Advances in Treatment of Myocardial Infarction by Mesenchymal Stem Cell Transplantation_Journal of Biomedical Engineering

Authors：

CHENHuizhu , GUOYingkun ,  NINGGang

Department of Medical Imaging, West China Second Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

NINGGang, Email: ng6611@163.com

Keywords：

mesenchymal stem cell; transplantation; myocardial infarction

DOI：

10.7507/1001-5515.20140177

Video：

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Mesenchymal stem cells(MSCs)is a kind of non hematopoietic stem cell from the mesoderm, which can self renew, proliferate and perform multilineage differentiation. Due to the characteristics of acquiring easily and low immunogenicity, it has become the main cell for myocardial infarction. In this article, the biology and the immunology of the MSCs is reviewed, the safety and the validity of the therapy on myocardial infarction with MSCs and the HGF/MSCs is introduced. And furthermore, it also explains the possible mechanism and the problems of how to improve the cardial function.

Citation： CHENHuizhu, GUOYingkun, NINGGang. Advances in Treatment of Myocardial Infarction by Mesenchymal Stem Cell Transplantation. Journal of Biomedical Engineering, 2014, 31(4): 939-944. doi: 10.7507/1001-5515.20140177 Copy

1.	LASALA G P, MINGUELL J J. Bone marrow-derived stem/progenitor cells: their use in clinical studies for the treatment of myocardial infarction[J]. Heart Lung Circ, 2009, 18(3):171-180.
2.	GNECCHI M, DANIELI P, CERVIO E. Mesenchymal stem cell therapy for heart disease[J]. Vascul Pharmacol, 2012, 57(1):48-55.
3.	VONO R, SPINETTI G, GUBERNATOR M, et al. What's new in regene rative medicine: split up of the mesenchymal stem cell family promises new hope for cardiovascular Repair[J]. J Cardiovasc Transl Res, 2012, 5(5):689-699.
4.	KURAITIS D, RUEL M, SUURONEN E J. Mesenchymal stem cell for cardiovascular regeneration[J]. Cardiovasc Drugs Ther, 2011, 25(4): 349-362.
5.	WILLIAMS A R, HARE J M. Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease[J]. Circ Res, 2011, 109(8):923-940.
6.	HAO L, SUN H, WANG J, et al. Mesenchymal stromal cells for cell therapy: besides supporting hematopoiesis[J]. Int J Hematol, 2012, 95(1):34-46.
7.	BADILLO A T, BEGGS K J, JAVAZON E H, et al. Murine bone marrow stromal progenitor cells elicit an in vivo cellular and humoral alloimmune response[J]. Biol Blood Marrow Transplant, 2007, 13(4): 412-422.
8.	HARE J M, TRAVERSE J H, HENRY T D, et al. A randomized, double-blind, placebo-controlled,dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction[J]. J Am Coll Cardiol, 2009, 54(24):2277-2286.
9.	W?HRLE J, MERKLE N, MAIL?NDER V, et al. Results of intracoronary stem cell therapy after acute myocardial infarction[J]. Am J Cardiol, 2010,105(6):804-812.
10.	MADONNA R, CEVIK C, NASSER M, et al. Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regenaration[J]. Thromb Haemost, 2012, 107(4):656-661.
11.	JIN Y N, INUBUSHI M, MASAMOTO K, et al. Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model[J]. Gene Ther, 2012, 19(8):836-843.
12.	LU F, ZHAO X, WU J, et al. MSCs transfected with hepatocyte growth factor or vascular endothelial growth factor improve cardiac function in the infracted porcine heart by increasing angiogenesis and reducing fibrosis[J]. Int J Cardiol, 2012, 8(3): 467-474.
13.	YANG Z J, CHEN B, SHENG Z, et al. Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups[J]. Mol Biol Rep, 2010, 37(4):2075-2081.
14.	SAEED M, SALONER D, DO L, et al. Cardiovascular magnetic resonance imaging in delivering and evaluating the efficacy of hepatocyte growth factor gene in chronic infarct scar[J]. Cardiovasc Revasc Med, 2011, 12(2):111-122.
15.	WANG S, QIN X, SUN D, et al. Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodeling and function improvement in infracted rat hearts[J]. Cell Biochem Funct, 2012, 30(7):574-581.
16.	WEN Z, ZHENG S, ZHOU C, et al. Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction[J]. J Cell Mol Med, 2011, 15(5):1032-1043.
17.	DAYAN V, YANNARELLI G, FILOMENO P, et al. Human mesenchymal stromal cells improve scar thickness without enhancing cardiac function in a chronic ischaemic heart failure model[J]. Interact Cardiovasc Thrac, 2012, 14(5):516-520.
18.	舒永華.心梗后骨髓間充質干細胞移植的最佳時間研究[D]. 遵義醫學院, 2011, 6.
19.	刑云利,沈潞華,趙林,等.干細胞移植治療心肌梗死的時機問題[J]. 臨床和實驗醫學雜志,2011,10(4):298-299.
20.	張雷楊,陳鑫,徐順霖,等. 不同劑量的骨髓間充質干細胞移植與改善缺血心臟功能的量效關系[J]. 中國胸心血管外科臨床雜志,2007,14(6):447-451.
21.	郭啟倉,王玉芳,張宇,等. 不同方法移植骨髓間充質干細胞在體內重要器官的分布及分化[J]. 中國組織工程研究與臨床康復,2010,14(23):4275-4280.
22.	LE VISAGE C, GOURNAY O, BENGUIRAT N, et al. Mesenchymal stem cell delivery into rat infarcted myocardium using a porous polysaccharide-based scaffold: a quantitative comparison with endocardial injection[J]. Tissue Eng Part A, 2012, 18(1-2):35-44.
23.	EUN L Y, SONG B W, CHA M J, et al. Overexpression of phosphoinositide-3-kinase class II alpha enhances mesenchymal stem cell survival in infarcted myocardium[J]. Biochem Biophys Res Commum, 2010, 402(2):272-279.
24.	SHU T, ZENG B, REN X, et al. HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium[J]. Tissue Cell, 2010, 42(4):217-222.
25.	HERRMANN J L, ABARBANELL A M, WEIL B R, et al. Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-α improves acute myocardial function[J]. Am J Physiol Regul Inteqr Comp Physiol, 2010, 299(1): R371-R378.
26.	BAO C, GUO J, ZHENG M, et al. Enhancement of the survival of engrafted mesenchymal stem cells in the ischemic heart by TNFR gene transfection[J]. Biochem Cell Biol, 2010, 88(4):629-634.
27.	TANG J, WANG J, GUO L, et al. Mesenchymal stem cells modified with stromal cell-derived factor 1α improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction[J]. Mol Cells, 2010, 29(1):9-19.
28.	YANG K, XIANG P, ZHANG C, et al. Magnetic resonance evaluation of transplanted mesenchymal stem cells after myocardial infarction in swine[J]. Can J Cardiol, 2011, 27(6):818-825.
29.	LIAN W S, CHENG W T, CHENG C C, et al. In vivo therapy of myocardial infarction with mesenchymal stem cells modified with prostaglandin I synthase gene improves cardiac performance in mice[J]. Life Sci, 2011, 88(9-10):455-464.
30.	NUMASAWA Y, KIMURA T, MIYOSHI S, et al. Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis[J]. Stem Cells, 2011, 29(9):1405-1414.
31.	WANG D, JIN Y, DING C, et al. Intracoronary delivery of mesenchymal stem cells reduces proarrhythmogenic risks in swine with myocardial infarction[J]. Ir J Med Sci, 2011, 180(2):379-385.
32.	TONG Y, XU W, HAN H, et al. Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model[J]. Phytomedicine, 2011, 18(6):443-450.
33.	CHO J, ZHAI P, MAEJIMA Y, et al. Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction[J]. Circ Res, 2011, 108(4):478-489.
34.	SHINMURA D, TOGASHI I, MIYOSHI S, et al. Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and cardiac function[J]. Stem Cells, 2011, 29(2):357-366.
35.	CHI N H, YANG M C, CHUNG T W, et al. Cardiac repair achieved by bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid patches in a rat of myocardial infarction model[J]. Biomaterials, 2012, 33(22):5541-5551.
36.	ZHAO Y, LI T, WEI X, et al. Mesenchymal stem cell transplantation improves regional cardiac remodeling following ovine infarction[J]. Stem Cells Transl Med, 2012, 1(9):685-695.
37.	ZHU K, LAI H, GUO C, et al. Novel vascular endothelial growth factor gene delivery system-manipulated mesenchymal stem cells repair infarcted myocardium[J].Exp Biol Med (Maywood), 2012, 237(6):678-687.
38.	LEE S Y, HAM O, CHA M J, et al. The promotion of cardiogenic differentiation of hMSCs by targeting epidermal growth factor receptor using microRNA-133a[J]. Biomaterials, 2013, 34(1):92-99.
39.	PENG C, YANG K, XIANG P, et al. Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarction[J]. Int J Cardiol, 2013, 162(3):158-165.
40.	LI Q, TURDI S, THOMAS D P, et al. Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction[J]. Toxicol Lett, 2010, 195(2-3):119-126.
41.	CERRADA I RUIZ-SAURI A, CARRERO R, et al. Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair[J]. Stem Cell Dev, 2013, 22(3):501-511.
42.	XIE J, WANG H, SONG T, et al. Tanshinone IIA and astragaloside IV promote the migration of mesenchy mal stem cells by up-regulation of CXCR4[J]. Protoplasma, 2013, 250(2):521-530.
43.	CAI A, ZHENG D, DONG Y, et al. Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction[J]. Acta Biochim Biophys Sin(Shanghai), 2011, 43(11):857-866.
44.	BAGNO L L, WERNECK-DE-CASTRO J P, OLIVEIRA P F, et al. Adipose-derived stromal cell therapy improves cardiac function after coronary occlusion in rats[J]. Cell Transplant, 2012, 21(9):1985-1996.
45.	OTTO BEITNES J, OIE E, SHAHDADFAR A, et al. Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function[J]. Cell Transplant, 2012, 21(8):1697-1709.
46.	KIM S W, ZHANG H Z, KIM C E, et al. Amniotic mesenchymal stem cells with robust chemotactic properties are effective in the treatment of a myocardial infarction model[J]. Int J Cardiol, 2012[Epub ahead of print].
47.	ZHANG J, CHEN G H, WANG Y W, et al. Hydrogen peroxide preconditioning enhances the therapeutic efficacy of Wharton's Jelly mesenchymal stem cells after myocardial infarction[J]. Chin Med J(Engl), 2012, 125(19):3472-3478.

1. LASALA G P, MINGUELL J J. Bone marrow-derived stem/progenitor cells: their use in clinical studies for the treatment of myocardial infarction[J]. Heart Lung Circ, 2009, 18(3):171-180.
2. GNECCHI M, DANIELI P, CERVIO E. Mesenchymal stem cell therapy for heart disease[J]. Vascul Pharmacol, 2012, 57(1):48-55.
3. VONO R, SPINETTI G, GUBERNATOR M, et al. What's new in regene rative medicine: split up of the mesenchymal stem cell family promises new hope for cardiovascular Repair[J]. J Cardiovasc Transl Res, 2012, 5(5):689-699.
4. KURAITIS D, RUEL M, SUURONEN E J. Mesenchymal stem cell for cardiovascular regeneration[J]. Cardiovasc Drugs Ther, 2011, 25(4): 349-362.
5. WILLIAMS A R, HARE J M. Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease[J]. Circ Res, 2011, 109(8):923-940.
6. HAO L, SUN H, WANG J, et al. Mesenchymal stromal cells for cell therapy: besides supporting hematopoiesis[J]. Int J Hematol, 2012, 95(1):34-46.
7. BADILLO A T, BEGGS K J, JAVAZON E H, et al. Murine bone marrow stromal progenitor cells elicit an in vivo cellular and humoral alloimmune response[J]. Biol Blood Marrow Transplant, 2007, 13(4): 412-422.
8. HARE J M, TRAVERSE J H, HENRY T D, et al. A randomized, double-blind, placebo-controlled,dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction[J]. J Am Coll Cardiol, 2009, 54(24):2277-2286.
9. W?HRLE J, MERKLE N, MAIL?NDER V, et al. Results of intracoronary stem cell therapy after acute myocardial infarction[J]. Am J Cardiol, 2010,105(6):804-812.
10. MADONNA R, CEVIK C, NASSER M, et al. Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regenaration[J]. Thromb Haemost, 2012, 107(4):656-661.
11. JIN Y N, INUBUSHI M, MASAMOTO K, et al. Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model[J]. Gene Ther, 2012, 19(8):836-843.
12. LU F, ZHAO X, WU J, et al. MSCs transfected with hepatocyte growth factor or vascular endothelial growth factor improve cardiac function in the infracted porcine heart by increasing angiogenesis and reducing fibrosis[J]. Int J Cardiol, 2012, 8(3): 467-474.
13. YANG Z J, CHEN B, SHENG Z, et al. Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups[J]. Mol Biol Rep, 2010, 37(4):2075-2081.
14. SAEED M, SALONER D, DO L, et al. Cardiovascular magnetic resonance imaging in delivering and evaluating the efficacy of hepatocyte growth factor gene in chronic infarct scar[J]. Cardiovasc Revasc Med, 2011, 12(2):111-122.
15. WANG S, QIN X, SUN D, et al. Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodeling and function improvement in infracted rat hearts[J]. Cell Biochem Funct, 2012, 30(7):574-581.
16. WEN Z, ZHENG S, ZHOU C, et al. Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction[J]. J Cell Mol Med, 2011, 15(5):1032-1043.
17. DAYAN V, YANNARELLI G, FILOMENO P, et al. Human mesenchymal stromal cells improve scar thickness without enhancing cardiac function in a chronic ischaemic heart failure model[J]. Interact Cardiovasc Thrac, 2012, 14(5):516-520.
18. 舒永華.心梗后骨髓間充質干細胞移植的最佳時間研究[D]. 遵義醫學院, 2011, 6.
19. 刑云利,沈潞華,趙林,等.干細胞移植治療心肌梗死的時機問題[J]. 臨床和實驗醫學雜志,2011,10(4):298-299.
20. 張雷楊,陳鑫,徐順霖,等. 不同劑量的骨髓間充質干細胞移植與改善缺血心臟功能的量效關系[J]. 中國胸心血管外科臨床雜志,2007,14(6):447-451.
21. 郭啟倉,王玉芳,張宇,等. 不同方法移植骨髓間充質干細胞在體內重要器官的分布及分化[J]. 中國組織工程研究與臨床康復,2010,14(23):4275-4280.
22. LE VISAGE C, GOURNAY O, BENGUIRAT N, et al. Mesenchymal stem cell delivery into rat infarcted myocardium using a porous polysaccharide-based scaffold: a quantitative comparison with endocardial injection[J]. Tissue Eng Part A, 2012, 18(1-2):35-44.
23. EUN L Y, SONG B W, CHA M J, et al. Overexpression of phosphoinositide-3-kinase class II alpha enhances mesenchymal stem cell survival in infarcted myocardium[J]. Biochem Biophys Res Commum, 2010, 402(2):272-279.
24. SHU T, ZENG B, REN X, et al. HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium[J]. Tissue Cell, 2010, 42(4):217-222.
25. HERRMANN J L, ABARBANELL A M, WEIL B R, et al. Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-α improves acute myocardial function[J]. Am J Physiol Regul Inteqr Comp Physiol, 2010, 299(1): R371-R378.
26. BAO C, GUO J, ZHENG M, et al. Enhancement of the survival of engrafted mesenchymal stem cells in the ischemic heart by TNFR gene transfection[J]. Biochem Cell Biol, 2010, 88(4):629-634.
27. TANG J, WANG J, GUO L, et al. Mesenchymal stem cells modified with stromal cell-derived factor 1α improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction[J]. Mol Cells, 2010, 29(1):9-19.
28. YANG K, XIANG P, ZHANG C, et al. Magnetic resonance evaluation of transplanted mesenchymal stem cells after myocardial infarction in swine[J]. Can J Cardiol, 2011, 27(6):818-825.
29. LIAN W S, CHENG W T, CHENG C C, et al. In vivo therapy of myocardial infarction with mesenchymal stem cells modified with prostaglandin I synthase gene improves cardiac performance in mice[J]. Life Sci, 2011, 88(9-10):455-464.
30. NUMASAWA Y, KIMURA T, MIYOSHI S, et al. Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis[J]. Stem Cells, 2011, 29(9):1405-1414.
31. WANG D, JIN Y, DING C, et al. Intracoronary delivery of mesenchymal stem cells reduces proarrhythmogenic risks in swine with myocardial infarction[J]. Ir J Med Sci, 2011, 180(2):379-385.
32. TONG Y, XU W, HAN H, et al. Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model[J]. Phytomedicine, 2011, 18(6):443-450.
33. CHO J, ZHAI P, MAEJIMA Y, et al. Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction[J]. Circ Res, 2011, 108(4):478-489.
34. SHINMURA D, TOGASHI I, MIYOSHI S, et al. Pretreatment of human mesenchymal stem cells with pioglitazone improved efficiency of cardiomyogenic transdifferentiation and cardiac function[J]. Stem Cells, 2011, 29(2):357-366.
35. CHI N H, YANG M C, CHUNG T W, et al. Cardiac repair achieved by bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid patches in a rat of myocardial infarction model[J]. Biomaterials, 2012, 33(22):5541-5551.
36. ZHAO Y, LI T, WEI X, et al. Mesenchymal stem cell transplantation improves regional cardiac remodeling following ovine infarction[J]. Stem Cells Transl Med, 2012, 1(9):685-695.
37. ZHU K, LAI H, GUO C, et al. Novel vascular endothelial growth factor gene delivery system-manipulated mesenchymal stem cells repair infarcted myocardium[J].Exp Biol Med (Maywood), 2012, 237(6):678-687.
38. LEE S Y, HAM O, CHA M J, et al. The promotion of cardiogenic differentiation of hMSCs by targeting epidermal growth factor receptor using microRNA-133a[J]. Biomaterials, 2013, 34(1):92-99.
39. PENG C, YANG K, XIANG P, et al. Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarction[J]. Int J Cardiol, 2013, 162(3):158-165.
40. LI Q, TURDI S, THOMAS D P, et al. Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction[J]. Toxicol Lett, 2010, 195(2-3):119-126.
41. CERRADA I RUIZ-SAURI A, CARRERO R, et al. Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair[J]. Stem Cell Dev, 2013, 22(3):501-511.
42. XIE J, WANG H, SONG T, et al. Tanshinone IIA and astragaloside IV promote the migration of mesenchy mal stem cells by up-regulation of CXCR4[J]. Protoplasma, 2013, 250(2):521-530.
43. CAI A, ZHENG D, DONG Y, et al. Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction[J]. Acta Biochim Biophys Sin(Shanghai), 2011, 43(11):857-866.
44. BAGNO L L, WERNECK-DE-CASTRO J P, OLIVEIRA P F, et al. Adipose-derived stromal cell therapy improves cardiac function after coronary occlusion in rats[J]. Cell Transplant, 2012, 21(9):1985-1996.
45. OTTO BEITNES J, OIE E, SHAHDADFAR A, et al. Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function[J]. Cell Transplant, 2012, 21(8):1697-1709.
46. KIM S W, ZHANG H Z, KIM C E, et al. Amniotic mesenchymal stem cells with robust chemotactic properties are effective in the treatment of a myocardial infarction model[J]. Int J Cardiol, 2012[Epub ahead of print].
47. ZHANG J, CHEN G H, WANG Y W, et al. Hydrogen peroxide preconditioning enhances the therapeutic efficacy of Wharton's Jelly mesenchymal stem cells after myocardial infarction[J]. Chin Med J(Engl), 2012, 125(19):3472-3478.

Journal of Biomedical Engineering

Advances in Treatment of Myocardial Infarction by Mesenchymal Stem Cell Transplantation

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