Preparation and study of vaccarin-loaded nanofibers used as wound healing material_Journal of Biomedical Engineering

Authors：

QIU Yuyu ¹ , CAI Weiwei ¹ , QIU Liying ¹ , WANG Qingqing ² ,  WEI Qufu ²

1. Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu 214122, P.R.China;
2. Key Laboratory of Eco-Textile, Ministry of Education, Jiangnan University, Wuxi, Jiangsu 214122, P.R.China;

Corresponding?author：

WEI Qufu, Email: qfwei@jiangnan.edu.cn

Keywords：

electrospinning; polymer poly (vinyl alcohol)-stilbazole quaternized; Zein; nanofibers; wound healing material

DOI：

10.7507/1001-5515.201603001

Video：

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A drug vaccarin loaded polymer poly (vinyl alcohol) (PVA)-stilbazole quaternized (SbQ)/Zein was prepared in this study, using co-electrospun method. Then the morphologies and structures of PVA-SbQ/Zein composite nanofibers were observed by scanning electron microscope (SEM) and Fourier transform infrared spectrum (FTIR), respectively. Finally, biocompatibility of PVA-SbQ/Zein nanofibers with drug and without drug was evaluated. Results showed that vaccarin-loaded PVA-SbQ/Zein nanofibers had smooth surface and showed non-toxic to L929 cells. Drug vaccarin could promote cells attachment on nanofibers. The wound healing performance was examined in vivo by rat skin models and histological observations, and PVA-SbQ/Zein/vaccarin nanofibers showed better wound healing performance than petrolatum gauze group.

Citation： QIU Yuyu, CAI Weiwei, QIU Liying, WANG Qingqing, WEI Qufu. Preparation and study of vaccarin-loaded nanofibers used as wound healing material. Journal of Biomedical Engineering, 2017, 34(3): 394-400. doi: 10.7507/1001-5515.201603001 Copy

1.	杜天樂, 劉東林, 景春暉. 創傷敷料對促進創面愈合的研究進展. 醫學綜述, 2015, 21(6): 969-971.
2.	Shankhwar N, Kumar M, Mandal B B, et al. Electrospun polyvinyl alcohol-polyvinyl pyrrolidone nanofibrous membranes for interactive wound dressing application. J Biomater Sci Polym Ed, 2016, 27(3): 247-262.
3.	Unnithan A R, Gnanasekaran G, Sathishkumar Y, et al. Electrospun antibacterial polyurethane-cellulose acetate-zein composite mats for wound dressing. Carbohydr Polym, 2014, 102: 884-892.
4.	Lin Jiantao, Li Caihong, Zhao Yi, et al. Co-electrospun nanofibrous membranes of collagen and zein for wound healing. ACS Appl Mater Interfaces, 2012, 4(2): 1050-1057.
5.	Zhang Hailong, Ma Yong, Sun Xuelong. Recent developments in carbohydrate-decorated targeted drug/gene delivery. Med Res Rev, 2010, 30(2): 270-289.
6.	Wang Zhenbei, Qian Yuna, Li Linhao, et al. Evaluation of emulsion electrospun polycaprolactone/hyaluronan/epidermal growth factor nanofibrous scaffolds for wound healing. J Biomater Appl, 2016, 30(6): 686-698.
7.	謝鳳珊, 馮磊, 馬麗萍, 等. 王不留行黃酮苷對過氧化氫和高糖誘導損傷的人臍靜脈內皮細胞的保護作用. 天然產物研究與開發, 2014(07): 1009-1013.
8.	Xie Fengshan, Feng Lei, Cai Weiwei, et al. Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo. Mol Med Rep, 2015, 12(1): 1131-1136.
9.	Askari P, Zahedi P, Rezaeian I. Three-layered electrospun PVA/PCL/PVA nanofibrous mats containing tetracycline hydrochloride and phenytoin Sodium: A case study on sustained control release, antibacterial, and cell culture properties. J Appl Polym Sci, 2016, 133(16). DOI: 10.1002/app.43309.
10.	Llorens E, del Valle L J, Puiggalí J. Multifunctional ternary drug-loaded electrospun scaffolds. J Appl Polym Sci, 2016, 133(8). DOI: 10.1002/app.42751.
11.	Cui Jing, Qiu Liying, Qiu Yuyu, et al. Co-electrospun nanofibers of PVA-SbQ and Zein for wound healing. J Appl Polym Sci, 2015, 132(39). DOI: 10.1002/app.42565.
12.	余珍, 章志量, 尹洪萍, 等. 殼聚糖天然高分子衍生物促進大鼠皮膚愈合. 生物醫學工程學雜志, 2015, 31(1): 142-145.
13.	Luo Y, Wang T T T, Teng Z, et al. Encapsulation of indole-3-carbinol and 3, 3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. Food Chem, 2013, 139(1/4): 224-230.
14.	Tao Youhua, Xu Jing, Chen Mingqing, et al. Core cross-linked hyaluronan-styrylpyridinium micelles as a novel carrier for paclitaxel. Carbohydr Polym, 2012, 88(1): 118-124.
15.	Kidoaki S, Kwon I K, Matsuda T. Mesoscopic spatial designs of nano-and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques. Biomaterials, 2005, 26(1): 37-46.
16.	Luo Yanling, Zhang Changhu, Xu Feng, et al. Novel THTPBA/PEG-derived highly branched polyurethane scaffolds with improved mechanical property and biocompatibility. Polym Adv Technol, 2012, 23(3): 551-557.
17.	趙娜, 魏坤, 苗國厚, 等. MTT 法評價鑭原位改性 HMS 材料的細胞毒性. 中國組織工程研究與臨床康復, 2010, 14(25): 4603-4606.
18.	Mohamad N, Mohd Amin M C, Pandey M, et al. Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation: accelerated burn wound healing in an animal model. Carbohydr Polym, 2014, 114: 312-320.

1. 杜天樂, 劉東林, 景春暉. 創傷敷料對促進創面愈合的研究進展. 醫學綜述, 2015, 21(6): 969-971.
2. Shankhwar N, Kumar M, Mandal B B, et al. Electrospun polyvinyl alcohol-polyvinyl pyrrolidone nanofibrous membranes for interactive wound dressing application. J Biomater Sci Polym Ed, 2016, 27(3): 247-262.
3. Unnithan A R, Gnanasekaran G, Sathishkumar Y, et al. Electrospun antibacterial polyurethane-cellulose acetate-zein composite mats for wound dressing. Carbohydr Polym, 2014, 102: 884-892.
4. Lin Jiantao, Li Caihong, Zhao Yi, et al. Co-electrospun nanofibrous membranes of collagen and zein for wound healing. ACS Appl Mater Interfaces, 2012, 4(2): 1050-1057.
5. Zhang Hailong, Ma Yong, Sun Xuelong. Recent developments in carbohydrate-decorated targeted drug/gene delivery. Med Res Rev, 2010, 30(2): 270-289.
6. Wang Zhenbei, Qian Yuna, Li Linhao, et al. Evaluation of emulsion electrospun polycaprolactone/hyaluronan/epidermal growth factor nanofibrous scaffolds for wound healing. J Biomater Appl, 2016, 30(6): 686-698.
7. 謝鳳珊, 馮磊, 馬麗萍, 等. 王不留行黃酮苷對過氧化氫和高糖誘導損傷的人臍靜脈內皮細胞的保護作用. 天然產物研究與開發, 2014(07): 1009-1013.
8. Xie Fengshan, Feng Lei, Cai Weiwei, et al. Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo. Mol Med Rep, 2015, 12(1): 1131-1136.
9. Askari P, Zahedi P, Rezaeian I. Three-layered electrospun PVA/PCL/PVA nanofibrous mats containing tetracycline hydrochloride and phenytoin Sodium: A case study on sustained control release, antibacterial, and cell culture properties. J Appl Polym Sci, 2016, 133(16). DOI: 10.1002/app.43309.
10. Llorens E, del Valle L J, Puiggalí J. Multifunctional ternary drug-loaded electrospun scaffolds. J Appl Polym Sci, 2016, 133(8). DOI: 10.1002/app.42751.
11. Cui Jing, Qiu Liying, Qiu Yuyu, et al. Co-electrospun nanofibers of PVA-SbQ and Zein for wound healing. J Appl Polym Sci, 2015, 132(39). DOI: 10.1002/app.42565.
12. 余珍, 章志量, 尹洪萍, 等. 殼聚糖天然高分子衍生物促進大鼠皮膚愈合. 生物醫學工程學雜志, 2015, 31(1): 142-145.
13. Luo Y, Wang T T T, Teng Z, et al. Encapsulation of indole-3-carbinol and 3, 3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. Food Chem, 2013, 139(1/4): 224-230.
14. Tao Youhua, Xu Jing, Chen Mingqing, et al. Core cross-linked hyaluronan-styrylpyridinium micelles as a novel carrier for paclitaxel. Carbohydr Polym, 2012, 88(1): 118-124.
15. Kidoaki S, Kwon I K, Matsuda T. Mesoscopic spatial designs of nano-and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques. Biomaterials, 2005, 26(1): 37-46.
16. Luo Yanling, Zhang Changhu, Xu Feng, et al. Novel THTPBA/PEG-derived highly branched polyurethane scaffolds with improved mechanical property and biocompatibility. Polym Adv Technol, 2012, 23(3): 551-557.
17. 趙娜, 魏坤, 苗國厚, 等. MTT 法評價鑭原位改性 HMS 材料的細胞毒性. 中國組織工程研究與臨床康復, 2010, 14(25): 4603-4606.
18. Mohamad N, Mohd Amin M C, Pandey M, et al. Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation: accelerated burn wound healing in an animal model. Carbohydr Polym, 2014, 114: 312-320.

Journal of Biomedical Engineering

Preparation and study of vaccarin-loaded nanofibers used as wound healing material

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