Research progress on artificial meniscus implants_Journal of Biomedical Engineering

Authors：

LI Jinge ¹ , XIAO Jianlin ² , ZUO Jianlin ² ,  YANG Xiaoniu ¹

1. Polymer Composites Engineering Laboratory, Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun 130022, P.R.China;
2. Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, P.R.China;

Corresponding?author：

Keywords：

meniscus reconstruction; artificial meniscus implants; meniscus tissue engineering scaffolds; meniscus implants

DOI：

10.7507/1001-5515.201710038

Video：

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Meniscus injury has been one of the most common knee injuries in current society. The research on artificial meniscus implants as substitutes in meniscus reconstruction therapy has become global focus in order to solve clinical problems such as irreparable meniscus injury and symptoms after full or partial meniscectomy. At present, researches on artificial meniscus implants mainly focus on biodegradable meniscus scaffolds and non-biodegradable meniscus substitutes. Although the commercialized meniscal implants, such as CMI^?, Actifit^? and NUsurface^?, have been applied in the clinical, none of them can perfectively restore or permanently replace the natural meniscus tissue, effectively solve the symptoms after meniscectomy, and prevent cartilage degenerative diseases. The research progress, application, advantages and disadvantages of different kinds of artificial meniscus implants are reviewed in this manuscript, and the prospect is provided.

Citation： LI Jinge, XIAO Jianlin, ZUO Jianlin, YANG Xiaoniu. Research progress on artificial meniscus implants. Journal of Biomedical Engineering, 2018, 35(3): 488-492. doi: 10.7507/1001-5515.201710038 Copy

1.	Rongen J J, van Tienen T G, van Bochove B, et al. Biomaterials in search of a meniscus substitute. Biomaterials, 2014, 35(11): 3527-3540.
2.	Meniscus Injuries. Medscape Reference 2016. RefType: Online Source. http://emedicine.medscape.com/article/90661-overview.
3.	Meniscal Tear on MIR. Medscape Reference 2016. RefType: Online Source. http://emedicine.medscape.com/article/399552-overview.
4.	Fox A J, Wanivenhaus F, Burge A J, et al. The human meniscus: a review of anatomy, function, injury, and advances in treatment. Clinical Anatomy, 2015, 28(2): 269-287.
5.	金昕, 石仕元, 賴震, 等. 半月板損傷的診治進展. 浙江中西醫結合雜志, 2016, 26(09): 870-873.
6.	朱衛星. 中醫綜合療法治療早期創傷性半月板損傷臨床研究. 中醫學報, 2017, 32(07): 1293-1296.
7.	李貴星. 關節腔內注射玻璃酸鈉治療半月板損傷效果分析. 海峽藥學, 2017, 29(04): 135-136.
8.	夏琪鵬. 半月板損傷關節鏡術后透明質酸關節腔內注射的應用分析. 藥品評價, 2017, 4(20): 23-25.
9.	王宇, 劉松波, 劉憲民, 等. 關節鏡下外側半月板前角縫合 34 例臨床觀察. 創傷與急危重病醫學, 2017, 5(1): 41-44.
10.	張新濤, 江小成, 尤田, 等. 同種異體半月板移植 61 例的中期療效觀察. 中華關節外科雜志:電子版, 2016, 10(1): 15-19.
11.	王小飛. 關節鏡下半月板成形術與半月板切除術治療膝關節半月板損傷對比研究. 包頭醫學, 2017, 41(02): 82-83.
12.	鄭沖, 甄志雷, 楊國夫. 半月板損傷修復與重建研究進展. 醫學研究雜志, 2016, 45(4): 178-180, 112.
13.	Stone K R, Rodkey W G, Webber R J, et al. Future directions. collagen-based prostheses for meniscal regeneration. Clin Orthop Relat Res, 1990(252): 129-135.
14.	Heo J, Koh R H, Shim W, et al. Riboflavin-induced photo-crosslinking of collagen hydrogel and its application in meniscus tissue engineering. Drug Deliv Transl Res, 2016, 6(2): 148-158.
15.	Na Yin, Chen Shiyan, Cao Yimeng. Improvement in mechanical properties and biocompatibility of biosynthetic bacterial cellulose/lotus root starch composites. Chinese Journal of Polymer Science, 2017, 35(03): 354-364.
16.	Mandal B B, Park S H, Gil E S, et al. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials, 2011, 32(2): 639-651.
17.	Li Gang, Li Fei, Zheng Zhaozhu, et al. Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. Journal of Materials Science, 2016, 51(6): 3025-3035.
18.	Sun Jie, Vijayavenkataraman S, Liu Hang. An overview of scaffold design and fabrication technology for engineered knee meniscus. Materials (Basel), 2017, 10(1): 19.
19.	Welsing R T, van Tienen T G, Ramrattan N A, et al. Effect on tissue differentiation and articular cartilage degradation of a polymer meniscus implant. A 2-year follow-up study in dogs. American Journal of Sports Medicine, 2008, 36(10): 1978-1989.
20.	Maher S A, Rodeo S A, Doty S B, et al. Evaluation of a porous polyurethane scaffold in a partial meniscal defect ovine model. Arthroscopy, 2010, 26(11): 1510-1519.
21.	Bulgheroni E, Grassi A, Campagnolo M, et al. Comparative study of collagen versus synthetic-based meniscal scaffolds in treating meniscal deficiency in young active population. Cartilage, 2016, 7(1): 29-38.
22.	Gelber P E, Petrica A M, Isart A, et al. The magnetic resonance aspect of a polyurethane meniscal scaffold is worse in advanced cartilage defects without deterioration of clinical outcomes after a minimum two-year follow-up. Knee, 2015, 22(5): 389-394.
23.	Chiari C, Koller U, Dorotka R, et al. A tissue engineering approach to meniscus regeneration in a sheep model. Osteoarthritis and Cartilage, 2006, 14(10): 1056-1065.
24.	Kon E, Filardo G, Tschon M, et al. Tissue engineering for total meniscal substitution: animal study in sheep model-results at 12 months. Tissue Eng Part A, 2012, 18(15/16): 1573-1582.
25.	Baek J, Chen Xian, Sovani S, et al. Meniscus tissue engineering using a novel combination of electrospun scaffolds and human meniscus cells embedded within an extracellular matrix hydrogel. J Orthop Res, 2015, 33(4): 572-583.
26.	楊軍忠, 劉卅. 生物再生材料迎來產業快速發展期. 中國醫療器械信息, 2015(11): 35-36, 45.
27.	Yuan Zhiguo, Liu Shuyun, Hao Chunxiang, et al. AMECM/DCB scaffold prompts successful total meniscus Reconstruction in a rabbit total meniscectomy model. Biomaterials, 2016, 111: 13-26.
28.	Gao Shuang, Yuan Zhiguo, Xi Tingfei, et al. Characterization of decellularized scaffold derived from porcine meniscus for tissue engineering applications. Front Mater Sci, 2016, 10(2): 101-112.
29.	Gao Shuang, Yuan Zhiguo, Guo Weimin, et al. Comparison of glutaraldehyde and carbodiimides to crosslink tissue engineering scaffolds fabricated by decellularized porcine menisci. Mater Sci Eng C Mater Biol Appl, 2017, 71: 891-900.
30.	Gao Shuang, Guo Weimin, Chen Mingxue, et al. Fabrication and characterization of electrospun nanofibers composed of decellularized meniscus extracellular matrix and polycaprolactone for meniscus tissue engineering. Journal of Materials Chemistry B, 2017, 5(12): 2273-2285.
31.	Merriam A R, Patel J M, Culp B M, et al. Successful total meniscus reconstruction using a novel fiber-reinforced scaffold: a 16- and 32-week study in an ovine model. Am J Sports Med, 2015, 43(10): 2528-2537.
32.	Kobayashi M, Chang Yongshun, Oka Masanori. A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus. Biomaterials, 2005, 26(16): 3243-3248.
33.	Hayes J C, Kennedy J E. An evaluation of the biocompatibility properties of a salt-modified polyvinyl alcohol hydrogel for a knee meniscus application. Mater Sci Eng C Mater Biol Appl, 2016, 59: 894-900.
34.	Hayes J C, Curley C, Tierney P, et al. Biomechanical analysis of a salt-modified polyvinyl alcohol hydrogel for knee meniscus applications, including comparison with human donor samples. J Mech Behav Biomed Mater, 2016, 56: 156-164.
35.	Majd S E, Kuijer R, Schmidt T A, et al. Role of hydrophobicity on the adsorption of synovial fluid proteins and biolubrication of polycarbonate urethanes: materials for permanent meniscus implants. Mater Des, 2015, 83: 514-521.
36.	Majd S E, Rizqy A I, Kaper H J, et al. An in vitro study of cartilage-meniscus tribology to understand the changes caused by a meniscus implant. Colloids Surf B Biointerfaces, 2017, 155: 294-303.
37.	Vrancken A C, Madej W, Hannink G, et al. Short term evaluation of an anatomically shaped polycarbonate urethane total meniscus replacement in a goat model. PLoS One, 2015, 10(7): e0133138.
38.	Vrancken A C, Eggermont F, van Tienen T G, et al. Functional biomechanical performance of a novel anatomically shaped polycarbonate urethane total meniscus replacement. Knee Surg Sports Traumatol Arthrosc, 2016, 24(5): 1485-1494.
39.	Vrancken A C, Hannink G, Madej W, et al. In vivo performance of a novel, anatomically shaped, total meniscal prosthesis made of polycarbonate urethane: a 12-month evaluation in goats. Am J Sports Med, 2017, 45(12): 2824-2834.
40.	Chen Mingxue, Gao Shuang, Wang Pei, et al. The application of electrospinning used in meniscus tissue engineering. J Biomater Sci Polym Ed, 2018, 29(5): 461-475.

1. Rongen J J, van Tienen T G, van Bochove B, et al. Biomaterials in search of a meniscus substitute. Biomaterials, 2014, 35(11): 3527-3540.
2. Meniscus Injuries. Medscape Reference 2016. RefType: Online Source. http://emedicine.medscape.com/article/90661-overview.
3. Meniscal Tear on MIR. Medscape Reference 2016. RefType: Online Source. http://emedicine.medscape.com/article/399552-overview.
4. Fox A J, Wanivenhaus F, Burge A J, et al. The human meniscus: a review of anatomy, function, injury, and advances in treatment. Clinical Anatomy, 2015, 28(2): 269-287.
5. 金昕, 石仕元, 賴震, 等. 半月板損傷的診治進展. 浙江中西醫結合雜志, 2016, 26(09): 870-873.
6. 朱衛星. 中醫綜合療法治療早期創傷性半月板損傷臨床研究. 中醫學報, 2017, 32(07): 1293-1296.
7. 李貴星. 關節腔內注射玻璃酸鈉治療半月板損傷效果分析. 海峽藥學, 2017, 29(04): 135-136.
8. 夏琪鵬. 半月板損傷關節鏡術后透明質酸關節腔內注射的應用分析. 藥品評價, 2017, 4(20): 23-25.
9. 王宇, 劉松波, 劉憲民, 等. 關節鏡下外側半月板前角縫合 34 例臨床觀察. 創傷與急危重病醫學, 2017, 5(1): 41-44.
10. 張新濤, 江小成, 尤田, 等. 同種異體半月板移植 61 例的中期療效觀察. 中華關節外科雜志:電子版, 2016, 10(1): 15-19.
11. 王小飛. 關節鏡下半月板成形術與半月板切除術治療膝關節半月板損傷對比研究. 包頭醫學, 2017, 41(02): 82-83.
12. 鄭沖, 甄志雷, 楊國夫. 半月板損傷修復與重建研究進展. 醫學研究雜志, 2016, 45(4): 178-180, 112.
13. Stone K R, Rodkey W G, Webber R J, et al. Future directions. collagen-based prostheses for meniscal regeneration. Clin Orthop Relat Res, 1990(252): 129-135.
14. Heo J, Koh R H, Shim W, et al. Riboflavin-induced photo-crosslinking of collagen hydrogel and its application in meniscus tissue engineering. Drug Deliv Transl Res, 2016, 6(2): 148-158.
15. Na Yin, Chen Shiyan, Cao Yimeng. Improvement in mechanical properties and biocompatibility of biosynthetic bacterial cellulose/lotus root starch composites. Chinese Journal of Polymer Science, 2017, 35(03): 354-364.
16. Mandal B B, Park S H, Gil E S, et al. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials, 2011, 32(2): 639-651.
17. Li Gang, Li Fei, Zheng Zhaozhu, et al. Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. Journal of Materials Science, 2016, 51(6): 3025-3035.
18. Sun Jie, Vijayavenkataraman S, Liu Hang. An overview of scaffold design and fabrication technology for engineered knee meniscus. Materials (Basel), 2017, 10(1): 19.
19. Welsing R T, van Tienen T G, Ramrattan N A, et al. Effect on tissue differentiation and articular cartilage degradation of a polymer meniscus implant. A 2-year follow-up study in dogs. American Journal of Sports Medicine, 2008, 36(10): 1978-1989.
20. Maher S A, Rodeo S A, Doty S B, et al. Evaluation of a porous polyurethane scaffold in a partial meniscal defect ovine model. Arthroscopy, 2010, 26(11): 1510-1519.
21. Bulgheroni E, Grassi A, Campagnolo M, et al. Comparative study of collagen versus synthetic-based meniscal scaffolds in treating meniscal deficiency in young active population. Cartilage, 2016, 7(1): 29-38.
22. Gelber P E, Petrica A M, Isart A, et al. The magnetic resonance aspect of a polyurethane meniscal scaffold is worse in advanced cartilage defects without deterioration of clinical outcomes after a minimum two-year follow-up. Knee, 2015, 22(5): 389-394.
23. Chiari C, Koller U, Dorotka R, et al. A tissue engineering approach to meniscus regeneration in a sheep model. Osteoarthritis and Cartilage, 2006, 14(10): 1056-1065.
24. Kon E, Filardo G, Tschon M, et al. Tissue engineering for total meniscal substitution: animal study in sheep model-results at 12 months. Tissue Eng Part A, 2012, 18(15/16): 1573-1582.
25. Baek J, Chen Xian, Sovani S, et al. Meniscus tissue engineering using a novel combination of electrospun scaffolds and human meniscus cells embedded within an extracellular matrix hydrogel. J Orthop Res, 2015, 33(4): 572-583.
26. 楊軍忠, 劉卅. 生物再生材料迎來產業快速發展期. 中國醫療器械信息, 2015(11): 35-36, 45.
27. Yuan Zhiguo, Liu Shuyun, Hao Chunxiang, et al. AMECM/DCB scaffold prompts successful total meniscus Reconstruction in a rabbit total meniscectomy model. Biomaterials, 2016, 111: 13-26.
28. Gao Shuang, Yuan Zhiguo, Xi Tingfei, et al. Characterization of decellularized scaffold derived from porcine meniscus for tissue engineering applications. Front Mater Sci, 2016, 10(2): 101-112.
29. Gao Shuang, Yuan Zhiguo, Guo Weimin, et al. Comparison of glutaraldehyde and carbodiimides to crosslink tissue engineering scaffolds fabricated by decellularized porcine menisci. Mater Sci Eng C Mater Biol Appl, 2017, 71: 891-900.
30. Gao Shuang, Guo Weimin, Chen Mingxue, et al. Fabrication and characterization of electrospun nanofibers composed of decellularized meniscus extracellular matrix and polycaprolactone for meniscus tissue engineering. Journal of Materials Chemistry B, 2017, 5(12): 2273-2285.
31. Merriam A R, Patel J M, Culp B M, et al. Successful total meniscus reconstruction using a novel fiber-reinforced scaffold: a 16- and 32-week study in an ovine model. Am J Sports Med, 2015, 43(10): 2528-2537.
32. Kobayashi M, Chang Yongshun, Oka Masanori. A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus. Biomaterials, 2005, 26(16): 3243-3248.
33. Hayes J C, Kennedy J E. An evaluation of the biocompatibility properties of a salt-modified polyvinyl alcohol hydrogel for a knee meniscus application. Mater Sci Eng C Mater Biol Appl, 2016, 59: 894-900.
34. Hayes J C, Curley C, Tierney P, et al. Biomechanical analysis of a salt-modified polyvinyl alcohol hydrogel for knee meniscus applications, including comparison with human donor samples. J Mech Behav Biomed Mater, 2016, 56: 156-164.
35. Majd S E, Kuijer R, Schmidt T A, et al. Role of hydrophobicity on the adsorption of synovial fluid proteins and biolubrication of polycarbonate urethanes: materials for permanent meniscus implants. Mater Des, 2015, 83: 514-521.
36. Majd S E, Rizqy A I, Kaper H J, et al. An in vitro study of cartilage-meniscus tribology to understand the changes caused by a meniscus implant. Colloids Surf B Biointerfaces, 2017, 155: 294-303.
37. Vrancken A C, Madej W, Hannink G, et al. Short term evaluation of an anatomically shaped polycarbonate urethane total meniscus replacement in a goat model. PLoS One, 2015, 10(7): e0133138.
38. Vrancken A C, Eggermont F, van Tienen T G, et al. Functional biomechanical performance of a novel anatomically shaped polycarbonate urethane total meniscus replacement. Knee Surg Sports Traumatol Arthrosc, 2016, 24(5): 1485-1494.
39. Vrancken A C, Hannink G, Madej W, et al. In vivo performance of a novel, anatomically shaped, total meniscal prosthesis made of polycarbonate urethane: a 12-month evaluation in goats. Am J Sports Med, 2017, 45(12): 2824-2834.
40. Chen Mingxue, Gao Shuang, Wang Pei, et al. The application of electrospinning used in meniscus tissue engineering. J Biomater Sci Polym Ed, 2018, 29(5): 461-475.

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