Research Progress of Silk Fibroin As a Drug Delivery Materials_Journal of Biomedical Engineering

Authors：

JILijing , KEJing , JIALan , GUOLi ,  ZHUJingxin

College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China;

Corresponding?author：

ZHUJingxin, Email: zhujingxin@tyut.edu.cn

Keywords：

silk fibroin; drug release; carrier

DOI：

10.7507/1001-5515.20150241

Video：

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Recently, drug delivery materials have become the hotspot of medical study. Suitable delivery material plays an important role in constructing an excellent drug delivery system. Silk fibroin is a naturally occurring protein polymer with excellent biocompatibility, remarkable mechanical properties, biodegradability and outstanding processability. Due to its unique properties, silk fibroin has become a favorable carrier material for the incorporation and delivery of a range of therapeutic agents. Based on the structure and characteristics of silk fibroin, this article provides an overview of the recent research progress of silk fibroin used as drug delivery materials.

Citation： JILijing, KEJing, JIALan, GUOLi, ZHUJingxin. Research Progress of Silk Fibroin As a Drug Delivery Materials. Journal of Biomedical Engineering, 2015, 32(6): 1364-1368. doi: 10.7507/1001-5515.20150241 Copy

1.	袁青青.再生絲蛋白材料的制備及其結構與性能的研究[D].上海:復旦大學, 2010.
2.	INOUE S, TANAKA K, ARISAKA F, et al. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with 6:6:1 molar ratio[J]. J Biol Chem, 2000, 275(51):40517-40528.
3.	韋俏娜, 馬林, 黃愛民, 等.甲醇-水混合溶劑后處理制備絲素蛋白膜及其藥物釋放研究[J].化學學報, 2012, 70(6):714-720.
4.	黃溪, 王芋驍, 董燕, 等.絲素蛋白/聚乙二醇薄膜結構性質和藥物釋放研究[J].廣西大學學報:自然科學版, 2013, 38(3):576-583.
5.	SEIB F P, KAPLAN D L. Doxorubicin-loaded silk films:Drug-silk interactions and in vivo performance in human orthotopic breast cancer[J]. Biomaterials, 2012, 33(33):8442-8450.
6.	PRITCHARD E M, SZYBALA C, BOISON D, et al. Silk fibroin encapsulated powder reservoirs for sustained release of adenosine[J]. J Contr Rel, 2010, 144(2):159-167.
7.	ZHOU Jian, FANG Taolin, WEN Jianchuan, et al. Silk coating on poly(epsilon-caprolactone) microspheres for the delayed release of vancomycin[J]. J Microencapsul, 2011, 28(2):99-107.
8.	PRITCHARD E M, VALENTIN T, PANILAITIS B A, et al. Antibiotic-releasing silk biomaterials for infection prevention and treatment[J]. Adv Funct Mater, 2013, 23(7):854-861.
9.	ZHAO Zheng, CHEN Aizheng, LI Yi, et al. Fabrication of silk fibroin nanoparticles for controlled drug delivery[J]. J Nanopart Res, 2012, 14(4):1-10.
10.	吳豪翔.一種絲素微球的制備方法:中國, 201310228078.4[P].2013-10-09.
11.	黃永利, 呂強, 李明忠, 等.電場調控載藥絲素蛋白微球的制備[J].科學通報, 2011, 56(13):1013-1018.
12.	PARK C H, JEONG L, CHO D, et al. Effect of methylcellulose on the formation and drug release behavior of silk fibroin hydrogel[J]. Carbohydr Polym, 2013, 98(1):1179-1185.
13.	馬曉曄, 施麗君, 周涓, 等.聚丙烯酸鈉和絲素蛋白自膨脹水凝膠的制備及其釋藥性能[J].有機化學, 2013, 33(5):1080-1087.
14.	SEIB F P, PRITCHARD E M, KAPLAN D L. Self-Assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer[J]. Adv Funct Mater, 2013, 23(1):58-65.
15.	王立新, 張幼珠, 何莉.靜電紡再生絲素納米纖維載藥體系研究[J].絲綢, 2007(6):17-19.
16.	ELAKKIYA T, MALARVIZHI G, RAJIV S A. Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery[J]. Polym Int, 2014, 63(1):100-105.
17.	SHENG Xiaoyue, FAN Linpeng, HE Chuanglong, et al. Vitamin E-loaded silk fibroin nanofibrous mats fabricated by green process for skin care application[J]. Int J Biol Macromol, 2013, 56:49-56.
18.	KASOJU N, BORA U. Fabrication and characterization of curcumin-releasing silk fibroin scaffold[J]. J Biomed Mater Res B Appl Biomater, 2012, 100B(7):1854-1866.
19.	馬寅孫, 蔡玉榮, 劉琳, 等.肝素化絲素支架作為骨形態發生蛋白-2緩釋載體的研究[J].化學學報, 2012, 70(4):479-484.
20.	ZHANG Yufeng, CHENG Ning, MIRON R, et al. Delivery of PDGF-B and BMP-7 by mesoporous bioglass/silk fibrin scaffolds for the repair of osteoporotic defects[J]. Biomaterials, 2012, 33(28):6698-6708.
21.	NUMATA K, YAMAZAKI S, NAGA N. Biocompatible and biodegradable dual-drug release system based on silk hydrogel containing silk nanoparticles[J]. Biomacromolecules, 2012, 13(5):1383-1389.
22.	WILZ A, PRITCHARD E M, LI Tianfu, et al. Silk polymer-based adenosine release:therapeutic potential for epilepsy[J]. Biomaterials, 2008, 29(26):3609-3616.
23.	FAROKHI M, MOTTAGHITALAB F, AI J, et al. Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold[J]. Int J Pharm, 2013, 454(1):216-225.
24.	YOU Xueqiu, CHANG J H, JU B K, et al. Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng C Mater Biol Appl, 2011, 31(8):1632-1636.
25.	DEMUTH P C, MIN Y, IRVINE D J, et al. Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization[J]. Adv Healthc Mater, 2014, 3(1):47-58.
26.	SHCHEPELINA O, DRACHUK I, GUPTA M K, et al. Silk-on-silk layer-by-layer microcapsules[J]. Advanced Materials, 2011, 23(40):4655-4660.
27.	ZARKOOB S, EBY R K, RENEKER D H, et al. Structure and morphology of electrospun silk nanofibers[J]. Polymer (Guildf), 2004, 45(11):3973-3977.
28.	柯靖, 朱晶心, 馬彥龍, 等.不同礦化方式下絲素蛋白電紡纖維的仿生礦化[J].絲綢, 2014, 51(5):1-6.
29.	游學秋, 盧家賓, 王曉誠.一種絲素微針系統和絲素納米顆粒及制備:中國, 201210048238.2[P].2012-07-18.

1. 袁青青.再生絲蛋白材料的制備及其結構與性能的研究[D].上海:復旦大學, 2010.
2. INOUE S, TANAKA K, ARISAKA F, et al. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with 6:6:1 molar ratio[J]. J Biol Chem, 2000, 275(51):40517-40528.
3. 韋俏娜, 馬林, 黃愛民, 等.甲醇-水混合溶劑后處理制備絲素蛋白膜及其藥物釋放研究[J].化學學報, 2012, 70(6):714-720.
4. 黃溪, 王芋驍, 董燕, 等.絲素蛋白/聚乙二醇薄膜結構性質和藥物釋放研究[J].廣西大學學報:自然科學版, 2013, 38(3):576-583.
5. SEIB F P, KAPLAN D L. Doxorubicin-loaded silk films:Drug-silk interactions and in vivo performance in human orthotopic breast cancer[J]. Biomaterials, 2012, 33(33):8442-8450.
6. PRITCHARD E M, SZYBALA C, BOISON D, et al. Silk fibroin encapsulated powder reservoirs for sustained release of adenosine[J]. J Contr Rel, 2010, 144(2):159-167.
7. ZHOU Jian, FANG Taolin, WEN Jianchuan, et al. Silk coating on poly(epsilon-caprolactone) microspheres for the delayed release of vancomycin[J]. J Microencapsul, 2011, 28(2):99-107.
8. PRITCHARD E M, VALENTIN T, PANILAITIS B A, et al. Antibiotic-releasing silk biomaterials for infection prevention and treatment[J]. Adv Funct Mater, 2013, 23(7):854-861.
9. ZHAO Zheng, CHEN Aizheng, LI Yi, et al. Fabrication of silk fibroin nanoparticles for controlled drug delivery[J]. J Nanopart Res, 2012, 14(4):1-10.
10. 吳豪翔.一種絲素微球的制備方法:中國, 201310228078.4[P].2013-10-09.
11. 黃永利, 呂強, 李明忠, 等.電場調控載藥絲素蛋白微球的制備[J].科學通報, 2011, 56(13):1013-1018.
12. PARK C H, JEONG L, CHO D, et al. Effect of methylcellulose on the formation and drug release behavior of silk fibroin hydrogel[J]. Carbohydr Polym, 2013, 98(1):1179-1185.
13. 馬曉曄, 施麗君, 周涓, 等.聚丙烯酸鈉和絲素蛋白自膨脹水凝膠的制備及其釋藥性能[J].有機化學, 2013, 33(5):1080-1087.
14. SEIB F P, PRITCHARD E M, KAPLAN D L. Self-Assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer[J]. Adv Funct Mater, 2013, 23(1):58-65.
15. 王立新, 張幼珠, 何莉.靜電紡再生絲素納米纖維載藥體系研究[J].絲綢, 2007(6):17-19.
16. ELAKKIYA T, MALARVIZHI G, RAJIV S A. Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery[J]. Polym Int, 2014, 63(1):100-105.
17. SHENG Xiaoyue, FAN Linpeng, HE Chuanglong, et al. Vitamin E-loaded silk fibroin nanofibrous mats fabricated by green process for skin care application[J]. Int J Biol Macromol, 2013, 56:49-56.
18. KASOJU N, BORA U. Fabrication and characterization of curcumin-releasing silk fibroin scaffold[J]. J Biomed Mater Res B Appl Biomater, 2012, 100B(7):1854-1866.
19. 馬寅孫, 蔡玉榮, 劉琳, 等.肝素化絲素支架作為骨形態發生蛋白-2緩釋載體的研究[J].化學學報, 2012, 70(4):479-484.
20. ZHANG Yufeng, CHENG Ning, MIRON R, et al. Delivery of PDGF-B and BMP-7 by mesoporous bioglass/silk fibrin scaffolds for the repair of osteoporotic defects[J]. Biomaterials, 2012, 33(28):6698-6708.
21. NUMATA K, YAMAZAKI S, NAGA N. Biocompatible and biodegradable dual-drug release system based on silk hydrogel containing silk nanoparticles[J]. Biomacromolecules, 2012, 13(5):1383-1389.
22. WILZ A, PRITCHARD E M, LI Tianfu, et al. Silk polymer-based adenosine release:therapeutic potential for epilepsy[J]. Biomaterials, 2008, 29(26):3609-3616.
23. FAROKHI M, MOTTAGHITALAB F, AI J, et al. Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold[J]. Int J Pharm, 2013, 454(1):216-225.
24. YOU Xueqiu, CHANG J H, JU B K, et al. Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng C Mater Biol Appl, 2011, 31(8):1632-1636.
25. DEMUTH P C, MIN Y, IRVINE D J, et al. Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization[J]. Adv Healthc Mater, 2014, 3(1):47-58.
26. SHCHEPELINA O, DRACHUK I, GUPTA M K, et al. Silk-on-silk layer-by-layer microcapsules[J]. Advanced Materials, 2011, 23(40):4655-4660.
27. ZARKOOB S, EBY R K, RENEKER D H, et al. Structure and morphology of electrospun silk nanofibers[J]. Polymer (Guildf), 2004, 45(11):3973-3977.
28. 柯靖, 朱晶心, 馬彥龍, 等.不同礦化方式下絲素蛋白電紡纖維的仿生礦化[J].絲綢, 2014, 51(5):1-6.
29. 游學秋, 盧家賓, 王曉誠.一種絲素微針系統和絲素納米顆粒及制備:中國, 201210048238.2[P].2012-07-18.

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