Design and research progress of zero profile cervical Interbody cage_Journal of Biomedical Engineering

Authors：

ZHU Jia ^1,2 , WANG Song ³ , LIAO Zhenhua ³ [綜述] ,  LIU Weiqiang ^1,3 [審校]

1. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R.China;
2. Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R.China;
3. Research Institute of Tsinghua University in Shenzhen, Shenzhen, Guangdong 518057, P.R.China;

Corresponding?author：

LIU Weiqiang, Email: weiqliu@hotmail.com

Keywords：

zero profile cage; cervical spine; structure design; material research; design for target population

DOI：

10.7507/1001-5515.201604049

Video：

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Zero profile cervical interbody cage is an improvement of traditional fusion products and necessary supplement of emerging artificial intervertebral disc products. When applied in Anterior Cervical Decompression Fusion (ACDF), zero profile cervical interbody cage can preserve the advantages of traditional fusion and reduce the incidence of postoperative complications. Moreover, zero profile cervical interbody cage can be applied under the tabu symptoms of Artificial Cervical Disc Replacement (ACDR). This article summarizes zero profile interbody cage products that are commonly recognized and widely used in clinical practice in recent years, and reviews the progress of structure design and material research of zero profile cervical interbody cage products. Based on the latest clinical demands and research progress, this paper also discusses the future development directions of zero profile interbody cage.

Citation： ZHUJia, WANGSong. Design and research progress of zero profile cervical Interbody cage. Journal of Biomedical Engineering, 2017, 34(1): 150-155. doi: 10.7507/1001-5515.201604049 Copy

1.	?柯尊華, 王靜怡. 頸椎病流行病學及發病機理研究進展. 頸腰痛雜志, 2014, 35(1): 62-64.
2.	吳佳潤, 趙斌霞. 頸椎病易發群體發病率與主要發病原因的研究. 當代體育科技, 2015, 5(23): 26-27.
3.	Hisey M S, Bae H W, Davis R, et al. Multi-center, prospective, randomized, controlled investigational device exemption clinical trial comparing Mobi-C Cervical Artificial Disc to anterior discectomy and fusion in the treatment of symptomatic degenerative disc disease in the cervical spine. International journal of spine surgery, 2014, 8: 7.
4.	Skovrlj B, Lee D H, Caridi J M, et al. Reoperations following cervical disc replacement. Asian Spine J, 2015, 9(3): 471-482.
5.	Quinn J C, Kiely P D, Lebl D R, et al. Anterior surgical treatment of cervical spondylotic myelopathy. HSS J, 2015, 11(1): 15-25.
6.	Lane P D, Cox J L, Gaskins R B, et al. Early radiographic and clinical outcomes study evaluating an integrated screw and interbody spacer for One- and Two-Level ACDF. International journal of spine surgery, 2015, 9: 39.
7.	Wang Zhiwen, Jiang Weimin, Li Xuefeng, et al. The application of zero-profile anchored spacer in anterior cervical discectomy and fusion. Eur Spine J, 2015, 24(1): 148-154.
8.	Yang Haisong, Chen Deyu, Wang Xinwei, et al. Zero-profile integrated plate and spacer device reduces rate of adjacent-level ossification development and dysphagia compared to ACDF with plating and cage system. Arch Orthop Trauma Surg, 2015, 135(6): 781-787.
9.	Hofstetter C P, Kesavabhotla K, Boockvar J A. Zero-profile Anchored Spacer Reduces Rate of Dysphagia Compared With ACDF With Anterior Plating. J Spinal Disord Tech, 2015, 28(5): E284-E290.
10.	黃吉軍, 楊建東, 陶玉平, 等. 頸椎 Zero-P 植入與前路減壓植骨融合術的對照研究. 實用骨科雜志, 2014, 20(4): 289-292.
11.	Chong E, Pelletier M H, Mobbs R J, et al. The design evolution of interbody cages in anterior cervical discectomy and fusion: a systematic review. BMC Musculoskelet Disord, 2015, 16: 99.
12.	Rao P J, Pelletier M H, Walsh W R, et al. Spine interbody implants: material selection and modification, functionalization and bioactivation of surfaces to improve osseointegration. Orthop Surg, 2014, 6(2): 81-89.
13.	劉延群, 張俊忠. 不同材料椎間融合器的生物力學性能評估. 中國醫學創新, 2010, 7(36): 186-188.
14.	王成健, 孟增東, 張玉勤, 等. 鎳鈦形狀記憶合金的生物相容性研究進展. 生物骨科材料與臨床研究, 2016, 13(1): 65-68.
15.	王華強, 滕勇. 腰椎椎間融合材料研究進展[J]. 國際骨科學雜志, 2016, 37(1): 14-17.
16.	Yoo M, Kim W H, Hyun S J, et al. Comparison between two different cervical interbody fusion cages in one level stand-alone ACDF: carbon fiber composite frame cage versus polyetheretherketone cage. Korean Journal of Spine, 2014, 11(3): 127-135.
17.	Hak D J, Mauffrey C, Seligson D, et al. Use of carbon-fiber-reinforced composite implants in orthopedic surgery. Orthopedics, 2014, 37(12): 825-830.
18.	李嵩, 祁敏, 曹鵬, 等. 可吸收脊柱椎間融合器的研究與應用進展. 脊柱外科雜志, 2014, 12(2): 103-106.
19.	Li Xiaohui, Song Yueming, Duan Hong. Reconstruction of segmental stability of goat cervical spine with poly (D, l-lactic acid) cage. Orthop Surg, 2015, 7(3): 266-272.
20.	Smith A J, Arginteanu M, Moore F, et al. Increased incidence of cage migration and nonunion in instrumented transforaminal lumbar interbody fusion with bioabsorbable cages. J Neurosurg Spine, 2010, 13(3): 388-393.
21.	陶敬橋, 張海鐘. 不同固定材料治療下頜骨髁狀突骨折療效比較. 現代中西醫結合雜志, 2013, 22(34): 3797-3798.
22.	王運鋒, 何蕾, 郭薇. 醫用鈦合金的研究及應用現狀. 鈦工業進展, 2015, 32(1): 1-6.
23.	Reigstad O, Johansson C, Stenport V, et al. Different patterns of bone fixation with hydroxyapatite and resorbable CaP coatings in the rabbit tibia at 6, 12, and 52 weeks. J Biomed Mater Res B Appl Biomater, 2011, 99(1): 14-20.
24.	Chen Yu, Wang Xinwei, Lu Xuhua, et al. Comparison of Titanium and polyetheretherketone (PEEK) cages in the surgical treatment of multilevel cervical spondylotic myelopathy: a prospective, randomized, control study with over 7-year follow-up. Eur Spine J, 2013, 22(7): 1539-1546.
25.	Stein M I, Nayak A N, Gaskins R B, et al. Biomechanics of an integrated interbody device versus ACDF anterior locking plate in a single-level cervical spine fusion construct. Spine J, 2014, 14(1): 128-136.
26.	Kienle A, Graf N, Wilk H J. Does impaction of titanium-coated interbody fusion cages into the disc space cause wear debris or delamination. The Spine Journal, 2016, 16: 235-242.
27.	史繼德, 周賦, 王景, 等. 頸椎前路植入 PEEK PREVAIL 系統手術方式治療單節段頸椎病. 實用骨科雜志, 2015, 21(11): 961-964, 1044.
28.	張衛紅, 袁碩, 孟純陽, 等. MC+? 和 ROI-CTM 頸椎融合器治療頸椎病: 術后早期頸椎穩定性及融合率比較. 中國組織工程研究, 2014, 18(31): 4973-4979.

1. ?柯尊華, 王靜怡. 頸椎病流行病學及發病機理研究進展. 頸腰痛雜志, 2014, 35(1): 62-64.
2. 吳佳潤, 趙斌霞. 頸椎病易發群體發病率與主要發病原因的研究. 當代體育科技, 2015, 5(23): 26-27.
3. Hisey M S, Bae H W, Davis R, et al. Multi-center, prospective, randomized, controlled investigational device exemption clinical trial comparing Mobi-C Cervical Artificial Disc to anterior discectomy and fusion in the treatment of symptomatic degenerative disc disease in the cervical spine. International journal of spine surgery, 2014, 8: 7.
4. Skovrlj B, Lee D H, Caridi J M, et al. Reoperations following cervical disc replacement. Asian Spine J, 2015, 9(3): 471-482.
5. Quinn J C, Kiely P D, Lebl D R, et al. Anterior surgical treatment of cervical spondylotic myelopathy. HSS J, 2015, 11(1): 15-25.
6. Lane P D, Cox J L, Gaskins R B, et al. Early radiographic and clinical outcomes study evaluating an integrated screw and interbody spacer for One- and Two-Level ACDF. International journal of spine surgery, 2015, 9: 39.
7. Wang Zhiwen, Jiang Weimin, Li Xuefeng, et al. The application of zero-profile anchored spacer in anterior cervical discectomy and fusion. Eur Spine J, 2015, 24(1): 148-154.
8. Yang Haisong, Chen Deyu, Wang Xinwei, et al. Zero-profile integrated plate and spacer device reduces rate of adjacent-level ossification development and dysphagia compared to ACDF with plating and cage system. Arch Orthop Trauma Surg, 2015, 135(6): 781-787.
9. Hofstetter C P, Kesavabhotla K, Boockvar J A. Zero-profile Anchored Spacer Reduces Rate of Dysphagia Compared With ACDF With Anterior Plating. J Spinal Disord Tech, 2015, 28(5): E284-E290.
10. 黃吉軍, 楊建東, 陶玉平, 等. 頸椎 Zero-P 植入與前路減壓植骨融合術的對照研究. 實用骨科雜志, 2014, 20(4): 289-292.
11. Chong E, Pelletier M H, Mobbs R J, et al. The design evolution of interbody cages in anterior cervical discectomy and fusion: a systematic review. BMC Musculoskelet Disord, 2015, 16: 99.
12. Rao P J, Pelletier M H, Walsh W R, et al. Spine interbody implants: material selection and modification, functionalization and bioactivation of surfaces to improve osseointegration. Orthop Surg, 2014, 6(2): 81-89.
13. 劉延群, 張俊忠. 不同材料椎間融合器的生物力學性能評估. 中國醫學創新, 2010, 7(36): 186-188.
14. 王成健, 孟增東, 張玉勤, 等. 鎳鈦形狀記憶合金的生物相容性研究進展. 生物骨科材料與臨床研究, 2016, 13(1): 65-68.
15. 王華強, 滕勇. 腰椎椎間融合材料研究進展[J]. 國際骨科學雜志, 2016, 37(1): 14-17.
16. Yoo M, Kim W H, Hyun S J, et al. Comparison between two different cervical interbody fusion cages in one level stand-alone ACDF: carbon fiber composite frame cage versus polyetheretherketone cage. Korean Journal of Spine, 2014, 11(3): 127-135.
17. Hak D J, Mauffrey C, Seligson D, et al. Use of carbon-fiber-reinforced composite implants in orthopedic surgery. Orthopedics, 2014, 37(12): 825-830.
18. 李嵩, 祁敏, 曹鵬, 等. 可吸收脊柱椎間融合器的研究與應用進展. 脊柱外科雜志, 2014, 12(2): 103-106.
19. Li Xiaohui, Song Yueming, Duan Hong. Reconstruction of segmental stability of goat cervical spine with poly (D, l-lactic acid) cage. Orthop Surg, 2015, 7(3): 266-272.
20. Smith A J, Arginteanu M, Moore F, et al. Increased incidence of cage migration and nonunion in instrumented transforaminal lumbar interbody fusion with bioabsorbable cages. J Neurosurg Spine, 2010, 13(3): 388-393.
21. 陶敬橋, 張海鐘. 不同固定材料治療下頜骨髁狀突骨折療效比較. 現代中西醫結合雜志, 2013, 22(34): 3797-3798.
22. 王運鋒, 何蕾, 郭薇. 醫用鈦合金的研究及應用現狀. 鈦工業進展, 2015, 32(1): 1-6.
23. Reigstad O, Johansson C, Stenport V, et al. Different patterns of bone fixation with hydroxyapatite and resorbable CaP coatings in the rabbit tibia at 6, 12, and 52 weeks. J Biomed Mater Res B Appl Biomater, 2011, 99(1): 14-20.
24. Chen Yu, Wang Xinwei, Lu Xuhua, et al. Comparison of Titanium and polyetheretherketone (PEEK) cages in the surgical treatment of multilevel cervical spondylotic myelopathy: a prospective, randomized, control study with over 7-year follow-up. Eur Spine J, 2013, 22(7): 1539-1546.
25. Stein M I, Nayak A N, Gaskins R B, et al. Biomechanics of an integrated interbody device versus ACDF anterior locking plate in a single-level cervical spine fusion construct. Spine J, 2014, 14(1): 128-136.
26. Kienle A, Graf N, Wilk H J. Does impaction of titanium-coated interbody fusion cages into the disc space cause wear debris or delamination. The Spine Journal, 2016, 16: 235-242.
27. 史繼德, 周賦, 王景, 等. 頸椎前路植入 PEEK PREVAIL 系統手術方式治療單節段頸椎病. 實用骨科雜志, 2015, 21(11): 961-964, 1044.
28. 張衛紅, 袁碩, 孟純陽, 等. MC+? 和 ROI-CTM 頸椎融合器治療頸椎病: 術后早期頸椎穩定性及融合率比較. 中國組織工程研究, 2014, 18(31): 4973-4979.

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Design and research progress of zero profile cervical Interbody cage

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