatial and temporal pattern of ischemia and abnormal vascular function following traumatic brain injury. JAMA Neurol, 2020, 77(3): 339-349.
4.	Schr?der J, Heinze M, Günther M, et al. Dynamics of brain perfusion and cognitive performance in revascularization of carotid artery stenosis. Neuroimage Clin, 2019, 22: 101779.
5.	黎秀娟, 王梅珍, 陳茹芬. 彈丸式注射與核素腎動態顯像的關系分析. 當代護士(學術版), 2011(10): 98-100.
6.	楊寶軍, 李險峰, 趙德善. 彈丸注射質量與Gates法腎動態顯像結果的關系. 山西醫藥雜志, 2009, 38(9): 426-427.
7.	李沛, 高永舉, 施婧琦, 等. 采用靜脈留置針“彈丸”注射法行⁹⁹Tc^m-DTPA腎動態顯像. 中國醫學影像技術, 2021, 37(11): 1752-1754.
8.	呂延娟. 護理干預在放射性核素腎動態顯像檢查患者中的應用效果分析. 世界最新醫學信息文摘, 2018(39): 28-29.
9.	石瑾, 溫慶祥, 崔璨, 等. 三通法彈丸注射殘留藥物對腎小球濾過率的影響. 標記免疫分析與臨床, 2017, 24(6): 642-643.
10.	嚴春雷, 孔令華, 李冬娟, 等. 不同彈丸式注射對腎動態顯像結果的影響. 交通醫學, 2014, 28(5): 513-514.
11.	段艷梅, 張少麗, 王英, 等. 改良留置針注射法在腎動態顯像檢查中的應用. 中國臨床研究, 2020, 33(5): 661-664.
12.	Zhu Lei, Liu Haibo, Wang Rui, et al. Mechanism of pulsatile flushing technique for saline injection via a peripheral intravenous catheter. Clin Biomech, 2020, 80: 105103.
13.	Zhao Peng, Chong Yinbao, Zhao An, et al. A rapid infusion pump driven by micro electromagnetic linear actuation for pre-hospital intravenous fluid administration. Proc Inst Mech Eng H, 2015, 229(2): 101-109.
14.	王岐, 薛建軍, 楊路路, 等. 彈丸注射質量對Gates法測定活體腎移植供者GFR的影響. 標記免疫分析與臨床, 2021, 28(7): 1141-1145.
15.	Wesolowski C A, Hogendoorn P, Vandierendonck R, et al. Bolus injections of measured amounts of radioactivity. J Nucl Med Tech, 1988, 16(1): 1-4.
16.	熊小兵, 杜飛平, 何玲. 2015-2018年四川省介入與核醫學放射工作人員職業外照射個人劑量分析. 職業衛生與病傷, 2019, 34(6): 336-339.
17.	Fathy M, Khalil M M, Elshemey W M, et al. Occupational radiation dose to nuclear medicine staff due to Tc99m, F18-FDG PET and therapeutic I-131 based examinations. Radiat Prot Dosim, 2019, 186(4): 443-451.
18.	Covens P, Berus D, Vanhavere F, et al. The introduction of automated dispensing and injection during PET procedures: a step in the optimisation of extremity doses and whole-body doses of nuclear medicine staff. Radiat Prot Dosim, 2010, 140(3): 250-258.
19.	Merce M S, Ruiz N, Barth I, et al. Extremity exposure in nuclear medicine: preliminary results of a European study. Radiat Prot Dosim, 2011, 144(1-4): 515-520.
20.	Lecchi M, Lucignani G, Maioli C. Validation of a new protocol for 18F-FDG infusion using an automatic combined dispenser and injector system. Eur J Nucl Med Mol Imaging, 2012, 39(11): 1720-1729.
21.	Sánchez R M, Vano E, Fernández J M, et al. Evaluation of an automated FDG dose infuser to PET-CT patients. Radiat Prot Dosim, 2015, 165(1-4): 457-460.
22.	王瞳, 趙海燕, 任超, 等. PET自動給藥系統注射與傳統注射對比的研究. 中國醫學裝備, 2021, 18(6): 35-38.
23.	郭寧, 王瞳, 霍力, 等. 正電子放射性藥物自動分裝注射系統的設計與測試. 中國醫學科學院學報, 2021, 43(3): 429-434.
24.	Sakat M S, Sade R, Kilic K, et al. The use of dynamic contrast-enhanced perfusion MRI in differentiating benign and malignant thyroid nodules. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 1): 706-711.
25.	Malla S R, Bhalla A S, Manchanda S, et al. Dynamic contrast-enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma. Head Neck, 2021, 43(9): 2611-2622.
26.	Feichtinger M, Eder H, Holl A, et al. Automatic and remote controlled ictal SPECT injection for seizure focus localization by use of a commercial contrast agent application pump. Epilepsia, 2010, 48(7): 1409-1413.
27.	陸素青, 盧彥祺, 付巍. 血管評估監測表在核素腎動態顯像中的應用研究. 標記免疫分析與臨床, 2019, 26(9): 1528-1531.
28.	陸素青, 盧彥祺, 付巍. 放射性核素腎動態顯像彈丸注射方法的應用研究進展. 國際放射醫學核醫學雜志, 2020, 44(10): 667-671.

1. Jeong S, Park S B, Chang I H, et al. Estimation of renal function using kidney dynamic contrast material-enhanced CT perfusion: accuracy and feasibility. Abdom Radiol (NY), 2021, 46(5): 2045-2051.
2. Marripudi K, Tulasi R K. Bone scan and MRI findings in a case of paediatric multifocal osteomyelitis. Clin Radiol Extra, 2021, 1(65): 99-200.
3. Launey Y, Fryer T D, Hong Y T, et al. Spatial and temporal pattern of ischemia and abnormal vascular function following traumatic brain injury. JAMA Neurol, 2020, 77(3): 339-349.
4. Schr?der J, Heinze M, Günther M, et al. Dynamics of brain perfusion and cognitive performance in revascularization of carotid artery stenosis. Neuroimage Clin, 2019, 22: 101779.
5. 黎秀娟, 王梅珍, 陳茹芬. 彈丸式注射與核素腎動態顯像的關系分析. 當代護士(學術版), 2011(10): 98-100.
6. 楊寶軍, 李險峰, 趙德善. 彈丸注射質量與Gates法腎動態顯像結果的關系. 山西醫藥雜志, 2009, 38(9): 426-427.
7. 李沛, 高永舉, 施婧琦, 等. 采用靜脈留置針“彈丸”注射法行⁹⁹Tc^m-DTPA腎動態顯像. 中國醫學影像技術, 2021, 37(11): 1752-1754.
8. 呂延娟. 護理干預在放射性核素腎動態顯像檢查患者中的應用效果分析. 世界最新醫學信息文摘, 2018(39): 28-29.
9. 石瑾, 溫慶祥, 崔璨, 等. 三通法彈丸注射殘留藥物對腎小球濾過率的影響. 標記免疫分析與臨床, 2017, 24(6): 642-643.
10. 嚴春雷, 孔令華, 李冬娟, 等. 不同彈丸式注射對腎動態顯像結果的影響. 交通醫學, 2014, 28(5): 513-514.
11. 段艷梅, 張少麗, 王英, 等. 改良留置針注射法在腎動態顯像檢查中的應用. 中國臨床研究, 2020, 33(5): 661-664.
12. Zhu Lei, Liu Haibo, Wang Rui, et al. Mechanism of pulsatile flushing technique for saline injection via a peripheral intravenous catheter. Clin Biomech, 2020, 80: 105103.
13. Zhao Peng, Chong Yinbao, Zhao An, et al. A rapid infusion pump driven by micro electromagnetic linear actuation for pre-hospital intravenous fluid administration. Proc Inst Mech Eng H, 2015, 229(2): 101-109.
14. 王岐, 薛建軍, 楊路路, 等. 彈丸注射質量對Gates法測定活體腎移植供者GFR的影響. 標記免疫分析與臨床, 2021, 28(7): 1141-1145.
15. Wesolowski C A, Hogendoorn P, Vandierendonck R, et al. Bolus injections of measured amounts of radioactivity. J Nucl Med Tech, 1988, 16(1): 1-4.
16. 熊小兵, 杜飛平, 何玲. 2015-2018年四川省介入與核醫學放射工作人員職業外照射個人劑量分析. 職業衛生與病傷, 2019, 34(6): 336-339.
17. Fathy M, Khalil M M, Elshemey W M, et al. Occupational radiation dose to nuclear medicine staff due to Tc99m, F18-FDG PET and therapeutic I-131 based examinations. Radiat Prot Dosim, 2019, 186(4): 443-451.
18. Covens P, Berus D, Vanhavere F, et al. The introduction of automated dispensing and injection during PET procedures: a step in the optimisation of extremity doses and whole-body doses of nuclear medicine staff. Radiat Prot Dosim, 2010, 140(3): 250-258.
19. Merce M S, Ruiz N, Barth I, et al. Extremity exposure in nuclear medicine: preliminary results of a European study. Radiat Prot Dosim, 2011, 144(1-4): 515-520.
20. Lecchi M, Lucignani G, Maioli C. Validation of a new protocol for 18F-FDG infusion using an automatic combined dispenser and injector system. Eur J Nucl Med Mol Imaging, 2012, 39(11): 1720-1729.
21. Sánchez R M, Vano E, Fernández J M, et al. Evaluation of an automated FDG dose infuser to PET-CT patients. Radiat Prot Dosim, 2015, 165(1-4): 457-460.
22. 王瞳, 趙海燕, 任超, 等. PET自動給藥系統注射與傳統注射對比的研究. 中國醫學裝備, 2021, 18(6): 35-38.
23. 郭寧, 王瞳, 霍力, 等. 正電子放射性藥物自動分裝注射系統的設計與測試. 中國醫學科學院學報, 2021, 43(3): 429-434.
24. Sakat M S, Sade R, Kilic K, et al. The use of dynamic contrast-enhanced perfusion MRI in differentiating benign and malignant thyroid nodules. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 1): 706-711.
25. Malla S R, Bhalla A S, Manchanda S, et al. Dynamic contrast-enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma. Head Neck, 2021, 43(9): 2611-2622.
26. Feichtinger M, Eder H, Holl A, et al. Automatic and remote controlled ictal SPECT injection for seizure focus localization by use of a commercial contrast agent application pump. Epilepsia, 2010, 48(7): 1409-1413.
27. 陸素青, 盧彥祺, 付巍. 血管評估監測表在核素腎動態顯像中的應用研究. 標記免疫分析與臨床, 2019, 26(9): 1528-1531.
28. 陸素青, 盧彥祺, 付巍. 放射性核素腎動態顯像彈丸注射方法的應用研究進展. 國際放射醫學核醫學雜志, 2020, 44(10): 667-671.

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Application of automatic injection device based on automatic hemostasis in injection of radiopharmaceutical bolus injection

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