Research Progress of the Regulation Function of Epigenetics on Bone Marrow Mesenchymal Stem Cells_Journal of Biomedical Engineering

Authors：

CHENZhihao ¹ , FANGShubin ¹ ,  TIANJing ²

1. Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China;
2. Orthopedic Center, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China;

Corresponding?author：

TIANJing, Email: tian_jing6723@aliyun.com

Keywords：

DNA methylation; histone acetylation; small interfering RNA; microRNA; bone marrow mesenchymal stem cell

DOI：

10.7507/1001-5515.20150123

Video：

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The regulation of epigenetics on bone marrow mesenchymal stem cells (BMSCs) has been a research hot spot in medical area. This paper mainly summarizes the progress of the regulation of DNA methylation, histone acetylation, small interfering RNA (siRNA) induced gene silence and microRNA (miRNA) on BMSCs. Our analysis shows that the regulation of epigenetics on BMSCs plays a significant role in the repair of bone tissue, nervous tissue and cardiac muscle.

Citation： CHENZhihao, FANGShubin, TIANJing. Research Progress of the Regulation Function of Epigenetics on Bone Marrow Mesenchymal Stem Cells. Journal of Biomedical Engineering, 2015, 32(3): 680-683. doi: 10.7507/1001-5515.20150123 Copy

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2.	PITTENGER M F, MACKAY A M, BECK S C, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284(5411):143-147.
3.	EGGER G, LIANG Gangning, APARICIO A, et al. Epigenetics in human disease and prospects for epigenetic therapy[J]. Nature, 2004, 429(6990):457-463.
4.	CHOI M R, IN Y H, PARK J, et al. Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture[J]. Exp Mol Med, 2012, 44(8):503-512.
5.	NAEEM N, HANEEF K, KABIR N, et al. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes[J]. Cardiovasc Ther, 2013, 31(4):201-209.
6.	SMITH Z D, MEISSNER A. DNA methylation:roles in mammalian development[J]. Nat Rev Genet, 2013, 14(3):204-220.
7.	DONG Xuejun, PAN Ruolang, ZHANG Hui, et al. Modification of histone acetylation facilitates hepatic differentiation of human bone marrow mesenchymal stem cells[J]. PLoS One, 2013, 8(5):e63405.
8.	陸超, 陳吉慶, 周國平, 等.Par-4基因沉默對人骨髓間充質干細胞中Smac基因表達和半胱氨酸蛋白水解酶3酶活性的影響及其抗凋亡作用Par-4基因沉默對人骨髓間充質干細胞中Smac基因表達和半胱氨酸蛋白水解酶3酶活性的影響及其抗凋亡作用[J].中華醫學雜志, 2008, 88(6):411-415.
9.	陸超, 陳吉慶, 周國平, 等.小RNA干擾靶向抑制Par-4基因表達對人骨髓間充質干細胞凋亡的影響[J].中華兒科雜志, 2008, 46(11):836-841.
10.	HUA Ping, LIU Libao, LIU Jialiang, et al. Inhibition of apoptosis by knockdown of caspase-3 with siRNA in rat bone marrow mesenchymal stem cells[J]. Exp Biol Med (Maywood), 2013, 238(9):991-998.
11.	周燕, 陳奎生, 高劍波, 等. miR-124-1促進大鼠骨髓間充質干細胞神經分化的實驗研究[J].中國當代兒科雜志, 2012, 14(3):215-220.
12.	WU Rui, WANG Na, LI Min, et al. Experimental study on the facilitative effects of miR-125b on the differentiation of rat bone marrow mesenchymal stem cells into neuron-like cells[J]. Cell Biol Int, 2013, 37(8):812-819.
13.	JING Lijun, JIA Yonglin, LU Jingjing, et al. MicroRNA-9 promotes differentiation of mouse bone mesenchymal stem cells into neurons by Notch signaling[J]. Neuroreport, 2011, 22(5):206-211.
14.	HAN Rui, KAN Quancheng, SUN Yingpu, et al. MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521[J]. Neurosci Lett, 2012, 515(2):147-152.
15.	魏均強, 張伯勛, 鄭曉飛, 等.誘導hBMSCs成骨分化中微小RNA和靶基因表達水平的變化[J].中國修復重建外科雜志, 2012, 26(4):483-488.
16.	魏均強, 陳華, 鄭曉飛, 等.hsa-miR-654-5p通過抑制骨形態發生蛋白2調控人骨髓基質干細胞成骨分化[J].南方醫科大學學報, 2012, 32(3):291-295.
17.	陸細紅, 鄧敏, 賀洪輝, 等.miR-125b通過靶向抑制Smad4調控骨髓間充質干細胞成骨分化[J].中南大學學報(醫學版), 2013, 38(4):341-346.
18.	BAGLìO S R, DEVESCOVI V, GRANCHI D, et al. MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31[J]. Gene, 2013, 527(1):321-331.
19.	匡威, 譚家莉, 張紅梅, 等.miR-146a調控骨髓間充質干細胞成骨分化的機制研究[J].生物醫學工程與臨床, 2011, 15(5):413-416, 封3.
20.	范龍坤, 華澤權, 金巖, 等.miR-26a對小鼠骨髓間充質干細胞成骨分化能力的調控作用[J].中國醫科大學學報, 2012, 41(7):591-595, 606.
21.	王海鵬, 高杰, 張小平, 等.miR-30a-5P在人骨髓間充質干細胞向成骨細胞分化過程中的生物學功能及驗證[J].中國醫藥導報, 2011, 8(16):23-26, 封3.
22.	LIU Ju-li, JIANG Li, LIN Qiu-xiong, et al. MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro[J]. Life Sci, 2012, 90(25-26):1020-1026.
23.	高杰, 韓建偉, 朱洪繁, 等.miR-424在人骨髓間充質干細胞分化過程中的表達[J].中華創傷雜志, 2010, 26(8):752-756.
24.	張鷺鷺, 劉驚今, 王永順, 等.microRNA499慢病毒載體轉染誘導大鼠骨髓間充質干細胞向心肌樣細胞分化[J].現代生物醫學進展, 2012, 12(26):5027-5031.

1. ?INBAR-FEIGENBERG M, CHOUFANI S, BUTCHER D T, et al. Basic concepts of epigenetics[J]. Fertil Steril, 2013, 99(3):607-615.
2. PITTENGER M F, MACKAY A M, BECK S C, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284(5411):143-147.
3. EGGER G, LIANG Gangning, APARICIO A, et al. Epigenetics in human disease and prospects for epigenetic therapy[J]. Nature, 2004, 429(6990):457-463.
4. CHOI M R, IN Y H, PARK J, et al. Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture[J]. Exp Mol Med, 2012, 44(8):503-512.
5. NAEEM N, HANEEF K, KABIR N, et al. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes[J]. Cardiovasc Ther, 2013, 31(4):201-209.
6. SMITH Z D, MEISSNER A. DNA methylation:roles in mammalian development[J]. Nat Rev Genet, 2013, 14(3):204-220.
7. DONG Xuejun, PAN Ruolang, ZHANG Hui, et al. Modification of histone acetylation facilitates hepatic differentiation of human bone marrow mesenchymal stem cells[J]. PLoS One, 2013, 8(5):e63405.
8. 陸超, 陳吉慶, 周國平, 等.Par-4基因沉默對人骨髓間充質干細胞中Smac基因表達和半胱氨酸蛋白水解酶3酶活性的影響及其抗凋亡作用Par-4基因沉默對人骨髓間充質干細胞中Smac基因表達和半胱氨酸蛋白水解酶3酶活性的影響及其抗凋亡作用[J].中華醫學雜志, 2008, 88(6):411-415.
9. 陸超, 陳吉慶, 周國平, 等.小RNA干擾靶向抑制Par-4基因表達對人骨髓間充質干細胞凋亡的影響[J].中華兒科雜志, 2008, 46(11):836-841.
10. HUA Ping, LIU Libao, LIU Jialiang, et al. Inhibition of apoptosis by knockdown of caspase-3 with siRNA in rat bone marrow mesenchymal stem cells[J]. Exp Biol Med (Maywood), 2013, 238(9):991-998.
11. 周燕, 陳奎生, 高劍波, 等. miR-124-1促進大鼠骨髓間充質干細胞神經分化的實驗研究[J].中國當代兒科雜志, 2012, 14(3):215-220.
12. WU Rui, WANG Na, LI Min, et al. Experimental study on the facilitative effects of miR-125b on the differentiation of rat bone marrow mesenchymal stem cells into neuron-like cells[J]. Cell Biol Int, 2013, 37(8):812-819.
13. JING Lijun, JIA Yonglin, LU Jingjing, et al. MicroRNA-9 promotes differentiation of mouse bone mesenchymal stem cells into neurons by Notch signaling[J]. Neuroreport, 2011, 22(5):206-211.
14. HAN Rui, KAN Quancheng, SUN Yingpu, et al. MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521[J]. Neurosci Lett, 2012, 515(2):147-152.
15. 魏均強, 張伯勛, 鄭曉飛, 等.誘導hBMSCs成骨分化中微小RNA和靶基因表達水平的變化[J].中國修復重建外科雜志, 2012, 26(4):483-488.
16. 魏均強, 陳華, 鄭曉飛, 等.hsa-miR-654-5p通過抑制骨形態發生蛋白2調控人骨髓基質干細胞成骨分化[J].南方醫科大學學報, 2012, 32(3):291-295.
17. 陸細紅, 鄧敏, 賀洪輝, 等.miR-125b通過靶向抑制Smad4調控骨髓間充質干細胞成骨分化[J].中南大學學報(醫學版), 2013, 38(4):341-346.
18. BAGLìO S R, DEVESCOVI V, GRANCHI D, et al. MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31[J]. Gene, 2013, 527(1):321-331.
19. 匡威, 譚家莉, 張紅梅, 等.miR-146a調控骨髓間充質干細胞成骨分化的機制研究[J].生物醫學工程與臨床, 2011, 15(5):413-416, 封3.
20. 范龍坤, 華澤權, 金巖, 等.miR-26a對小鼠骨髓間充質干細胞成骨分化能力的調控作用[J].中國醫科大學學報, 2012, 41(7):591-595, 606.
21. 王海鵬, 高杰, 張小平, 等.miR-30a-5P在人骨髓間充質干細胞向成骨細胞分化過程中的生物學功能及驗證[J].中國醫藥導報, 2011, 8(16):23-26, 封3.
22. LIU Ju-li, JIANG Li, LIN Qiu-xiong, et al. MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro[J]. Life Sci, 2012, 90(25-26):1020-1026.
23. 高杰, 韓建偉, 朱洪繁, 等.miR-424在人骨髓間充質干細胞分化過程中的表達[J].中華創傷雜志, 2010, 26(8):752-756.
24. 張鷺鷺, 劉驚今, 王永順, 等.microRNA499慢病毒載體轉染誘導大鼠骨髓間充質干細胞向心肌樣細胞分化[J].現代生物醫學進展, 2012, 12(26):5027-5031.

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