Progress in Proteomic Study of the Penicillin Producer---<i>Penicillium Chrysogenum</i>_Journal of Biomedical Engineering

Authors：

WANGShun , WANGPeihong , ZHANGNan ,  GAORuichang

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

Corresponding?author：

GAORuichang, Email: pharmacy@tju.edu.cn

Keywords：

penicillin; Penicillium chrysogenum; proteome; proteomics

DOI：

10.7507/1001-5515.20150239

Video：

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Penicillin is a kind ofβ-lactam drug which has been applied in the clinical treatment firstly in the world, and it has still been widely used at present. The synthesis and regulation mechanism of Penicillium chrysogenum, which is used to produce penicillin, has been studied quite maturely, but its proteomics research started relatively late and fewer reports were published. This paper reviews the synthesis and application of penicillin, transformation of Penicillium chrysogenum, and the research progress of its proteomics. On this basis, the study highlights the advantages of proteomics in the research of protein expression.

Citation： WANGShun, WANGPeihong, ZHANGNan, GAORuichang. Progress in Proteomic Study of the Penicillin Producer---Penicillium Chrysogenum. Journal of Biomedical Engineering, 2015, 32(6): 1354-1358. doi: 10.7507/1001-5515.20150239 Copy

1.	劉麗華.β-內酰胺類抗生素的臨床應用[J].中國藥物經濟學, 2013(6):245-246.
2.	VAN DEN BERG M A. Functional characterisation of penicillin production strains[J]. Fungal Biol Rev, 2010, 24(1-2):73-78.
3.	VOIGT K, KIRK P M. Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi:impact in applied microbiology and environmental biotechnology[J]. Appl Microbiol Biotechnol, 2011, 90(1):41-57.
4.	SCHECKHUBER C Q, VEENHUIS M, VAN DER KLEI I J. Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction[J]. Metab Eng, 2013, 18:36-43.
5.	OZCENGIZ G, DEMAIN A L. Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation[J]. Biotechnol Adv, 2013, 31(2):287-311.
6.	VEIGA T, SOLIS-ESCALANTE D, ROMAGNOLI G, et al. Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum[J]. Eukaryot Cell, 2012, 11(2):238-249.
7.	MARTíN J F, GARCíA-ESTRADA C, ULLáN R V. Transport of substrates into peroxisomes:the paradigm ofβ-lactam biosynthetic intermediates[J]. Biomol Concepts, 2013, 4(2):197-211.
8.	FERNáNDEZ-AGUADO M, ULLáN R V, TEIJEIRA F, et al. The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum[J]. Appl Microbiol Biotechnol, 2013, 97(7):3073-3084.
9.	錢小紅.定量蛋白質組學分析方法[J].色譜, 2013, 31(8):719-723.
10.	姜麗麗, 郝欣霞, 張東澤.有關蛋白質組學概述[J].內蒙古科技與經濟, 2013, 277(3):108-109.
11.	RAY S, REDDY P J, JAIN R, et al. Proteomic technologies for the identification of disease biomarkers in serum:advances and challenges ahead[J]. Proteomics, 2011, 11(11):2139-2161.
12.	VILLANUEVA J, CARRASCAL M, ABIAN J. Isotope dilution mass spectrometry for absolute quantification in proteomics:Concepts and strategies[J]. J Proteomics, 2014, 96:184-199.
13.	DíEZ P, DASILVA N, GONZáLEZ-GONZáLEZ M, et al. Data analysis strategies for protein microarrays[J]. Microarrays, 2012, 1(2):64-83.
14.	張瑩, 楊芃原, 陸豪杰.基于多級質譜的蛋白質組定量新方法新技術進展[J].色譜, 2013, 31(6):503-509.
15.	袁建豐, 李林林, 孫敏華, 等.iTRAQ標記技術及其在微生物比較蛋白質組學中的研究進展[J].中國預防獸醫學報, 2013, 35(10):859-862.
16.	JIANG Yan, GUO Liang, XIE Li-qi, et al. Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS[J]. J Proteome Res, 2014, 13(3):1307-1314.
17.	胡彬彬, 林連兵, 魏云林, 等.一種高效的真菌總蛋白質提取方法[J].中國生物工程雜志, 2013, 33(9):53-58.
18.	THIEDE B, KOEHLER C J, STROZYNSKI M, et al. High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture (SILAC), two-dimensional gel electrophoresis (2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer[J]. Mol Cell Proteomics, 2013, 12(2):529-538.
19.	WU Xiaolin, GONG Fangping, WANG Wei. Protein extraction from plant tissues for 2DE and its application in proteomic analysis[J]. Proteomics, 2014, 14(6):645-658.
20.	劉紅, 劉艷, 謝麗萍, 等.頂頭孢霉蛋白質組的制備[J].中國醫藥工業雜志, 2011, 42(6):412-415.
21.	MARTíNEZ-ESTESO M J, VILELLA-ANTóN M T, PEDRE?O M A, et al. iTRAQ-based protein profiling provides insights into the central metabolism changes driving grape berry development and ripening[J]. BMC Plant Biol, 2013, 13(167):1-20.
22.	崔少飛.利迪鏈霉菌對外源谷氨酸和脯氨酸的代謝響應研究[D].天津:天津大學, 2013.
23.	JAMI M S, BARREIRO C, GARCíA-ESTRADA C, et al. Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement[J]. Molecular & Cellular Proteomics, 2010, 9(6):1182-1198.
24.	BARREIRO C, MARTíN J F, GARCíA-ESTRADA C. Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum[J]. J Biomed Biotechnol, 2012, 2012:105109.
25.	GARCíA-ESTRADA C, BARREIRO C, JAMI M S, et al. The inducers 1, 3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction[J]. J Proteomics, 2013, 85:129-159.
26.	MARTíN J, GARCíA-ESTRADA C, RUMBERO A, et al. Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum[J]. Appl Environ Microbiol, 2011, 77(16):5688-5696.
27.	GOODMAN V, MVLLER A, GR?GER-ARNDT H, et al. Identification of spore specific allergens from Penicillium chrysogenum[J]. J Integr OMICS, 2011, 1(2):272-279.
28.	JAMI M S, GARCíA-ESTRADA C, BARREIRO C, et al. The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology[J]. Mol Cell Proteomics, 2010, 9(12):2729-2744.
29.	NICKEL W, RABOUILLE C. Mechanisms of regulated unconventional protein secretion[J]. Nat Rev Mol Cell Biol, 2009, 10(2):148-155.
30.	KIEL J A, VAN DEN BERG M A, FUSETTI F, et al. Matching the proteome to the genome:the microbody of penicillin-producing Penicillium chrysogenum cells[J]. Funct Integr Genomics, 2009, 9(2):167-184.

1. 劉麗華.β-內酰胺類抗生素的臨床應用[J].中國藥物經濟學, 2013(6):245-246.
2. VAN DEN BERG M A. Functional characterisation of penicillin production strains[J]. Fungal Biol Rev, 2010, 24(1-2):73-78.
3. VOIGT K, KIRK P M. Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi:impact in applied microbiology and environmental biotechnology[J]. Appl Microbiol Biotechnol, 2011, 90(1):41-57.
4. SCHECKHUBER C Q, VEENHUIS M, VAN DER KLEI I J. Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction[J]. Metab Eng, 2013, 18:36-43.
5. OZCENGIZ G, DEMAIN A L. Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation[J]. Biotechnol Adv, 2013, 31(2):287-311.
6. VEIGA T, SOLIS-ESCALANTE D, ROMAGNOLI G, et al. Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum[J]. Eukaryot Cell, 2012, 11(2):238-249.
7. MARTíN J F, GARCíA-ESTRADA C, ULLáN R V. Transport of substrates into peroxisomes:the paradigm ofβ-lactam biosynthetic intermediates[J]. Biomol Concepts, 2013, 4(2):197-211.
8. FERNáNDEZ-AGUADO M, ULLáN R V, TEIJEIRA F, et al. The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum[J]. Appl Microbiol Biotechnol, 2013, 97(7):3073-3084.
9. 錢小紅.定量蛋白質組學分析方法[J].色譜, 2013, 31(8):719-723.
10. 姜麗麗, 郝欣霞, 張東澤.有關蛋白質組學概述[J].內蒙古科技與經濟, 2013, 277(3):108-109.
11. RAY S, REDDY P J, JAIN R, et al. Proteomic technologies for the identification of disease biomarkers in serum:advances and challenges ahead[J]. Proteomics, 2011, 11(11):2139-2161.
12. VILLANUEVA J, CARRASCAL M, ABIAN J. Isotope dilution mass spectrometry for absolute quantification in proteomics:Concepts and strategies[J]. J Proteomics, 2014, 96:184-199.
13. DíEZ P, DASILVA N, GONZáLEZ-GONZáLEZ M, et al. Data analysis strategies for protein microarrays[J]. Microarrays, 2012, 1(2):64-83.
14. 張瑩, 楊芃原, 陸豪杰.基于多級質譜的蛋白質組定量新方法新技術進展[J].色譜, 2013, 31(6):503-509.
15. 袁建豐, 李林林, 孫敏華, 等.iTRAQ標記技術及其在微生物比較蛋白質組學中的研究進展[J].中國預防獸醫學報, 2013, 35(10):859-862.
16. JIANG Yan, GUO Liang, XIE Li-qi, et al. Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS[J]. J Proteome Res, 2014, 13(3):1307-1314.
17. 胡彬彬, 林連兵, 魏云林, 等.一種高效的真菌總蛋白質提取方法[J].中國生物工程雜志, 2013, 33(9):53-58.
18. THIEDE B, KOEHLER C J, STROZYNSKI M, et al. High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture (SILAC), two-dimensional gel electrophoresis (2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer[J]. Mol Cell Proteomics, 2013, 12(2):529-538.
19. WU Xiaolin, GONG Fangping, WANG Wei. Protein extraction from plant tissues for 2DE and its application in proteomic analysis[J]. Proteomics, 2014, 14(6):645-658.
20. 劉紅, 劉艷, 謝麗萍, 等.頂頭孢霉蛋白質組的制備[J].中國醫藥工業雜志, 2011, 42(6):412-415.
21. MARTíNEZ-ESTESO M J, VILELLA-ANTóN M T, PEDRE?O M A, et al. iTRAQ-based protein profiling provides insights into the central metabolism changes driving grape berry development and ripening[J]. BMC Plant Biol, 2013, 13(167):1-20.
22. 崔少飛.利迪鏈霉菌對外源谷氨酸和脯氨酸的代謝響應研究[D].天津:天津大學, 2013.
23. JAMI M S, BARREIRO C, GARCíA-ESTRADA C, et al. Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement[J]. Molecular & Cellular Proteomics, 2010, 9(6):1182-1198.
24. BARREIRO C, MARTíN J F, GARCíA-ESTRADA C. Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum[J]. J Biomed Biotechnol, 2012, 2012:105109.
25. GARCíA-ESTRADA C, BARREIRO C, JAMI M S, et al. The inducers 1, 3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction[J]. J Proteomics, 2013, 85:129-159.
26. MARTíN J, GARCíA-ESTRADA C, RUMBERO A, et al. Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum[J]. Appl Environ Microbiol, 2011, 77(16):5688-5696.
27. GOODMAN V, MVLLER A, GR?GER-ARNDT H, et al. Identification of spore specific allergens from Penicillium chrysogenum[J]. J Integr OMICS, 2011, 1(2):272-279.
28. JAMI M S, GARCíA-ESTRADA C, BARREIRO C, et al. The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology[J]. Mol Cell Proteomics, 2010, 9(12):2729-2744.
29. NICKEL W, RABOUILLE C. Mechanisms of regulated unconventional protein secretion[J]. Nat Rev Mol Cell Biol, 2009, 10(2):148-155.
30. KIEL J A, VAN DEN BERG M A, FUSETTI F, et al. Matching the proteome to the genome:the microbody of penicillin-producing Penicillium chrysogenum cells[J]. Funct Integr Genomics, 2009, 9(2):167-184.

Journal of Biomedical Engineering

Progress in Proteomic Study of the Penicillin Producer---Penicillium Chrysogenum

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