Simulation of the relationship between magnetic medium parameters and heating temperature in magnetic fluid hyperthermia_Journal of Biomedical Engineering

Authors：

QU Yingjiao ,  LU Mai , LIU Xi , LIN Yanping

Key Laboratory of Optoelectronic Technology and Intelligent Control of Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, P.R.China;

Corresponding?author：

LU Mai, Email: mai.lu@hotmail.com

Keywords：

tumor; magnetic fluid hyperthermia; magnetic medium; finite element analysis

DOI：

10.7507/1001-5515.201806014

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

In this paper, we established magnetic fluid hyperthermia (MFH) model for rat tumor using the finite element software COMSOL based on the linear response theory. By analyzing four kinds of magnetic medium within relaxation mechanism, such as Fe₃O₄、FeCo、fccFePt and L1₀FePt, we studied the influence of the change of magnetic medium radius on dissipation power and temperature field, respectively. At the same time, the optimization method for the parameters of several magnetic medium is proposed, and the applications of four kinds of magnetic medium are given as well. By increasing the dissipation power of the magnetic medium as much as possible, the dose of magnetic medium used in the treatment can be reduced, meanwhile, the adverse effects on health tissue surrounding the tumor will be minimized. The conclusions of this paper can provide reference for magnetic medium preparation applied to MFH.

Citation： QU Yingjiao, LU Mai, LIU Xi, LIN Yanping. Simulation of the relationship between magnetic medium parameters and heating temperature in magnetic fluid hyperthermia. Journal of Biomedical Engineering, 2019, 36(2): 206-212. doi: 10.7507/1001-5515.201806014 Copy

1.	熊青青, 王建, 白楊. 納米藥物在肝癌治療領域的研究進展. 生物醫學工程學雜志, 2018, 35(2): 314-319.
2.	卓子寒, 翟偉明, 蔡東陽, 等. 腫瘤感應熱療計劃系統與現代醫療信息系統集成應用研究. 生物醫學工程學雜志, 2014, 31(1): 187-191.
3.	薛陽, 趙凌云, 唐勁天, 等. 金納米復合材料在生物醫學中的應用研究進展. 生物醫學工程學雜志, 2014, 31(2): 462-466.
4.	Kurgan E, Gas P. Analysis of electromagnetic heating in magnetic fluid deep hyperthermia//Proceedings of 2016 17th International Conference Computational Problems of Electrical Engineering (CPEE), 2016: 1-4.
5.	胡冠中. 磁流體熱療系統多物理場耦合分析與優化設計. 杭州: 浙江大學, 2016.
6.	John A P, Member L S, Petryk A A. Mumerical model study of in vivo magnetic nanoparticle tumor heating. Trans Biom Eng, 2017, 64(12): 2813-2823.
7.	邱慶偉. 磁性納米顆粒電磁致熱效應在醫學中的應用研究. 北京: 北京理工大學, 2015.
8.	Lee J H, Jang J T, Choi J S, et al. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol, 2011, 6(7): 418-422.
9.	Rosensweig R E. Heating magnetic fluid with alternating magnetic field. Journal of Magnetism and Magnetic Materials, 2002, 252: 370-374.
10.	Tang Y D, Jin T, Flesch R C. Numerical temperature analysis of magnetic hyperthermia considering nanoparticle clustering and blood vessels. IEEE Trans Magn, 2017, 53(10): 1-6.
11.	王軍, 逯邁, 劉曦. 用于小動物磁感應熱療線圈的優化設計模擬. 航天醫學與醫學工程, 2018, 31(4): 380-387.
12.	Pavel M, Gradinariu G, Stancu A. Study of the optimum dose of ferromagnetic nanoparticles suitable for cancer therapy using MFH. IEEE Trans Magn, 2008, 44(11): 3205-3208.
13.	陸森, 錢建民, 黃海清, 等. 幾種不同預測大鼠肝臟體積(重量)方法的比較. 中華實驗外科雜志, 2002, 19(3): 252-253.
14.	Maenosono S, Saita S. Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia. IEEE Trans Magn, 2006, 42(6): 1638-1641.
15.	Lv Yonggang, Deng Zhongshan S, Liu Jing. 3-D numerical study on the induced heating effects of embedded micro/nanoparticles on human body subject to external medical electromagnetic field. IEEE Trans Nanobiosci, 2005, 4(4): 284-294.
16.	Pavel M, Stancu A. Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy. IEEE Trans Magn, 2009, 45(11): 5251-5254.
17.	Pavel M, Stancu A. Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH. IEEE Trans Magn, 2009, 45(10): 4825-4828.
18.	COMSOL Multiphysics, AC/DC Module, User's Guide: 187-192.
19.	李康. 磁流體腫瘤熱療的理論與實驗研究. 北京: 北京交通大學, 2017.
20.	Wu Lei, Cheng Jingjing, Liu Wenzhong, et al. Numerical analysis of electromagnetically induced heating and bioheat transfer for magnetic fluid hyperthermia. IEEE Trans Magn, 2015, 51(2): 1-4.
21.	Lahonian M, Colneshan A A. Numerical study of temperature distribution in a spherical tissue in magnetic fluid hyperthermia using boltzmann method. IEEE Trans Nanobiosci, 2011, 10(4): 262-268.

1. 熊青青, 王建, 白楊. 納米藥物在肝癌治療領域的研究進展. 生物醫學工程學雜志, 2018, 35(2): 314-319.
2. 卓子寒, 翟偉明, 蔡東陽, 等. 腫瘤感應熱療計劃系統與現代醫療信息系統集成應用研究. 生物醫學工程學雜志, 2014, 31(1): 187-191.
3. 薛陽, 趙凌云, 唐勁天, 等. 金納米復合材料在生物醫學中的應用研究進展. 生物醫學工程學雜志, 2014, 31(2): 462-466.
4. Kurgan E, Gas P. Analysis of electromagnetic heating in magnetic fluid deep hyperthermia//Proceedings of 2016 17th International Conference Computational Problems of Electrical Engineering (CPEE), 2016: 1-4.
5. 胡冠中. 磁流體熱療系統多物理場耦合分析與優化設計. 杭州: 浙江大學, 2016.
6. John A P, Member L S, Petryk A A. Mumerical model study of in vivo magnetic nanoparticle tumor heating. Trans Biom Eng, 2017, 64(12): 2813-2823.
7. 邱慶偉. 磁性納米顆粒電磁致熱效應在醫學中的應用研究. 北京: 北京理工大學, 2015.
8. Lee J H, Jang J T, Choi J S, et al. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol, 2011, 6(7): 418-422.
9. Rosensweig R E. Heating magnetic fluid with alternating magnetic field. Journal of Magnetism and Magnetic Materials, 2002, 252: 370-374.
10. Tang Y D, Jin T, Flesch R C. Numerical temperature analysis of magnetic hyperthermia considering nanoparticle clustering and blood vessels. IEEE Trans Magn, 2017, 53(10): 1-6.
11. 王軍, 逯邁, 劉曦. 用于小動物磁感應熱療線圈的優化設計模擬. 航天醫學與醫學工程, 2018, 31(4): 380-387.
12. Pavel M, Gradinariu G, Stancu A. Study of the optimum dose of ferromagnetic nanoparticles suitable for cancer therapy using MFH. IEEE Trans Magn, 2008, 44(11): 3205-3208.
13. 陸森, 錢建民, 黃海清, 等. 幾種不同預測大鼠肝臟體積(重量)方法的比較. 中華實驗外科雜志, 2002, 19(3): 252-253.
14. Maenosono S, Saita S. Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia. IEEE Trans Magn, 2006, 42(6): 1638-1641.
15. Lv Yonggang, Deng Zhongshan S, Liu Jing. 3-D numerical study on the induced heating effects of embedded micro/nanoparticles on human body subject to external medical electromagnetic field. IEEE Trans Nanobiosci, 2005, 4(4): 284-294.
16. Pavel M, Stancu A. Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy. IEEE Trans Magn, 2009, 45(11): 5251-5254.
17. Pavel M, Stancu A. Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH. IEEE Trans Magn, 2009, 45(10): 4825-4828.
18. COMSOL Multiphysics, AC/DC Module, User's Guide: 187-192.
19. 李康. 磁流體腫瘤熱療的理論與實驗研究. 北京: 北京交通大學, 2017.
20. Wu Lei, Cheng Jingjing, Liu Wenzhong, et al. Numerical analysis of electromagnetically induced heating and bioheat transfer for magnetic fluid hyperthermia. IEEE Trans Magn, 2015, 51(2): 1-4.
21. Lahonian M, Colneshan A A. Numerical study of temperature distribution in a spherical tissue in magnetic fluid hyperthermia using boltzmann method. IEEE Trans Nanobiosci, 2011, 10(4): 262-268.

Previous Article
Influence of valve height on the opening/closure performance of transplanted aortic valve
Next Article
Kinematics and workspace analysis of a spherical exoskeleton parallel mechanism

Journal of Biomedical Engineering

Simulation of the relationship between magnetic medium parameters and heating temperature in magnetic fluid hyperthermia

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content