Research Progress of Brain Functional Magnetic Resonance Imaging in Post-traumatic Stress Disorder_Journal of Biomedical Engineering

Authors：

WANGTing ¹ ,  ZHANGJunran ^1,2 , HUANGHua ¹ , GONGQiyong ²

1. Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu 610065, China;
2. Huaxi Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

ZHANGJunran, Email: zhangjunran@126.com

Keywords：

post-traumatic stress disorder; task-related functional magnetic resonance imaging; resting-state functional magnetic resonance imaging

DOI：

10.7507/1001-5515.20140129

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Post-traumatic stress disorder (PTSD) is a mental disorder causing great distress to individuals, families and even society, and there is not yet effective way of unified prevention and treatment up till now. Lots of neuroimaging techniques, however, such as the magnetic resonance imaging, are widely used to the study of the pathogenesis of PTSD with the development of medical imaging. Functional magnetic resonance imaging (fMRI) can be applied to detect the abnormalities not only of the brain morphology but also of the function of various cerebral areas and neural circuit, and plays an important role in studying the pathogenesis of psychiatric diseases. In this paper, we mainly review the task-related and resting-state functional magnetic resonance imaging studies of the PTSD, and finally suggest possible directions for future research.

Citation： WANGTing, ZHANGJunran, HUANGHua, GONGQiyong. Research Progress of Brain Functional Magnetic Resonance Imaging in Post-traumatic Stress Disorder. Journal of Biomedical Engineering, 2014, 31(3): 691-697. doi: 10.7507/1001-5515.20140129 Copy

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2.	王志陽,湯月芬,施慎遜.創傷后應激障礙國內研究現狀[J].上海精神醫學,2006,18(6):372-374.
3.	WANG Z,NEYLAN T C,MUELLER S G,et al.Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder[J].Arch Gen Psychiatry,2010,67(3):296-303.
4.	朱丞,趙虎,孫曉海,等.創傷后應激障礙患者海馬體積及代謝物水平變化的在體研究[J].全科醫學臨床與教育,2011,9(6):619-621.
5.	KLEISER R,STAEMPFLI P,VALAVANIS A,et al.Impact of fMRI-guided advanced DTI fiber tracking techniques on their clinical applications in patients with brain tumors[J].Neuroradiology,2010,52(1):37-46.
6.	BROHAWN K H,OFFRINGA R,PFAFF D L,et al.The neural correlates of emotional memory in posttraumatic stress disorder[J].Biol Psychiatry,2010,68(11):1023-1030.
7.	JURUENA M F,GIAMPIETRO V P,SMITH S D,et al.Amygdala activation to masked happy facial expressions[J].J Int Neuropsychol Soc,2010,16(2):383-387.
8.	HAYES J P,LABAR K S,MCCARTHY G,et al.Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD[J].J Psychiatr Res,2011,45(5):660-669.
9.	陳樹林,李凌江,汪永光,等.前扣帶回與創傷后應激障礙關系的功能磁共振成像研究[J].中國神經精神疾病雜志,2008,34(7):406-409.
10.	CARRION V G,HAAS B W,GARRETT A,et al.Reduced hippocampal activity in youth with posttraumatic stress symptoms:an FMRI study[J].J Pediatr Psychol,2010,35(5):559-569.
11.	張麗,鄭會蓉,李衛暉,等.慢性創傷后應激障礙患者的腦功能磁共振研究[J].中國臨床心理學雜志,2011,19(1):4-9.
12.	KIM M J,CHEY J,CHUNG A,et al.Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder[J].J Psychiatr Res,2008,42(4):268-277.
13.	鄒吉林,周仁來,張環,等.情緒記憶權衡效應:對復雜情緒刺激的記憶[J].心理科學進展,2011,19(10):1460-1470.
14.	張麗,李衛暉,李凌江,等.慢性創傷后應激障礙患者對短期記憶提取任務的腦功能磁共振研究[J].中國臨床心理學雜志,2011,19(2):143-145.
15.	STRIGO I A,SIMMONS A N,MATTHEWS S C,et al.Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence[J].Biol Psychiatry,2010,68(5):442-450.
16.	黃清玲,唐勇,王沛弟,等.創傷后應激障礙患者杏仁核為主的邊緣系統靜息態腦功能磁共振研究[J].中國神經精神疾病雜志,2011,37(12):705-709.
17.	FRINGS L,WAGNER K,QUISKE A,et al.Precuneus is involved in allocentric spatial location encoding and recognition[J].Exp Brain Res,2006,173(4):661-672.
18.	YIN Y,LI L,JIN C,et al.Abnormal baseline brain activity in posttraumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Lett,2011,498(3):185-189.
19.	YIN Y,JIN C,EYLER L T,et al.Altered regional homogeneity in post-traumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Bull,2012,28(5):541-549.
20.	堯德中,羅程,雷旭,等.腦成像與腦連接[J].中國生物醫學工程學報,2011,30(1):6-10.
21.	張曄,邱明國,謝兵,等.創傷后應激障礙患者靜息狀態下腦默認網絡研究[J].第三軍醫大學學報,2011,33(21):2271-2273.
22.	武瑞芝,張俊然,邱昌建,等.地震創傷后應激障礙患者腦靜息態默認網絡研究[J].四川大學學報(醫學版),2011,42(3):397-400.
23.	SRIPADA R K,KING A P,GARFINKEL S N,et al.Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder[J].J Psychiatry Neurosci,2012,37(4):241-249.
24.	YIN Y,JIN C,HU X,et al.Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder:a functional magnetic resonance imaging study[J].Brain Res,2011,1411(2011):98-107.
25.	ZHOU Y,WANG Z,QIN L D,et al.Early altered resting-state functional connectivity predicts the severity of post-traumatic stress disorder symptoms in acutely traumatized subjects[J].PloS one,2012,7(10):1-6.
26.	蔣田仔,劉勇,李永輝.腦網絡:從腦結構到腦功能[J].生命科學,2009,21(2):181-188.
27.	BLUHM R L,WILLIAMSON P C,OSUCH E A,et al.Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma[J].J Psychiatry Neurosci,2009,34(3):187-194.
28.	SRIPADA R K,KING A P,WELSH R C,et al.Neural dysregulation in posttraumatic stress disorder:evidence for disrupted equilibrium between salience and default mode brain networks[J].Psychosom Med,2012,74(9):904-911.
29.	MOREY R A,GOLD A L,LABAR K S,et al.Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group[J].Arch Gen Psychiatry,2012,69(11):1169-1178.
30.	王小玲,李松蔚,錢銘怡.創傷后應激障礙患者情緒記憶優勢研究述評[J].心理科學進展,2012,20(2):248-255.

1. 戚榮豐,盧光明.創傷后應激障礙腦功能神經影像學研究和進展[J].醫學影像學雜志,2012,22(6):1023-1026.
2. 王志陽,湯月芬,施慎遜.創傷后應激障礙國內研究現狀[J].上海精神醫學,2006,18(6):372-374.
3. WANG Z,NEYLAN T C,MUELLER S G,et al.Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder[J].Arch Gen Psychiatry,2010,67(3):296-303.
4. 朱丞,趙虎,孫曉海,等.創傷后應激障礙患者海馬體積及代謝物水平變化的在體研究[J].全科醫學臨床與教育,2011,9(6):619-621.
5. KLEISER R,STAEMPFLI P,VALAVANIS A,et al.Impact of fMRI-guided advanced DTI fiber tracking techniques on their clinical applications in patients with brain tumors[J].Neuroradiology,2010,52(1):37-46.
6. BROHAWN K H,OFFRINGA R,PFAFF D L,et al.The neural correlates of emotional memory in posttraumatic stress disorder[J].Biol Psychiatry,2010,68(11):1023-1030.
7. JURUENA M F,GIAMPIETRO V P,SMITH S D,et al.Amygdala activation to masked happy facial expressions[J].J Int Neuropsychol Soc,2010,16(2):383-387.
8. HAYES J P,LABAR K S,MCCARTHY G,et al.Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD[J].J Psychiatr Res,2011,45(5):660-669.
9. 陳樹林,李凌江,汪永光,等.前扣帶回與創傷后應激障礙關系的功能磁共振成像研究[J].中國神經精神疾病雜志,2008,34(7):406-409.
10. CARRION V G,HAAS B W,GARRETT A,et al.Reduced hippocampal activity in youth with posttraumatic stress symptoms:an FMRI study[J].J Pediatr Psychol,2010,35(5):559-569.
11. 張麗,鄭會蓉,李衛暉,等.慢性創傷后應激障礙患者的腦功能磁共振研究[J].中國臨床心理學雜志,2011,19(1):4-9.
12. KIM M J,CHEY J,CHUNG A,et al.Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder[J].J Psychiatr Res,2008,42(4):268-277.
13. 鄒吉林,周仁來,張環,等.情緒記憶權衡效應:對復雜情緒刺激的記憶[J].心理科學進展,2011,19(10):1460-1470.
14. 張麗,李衛暉,李凌江,等.慢性創傷后應激障礙患者對短期記憶提取任務的腦功能磁共振研究[J].中國臨床心理學雜志,2011,19(2):143-145.
15. STRIGO I A,SIMMONS A N,MATTHEWS S C,et al.Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence[J].Biol Psychiatry,2010,68(5):442-450.
16. 黃清玲,唐勇,王沛弟,等.創傷后應激障礙患者杏仁核為主的邊緣系統靜息態腦功能磁共振研究[J].中國神經精神疾病雜志,2011,37(12):705-709.
17. FRINGS L,WAGNER K,QUISKE A,et al.Precuneus is involved in allocentric spatial location encoding and recognition[J].Exp Brain Res,2006,173(4):661-672.
18. YIN Y,LI L,JIN C,et al.Abnormal baseline brain activity in posttraumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Lett,2011,498(3):185-189.
19. YIN Y,JIN C,EYLER L T,et al.Altered regional homogeneity in post-traumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Bull,2012,28(5):541-549.
20. 堯德中,羅程,雷旭,等.腦成像與腦連接[J].中國生物醫學工程學報,2011,30(1):6-10.
21. 張曄,邱明國,謝兵,等.創傷后應激障礙患者靜息狀態下腦默認網絡研究[J].第三軍醫大學學報,2011,33(21):2271-2273.
22. 武瑞芝,張俊然,邱昌建,等.地震創傷后應激障礙患者腦靜息態默認網絡研究[J].四川大學學報(醫學版),2011,42(3):397-400.
23. SRIPADA R K,KING A P,GARFINKEL S N,et al.Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder[J].J Psychiatry Neurosci,2012,37(4):241-249.
24. YIN Y,JIN C,HU X,et al.Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder:a functional magnetic resonance imaging study[J].Brain Res,2011,1411(2011):98-107.
25. ZHOU Y,WANG Z,QIN L D,et al.Early altered resting-state functional connectivity predicts the severity of post-traumatic stress disorder symptoms in acutely traumatized subjects[J].PloS one,2012,7(10):1-6.
26. 蔣田仔,劉勇,李永輝.腦網絡:從腦結構到腦功能[J].生命科學,2009,21(2):181-188.
27. BLUHM R L,WILLIAMSON P C,OSUCH E A,et al.Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma[J].J Psychiatry Neurosci,2009,34(3):187-194.
28. SRIPADA R K,KING A P,WELSH R C,et al.Neural dysregulation in posttraumatic stress disorder:evidence for disrupted equilibrium between salience and default mode brain networks[J].Psychosom Med,2012,74(9):904-911.
29. MOREY R A,GOLD A L,LABAR K S,et al.Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group[J].Arch Gen Psychiatry,2012,69(11):1169-1178.
30. 王小玲,李松蔚,錢銘怡.創傷后應激障礙患者情緒記憶優勢研究述評[J].心理科學進展,2012,20(2):248-255.

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Research Progress of Brain Functional Magnetic Resonance Imaging in Post-traumatic Stress Disorder

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