Caveolin-1 in relation with mitochondria and cancer metabolism—a promising target for cancer therapy_Journal of Biomedical Engineering

Authors：

JIANG Ying , LI Shun , YANG Hong , WU Chunhui ,  LIU Yiyao

Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P.R.China;

Corresponding?author：

LIU Yiyao, Email: liuyiyao@uestc.edu.cn

Keywords：

caveolin-1; metabolism; mitochondria; reactive oxygen species; malignant phenotype

DOI：

10.7507/1001-5515.201703037

Video：

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Abstract Full text Figures/Tables Video References Cited by

To aggressively proliferate and metastasize, cancer cells are in extreme need of energy supply and nutrients. Therefore, a promising cancer therapy strategy is developed to target its hallmark feature of metabolism. Recent findings revealed the regulatory role of caveolin-1 (Cav-1), a structural protein of caveolae, in cancer metabolism. And low Cav-1 expression in tumor stroma was proved to be a central player of cancer malignant phenotype. Here, we summarized the progressions of studies on Cav-1, mitochondria and cancer metabolism to indicate that the altered metabolism induced by Cav-1 and mitochondria association is a major cause of cancer malignant phenotype.

Citation： JIANG Ying, LI Shun, YANG Hong, WU Chunhui, LIU Yiyao. Caveolin-1 in relation with mitochondria and cancer metabolism—a promising target for cancer therapy. Journal of Biomedical Engineering, 2017, 34(5): 803-806. doi: 10.7507/1001-5515.201703037 Copy

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2.	Cheng J P, Nichols B J. Caveolae: one function or many?. Trends Cell Biol, 2016, 26(3): 177-189.
3.	Fridolfsson H N, Roth D M, Insel P A, et al. Regulation of intracellular signaling and function by caveolin. FASEB J, 2014, 28(9): 3823-3831.
4.	Caravia L, Dudau M, Gherghiceanu M, et al. Could caveolae be acting as warnings of mitochondrial ageing? Mech Ageing Dev, 2015, 146-148: 81-87.
5.	Shiroto T, Romero N, Sugiyama T, et al. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One, 2014, 9(2): e87871.
6.	Schilling J M, Patel H H. Non-canonical roles for caveolin in regulation of membrane repair and mitochondria: implications for stress adaptation with age. J Physiol, 2016, 594(16): 4581-4589.
7.	Bartholomew J N, Galbiati F. Mapping of oxidative stress response elements of the caveolin-1 promoter. Methods Mol Biol, 2010, 594: 409-423.
8.	Coelho-Santos V, Socodato R, Portugal C, et al. Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphory-lation in human brain endothelial cells. Cell Mol Life Sci, 2016, 73(24): 4701-4716.
9.	Volonte D, Galbiati F. Polymerase Ⅰ and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence. J Biol Chem, 2011, 286(33): 28657-28661.
10.	Eiró N, Fernandez-Garcia B, Vázquez J, et al. A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer. Oncoimmunology, 2015, 4(7): e992222.
11.	Kim H M, Jung W H, Koo J S. Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis. J Transl Med, 2015, 13: 222.
12.	Park C K, Jung W H, Koo J S. Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma. Breast Cancer Res Treat, 2016, 159(1): 55-69.
13.	Zhu Xue, Wang Ke, Zhang Kai, et al. Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression. Acta Biochim Biophys Sin (Shanghai), 2016, 48(5): 462-467.
14.	Yu Y, Xiao C H, Tan L D, et al. Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling. Br J Cancer, 2014, 110(3): 724-732.
15.	Katanov C, Lerrer S, Liubomirski Y, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway. Stem Cell Res Ther, 2015, 6: 87.
16.	Kubo N, Araki K, Kuwano H, et al. Cancer-associated fibroblasts in hepatocellular carcinoma. World J Gastroenterol, 2016, 22(30): 6841-6850.
17.	Folgueira M A, Maistro S, Katayama M L, et al. Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Biosci Rep, 2013, 33(6). pii: e00085..
18.	Shan Tao, Chen Shuo, Chen Xi, et al. Prometastatic mechanisms of CAF-mediated EMT regulation in pancreatic cancer cells. Int J Oncol, 2017, 50(1): 121-128.
19.	Pavlides S, Whitaker-Menezes D, Castello-Cros R, et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle, 2009, 8(23): 3984-4001.
20.	Somasundaram V, Nadhan R, Hemalatha S K, et al. Nitric oxide and reactive oxygen species: Clues to target oxidative damage repair defective breast cancers. Crit Rev Oncol Hematol, 2016, 101: 184-192.
21.	Shan Tao, Chen Shuo, Chen Xi, et al. Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism. Oncol Rep, 2017, 37(4): 1971-1979.
22.	Morais-Santos F, Granja S, Miranda-Gon?alves V, et al. Targeting lactate transport suppresses in <italic>vivo</italic> breast tumour growth. Oncotarget, 2015, 6(22): 19177-19189.
23.	Martel F, Guedes M, Keating E. Effect of polyphenols on glucose and lactate transport by breast cancer cells. Breast Cancer Res Treat, 2016, 157(1): 1-11.
24.	趙朋月, 刁路明, 陳洪雷. 基質窖蛋白-1 和腫瘤能量代謝的研究進展. 中華病理學雜志, 2012, 41(7): 498-5000.
25.	Nwosu Z C, Ebert M P, Dooley S, et al. Caveolin-1 in the regulation of cell metabolism: a cancer perspective. Mol Cancer, 2016, 15(1): 71.

1. Parton R G, Collins B M. Unraveling the architecture of caveolae. Proc Natl Acad Sci U S A, 2016, 113(50): 14170-14172.
2. Cheng J P, Nichols B J. Caveolae: one function or many?. Trends Cell Biol, 2016, 26(3): 177-189.
3. Fridolfsson H N, Roth D M, Insel P A, et al. Regulation of intracellular signaling and function by caveolin. FASEB J, 2014, 28(9): 3823-3831.
4. Caravia L, Dudau M, Gherghiceanu M, et al. Could caveolae be acting as warnings of mitochondrial ageing? Mech Ageing Dev, 2015, 146-148: 81-87.
5. Shiroto T, Romero N, Sugiyama T, et al. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One, 2014, 9(2): e87871.
6. Schilling J M, Patel H H. Non-canonical roles for caveolin in regulation of membrane repair and mitochondria: implications for stress adaptation with age. J Physiol, 2016, 594(16): 4581-4589.
7. Bartholomew J N, Galbiati F. Mapping of oxidative stress response elements of the caveolin-1 promoter. Methods Mol Biol, 2010, 594: 409-423.
8. Coelho-Santos V, Socodato R, Portugal C, et al. Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphory-lation in human brain endothelial cells. Cell Mol Life Sci, 2016, 73(24): 4701-4716.
9. Volonte D, Galbiati F. Polymerase Ⅰ and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence. J Biol Chem, 2011, 286(33): 28657-28661.
10. Eiró N, Fernandez-Garcia B, Vázquez J, et al. A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer. Oncoimmunology, 2015, 4(7): e992222.
11. Kim H M, Jung W H, Koo J S. Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis. J Transl Med, 2015, 13: 222.
12. Park C K, Jung W H, Koo J S. Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma. Breast Cancer Res Treat, 2016, 159(1): 55-69.
13. Zhu Xue, Wang Ke, Zhang Kai, et al. Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression. Acta Biochim Biophys Sin (Shanghai), 2016, 48(5): 462-467.
14. Yu Y, Xiao C H, Tan L D, et al. Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling. Br J Cancer, 2014, 110(3): 724-732.
15. Katanov C, Lerrer S, Liubomirski Y, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway. Stem Cell Res Ther, 2015, 6: 87.
16. Kubo N, Araki K, Kuwano H, et al. Cancer-associated fibroblasts in hepatocellular carcinoma. World J Gastroenterol, 2016, 22(30): 6841-6850.
17. Folgueira M A, Maistro S, Katayama M L, et al. Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Biosci Rep, 2013, 33(6). pii: e00085..
18. Shan Tao, Chen Shuo, Chen Xi, et al. Prometastatic mechanisms of CAF-mediated EMT regulation in pancreatic cancer cells. Int J Oncol, 2017, 50(1): 121-128.
19. Pavlides S, Whitaker-Menezes D, Castello-Cros R, et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle, 2009, 8(23): 3984-4001.
20. Somasundaram V, Nadhan R, Hemalatha S K, et al. Nitric oxide and reactive oxygen species: Clues to target oxidative damage repair defective breast cancers. Crit Rev Oncol Hematol, 2016, 101: 184-192.
21. Shan Tao, Chen Shuo, Chen Xi, et al. Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism. Oncol Rep, 2017, 37(4): 1971-1979.
22. Morais-Santos F, Granja S, Miranda-Gon?alves V, et al. Targeting lactate transport suppresses in <italic>vivo</italic> breast tumour growth. Oncotarget, 2015, 6(22): 19177-19189.
23. Martel F, Guedes M, Keating E. Effect of polyphenols on glucose and lactate transport by breast cancer cells. Breast Cancer Res Treat, 2016, 157(1): 1-11.
24. 趙朋月, 刁路明, 陳洪雷. 基質窖蛋白-1 和腫瘤能量代謝的研究進展. 中華病理學雜志, 2012, 41(7): 498-5000.
25. Nwosu Z C, Ebert M P, Dooley S, et al. Caveolin-1 in the regulation of cell metabolism: a cancer perspective. Mol Cancer, 2016, 15(1): 71.

Journal of Biomedical Engineering

Caveolin-1 in relation with mitochondria and cancer metabolism—a promising target for cancer therapy

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